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RuBi GABA trimethylphosphine

Catalog #: 4709 Datasheet
Catalog # Availability Size / Price Qty
4709/10
RuBi GABA trimethylphosphine | GABA-B Receptor Agonists
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Description: Caged GABA; inhibits neural activity
Alternative Names: RuBi-GABA-PMe3

Chemical Name: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-4-aminobutyric acid ruthenium complex sodium hexafluorophosphate salt

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Biological Activity

RuBi GABA trimethylphosphine is a modified version of RuBi-GABA (Cat. No. 3400). Suppresses cortical local field potential (LFP) activity in anesthetized mice after activation with a blue laser pulse (473 nm); inhibits neural activity.

Technical Data

M.Wt:
904.56
Formula:
C27H33N5O2PRu.PF6.NaPF6
Solubility:
Soluble to 50 mM in water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under licence from Columbia University

Background References

  1. RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity.
    Filevich et al.
    Photochem.Photobiol.Sci., 2013;12:1565
  2. In vivo photorelease of GABA in the mouse cortex.
    Lopes-dos-Santos et al.
    Braz.J.Med.Biol.Res., 2011;44:688

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