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SR 0987

Catalog #: 5868 Datasheet
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5868/10
5868/50
SR 0987 | CAS No. 303126-97-8 | Nuclear Receptor Agonists
1 Image
Description: T cell-specific RORγ (RORγt) agonist

Chemical Name: 2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide

Purity: ≥98%

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Biological Activity

SR 0987 is a T cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro.

Technical Data

M.Wt:
397.7
Formula:
C16H10ClF6NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
303126-97-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthetic RORγt agonists enhance protective immunity.
    Chang et al.
    ACS Chem.Biol., 2016;11:1012

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