SB 297006
1 Image
Description: Potent and selective CCR3 antagonist
Chemical Name: N-Benzoyl-4-nitroaniline ethyl ester
Purity: ≥99%
Biological Activity
SB 297006 is a potent and selective CCR3 antagonist (IC50 = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC50 >27 μM). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC50 values are 80, 90 and 210 nM respectively).Technical Data
M.Wt:
342.35
Formula:
C18H18N2O5
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
58816-69-6
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Quantitative structure-activity relationships of D- and L-N-actyl-alpha-aminoamide ligands binding to chymotrypsin. On the problem of combined treatment of stereoisomers.
Yoshimoto and Hansch
J.Org.Chem., 1976;41:2269 -
Identification of a potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration.
White et al.
J.Biol.Chem., 2000;275:36626
Product Datasheets
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for SB 297006
There are currently no reviews for this product. Be the first to review SB 297006 and earn rewards!
Have you used SB 297006?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris Bioscience is the leading supplier of novel and exclusive
tools for
life science research with over 30 years' experience in the
industry.
Tocris is a Bio-Techne brand.
