Resveratrol

Biological Activity

Resveratrol is a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. Inhibits cytochrome P450 1A1 (IC₅₀ = 23 μM) and displays mixed agonist/antagonist actions at ERα and ERβ estrogen receptors. Converted into the anticancer agent piceatannol (Cat. No. 1554) by cytochrome P450 1B1. Activates autophagy. Also activates TRPA1 in prostate cancer-associated fibroblasts. Also SIRT1 activator.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Regulation of histone H2A.Z exprsesion is mediated by sirtuin 1 in prostate cancer.
   Baptista et al.
   Oncotarget, 2013;4:1673
2. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
   Galluzzi et al.
   Nat.Rev.Drug.Discov., 2017;
3. Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF).
   Vancauwenberghe et al.
   Mol.Carcinog., 2017;56:1851
4. Resveratrol is a selective human cytochrome P450 1A1 inhibitor.
   Chun et al.
   Biochem.Biophys.Res.Commun., 1999;262:20
5. Therapeutic potential of resveratrol: the in vivo evidence.
   Baur and Sinclair
   Nat.Rev.Drug Discov., 2006;5:493
6. Biological effects of resveratrol.
   Fremont
   Life Sci., 2000;66:663
7. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β.
   Bowers et al.
   Endocrinology, 2000;141:3657
8. Effects of stilbenes on arachidonate metabolism in leukocytes.
   Kimura et al.
   Biochim.Biophys.Acta, 1985;834:275

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