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SKI II

Catalog #: 2097
6 Citations Datasheet
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2097/10
2097/50
SKI II | CAS No. 312636-16-1 | Sphingosine Kinase Inhibitors
1 Image
Description: Selective non-lipid inhibitor of sphingosine kinase

Chemical Name: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol

Purity: ≥98%

Product Details
Citations (6)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SKI II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).

Technical Data

M.Wt:
302.78
Formula:
C15H11ClN2OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
312636-16-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antitumor activity of sphingosine kinase inhibitors.
    French et al.
    J.Pharmacol.Exp.Ther., 2006;318:596
  2. Discovery and evaluation of inhibitors of human sphingosine kinase.
    French et al.
    Cancer Res., 2003;63:5862

Product Datasheets

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Citations for SKI II

The citations listed below are publications that use Tocris products. Selected citations for SKI II include:

6 Citations: Showing 1 - 6

  1. A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis.
    Authors: Seong Et al.
    Cancer Res  2017;77:696
  2. Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex.
    Authors: Reid Et al.
    Am J Nephrol  2015;4:e61
  3. Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.
    Authors: Xun Et al.
    J Exp Clin Cancer Res  2015;34:94
  4. The role of ANK interactions with MYBBP1a and SPHK1 in catabolic events of articular chondrocytes.
    Authors: Minashima Et al.
    Osteoarthritis Cartilage  2014;22:852
  5. A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury.
    Authors: Park Et al.
    Am J Physiol Renal Physiol  2012;303:F721
  6. Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation.
    Authors: Kim Et al.
    J Biol Chem  2010;31:353

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