Home / mAChR M2 Antagonists / (S)-(+)-Dimethindene maleate

(S)-(+)-Dimethindene maleate

Catalog #: 1425
6 Citations Datasheet
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1425/10
1425/50
(S)-(+)-Dimethindene maleate | CAS No. 136152-65-3 | mAChR M2 Antagonists
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Description: Selective M2 antagonist

Chemical Name: N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate

Purity: ≥99%

Product Details
Citations (6)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

(S)-(+)-Dimethindene maleate is an enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Also H1 histamine receptor antagonist (pKi = 7.48). Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), minocycline hydrochloride (Cat.No. 3268) and human leukemia inhibitory factor.

For more information about how Dimethindene maleate may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail).

Technical Data

M.Wt:
408.5
Formula:
C20H24N2.C4H4O4
Solubility:
Soluble to 100 mM in water with gentle warming
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
136152-65-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for (S)-(+)-Dimethindene maleate

The citations listed below are publications that use Tocris products. Selected citations for (S)-(+)-Dimethindene maleate include:

6 Citations: Showing 1 - 6

  1. Generation of blastocyst-like structures from mouse embryonic and adult cell cultures.
    Authors: Li Et al.
    Cell  2019;179:687
  2. Efficient derivation of extended pluripotent stem cells from NOD-scid Il2rg-/- mice.
    Authors: Du Et al.
    Protein Cell  2019;10:31
  3. Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system.
    Authors: Xu Et al.
    Stem Cell Res Ther  2019;10:193
  4. Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation.
    Authors: Li Et al.
    Protein Cell  2018;
  5. Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency.
    Authors: Yang Et al.
    Cell  2017;169:243
  6. Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats.
    Authors: Matsumoto Et al.
    Urology  2010;75:862

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