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SAG 21k

Catalog #: 5282
3 Citations Datasheet
Catalog # Availability Size / Price Qty
5282/10
SAG 21k | CAS No. 946002-48-8 | Hedgehog Signaling Activators
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Description: Hedgehog signaling activator; brain penetrant and orally bioavailable

Chemical Name: 3-Chloro-4,7-difluoro-N-[[2-methoxy-5-(4-pyridinyl)phenyl]methyl]-N-trans-4-(methylamino)cyclohexyl]benzo[b]thiophene-2-carboxamide

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SAG 21k is a potent Hedgehog signaling activator (EC50 = 0.4 nM). Orally bioavailable and brain penetrant.

Technical Data

M.Wt:
556.07
Formula:
C29H28ClF2N3O2S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
946002-48-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Potent agonists of the Hedgehog signaling pathway.
    Brunton et al.
    Bioorg.Med.Chem.Lett., 2009;19:4308

Product Datasheets

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Citations for SAG 21k

The citations listed below are publications that use Tocris products. Selected citations for SAG 21k include:

3 Citations: Showing 1 - 3

  1. Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration
    Authors: Norris Et al.
    Nat Commun  2023;14:3766
  2. Paraxial mesoderm organoids model development of human somites.
    Authors: Olivier Et al.
    Elife  2022;11
  3. Hedgehog signaling promotes endoneurial fibroblast migration and Vegf-A expression following facial nerve injury.
    Authors: M Et al.
    Brain Res  2021;1751:147204

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