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Spermine tetrahydrochloride

Catalog #: 0958
8 Citations Datasheet
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Spermine tetrahydrochloride | CAS No. 306-67-2 | Additional NMDA Receptor Compounds
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Description: Modulator at polyamine site

Chemical Name: N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

Product Details
Citations (8)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Spermine tetrahydrochloride is a polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.

Technical Data

M.Wt:
348.19
Formula:
C10H26N4.4HCl
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at +4°C
CAS No:
306-67-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Spermine tetrahydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Spermine tetrahydrochloride include:

8 Citations: Showing 1 - 8

  1. Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala.
    Authors: Kim and Cho
    Neuron  2017;95:1129
  2. Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons.
    Authors: Quintana Et al.
    Proc Natl Acad Sci U S A  2015;593:4373
  3. Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function.
    Authors: McGee Et al.
    J Neurosci  2015;35:16171
  4. Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors.
    Authors: Soto Et al.
    J Neurosci  2014;34:11673
  5. NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination.
    Authors: Biase Et al.
    J Physiol  2011;31:12650
  6. Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells.
    Authors: Zonouzi Et al.
    Nat Neurosci  2011;14:1430
  7. Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5.
    Authors: Soto Et al.
    Nat Neurosci  2009;12:277
  8. Stress-induced changes in nucleus accumbens glutamate synaptic plasticity.
    Authors: Campioni Et al.
    J Neurosci  2009;101:3192

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