SKF 97541
Chemical Name: 3-Aminopropyl(methyl)phosphinic acid
Biological Activity
SKF 97541 is a potent GABAB agonist (EC50 = 50 nM). SKF 97541 depresses striatal synaptic potentials and hyperpolarizes nigral neurons (EC50 values = 92 nM and 150 nM, respectively). SKF 97541 shows antidepressant effects in animal models and is also a GABAA-ρ antagonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Electrophysiological characterization of GABAB agonists and antagonists in dorso-lateral septal neurones in vitro.
Bon and Galvan
Br.J.Pharmacol., 1996;118:961 -
Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.
Froestl et al.
J.Med.Chem., 1995;38:3297 -
GABAC receptors: relatively simple transmitter-gated ion channels?
Johnston
TiPS, 1996;17:319 -
Electrophysiological characterization of potent agonists and antagonists on pre- and postsynaptic GABAB receptors on neurones in brain slices.
Seabrook et al.
Br.J.Pharmacol., 1990;101:949
Product Datasheets
Citations for SKF 97541
The citations listed below are publications that use Tocris products. Selected citations for SKF 97541 include:
8 Citations: Showing 1 - 8
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Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila.
Authors: Martelli and Fiala
Elife 2019;8
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Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive.
Authors: Ki and Lim
Elife 2019;8
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FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor.
Authors: Lecat-Guillet
Cell Chem Biol 2017;24(3):360
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Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila.
Authors: Ignell Et al.
Br J Pharmacol 2009;106:13070
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A presynaptic gain control mechanism fine-tunes olfactory behavior.
Authors: Root Et al.
Neuron 2008;59:311
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Differential regulation of mor. antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice.
Authors: Chen Et al.
Mol Pain 2008;4:41
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Peripheral GABAB agonists stimulate gastric acid secretion in mice.
Authors: Piqueras and Martínez
Br J Pharmacol 2004;142:1038
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The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
Authors: Wood Et al.
Mol Pain 2000;131:1050
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