SGC 3027

Catalog #: 6825 Datasheet

Catalog #	Availability	Size / Price	Qty
6825/5

SGC 3027 | CAS No. 2624313-13-7 | Protein Arginine Methyltransferase Inhibitors

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Description: Potent and selective PRMT7 inhibitor

Chemical Name: N-(4-((((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butyl)-N-((4'-chloro-[1,1'-biphenyl]-3-yl)methyl)-3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide

Purity: ≥97%

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SGC 3027 is a potent and selective PRMT7 inhibitor (IC₅₀ < 2.5 nM); pro-drug of SGC 8158. Methylates H2B (23-37). Exhibits > 40-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits methylation of HSP70 in C2C12 cells.

Negative control, SGC 3027N (Cat. No. 6838) also available.

Technical Data

M.Wt:

787.37

Formula:

C₄₁H₄₇ClN₆O₆S

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥97%

Storage:

Store at -20°C

CAS No:

2624313-13-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 3027 probe summary on the SGC website.

Background References

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress responses.
Szewczyk et al.
Nat.Commun., 2020;11:2396

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