Home / Tachykinin Agonists / Substance P

Substance P

Catalog #: 1156
15 Citations 1 Review Datasheet
Catalog # Availability Size / Price Qty
1156/5
Substance P
1 Image
Description: Sensory neuropeptide; inflammatory mediator

Purity: ≥95%

Product Details
Citations (15)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Substance P is a sensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission.

Technical Data

M.Wt:
1347.6
Formula:
C63H98N18O13S
Sequence:
RPKPQQFFGLM

(Modifications: Met-11 = C-terminal amide)

Solubility:
Soluble to 0.80 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
33507-63-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Tachykinins stimulate a subset of mouse taste cells.
    ,,
    PLoS ONE, 2012;7(2):e31697.
  2. Quinolones Modulate Ghrelin Receptor Signaling: Potential for a Novel Small Molecule Scaffold in the Treatment of Cachexia
    C Torres-Fue, E Pastor-Cav, R Cano, D Kandil, R Shanahan, R Juan, H Shaban, GP McGlacken, H Schelleken
    Int J Mol Sci, 2018;19(6):.
  3. Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice.
    Andoh et al.
    J.Pharmacol.Exp.Ther., 1998;286:1140
  4. Substance P.
    Pernow et al.
    Pharmacol.Rev., 1983;35:85
  5. Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators.
    Walsh et al.
    Br.J.Pharmacol., 1995;114:1343

Product Datasheets

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Citations for Substance P

The citations listed below are publications that use Tocris products. Selected citations for Substance P include:

15 Citations: Showing 1 - 10

  1. Neuropeptide-induced modulation of carcinogenesis in a metastatic breast cancer cell line (MDA-MB-231LUC+).
    Authors: Gutierrez and Boada
    Cancer Cell Int  2019;18:216
  2. Substance P increases CCN2 dependent on TGF-beta yet Collagen Type I via TGF-beta1 dependent and independent pathways in tenocytes.
    Authors: Frara Et al.
    Connect Tissue Res  2018;59:30
  3. Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing.
    Authors: Kowtharapu Et al.
    Int J Mol Sci  2018;19
  4. Endomorphin-2 Inhibition of Substance P Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats.
    Authors: Wan Et al.
    Front Mol Neurosci  2017;9:167
  5. Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors.
    Authors: Nogueras-Ortiz
    Mol Biol Cell  2017;28(24):3554
  6. Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury.
    Authors: Fisher Et al.
    J Cell Commun Signal  2015;9:37
  7. μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain.
    Authors: Chen Et al.
    Neuroscience  2014;267:67
  8. Long-term potentiation of excitatory synaptic strength in spinothalamic tract neurons of the rat spinal cord.
    Authors: Hur and Park
    Korean J Physiol Pharmacol  2013;17:553
  9. Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries.
    Authors: Alsaqati Et al.
    Purinergic Signal  2013;10:241
  10. Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones.
    Authors: Shanley Et al.
    J Neurosci  2011;8:10

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Very good stimulant of mast cells
By Anonymous on 05/30/2018

Used to stimulate mast cells to degranulate.

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