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SB 505124

Catalog #: 3263
5 Citations Datasheet
Catalog # Availability Size / Price Qty
3263/10
3263/50
SB 505124 | CAS No. 694433-59-5 | TGF-beta Receptor Inhibitors
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Description: Selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine

Purity: ≥98%

Product Details
Citations (5)
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Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SB 505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF-β and activin; does not inhibit other ALK family members. Promotes adenine base editor activity in vivo and in vitro at 10 μM.

Technical Data

M.Wt:
335.4
Formula:
C20H21N3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 2eq. HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
694433-59-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing
    SS Adkar, CL Wu, VP Willard, A Dicks, A Ettyreddy, N Steward, N Bhutani, CA Gersbach, F Guilak
    Stem Cells, 2018;0(0):.
  2. Myostatin regulates energy homeostasis in the heart and prevents heart failure.
    Biesemann N, Mendler L, Wietelmann A, Hermann S, Schafers M, Kruger M, Boettger T, Borchardt T, Braun T
    Circ Res, 2014;115(2):296-310.
  3. Reactive oxygen species production via NADPH oxidase mediates TGF-β-induced cytoskeletal alterations in endothelial cells.
    Hu et al.
    Am.J.Physiol.Renal Physiol., 2005;289:F816
  4. The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis.
    Noma et al.
    Gastroenterology, 2008;134:1981
  5. SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7.
    Byfield et al.
    Mol.Pharmacol., 2004;65:744

Product Datasheets

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Citations for SB 505124

The citations listed below are publications that use Tocris products. Selected citations for SB 505124 include:

5 Citations: Showing 1 - 5

  1. Establishment of mouse expanded potential stem cells.
    Authors: Yang Et al.
    Nature  2017;550:393
  2. Potential role of indoleamine 2,3-dioxygenase in primary biliary cirrhosis.
    Authors: Asghar Et al.
    Oncol Lett  2017;14:5497
  3. Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis.
    Authors: Zhu Et al.
    Oncogene  2016;35:5388
  4. A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain.
    Authors: Boxtel Et al.
    Dev Cell  2015;35:175
  5. The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands.
    Authors: Ramel and Hill
    Dev Biol  2013;378:170

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