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SecinH3

Catalog #: 2849
4 Citations Datasheet
Catalog # Availability Size / Price Qty
2849/5
SecinH3 | CAS No. 853625-60-2 | ARF GTPase Inhibitors
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Description: Sec7-specific GEF inhibitor; selective for cytohesin family

Chemical Name: N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide

Purity: ≥98%

Product Details
Citations (4)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SecinH3 is a Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.

Technical Data

M.Wt:
460.5
Formula:
C24H20N4O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
853625-60-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SecinH3

The citations listed below are publications that use Tocris products. Selected citations for SecinH3 include:

4 Citations: Showing 1 - 4

  1. CLIC4/Arf6 Pathway.
    Authors: Abdul-Salam Et al.
    Circ Res  2019;124:52
  2. Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry.
    Authors: Ford Et al.
    PLoS Pathog  2018;14:e1007051
  3. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport.
    Authors: Guichard Et al.
    PLoS Pathog  2017;13:e1006603
  4. Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype.
    Authors: Risse Et al.
    Pain  2011;300:L958

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