Sulfasalazine

Biological Activity

Sulfasalazine is an inhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system X_c (SXC). Inhibitor of folate transporter 1 (SLC19A1); inhibits cellular uptake of Methotrexate (Cat. No. 1230) and cyclic dinucleotides, including 2',3'-cGAMP (Cat.No. 5945). Anti-inflammatory. Induces ferroptosis.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Potential use fo the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer.
   Lo et al.
   Curr.Oncol., 2010;17:9
2. Sulfasalazine for brain cancer fits.
   Sontheimer and Bridges
   Expert Opin.Invest.Drugs, 2012;21:575
3. Ferroptosis: process and function.
   Xie et al.
   Cell.Death.Differ, 2016;23:369
4. Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis.
   Jansen et al.
   Arthritis Rheum., 2004;50:2130
5. SLC19A1 transports immunoreactive cyclic dinucleotides.
   Luteijn et al.
   Nature, 2019;573:434
6. In vitro and in vivo activity of the nuclear factor-κB inhbitor sulfasal. in human glioblastomas.
   Robe et al.
   Clin.Cancer Res., 2004;10:5595

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