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Stattic

Catalog #: 2798
18 Citations 1 Review Datasheet
Catalog # Availability Size / Price Qty
2798/10
2798/50
Stattic | CAS No. 19983-44-9 | STAT Inhibitors
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Description: Selective STAT3 inhibitor

Chemical Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide

Purity: ≥98%

Product Details
Citations (18)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Stattic is a small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.

Technical Data

M.Wt:
211.19
Formula:
C8H5NO4S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
19983-44-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity
    PR Taylor, S Roy, EC Meszaros, Y Sun, SJ Howell, CJ Malemud, E Pearlman
    J Leukoc Biol, 2016;0(0):.
  2. IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia.
    Hodge, Lucy S, Ziesmer, Steve C, Yang, Zhi Zhan, Secreto, Frank J, Gertz, Morie A, Novak, Anne J, Ansell, Stephen
    Blood, 2012;120(18):3774-82.
  3. Adiponectin inhibits leptin-induced oncogenic signalling in oesophageal cancer cells by activation of PTP1B.
    Beales I, Garcia-Morales C, Ogunwobi O, Mutungi G
    Mol Cell Endocrinol, 2014;382(1):150-8.
  4. Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival.
    Subramanian K, Neill D, Malak H, Spelmink L, Khandaker S, Dalla Libera Marchiori G, Dearing E, Kirby A, Yang M, Achour A, Nilvebrant J, Nygren P, Plant L, Kadioglu A, Henriques-Normark B
    Nat Microbiol, 0;0(0):.
  5. STAT3 modulation to enhance motor neuron differentiation in human neural stem cells.
    Natarajan, Rajalaxm, Singal, Vinamrat, Benes, Richard, Gao, Junling, Chan, Hoi, Chen, Haijun, Yu, Yongjia, Zhou, Jia, Wu, Ping
    PLoS ONE, 2014;9(6):e100405.
  6. STAT3 Inhibition Enhances the Therapeutic Efficacy of Immunogenic Chemotherapy by Stimulating Type 1 Interferon Production by Cancer Cells.
    Yang H, Yamazaki T, Pietrocola F, Zhou H, Zitvogel L, Ma Y, Kroemer G
    Cancer Res, 2015;75(18):3812-22.
  7. ADAM12 is a Novel Regulator of Tumor Angiogenesis via STAT3 Signaling
    R Roy, A Dagher, C Butterfiel, MA Moses
    Mol. Cancer Res., 2017;0(0):.
  8. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.
    Schust et al.
    Chem.Biol., 2006;13:1235
  9. Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis
    A Kuzumi, A Yoshizaki, KM Matsuda, H Kotani, Y Norimatsu, M Fukayama, S Ebata, T Fukasawa, A Yoshizaki-, Y Asano, K Morikawa, Y Kazoe, K Mawatari, T Kitamori, S Sato
    Nature Communications, 2021;12(1):5947.

Product Datasheets

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Citations for Stattic

The citations listed below are publications that use Tocris products. Selected citations for Stattic include:

18 Citations: Showing 1 - 10

  1. Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes.
    Authors: Petes Et al.
    Front Immunol  2018;9:256
  2. Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells.
    Authors: Fan Et al.
    Cell Death Discov  2018;4:15
  3. Interleukin-22 participates in the inflammatory process of vitiligo.
    Authors: Dong Et al.
    Oncotarget  2017;8:109161
  4. Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells.
    Authors: Banerjee Et al.
    Cell Signal  2017;36:154
  5. Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease.
    Authors: Peda Et al.
    Dis Model Mech  2016;9:1051
  6. STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9.
    Authors: Ko Et al.
    Yonsei Med J  2016;57:761
  7. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling  2016;14:32
  8. STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells.
    Authors: Okada Et al.
    PLoS One  2015;93:461
  9. STAT3 modulation to enhance motor neuron differentiation in human neural stem cells.
    Authors: Natarajan Et al.
    Cancer Res  2014;9:e100405
  10. PropF. mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT.
    Authors: Shravah Et al.
    Nat Commun  2014;3:e29554

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Excellent inhibitor
By Sagar Kale on 08/25/2023
Species: Mouse

Used invivo in mice to inhibit STAT3

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