Sitagliptin phosphate

Catalog #: 6816 Datasheet

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Sitagliptin phosphate | CAS No. 654671-78-0 | DPPIV/CD26 Inhibitors

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Description: Potent and selective DPP IV inhibitor

Chemical Name: (3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate

Purity: ≥98%

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Sitagliptin phosphate is a potent and selective DPP IV (DPP4) inhibitor (IC₅₀ = 18 nM). Displays >2600-fold selectivity for DPP IV over other proline specific peptidases. Reduces blood glucose and increases GLP-1 levels after oral glucose tolerance test in normal and diet-induced obese mice.

Technical Data

M.Wt:

505.31

Formula:

C₁₆H₁₅F₆N₅O.H₃O₄P

Solubility:

Soluble to 50 mM in water and to 50 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

654671-78-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-α]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Kim et al.
J.Med.Chem., 2005;48:141

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