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TAT-cyclo-CLLFVY

Catalog #: 5582
1 Citation Datasheet
Catalog # Availability Size / Price Qty
5582/1
TAT-cyclo-CLLFVY
1 Image
Description: Selective HIF-1 dimerization inhibitor

Purity: ≥95%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.

Technical Data

M.Wt:
2559.1
Formula:
C111H188N42O24S2
Sequence:
CLLFVY CGRKKRRQRRRPPQ*

(Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1446322-66-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.
    Miranda E, Nordgren IK, Male AL et al.
    J Am Chem Soc.

Product Datasheets

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Citation for TAT-cyclo-CLLFVY

The citations listed below are publications that use Tocris products. Selected citations for TAT-cyclo-CLLFVY include:

1 Citation: Showing 1 - 1

  1. CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux.
    Authors: Ying Et al.
    Autophagy  2022;18:726-744

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