(RS)-(±)-Sulpiride
Chemical Name: (RS)-(±)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
Purity: ≥98%
Biological Activity
(RS)-(±)-Sulpiride is a standard D2-like dopamine receptor antagonist.S-enantiomer also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
DA receptor pharmacology.
Seeman and Van Tol
Trends Pharmacol.Sci., 1994;15:264 -
DA D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective.
Seeman and Van Tol
Eur.J.Pharmacol., 1993;233:173
Product Datasheets
Citations for (RS)-(±)-Sulpiride
The citations listed below are publications that use Tocris products. Selected citations for (RS)-(±)-Sulpiride include:
7 Citations: Showing 1 - 7
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DA D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice.
Authors: Huang
Invest Ophthalmol Vis Sci 2018;59(6):2623
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DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs.
Authors: Zhang Et al.
Invest Ophthalmol Vis Sci 2018;59(11):4441
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Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
Authors: Matsui and Alvarez
Cell Rep 2018;23(13):3852
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Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex.
Authors: Leyrer-Jackson
Physiol Rep 2017;5(22):e13499
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Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues.
Authors: Holroyd Et al.
Brain 2015;40:1495
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Sucrose produces withdrawal and DA-sensitive reinforcing effects in planarians.
Authors: Zhang Et al.
Physiol Behav 2013;112-113:8
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Exposure to extremely low frequency magnetic fields induces fos-related antigen-immunoreactivity via activation of DArgic d1 receptor.
Authors: Shin Et al.
Neuropsychopharmacology 2011;20:130
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