Tamoxifen citrate
1 Image
Description: Estrogen receptor partial agonist/antagonist
Chemical Name: (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
Purity: ≥99%
Biological Activity
Tamoxifen citrate is an estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo. Also high affinity agonist at the membrane estrogen receptor GPER. Tamoxifen (Cat. No. 6432) is also available.Technical Data
M.Wt:
563.65
Formula:
C26H29NO.C6H8O7
Solubility:
Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
54965-24-1
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir
B Das, C Dobrowolsk, B Luttge, S Valadkhan, N Chomont, R Johnston, P Bacchetti, R Hoh, M Gandhi, SG Deeks, E Scully, J Karn
Proc. Natl. Acad. Sci. U.S.A., 2018;115(33):E7795-E7804. -
Non-steroidal anti-estrogens - receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells.
Wakeling et al.
J.Steroid.Biochem., 1984;20:111 -
Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat.
Mehta et al.
Neuroendocrinology, 2003;77:44 -
Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.
Thomas et al.
Endocrinology, 2005;146:624 -
Tamoxifen and ralox. suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake.
Todorova et al.
Cancer Chemother. Pharmacol., 2011;67:285 -
Both the immunosuppressant SR31747 and the antioestrogen tamox. bind to an emopamil-insensitive site of mammalian Δ8-Δ7 sterol isomerase.
Paul et al.
J.Pharmacol.Exp.Ther., 1998;285:1302
Product Datasheets
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⚠ WARNING: This product can expose you to chemicals including Tamoxifen citrate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
Citations for Tamoxifen citrate
The citations listed below are publications that use Tocris products. Selected citations for Tamoxifen citrate include:
11 Citations: Showing 1 - 10
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Tamoxifen synergizes with 4-(E)-{(4-hydroxyphenylimino)-methylbenzene, 1,2-diol} and 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol}, novel azaresveratrol analogs, in inhibiting the proliferation of breast cancer cells.
Authors: Ronghe Et al.
Oncotarget 2016;7:51747
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HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol.
Authors: Bertrand Et al.
Acta Pharm Sin B 2015;6:894
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DMH1 (4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy.
Authors: Sheng Et al.
J Urol 2015;5:330
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Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia.
Authors: Nicholson Et al.
PLoS One 2015;193:722
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Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone.
Authors: Todd Et al.
FEMS Immunol Med Microbiol 2015;10:e0140260
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Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line.
Authors: Mansouri-Attia Et al.
Biol Reprod 2014;91:100
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Role of GPR30 in mediating OE effects on acetylcholine release in the hippocampus.
Authors: Gibbs Et al.
Horm Behav 2014;66:339
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The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.
Authors: Gutierrez Et al.
J Biol Chem 2014;289:33568
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Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation.
Authors: Antoon Et al.
Cancer Biol Ther 2012;13:1026
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OE shapes auditory processing in the adult brain by regulating inhibitory transmission and plasticity-associated gene expression.
Authors: Tremere Et al.
J Neurosci 2009;29:5949
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Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
Authors: Wieland Et al.
J Neurosci 2006;47:296
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