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SEN 177

Catalog #: 6979 Datasheet
Catalog # Availability Size / Price Qty
6979/10
6979/50
SEN 177 | CAS No. 2117405-13-5 | Other Transferase Inhibitors
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Description: Potent glutaminyl cyclase inhibitor; disrupts binding of SIRP-α to CD47

Chemical Name: 6'-Fluoro-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3'-bipyridine

Purity: ≥98%

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Biological Activity

SEN 177 is a potent glutaminyl cyclase (QPCT) inhibitor (IC50 = 53 nM). SEN 177 reduces aggregation of mutant huntingtin (mHTT) through inhibition of QPCT and reduces Q80 aggregates in vitro. Inhibition of QPCT also reduces aggregate formation in in vivo models of Huntington's disease. SEN 177 potently inhibits QPCT-like protein (IC50 = 13 nM) and disrupts binding of SIRP-α to CD47. The compound increases antibody-dependent cellular phagocytosis and cytotoxicity in cancer cell lines.

Technical Data

M.Wt:
338.39
Formula:
C18H19FN6
Solubility:
Soluble to 20 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2117405-13-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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