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SPOP-i-6lc

Catalog #: 7498 Datasheet
Catalog # Availability Size / Price Qty
7498/10
SPOP-i-6lc | CAS No. 2136270-56-7 | Ubiquitin Ligase (E3) Inhibitors
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Description: SPOP E3 ubiquitin ligase inhibitor

Chemical Name: 1,5-Dihydro-2-imino-10-methyl-N-[2-(4-methyl-1-piperazinyl)ethyl]-5-oxo-1-[2-(2-thienyl)ethyl]-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide

Purity: ≥98%

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Biological Activity

SPOP-i-6lc is a selective SPOP E3 ubiquitin ligase inhibitor (IC50 = 2.1 μM and 3.5 μM, in A498 and OS-RC-2 cell lines, respectively). In vitro, SPOP-i-6lc suppresses viability and proliferation of A498 and OS-RC-2 kidney cancer cell lines. SPOP-i-6lc leads to the accumulation of tumor suppressors PTEN and DUSP7 and decreased levels of phosphorylated AKT and ERK in clear-cell renal cell carcinoma (ccRCC) cell lines.

Technical Data

M.Wt:
505.64
Formula:
C26H31N7O2S
Solubility:
Soluble to 5 mM in ethanol and to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2136270-56-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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