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SAG dihydrochloride

Catalog #: 6390
3 Citations Datasheet
Catalog # Availability Size / Price Qty
6390/1
6390/10
SAG dihydrochloride | CAS No. 2702366-44-5 | Smoothened Receptor Agonists
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Description: Dihydrochloride salt of SAG; Smo receptor agonist

Chemical Name: 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity

SAG dihydrochloride is a water-soluble dihydrochloride salt of SAG (Cat. No. 4366). SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM) and induces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons. The compound can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

Technical Data

M.Wt:
562.98
Formula:
C28H28ClN3OS.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2702366-44-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SAG dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SAG dihydrochloride include:

3 Citations: Showing 1 - 3

  1. Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation.
    Authors: Madeline A Et al.
    Nat Genet  2021;53:304-312
  2. HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened.
    Authors: Lucia Et al.
    J Lipid Res  2020;61:492-504
  3. Trisomy 21 Represses Cilia Formation and Function.
    Authors: Joaquin M Et al.
    Dev Cell  2018;46:641-650.e6

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