RHPS 4 methosulfate
Chemical Name: 3,11-Difluoro-6,8,13-trimethylquino[4,3,2-kl]acridinium methylsulfate
Purity: ≥98%
Biological Activity
RHPS 4 methosulfate is a telomerase inhibitor. Inhibits growth of medulloblastoma and glioblastoma cells in vitro. Induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice. Sensitizes radiation resistant glioblastoma cell lines to radiation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.
Lagah et al.
PLoS One, 2014;9:e86187 -
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
Salvati et al.
J.Clin.Invest., 2007;117:3236 -
Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.
Phatak et al.
Br.J.Cancer, 2007;96:1223 -
The G-quadruplex-stabilising agent RHPS4 induces telomeric dysfunction and enhances radiosensitivity in glioblastoma cells.
Berardinelli et al.
DNA Repair (Amst.), 2015;25:104 -
RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome
W Wu, R Bhowmick, I Vogel, Ö Özer, F Ghisays, RS Thakur, E Sanchez de, PH Richter, L Ren, JH Petrini, ID Hickson, Y Liu
Nat. Struct. Mol. Biol., 2020;27(5):424-437.
Product Datasheets
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