SNAP
Chemical Name: (S)-Nitroso-N-acetylpenicillamine
Biological Activity
SNAP is a stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t½ of 37h.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor.
Cross et al.
Neuropharmacology, 1994;33:915 -
Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production.
Ferrero et al.
Br.J.Pharmacol., 1999;127:779 -
Motor responses in rat ileum evoked by nitric oxide donors vs. field stimulation: modulation by pituitary adenylate cyclase-activating peptide, forskolin and guanylate cyclase inhibitors.
Ekblad and Sundler
J.Pharmacol.Exp.Ther., 1997;283:23 -
Differential thermodynamic effects and tolerance properties of nitrogly. and S-nitrosothiol in experimental heart failure.
Bauer and Fung
J.Pharmacol.Exp.Ther., 1991;256:249
Product Datasheets
Citations for SNAP
The citations listed below are publications that use Tocris products. Selected citations for SNAP include:
10 Citations: Showing 1 - 10
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Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress
Authors: Polter
Elife 2017;6:e23786
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Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors.
Authors: Sánchez Et al.
Br J Pharmacol 2014;171:5682
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Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel.
Authors: Cheng Et al.
FEBS Lett 2011;585:328
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NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor.
Authors: Rodríguez-Muñoz Et al.
Antioxid Redox Signal 2011;14:2413
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Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i
Authors: Sunters Et al.
J Biol Chem 2010;285:8743
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Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
Authors: Huang and Hsu
Cereb Cortex 2010;20:982
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Modulation of inhibitory activity by nitric oxide in the thalamus.
Authors: Yang
J Neurophysiol 2007;97:3386
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Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway.
Authors: Sachs Et al.
Proc Natl Acad Sci U S A 2004;101:3680
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High-Yield Method for Isolation and Culture of Endothelial Cells from Rat Coronary Blood Vessels Suitable for Analysis of Intracellular Calcium and Nitric Oxide Biosynthetic Pathways.
Authors: Nistri Et al.
Evid Based Complement Alternat Med 2002;4:32
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In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
Authors: Fedele Et al.
Br J Pharmacol 1996;119:590
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