RWJ 67657

Catalog #: 2999 Datasheet

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RWJ 67657 | CAS No. 215303-72-3 | p38 Inhibitors

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Description: Potent, selective p38α and p38β inhibitor

Chemical Name: 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol

Purity: ≥98%

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

RWJ 67657 is a selective p38α and p38β inhibitor (IC₅₀ values are 1 and 11 μM respectively) that displays no activity at p38γ, p38δ and a range of other kinases. Potently inhibits TNF-α and IL-1β release (IC₅₀ values are 3 and 11 nM respectively) and suppresses HIV-1 replication in T cells in vitro. Displays cardioprotective and anti-inflammatory activity in vivo. Orally active.

Technical Data

M.Wt:

425.5

Formula:

C₂₇H₂₄FN₃O

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at RT

CAS No:

215303-72-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Suppresssion of HIV-1 viral replication and cellular pathogenesis by a novel p38/JNK kinase inhibitor.
Muthumani et al.
AIDS, 2004;18:739
p38 mitogen activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling fowllowing myocardial infarction in the rat.
See et al.
J.Am.Coll.Cardiol., 2004;44:1679

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