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SGC 6870

Catalog #: 7182 Datasheet
Catalog # Availability Size / Price Qty
7182/25
7182/5
SGC 6870 | CAS No. 2561471-27-8 | Protein Arginine Methyltransferase Inhibitors
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Description: Potent and selective PRMT6 allosteric inhibitor

Chemical Name: (R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one

Purity: ≥98%

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Biological Activity

SGC 6870 is a potent and selective protein arginine methyltransferase 6 (PRMT6) allosteric inhibitor (IC50 = 77 nM). Exhibits selectivity over all other PRMTs and 23 methyltransferases. In HEK293T cells overexpressing PRMT6, inhibits asymmetric dimethylation of H3R2 (IC50 = 0.8 μM)

Negative control SGC 6870N (Cat. No. 7184) also available.

Technical Data

M.Wt:
469.4
Formula:
C23H21BrN2O2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2561471-27-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 6870 probe summary on the SGC website.

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