RP 001 hydrochloride
Chemical Name: N-[4-[5-[3-Cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine hydrochloride
Purity: ≥98%
Biological Activity
RP 001 hydrochloride is a potent agonist of S1P1 receptors (EC50 = 9 pM). Induces internalization and polyubiquitination of S1P1 in vitro. Selective for S1P1 over S1P2 - S1P4.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A sphingosine-1-phosphate receptor 1 agonist inhibits tertiary lymphoid tissue reactivation and hypersensitivity in the lung
CA Huppé, P Blais Leco, A Lechasseur, DR Gendron, AM Lemay, EY Bissonnett, MR Blanchet, C Duchaine, MC Morissette, H Rosen, D Marsolais
Mucosal Immunol, 2017;0(0):. -
Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in mice.
Cahalan et al.
Nat.Chem.Biol., 2011;7:254
Product Datasheets
Citations for RP 001 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for RP 001 hydrochloride include:
2 Citations: Showing 1 - 2
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RP001 hydrochloride improves neurological outcome after subarachnoid hemorrhage.
Authors: Li Et al.
J.Neurol.Sci. 2019;399:6
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Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.
Authors: Masato Et al.
Cell 2018;174:636-648.e18
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