SP 141
Chemical Name: 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
Purity: ≥98%
Biological Activity
SP 141 is a high affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. SP 141 inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. SP 141 attenuates growth of breast cancer xenograft tumors. SP 141 impairs liposarcoma growth in vitro and in human xenograft models. SP 141 is cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models.
Wang et al.
Nat.Commun., 2014;5:5086
Product Datasheets
Citations for SP 141
The citations listed below are publications that use Tocris products. Selected citations for SP 141 include:
2 Citations: Showing 1 - 2
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MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma.
Authors: Weiming Et al.
Pathol Oncol Res 2023;29:1610801
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MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53.
Authors: Carol Et al.
Proc Natl Acad Sci U S A 2021;118
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