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SW 033291

Catalog #: 5759 Datasheet
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5759/10
5759/50
SW 033291 | CAS No. 459147-39-8 | Dehydrogenase Inhibitors
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Description: High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation

Chemical Name: 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine

Purity: ≥98%

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Biological Activity

SW 033291 is a high affinity 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (Ki = 0.1 nM). Increases PGE2 levels in A549 cells in vitro, as well as in bone marrow, colon, lung and liver in mice. Promotes hematopoiesis, recovery from DSS-induced colitis, and hepatocyte proliferation after partial hepatectomy in mice.

Technical Data

M.Wt:
412.59
Formula:
C21H20N2OS3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
459147-39-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
    Zhang et al.
    Science, 2015;345:aaa2340

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