SPRi 3

Biological Activity

SPRi 3 is a potent sepiapterin reductase (SPR) inhibitor (IC₅₀ = 53 - 74 nM for human SPR). Inhibits BH4 synthesis pathway and attenuates proliferation in naive CD4⁺ T cells. Suppresses proliferation of human effector CD4⁺ T cells following stimulation. Reduces SPR activity in mouse primary cultures of sensory neurons (IC₅₀ = 450 nM). Ameliorates colitis, suppressing the intestinal infiltration of T cells and other immune cells in vivo. Also reduces immune-cell infiltration into mouse lungs. Reduces neuropathic and inflammatory pain in mouse models.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Tetrahydrobiopterin biosynthesis as a potential target of the kynurenine pathway metabolite xanthurenic acid.
   Haruki et al.
   J.Biol.Chem., 2016;291:652
2. Reduction of neuropathic and inflammatory pain through inhibition of the tetrahydrobiopterin pathway.
   Latremoliere et al.
   Neuron, 2015;86:1393
3. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
   Cronin et al.
   Nature, 2018;563:564

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