SU 16f
Chemical Name: 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Purity: ≥98%
Biological Activity
SU 16f is a potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM). Promotes conversion of fibroblasts to cardiomyocytes as part of 9C cocktail.For more information about how SU 16f may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Lymphatic endothelial cells support tumor growth in breast cancer.
Lee, Esak, Pandey, Niranjan, Popel, Aleksand
Sci Rep, 2014;4(0):5853. -
Conversion of human fibroblasts into functional cardiomyocytes by small molecules.
Cao et al.
Science, 2016;352:6290 -
Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.
Sun et al.
J.Med.Chem., 1999;42:5120
Product Datasheets
Citations for SU 16f
The citations listed below are publications that use Tocris products. Selected citations for SU 16f include:
5 Citations: Showing 1 - 5
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PDGF inhibits BMP2-induced bone healing.
Authors: Novak Et al.
NPJ Regen Med 2023;8:3
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Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth.
Authors: Chatterjee Et al.
iScience 2019;19:388
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A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion.
Authors: Jiang Et al.
Nat Commun 2017;8:15926
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Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells.
Authors: Andersen Et al.
Proc Natl Acad Sci U S A 2015;6:196
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Lymphatic endothelial cells support tumor growth in breast cancer.
Authors: Lee Et al.
Sci Rep 2014;4:5853
FAQs
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