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Risperidone

Catalog #: 2865
2 Citations Datasheet
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2865/10
2865/50
Risperidone | CAS No. 106266-06-2 | 5-HT2A Receptor Antagonists
1 Image
Description: 5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
Alternative Names: R 64 766

Chemical Name: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Purity: ≥99%

Product Details
Citations (2)
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Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Risperidone is an atypical antipsychotic agent that displays 5-HT2A receptor antagonism. Also displays high affinity at D2 receptors (Ki values are 0.4 and 3.13 nM for 5-HT2A and D2 receptors respectively).

Technical Data

M.Wt:
410.48
Formula:
C23H27FN4O2
Solubility:
Soluble to 10 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
106266-06-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Risperidone: a novel antipsychotic with balanced serotonin-DA antagonism, receptor occupancy profile, and pharmacologic activity.
    Leysen et al.
    J.Clin.Psychiatry, 1994;55:5
  2. Biochemical profile of risperidone, a new antipsychotic.
    Leysen et al.
    J.Pharmacol.Exp.Ther., 1988;247:661
  3. Risperidone: a novel antipsychotic with many "atypical" properties.
    Stathis et al.
    Psychopharmacol., 1996;127:181
  4. Structure of the D2 DA receptor bound to the atypical antipsychotic drug risperidone
    Wang et al.
    Nature, 2018;555:269

Product Datasheets

Citations for Risperidone

The citations listed below are publications that use Tocris products. Selected citations for Risperidone include:

2 Citations: Showing 1 - 2

  1. Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro.
    Authors: Canfrán-Duque Et al.
    Sci Rep  2015;10:e0141829
  2. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
    Authors: Kurita Et al.
    Nat Neurosci  2012;15:1245

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