SMER 28
Chemical Name: 6-Bromo-N-2-propenyl-4-quinazolinamine
Purity: ≥99%
Biological Activity
SMER 28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases.
Renna et al.
J.Biol.Chem., 2010;285:11061 -
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.
Sarkar et al.
Nat.Chem.Biol., 2010;3:331 -
Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation.
Zhang et al.
Cell Stem Cell, 2016;18:653
Product Datasheets
Citations for SMER 28
The citations listed below are publications that use Tocris products. Selected citations for SMER 28 include:
5 Citations: Showing 1 - 5
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Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.
Authors: Keith Et al.
Nat Commun 2022;13:4146
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The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A.
Authors: Puri Et al.
Dev Cell 2018;45:114
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mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding.
Authors: J K Et al.
Cell 2018;174:338-349.e20
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A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells.
Authors: Cicero Et al.
Sci Rep 2016;6:34798
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Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation.
Authors: Zhang Et al.
Cell Stem Cell 2016;18:653
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