Sal 003
Chemical Name: 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Purity: ≥99%
Biological Activity
Sal 003 is a cell-permeable inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Shown to prevent the induction of hippocampal long-term potentiation (LTP) and memory formation (LTM) in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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PKR and PKR-like endoplasmic reticulum kinase induce the protease-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2α phosphorylation.
Raven et al.
J.Biol.Chem., 2008;283:3097 -
The eIF2α kinases PERK and PKR activate glucogen synthase kinase 3 to promote the proteasomal degradation of p53.
Baltiz et al.
J.Biol.Chem., 2007;282:31675 -
eIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.
Costa-Mattioli et al.
Cell, 2007;129:195
Product Datasheets
Citations for Sal 003
The citations listed below are publications that use Tocris products. Selected citations for Sal 003 include:
5 Citations: Showing 1 - 5
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Integrated Stress Response Regulation of Corneal Epithelial Cell Motility and Cytokine Production.
Authors: Albert S Et al.
Invest Ophthalmol Vis Sci 2022;63:1
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Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
Authors: Jing Et al.
Cell Rep 2022;40:111092
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Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.
Authors: Jing Et al.
Mol Cell 2021;81:4191-4208.e8
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GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells.
Authors: Krokowski
Cell Rep 2017;21(10):2895
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Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice.
Authors: Devi and Ohno
PLoS One 2010;5:e12974
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