Home / Non-selective 5-HT1 Receptor Agonists / Sumatriptan succinate

Sumatriptan succinate

Catalog #: 3586
4 Citations Datasheet
Catalog # Availability Size / Price Qty
3586/10
3586/50
Sumatriptan succinate | CAS No. 103628-48-4 | Non-selective 5-HT1 Receptor Agonists
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Description: 5-HT1A, 5-HT1B and 5-HT1D agonist
Alternative Names: GR 43175

Chemical Name: 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate

Purity: ≥99%

Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Sumatriptan succinate is a 5-HT1 receptor agonist (Ki values are 17, 27 and 100 nM at 5-HT1D, 5-HT1B and 5-HT1A receptors respectively). Antimigraine agent.

Technical Data

M.Wt:
413.49
Formula:
C14H21N3O2S.C4H6O4
Solubility:
Soluble to 100 mM in water and to 75 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
103628-48-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Sumatriptan (GR 43175) interacts selectivity with 5-HT1B and 5-HT1D binding sites.
    Peroutka and McCarthy
    Eur.J.Pharmacol., 1989;163:133
  2. Sumatriptan in acute migraine: pharmacology and review of world experience.
    Peroutka
    Headache, 1990;30:554
  3. Effect of sumatr. in different models of pain in rats.
    Ottani et al.
    Eur.J.Pharmacol., 2004;497:181

Product Datasheets

Citations for Sumatriptan succinate

The citations listed below are publications that use Tocris products. Selected citations for Sumatriptan succinate include:

4 Citations: Showing 1 - 4

  1. Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens.
    Authors: Veronica A Et al.
    Cell Rep  2022;39:110795
  2. Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay.
    Authors: Gadgaard & Jensen
    Biochem Pharmacol  2020;175
  3. Pharmacologic Characterization of ALD1910, a Potent Humanized Monoclonal Antibody against the Pituitary Adenylate Cyclase-Activating Peptide.
    Authors: Leon F Et al.
    J Pharmacol Exp Ther  2019;369:26-36
  4. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
    Authors: Matsui & Alvarez
    Cell Rep  2018;23(13):3852

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