RN 1 dihydrochloride
Chemical Name: 1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride
Purity: ≥97%
Biological Activity
RN 1 dihydrochloride is a potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50 values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Brain-penetrant LSD1 inhibitors can block memory consolidation.
Neelamegam et al.
ACS Chem.Neurosci., 2012;3:120
Product Datasheets
Citation for RN 1 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for RN 1 dihydrochloride include:
1 Citation: Showing 1 - 1
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HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.
Authors: Llewellyn Et al.
J Neurovirol 2018;24:192
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