SPT Imidazopyridine 1
Chemical Name: 4-[6-(1-Oxoheptyl)imidazo[1,2-a]pyridin-8-yl]benzeneacetic acid
Purity: ≥98%
Biological Activity
SPT Imidazopyridine 1 is a potent serine palmitoyl transferase (SPT) inhibitor (IC50 = 5 nM). Dose-dependently inhibits incorporation of 14C-serine into ceramide. Reduces plasma ceramide levels in vivo. Also increases plasma HDL and reduces vLDL cholesterol levels in rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Imidazopyridine and pyrazolopiperidine derivatives as novel inhibitors of serine palmitoyl transferase.
Genin et al.
J.Med.Chem., 2016;59:5904
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