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(S)-Crizotinib

Catalog #: 6025
1 Citation Datasheet
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(S)-Crizotinib | CAS No. 1374356-45-2 | MTH1 Inhibitors
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Description: MTH1 inhibitor

Chemical Name: 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(S)-Crizotinib is a potent MTH1 inhibitor (IC50 = 72 nM). Induces DNA damage and disrupts nucleotide pool homeostasis in cancer cells. Also attenuates colony formation of KRAS-mutated PANC1 cells in vitro. Suppresses tumor growth ~50% in a colon cancer carcinoma xenograft model.

Technical Data

M.Wt:
450.34
Formula:
C21H22Cl2FN5O
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in 1eq. HCl with gentle warming
Purity:
≥98%
Storage:
Store at RT
CAS No:
1374356-45-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc

Background References

  1. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
    Huber et al.
    Nature, 2014;508:222

Product Datasheets

Citation for (S)-Crizotinib

The citations listed below are publications that use Tocris products. Selected citations for (S)-Crizotinib include:

1 Citation: Showing 1 - 1

  1. The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization.
    Authors: Noemi Et al.
    Oncogene  2020;39:603-616

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