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SB 24011

Catalog #: 8010 Datasheet
Catalog # Availability Size / Price Qty
8010/5
SB 24011 | CAS No. 1497415-41-4 | Protein Dimerizers
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Description: Inhibitor of STING-TRIM29 interaction; increases cellular STING levels

Chemical Name: 4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide

Purity: ≥98%

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Biological Activity

SB 24011 is an inhibitor of STING-TRIM29 interaction (IC50 = 3.85 μM in vitro). SB 24011 binds to STING and inhibits TRIM29-E3 ligase interaction to increase cellular STING levels. In syngeneic mouse models, SB 24011 dose-dependently reduces CT26 and B16F10 tumor volumes when co-admistered with cGAMP.

Technical Data

M.Wt:
614.7
Formula:
C34H38N4O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1497415-41-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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