Home / Class I Histone Deacetylases Inhibitors / RGFP 966

RGFP 966

Catalog #: 6728
1 Citation Datasheet
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6728/25
RGFP 966 | CAS No. 1357389-11-7 | Class I Histone Deacetylases Inhibitors
1 Image
Description: Potent and selective HDAC3 inhibitor

Chemical Name: (2E)-N-(2-Amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

RGFP 966 is a potent and selective HDAC3 inhibitor (IC50 = 80 nM); exhibits no effect on other HDAC (up to 15 μM). RGFP 966 reduces the frequency of striatal CAG repeat expansions in mouse models of Huntington's disease and reduces mHTT accumulation. RGFP 966 blocks the formation of reactive astrocytes and, in vivo, it is neuroprotective and enhances long-term object-location memory.

Technical Data

M.Wt:
362.4
Formula:
C21H19FN4O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1357389-11-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner.
    Malvaez et al.
    Proc.Natl.Acad.Sci.USA., 2013;110:2647

Product Datasheets

Citation for RGFP 966

The citations listed below are publications that use Tocris products. Selected citations for RGFP 966 include:

1 Citation: Showing 1 - 1

  1. NF-κB-dependent repression of Sox18 transcription factor requires the epigenetic regulators histone deacetylases 1 and 2 in acute lung injury.
    Authors: Ting Et al.
    Front Physiol  2022;13:947537

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