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SRT 1720

Catalog #: 7558 Datasheet
Catalog # Availability Size / Price Qty
7558/10
7558/50
SRT 1720 | CAS No. 925434-55-5 | Sirtuin 1/SIRT1
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Description: Selective SIRT1 activator; induces autophagy and mitochondrial biogenesis

Chemical Name: N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide

Purity: ≥98%

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Biological Activity

SRT 1720 is selective SIRT 1 activator (EC50 = 0.16 μM). SRT 1720 inhibits growth of bladder cancer organoids and xenografts (IC50 = 0.35 μM) and induces autophagy. In vitro, SRT 1720 increases mitochondrial biogenesis and recovery after oxidation injury and reduces palmitate-induced insulin resistance. Also improves survival and healthspan of obese mice.

Technical Data

M.Wt:
469.56
Formula:
C25H23N7OS
Solubility:
Soluble to 5 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
925434-55-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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