RS 504393

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer.
   Mazumdar, Sohini, Arendt, Lisa M, Phillips, Sarah, Sedic, Maja, Kuperwasser, Charlott, Gill, Grace
   PLoS ONE, 2015;10(3):e0121281.
2. Secreted Ectodomain of SIGLEC-9 and MCP-1 Synergistically Improve Acute Liver Failure in Rats by Altering Macrophage Polarity
   T Ito, M Ishigami, Y Matsushita, M Hirata, K Matsubara, T Ishikawa, H Hibi, M Ueda, Y Hirooka, H Goto, A Yamamoto
   Sci Rep, 2017;7(0):44043.
3. Levo-Corydalmine Alleviates Neuropathic Cancer Pain Induced by Tumor Compression via the CCL2/CCR2 Pathway
   Y Hu, ND Kodithuwak, L Zhou, C Li, D Han, W Fang, J Liu, Y Li
   Molecules, 2017;22(6):.
4. A circadian clock gene, Rev-erbalpha, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.
   Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T
   J Immunol, 2014;192(1):407-17.
5. Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages
   Takuya Matsumoto
   Arthritis Res Ther, 2016;18(1):133.
6. Monocytes infiltrate the pancreas via the MCP-1/CCR2 pathway and differentiate into stellate cells.
   Ino K, Masuya M, Tawara I, Miyata E, Oda K, Nakamori Y, Suzuki K, Ohishi K, Katayama N
   PLoS ONE, 2014;9(1):e84889.
7. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity.
   Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, Hashimoto N, Imagama S, Ishiguro N, Suzumura A, Ueda M, Furukawa K, Yamamoto A
   J Neurosci, 2015;35(6):2452-64.
8. Host gene-encoded severe lung TB: from genes to the potential pathways.
   Ganachari, M, Guio, H, Zhao, N, Flores-Villanueva, P O
   Genes Immun, 2012;13(8):605-20.
9. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
   Lourenco S, Teixeira V, Kalber T, Jose R, Floto R, Janes S
   J Immunol, 2015;194(7):3463-74.
10. Defective TGF-beta signaling in bone marrow-derived cells prevents hedgehog-induced skin tumors.
    Fan Q, Gu D, Liu H, Yang L, Zhang X, Yoder M, Kaplan M, Xie J
    Cancer Res, 2014;74(2):471-83.
11. The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent colitis
    X Pei, D Zheng, S She, J Ma, C Guo, X Mo, Y Zhang, Q Song, Y Zhang, D Ma, Y Wang
    Sci Rep, 2017;7(1):5107.
12. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists.
    Mirzadegan et al.
    J.Biol.Chem., 2000;275:25562
13. CCR2 signaling contributes to ischemia-reperfusion injury in kidney.
    Furuichi et al.
    J.Am.Soc.Nephrol., 2003;14:2503
14. Blockade of CCR2 ameliorates progressive fibrosis in kidney.
    Kitagawa et al.
    Am.J.Pathol., 2004;165:237
15. PD-1 blockade inhibits osteoclast formation and murine bone cancer pain
    K Wang, Y Gu, Y Liao, S Bang, CR Donnelly, O Chen, X Tao, AJ Mirando, MJ Hilton, RR Ji
    J. Clin. Invest., 2020;0(0):.

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