RS 100329 hydrochloride

Catalog #: 1325
3 Citations Datasheet

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RS 100329 hydrochloride | CAS No. 1215654-26-4 | Adrenergic alpha-1 Receptor Antagonists

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Description: Potent, subtype-selective α1A antagonist

Chemical Name: 5-Methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione hydrochloride

Purity: ≥99%

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Product Details

Citations (3)

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

RS 100329 hydrochloride is a subtype-selective α_1A-adrenoceptor antagonist (pK_i = 9.6 for human cloned α_1A receptors). Displays 126- and 50-fold selectivity over human α_1B and α_1D receptors respectively. Active in vivo.

Technical Data

M.Wt:

462.89

Formula:

C₂₀H₂₅F₃N₄O₃.HCl

Solubility:

Soluble to 100 mM in water

Purity:

≥99%

Storage:

Store at RT

CAS No:

1215654-26-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold with the permission of Roche Bioscience

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
The role of α₁-adrenoceptors and 5-HT_1A receptors in the control of the micturition reflex in male anaesthetized rats.
Conley et al.
Br.J.Pharmacol., 2001;133:61
α_1L-Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man.
Shannon Kava et al.
Br.J.Pharmacol., 1998;123:1359
In vitro α₁-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel α_1A-adrenoceptor selective antagonists.
Williams et al.
Br.J.Pharmacol., 1999;127:252

Product Datasheets

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Citations for RS 100329 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for RS 100329 hydrochloride include:

3 Citations: Showing 1 - 3

Identification of a new pharmacological activity of the phenylpiperazine derivative naftopidil: tubulin-binding drug.
Authors: Ishii and Sugimura
Front Cell Neurosci 2015;8:42618
High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes.
Authors: Zacharia Et al.
PLoS One 2013;8:e65969
Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens.
Authors: Cleary Et al.
Br J Pharmacol 2004;143:745

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