Sodium orthovanadate

Catalog #: 2821 Datasheet

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2821/100

Sodium orthovanadate | CAS No. 13721-39-6 | Protein Tyrosine Phosphatase Inhibitors

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Description: Protein tyrosine phosphatase inhibitor

Chemical Name: Trisodium vanadate

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and ATPases. Suppresses p53-mediated apoptosis by transcription-dependent and -independent pathways.

Technical Data

M.Wt:

183.91

Formula:

Na₃O₄V

Solubility:

Soluble to 100 mM in water

Storage:

Store at RT

CAS No:

13721-39-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Adiponectin inhibits leptin-induced oncogenic signalling in oesophageal cancer cells by activation of PTP1B.
Beales I, Garcia-Morales C, Ogunwobi O, Mutungi G
Mol Cell Endocrinol, 2014;382(1):150-8.
Inhibition of small-intestinal sugar absorption mediated by sodium orthovanadate Na₃VO₄ in rats and its mechanisms.
Ai et al.
World J.Gastroenterol., 2004;10:3612
Therapeutic time window and dose dependence of neuroprotective effects of sodium orthovanadate following transient middle cerebral artery occlusion in rats.
Hasegawa et al.
J.Pharmacol.Exp.Ther., 2006;317:875
Sodium orthovanadate enhances proliferation of progenitor cells in the adult rat subventricular zone after focal cerebral ischemia.
Matsumoto et al.
J.Pharmacol.Exp.Ther., 2006;318:982
Sodium orthovanadate inhibits p53-mediated apoptosis.
Morita et al.
Cancer Res., 2010;70:257

Product Datasheets

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SDS

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