SMER 3
Chemical Name: 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
Purity: ≥98%
Biological Activity
SMER 3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads
J Jain, SK Jain, LA Walker, BL Tekwani
BMC Pharmacol Toxicol, 2017;18(1):40. -
Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor.
Aghajanyy et al.
Nat.Biotechnol., 2010;28:738
Product Datasheets
Citation for SMER 3
The citations listed below are publications that use Tocris products. Selected citations for SMER 3 include:
1 Citation: Showing 1 - 1
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Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads.
Authors: Babu L Et al.
BMC Pharmacol Toxicol 2017;18:40
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