Recombinant Mouse M-CSF Protein Summary
Product Specifications
Lys33-Glu262, with an N-terminal Met
Analysis
Product Datasheets
416-ML (with carrier)
416-ML/CF (carrier free)
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
416-ML
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. |
Reconstitution | Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
416-ML/CF
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution | Reconstitute at 100 μg/mL in sterile PBS. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Scientific Data
Recombinant Mouse M-CSF Protein (Catalog # 416-ML) has a molecular weight (MW) of 50.7 kDa as analyzed by SEC-MALS, suggesting that this protein is a homodimer.
Recombinant Mouse M-CSF (416-ML) stimulates cell proliferation in the M-NFS-60 mouse myelogenous leukemia lymphoblast cell line in a dose-dependent manner. The ED50 for this effect is 0.5-3 ng/mL.
Background: M-CSF
M-CSF, also known as CSF-1, is a four-alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation (1-3). M-CSF protein is also essential for the survival and proliferation of osteoclast progenitors (1, 4). M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis (2, 3). M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta (5). Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells (1-5). The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. M-CSF mRNAs of various sizes occur (3-9). Full length mouse M-CSF transcripts encode a 520 amino acid (aa) type I transmembrane (TM) protein with a 462 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two proteolytically cleaved, secreted dimers. One is an N- and O- glycosylated 86 kDa dimer, while the other is modified by both glycosylation and chondroitin-sulfate proteoglycan (PG) to generate a 200 kDa subunit. Although PG-modified M-CSF protein can circulate, it may be immobilized by attachment to type V collagen (8). Shorter transcripts encode M‑CSF that lacks cleavage and PG sites and produces an N-glycosylated 68 kDa TM dimer and a slowly produced 44 kDa secreted dimer (7). Although forms may vary in activity and half-life, all contain the N-terminal 150 aa portion that is necessary and sufficient for interaction with the M-CSF receptor (10, 11). The first 229 aa of mature mouse M-CSF shares 87%, 83%, 82% and 81% aa identity with corresponding regions of rat, dog, cow and human M-CSF, respectively (12, 13). Human M‑CSF is active in the mouse, but mouse M-CSF is reported to be species-specific.
- Pixley, F.J. and E.R. Stanley (2004) Trends Cell Biol. 14:628.
- Chitu, V. and E.R. Stanley (2006) Curr. Opin. Immunol. 18:39.
- Fixe, P. and V. Praloran (1997) Eur. Cytokine Netw. 8:125.
- Ryan, G.R. et al. (2001) Blood 98:74.
- Makrigiannakis, A. et al. (2006) Trends Endocrinol. Metab. 17:178.
- Nandi, S. et al. (2006) Blood 107:786.
- Rettenmier, C.W. and M.F. Roussel (1988) Mol. Cell Biol. 8:5026.
- Suzu, S. et al. (1992) J. Biol. Chem. 267:16812.
- Manos, M.M. (1988) Mol. Cell. Biol. 8:5035.
- Koths, K. (1997) Mol. Reprod. Dev. 46:31.
- Jang, M-H. et al. (2006) J. Immunol. 177:4055.
- DeLamarter, J.F. et al. (1987) Nucleic Acids Res. 15:2389.
- Ladner, M.B. et al. (1988) Proc. Natl. Acad. Sci. USA 85:6706.
Citations for Recombinant Mouse M-CSF Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
634
Citations: Showing 1 - 10
Filter your results:
Filter by:
-
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Authors: Zhenqiang Yao, Akram Ayoub, Venkatesan Srinivasan, Jun Wu, Churou Tang, Rong Duan, Aleksa Milosavljevic, Lianping Xing, Frank H. Ebetino, Alison J. Frontier, and Brendan F. Boyce
Bone Res
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Vasorin-deficient mice display disturbed vitamin D and mineral homeostasis in combination with a low bone mass phenotype
Authors: Eijken, M;Krautzberger, AM;Scholze-Wittler, M;Boers-Sijmons, B;Koedam, M;Kosiol, B;Schrewe, H;van Leeuwen, JP;van der Eerden, BC;
Bone reports
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice
Authors: Richardson, KK;Adam, GO;Ling, W;Warren, A;Marques-Carvalho, A;Thostenson, JD;Krager, K;Aykin-Burns, N;Byrum, SD;Almeida, M;Kim, HN;
Molecular metabolism
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Prebiotics mitigate the detrimental effects of High-Fat diet on Memory, anxiety and microglia functionality in ageing mice
Authors: Vijaya, AK;Kuras, S;imoli?nas, E;Mingaila, J;Makovskyt?, K;Buias, R;Daliri, EB;Mekys, R;Baltriukien?, D;Burokas, A;
Brain, behavior, and immunity
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Alendronate Functionalized Bone-Targeting Pomolic Acid Liposomes Restore Bone Homeostasis for Osteoporosis Treatment
Authors: Xia, D;Qian, Q;Wang, S;Dong, X;Liu, Y;
International journal of nanomedicine
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Elevated Salt or Angiotensin II Levels Induce CD38+ Innate Immune Cells in the Presence of Granulocyte-Macrophage Colony Stimulating Factor
Authors: Smith, HL;Goodlett, BL;Navaneethabalakrishnan, S;Mitchell, BM;
Cells
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Crebanine mitigates glucocorticoid-induced osteonecrosis of the femoral head by restoring bone remodelling homeostasis via attenuating oxidative stress
Authors: Dong, S;Ge, J;Meng, Q;Yuan, T;Wang, Y;Li, Y;Lu, Q;Song, W;Li, Z;Sun, S;
Journal of cellular and molecular medicine
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tregs delivered post-myocardial infarction adopt an injury-specific phenotype promoting cardiac repair via macrophages in mice
Authors: Alshoubaki, YK;Nayer, B;Lu, YZ;Salimova, E;Lau, SN;Tan, JL;Amann-Zalcenstein, D;Hickey, PF;Del Monte-Nieto, G;Vasanthakumar, A;Martino, MM;
Nature communications
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Anti-inflammatory effect of the combined treatment of LMT-28 and kaempferol in a collagen-induced arthritis mouse model
Authors: Jeong, YJ;Park, SA;Park, YH;Kim, LK;Lee, HR;Kim, HJ;Heo, TH;
PloS one
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Osteoclast-Driven Polydopamine-to-Dopamine Release: An Upgrade Patch for Polydopamine-Functionalized Tissue Engineering Scaffolds
Authors: Wang, L;Hu, H;Ko, CC;
Journal of functional biomaterials
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Fat Phagocytosis Promotes Anti-Inflammatory Responses of Macrophages in a Mouse Model of Osteonecrosis
Authors: Deng, Z;Kim, HKW;Hernandez, PA;Ren, Y;
Cells
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The catheterized bladder environment induces dysregulation of macrophage polarization exacerbating bacterial UTI
Authors: Marrufo, AM;Molina, JJ;Gager, C;Andersen, MJ;LaBella, AA;Lucas, ER;Wongso, E;Urmi, T;Arias-Parbul, K;Webster, R;Stuckey, PV;Kohler, KN;Donahue, D;Ploplis, VA;Flick, MJ;Castellino, FJ;Santiago-Tirado, FH;Flores-Mireles, AL;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Deficiency of protein phosphatase 5 resists osteoporosis in diabetic mice
Authors: Wang, J;Zhao, C;Zhao, W;Li, S;
Heliyon
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MerTK Induces Dysfunctional Dendritic Cells by Metabolic Reprogramming
Authors: Zewdie, EY;Edwards, GM;Hunter, DM;Earp, HS;Holtzhausen, A;
Cancer immunology research
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Aryl hydrocarbon receptor confers protection against macrophage pyroptosis and intestinal inflammation through regulating polyamine biosynthesis
Authors: Gao, Y;Liu, KY;Xiao, W;Xie, X;Liang, Q;Tu, Z;Yang, L;Yu, H;Guo, H;Huang, S;Han, X;Fu, J;Zhou, Y;
Theranostics
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bacterial peptidoglycan signalling in microglia: Activation by MDP via the NF-?B/MAPK pathway
Authors: Spielbauer, J;Glotfelty, E;Sarlus, H;Harris, RA;Heijtz, RD;Karlsson, TE;
Brain, behavior, and immunity
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
XAF1 promotes osteoclast apoptosis by antagonizing the XIAP-caspase axis
Authors: Zhang, M;Huang, Y;Bai, J;Xu, W;Shan, H;Sheng, L;Gao, X;Han, Y;Wang, S;Bai, C;Tian, B;Ni, Y;Dong, Q;Ma, F;Zhou, X;
Journal of orthopaedic translation
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
14-3-3? Suppresses RANKL Signaling by Destabilizing TRAF6
Authors: Ayyasamy, R;Fan, S;Czernik, P;Lecka-Czernik, B;Chattopadhyay, S;Chakravarti, R;
The Journal of biological chemistry
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
History of tuberculosis disease is associated with genetic regulatory variation in Peruvians
Authors: Nieto-Caballero, VE;Reijneveld, JF;Ruvalcaba, A;Innocenzi, G;Abeydeera, N;Asgari, S;Lopez, K;Iwany, SK;Luo, Y;Nathan, A;Fernandez-Salinas, D;Chiñas, M;Huang, CC;Zhang, Z;León, SR;Calderon, RI;Lecca, L;Budzik, JM;Murray, M;Van Rhijn, I;Raychaudhuri, S;Moody, DB;Suliman, S;Gutierrez-Arcelus, M;
PLoS genetics
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Prolonged Cadmium Exposure and Osteoclastogenesis: A Mechanistic Mouse and in Vitro Study
Authors: Liu, Z;Wu, J;Dong, Z;Wang, Y;Wang, G;Chen, C;Wang, H;Yang, Y;Sun, Y;Yang, M;Fu, J;Li, J;Zhang, Q;Xu, Y;Pi, J;
Environmental health perspectives
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells, Transfected Whole Cells
Applications: Bioassay -
Mechanisms underlying TRPV4-mediated regulation of miR-146a expression
Authors: Dutta, B;Mahanty, M;Kesavalu, L;Rahaman, SO;
bioRxiv : the preprint server for biology
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MAFB in macrophages regulates cold-induced neuronal density in brown adipose tissue
Authors: Yadav, MK;Ishida, M;Gogoleva, N;Liao, CW;Salim, FN;Kanai, M;Kuno, A;Hayashi, T;Shahri, ZJ;Kulathunga, K;Samir, O;Lyu, W;Olivia, O;Mbanefo, EC;Takahashi, S;Hamada, M;
Cell reports
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Tacrolimus, FK506, promotes bone formation in bone defect mouse model
Authors: Nishida, S;Azetsu, Y;Chatani, M;Karakawa, A;Otake, K;Sugiki, H;Sakai, N;Maruoka, Y;Myers, M;Takami, M;
Journal of oral biosciences
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src
Authors: Li, Z;Yang, X;Fu, R;Wu, Z;Xu, S;Jiao, J;Qian, M;Zhang, L;Wu, C;Xie, T;Yao, J;Wu, Z;Li, W;Ma, G;You, Y;Chen, Y;Zhang, HK;Cheng, Y;Tang, X;Wu, P;Lian, G;Wei, H;Zhao, J;Xu, J;Ai, L;Siwko, S;Wang, Y;Ding, J;Song, G;Luo, J;Liu, M;Xiao, J;
Nature communications
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibitory effects of norcantharidin on titanium particle-induced osteolysis, osteoclast activation and bone resorption via MAPK pathways
Authors: Wang, J;Chen, G;Yang, X;Dou, W;Mao, Y;Zhang, Y;Shi, X;Xia, Y;You, Q;Liu, M;
International immunopharmacology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism
Authors: Peng, R;Dong, Y;Zheng, M;Kang, H;Wang, P;Zhu, M;Song, K;Wu, W;Li, F;
Cell death & disease
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Farrerol suppresses osteoclast differentiation and postmenopausal osteoporosis by inhibiting the nuclear factor kappa B signaling pathway
Authors: Lu, W;Qi, G;Yang, X;Li, D;Chen, W;Zeng, Q;Jiang, Z;
Journal of pharmacological sciences
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Planar catechin increases bone mass by regulating differentiation of osteoclasts in mice
Authors: Sugawara, D;Sakai, N;Sato, Y;Azetsu, Y;Karakawa, A;Chatani, M;Mizuno, M;Maruoka, Y;Myers, M;Fukuhara, K;Takami, M;
Journal of oral biosciences
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity
Authors: Zhang, H;Xue, K;Li, W;Yang, X;Gou, Y;Su, X;Qian, F;Sun, L;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Transient receptor potential melastatin 2 is involved in trinitrobenzene sulfonic acid-induced acute and chronic colitis-associated fibrosis progression in mice
Authors: Nakamoto, T;Matsumoto, K;Yasuda, H;Mori, Y;Kato, S;
Journal of pharmacological sciences
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CTRP6 promotes the macrophage inflammatory response, and its deficiency attenuates LPS-induced inflammation
Authors: Xu, C;Sarver, DC;Lei, X;Sahagun, A;Zhong, J;Na, CH;Rudich, A;Wong, GW;
The Journal of biological chemistry
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
RANKL-dependent osteoclast differentiation and gene expression in bone marrow-derived cells from adult mice is sexually dimorphic
Authors: Desai, S;Lång, P;Näreoja, T;Windahl, SH;Andersson, G;
Bone reports
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes
Authors: Kim, GM;Kim, J;Lee, JY;Park, MC;Lee, SY;
Experimental & molecular medicine
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Colon-targeted S100A8/A9-specific peptide systems ameliorate colitis and colitis-associated colorectal cancer in mouse models
Authors: Cho, E;Mun, SJ;Kim, HK;Ham, YS;Gil, WJ;Yang, CS;
Acta pharmacologica Sinica
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Osteoclast-derived exosomal miR-212-3p suppressed the anabolism and accelerated the catabolism of chondrocytes in osteoarthritis by targeting TGF-?1/Smad2 signaling
Authors: Dai, J;Hu, Z;Zeng, F;Gong, X;Tang, H;Deng, J;Li, J;Dong, S;
Archives of biochemistry and biophysics
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sesamin inhibits RANKL-induced osteoclastogenesis and attenuates LPS-induced osteolysis via suppression of ERK and NF-?B signalling pathways
Authors: Yu, X;Hu, J;Yang, X;Xu, Q;Chen, H;Zhan, P;Zhang, B;
Journal of cellular and molecular medicine
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Protective effects of macrophage-specific integrin ?5 in myocardial infarction are associated with accentuated angiogenesis
Authors: Li, R;Chen, B;Kubota, A;Hanna, A;Humeres, C;Hernandez, SC;Liu, Y;Ma, R;Tuleta, I;Huang, S;Venugopal, H;Zhu, F;Su, K;Li, J;Zhang, J;Zheng, D;Frangogiannis, NG;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A novel Glycyrrhiza glabra extract liquiritin targeting NFATc1 activity and ROS levels to counteract ovariectomy-induced osteoporosis and bone loss in murine model
Authors: Hong, G;Zhou, L;Zheng, G;Zheng, X;Chen, Z;He, W;Wei, Q;
Frontiers in pharmacology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Britanin inhibits titanium wear particle?induced osteolysis and osteoclastogenesis
Authors: Kim, JA;Lim, S;Ihn, HJ;Kim, JE;Yea, K;Moon, J;Choi, H;Park, EK;
Molecular medicine reports
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Osteoprotective effect by interleukin-4 (IL-4) on lipoprotein-induced periodontitis
Authors: Lima Teixeira, JF;Henning, P;Cintra Magalhães, FA;Coletto-Nunes, G;Floriano-Marcelino, T;Westerlund, A;Movérare-Skrtic, S;Oliveira, GJPL;Lerner, UH;Souza, PPC;
Cytokine
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
AMPK?1 negatively regulates osteoclastogenesis and mitigate pathological bone loss
Authors: Ribeiro, MSP;Venturini, LGR;Speck-Hernandez, CA;Alabarse, PVG;Xavier, T;Taira, TM;Rodrigues, LFD;Cunha, FQ;Fukada, SY;
The Journal of biological chemistry
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Excretory/secretory products from Trichinella spiralis adult worms ameliorate myocardial infarction by inducing M2 macrophage polarization in a mouse model
Authors: Wu, L;Yin, W;Wen, J;Wang, S;Li, H;Wang, X;Zhang, W;Duan, S;Zhu, Q;Gao, E;Wu, S;Zhan, B;Zhou, R;Yang, X;
Parasites & vectors
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Ulmus macrocarpa Hance trunk bark extracts inhibit RANKL-induced osteoclast differentiation and prevent ovariectomy-induced osteoporosis in mice
Authors: Jeong, C;Lee, CH;Lee, Y;Seo, J;Wang, W;Park, KH;Oh, E;Cho, Y;Park, C;Son, YJ;Yoon Park, JH;Kang, H;Lee, KW;
Journal of ethnopharmacology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release
Authors: Adrian, M;Weber, M;Tsai, MC;Glock, C;Kahn, OI;Phu, L;Cheung, TK;Meilandt, WJ;Rose, CM;Hoogenraad, CC;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
FEAST: A flow cytometry-based toolkit for interrogating microglial engulfment of synaptic and myelin proteins
Authors: Dissing-Olesen, L;Walker, AJ;Feng, Q;Barr, HJ;Walker, AC;Xie, L;Wilton, DK;Das, I;Benowitz, LI;Stevens, B;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BAP1 promotes osteoclast function by metabolic reprogramming
Authors: Rohatgi, N;Zou, W;Li, Y;Cho, K;Collins, PL;Tycksen, E;Pandey, G;DeSelm, CJ;Patti, GJ;Dey, A;Teitelbaum, SL;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
NLRP3 selectively drives IL-1? secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity
Authors: Minns, MS;Liboro, K;Lima, TS;Abbondante, S;Miller, BA;Marshall, ME;Tran Chau, J;Roistacher, A;Rietsch, A;Dubyak, GR;Pearlman, E;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Glycolytic metabolite phosphoenolpyruvate protects host from viral infection through promoting AATK expression
Authors: Zhao, L;Song, R;Liu, Y;
European journal of immunology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Echinococcus granulosus promotes bone resorption by increasing osteoclasts differentiation
Authors: Sun, H;Wang, S;Tan, W;Li, Y;Ren, Q;Liu, Y;Huang, Y;Shi, C;Li, J;
Acta tropica
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-10 increases macrophage-mediated chemotherapy resistance via FABP5 signaling in multiple myeloma
Authors: Zhang, M;Chen, J;Zhang, H;Dong, H;Yue, Y;Wang, S;
International immunopharmacology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Impaired mitophagy induces antimicrobial responses in macrophages infected with Mycobacterium tuberculosis
Authors: Lee, J;Lee, SA;Son, SH;Choi, JA;Nguyen, TD;Kim, J;Son, D;Song, CH;
Cell & bioscience
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Conditional Loss of MEF2C Expression in Osteoclasts Leads to a Sex-Specific Osteopenic Phenotype
Authors: Maisuria, R;Norton, A;Shao, C;Bradley, EW;Mansky, K;
International journal of molecular sciences
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
GV1001 Inhibits the Severity of the Ligature-Induced Periodontitis and the Vascular Lipid Deposition Associated with the Periodontitis in Mice
Authors: Kim, SY;Kim, YJ;Kim, S;Momeni, M;Lee, A;Treanor, A;Kim, S;Kim, RH;Park, NH;
International journal of molecular sciences
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction
Authors: Shimizu, K;Kikuta, J;Ohta, Y;Uchida, Y;Miyamoto, Y;Morimoto, A;Yari, S;Sato, T;Kamakura, T;Oshima, K;Imai, R;Liu, YC;Okuzaki, D;Hara, T;Motooka, D;Emoto, N;Inohara, H;Ishii, M;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Augmented effect of fibroblast growth factor 18 in bone morphogenetic protein 2-induced calvarial bone healing by activation of CCL2/CCR2 axis on M2 macrophage polarization
Authors: Namangkalakul, W;Nagai, S;Jin, C;Nakahama, KI;Yoshimoto, Y;Ueha, S;Akiyoshi, K;Matsushima, K;Nakashima, T;Takechi, M;Iseki, S;
Journal of tissue engineering
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice
Authors: Yu, L;Xu, L;Chu, H;Peng, J;Sacharidou, A;Hsieh, HH;Weinstock, A;Khan, S;Ma, L;Durán, JGB;McDonald, J;Nelson, ER;Park, S;McDonnell, DP;Moore, KJ;Huang, LJ;Fisher, EA;Mineo, C;Huang, L;Shaul, PW;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The checkpoint inhibitor PD-1H/VISTA controls osteoclast-mediated multiple myeloma bone disease
Authors: Fu, J;Li, S;Ma, H;Yang, J;Pagnotti, GM;Brown, LM;Weiss, SJ;Mapara, MY;Lentzsch, S;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MiR-662 is associated with metastatic relapse in early-stage breast cancer and promotes metastasis by stimulating cancer cell stemness
Authors: Puppo, M;Valluru, MK;Croset, M;Ceresa, D;Iuliani, M;Khan, A;Wicinski, J;Charafe-Jauffret, E;Ginestier, C;Pantano, F;Ottewell, PD;Clézardin, P;
British journal of cancer
Applications: Cell Culture -
Discovery and optimized extraction of the anti-osteoclastic agent epicatechin-7-O-beta -D-apiofuranoside from Ulmus macrocarpa Hance bark
Authors: Jeong, C;Cho, YJ;Lee, Y;Wang, W;Park, KH;Roh, E;Lee, CH;Son, YJ;Park, JHY;Kang, H;Lee, KW;
Scientific reports
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Accelerated Bone Loss in Transgenic Mice Expressing Constitutively Active TGF-beta Receptor Type I
Authors: Toejing, P;Sakunrangsit, N;Pho-On, P;Phetkong, C;Leelahavanichkul, A;Sridurongrit, S;Greenblatt, MB;Lotinun, S;
International journal of molecular sciences
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Polyphyllin VII protects from breast cancer-induced osteolysis by suppressing osteoclastogenesis via c-Fos/NFATc1 signaling
Authors: Yang, Q;Guo, J;Zheng, J;Chen, Y;Zou, B;Li, R;Ding, Z;Wang, Y;Li, L;Chen, Z;Mo, L;Liang, Q;Chen, F;Li, X;
International immunopharmacology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages
Authors: Lu, Y;Zhang, H;Pan, H;Zhang, Z;Zeng, H;Xie, H;Yin, J;Tang, W;Lin, R;Zeng, C;Cai, D;
Journal of translational medicine
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Predicting gene level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework
Authors: Cheemalavagu, N;Shoger, KE;Cao, YM;Michalides, BA;Botta, SA;Faeder, JR;Gottschalk, RA;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of NADPH Oxidase (NOX) 2 Mitigates Colitis in Mice with Impaired Macrophage AMPK Function
Authors: Banskota, S;Wang, H;Kwon, YH;Gautam, J;Haq, S;Grondin, J;Steinberg, GR;Khan, WI;
Biomedicines
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis
Authors: Stavre, Z;Kim, JM;Yang, YS;N�ndel, K;Chaugule, S;Sato, T;Park, KH;Gao, G;Gravallese, EM;Shim, JH;
Proceedings of the National Academy of Sciences of the United States of America
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IRAK4 inhibition: an effective strategy for immunomodulating peri-implant osseointegration via reciprocally-shifted polarization in the monocyte-macrophage lineage cells
Authors: Zhao, J;Li, J;Xu, A;Xu, Y;He, F;Mao, Y;
BMC oral health
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development
Authors: Cheu, JW;Chiu, DK;Kwan, KK;Yang, C;Yuen, VW;Goh, CC;Chui, NN;Shen, W;Law, CT;Li, Q;Zhang, MS;Bao, MH;Wong, BP;Chan, CY;Liu, CX;Sit, GF;Ooi, ZY;Deng, H;Tse, AP;Ng, IO;Wong, CC;
Science advances
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses
Authors: Y Yu, M Wang, XW Li, J Mao, YJ Zhu, N Wang, LH Yin, ZL Guo, H Cai, T Li, TT Liang, J Cui, T Zhou
Cell & bioscience, 2023-04-29;13(1):76.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Anti-Atopic Dermatitis Effects of Mentha arvensis Essential Oil Are Involved in the Inhibition of the NLRP3 Inflammasome in DNCB-Challenged Atopic Dermatitis BALB/c Mice
Authors: Kim, SY;Sapkota, A;Bae, YJ;Choi, SH;Bae, HJ;Kim, HJ;Cho, YE;Choi, YY;An, JY;Cho, SY;Hong, SH;Choi, JW;Park, SJ;
International journal of molecular sciences
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Distinct Responses to IL4 in Macrophages Mediated by JNK
Authors: Arpa, L;Batlle, C;Jiang, P;Caelles, C;Lloberas, J;Celada, A;
Cells
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice
Authors: S MacLauchla, P Kushwaha, A Tai, J Chen, C Manning, G Swarnkar, Y Abu-Amer, KA Fitzgerald, S Sharma, EM Gravallese
Proceedings of the National Academy of Sciences of the United States of America, 2023-04-06;120(15):e2210409120.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Matrix stiffness regulates osteoclast fate through integrin-dependent mechanotransduction
Authors: X Wang, L Ji, J Wang, C Liu
Bioactive materials, 2023-03-30;27(0):138-153.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Atf4 regulates angiogenic differences between alveolar bone and long bone macrophages by regulating M1 polarization, based on single-cell RNA sequencing, RNA-seq and ATAC-seq analysis
Authors: L Gu, Z Wang, H Gu, H Wang, L Liu, WB Zhang
Journal of Translational Medicine, 2023-03-14;21(1):193.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming
Authors: K Aso, M Kono, M Kanda, Y Kudo, K Sakiyama, R Hisada, K Karino, Y Ueda, D Nakazawa, Y Fujieda, M Kato, O Amengual, T Atsumi
Nature Communications, 2023-02-27;14(1):984.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cedrol, a Ginger-derived sesquiterpineol, suppresses estrogen-deficient osteoporosis by intervening NFATc1 and reactive oxygen species
Authors: C Xu, SQ Jin, C Jin, ZH Dai, YH Wu, GL He, HW Ma, CY Xu, WL Fang
International immunopharmacology, 2023-02-27;117(0):109893.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux
Authors: X Ji, J Hong, W Yang, M Yao, J Wang, G Jiang, Y Wang, C Li, J Lin, H Mou, C Li, S Li, Y Chen, M Shi, W Wang, F Lu, H Wu, X Zhao, Y Qi, S Yan
Redox Biology, 2023-02-27;61(0):102635.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts
Authors: PY Ng, ABP Ribet, Q Guo, BH Mullin, JWY Tan, E Landao-Bas, S Stephens, K Chen, J Yuan, L Abudulai, M Bollen, ETTT Nguyen, J Kular, JM Papadimitr, K Søe, RD Teasdale, J Xu, RG Parton, H Takayanagi, NJ Pavlos
Nature Communications, 2023-02-21;14(1):906.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
C3a-C3aR signaling is a novel modulator of skeletal homeostasis
Authors: MB Kuhn, HS VandenBerg, AJ Reynolds, MD Carson, AJ Warner, AC LaRue, CM Novince, JD Hathaway-S
Bone Reports, 2023-02-16;18(0):101662.
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Obacunone inhibits RANKL/M-CSF-mediated osteoclastogenesis by suppressing integrin- FAK-Src signaling
Authors: H Hu, X Wang, Y Huang, B He, J Zhu, K Sun, C Deng, Y Guo, D Hao, B Jian
Cytokine, 2023-02-15;164(0):156134.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
miRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 Signaling
Authors: H Lee, E Kim, S Kim
Biomolecules, 2023-02-09;13(2):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model
Authors: N Beckmann, A Neuhaus, S Zurbruegg, P Volkmer, C Patino, S Joller, D Feuerbach, A Doelemeyer, T Schweizer, S Rudin, U Neumann, R Berth, W Frieauff, F Gasparini, DR Shimshek
Journal of Neuroinflammation, 2023-02-08;20(1):29.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Probucol suppresses osteoclastogenesis via activating Nrf2 signaling and ameliorates ovariectomy-induced bone loss
Authors: J Guo, R Ren, Z Guo, K Sun, J He, J Shao, X Wang
International immunopharmacology, 2023-02-07;116(0):109820.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease
Authors: S De Scheppe, JZ Ge, G Crowley, LSS Ferreira, D Garceau, CE Toomey, D Sokolova, J Rueda-Carr, SH Shin, JS Kim, T Childs, T Lashley, JJ Burden, M Sasner, C Sala Frige, S Jung, S Hong
Nature Neuroscience, 2023-02-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Micro Ribonucleic Acid-29a (miR-29a) Antagonist Normalizes Bone Metabolism in Osteogenesis Imperfecta (OI) Mice Model
Authors: JY Ko, FS Wang, SH Chen, SJ Kuo
Biomedicines, 2023-02-05;11(2):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner Through Secreted Calpastatin
Authors: Williams J, Irwin M, Li Y et al.
Preprint
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Chemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling
Authors: P Silwal, YJ Kim, YJ Lee, IS Kim, SM Jeon, T Roh, JK Kim, MJ Lee, JY Heo, DS Jo, SH Lee, DH Cho, JM Kim, YT Kwon, EK Jo
Experimental & Molecular Medicine, 2023-02-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Optineurin regulates NRF2-mediated antioxidant response in a mouse model of Paget's disease of bone
Authors: X Hu, SW Wong, K Liang, TH Wu, S Wang, L Wang, J Liu, M Yamauchi, BL Foster, JP Ting, B Zhao, HC Tseng, CC Ko
Science Advances, 2023-01-27;9(4):eade6998.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Phosphatidylcholine Liposomes Reprogram Macrophages toward an Inflammatory Phenotype
Authors: DM Cauvi, D Hawisher, J Derunes, A De Maio
Membranes, 2023-01-21;13(2):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Obacunone targets macrophage migration inhibitory factor (MIF) to impede osteoclastogenesis and alleviate ovariectomy-induced bone loss
Authors: J He, L Zheng, X Li, F Huang, S Hu, L Chen, M Jiang, X Lin, H Jiang, Y Zeng, T Ye, D Lin, Q Liu, J Xu, K Chen
Journal of advanced research, 2023-01-16;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Osthole Inhibits M1 Macrophage Polarization and Attenuates Osteolysis in a Mouse Skull Model
Authors: F Wang, P Yang, T Wan, C Liu, Y Zhu, X Chen, H Liu
Oxidative Medicine and Cellular Longevity, 2023-01-12;2023(0):2975193.
-
The Mechanism of Osteoprotegerin-Induced Osteoclast Pyroptosis In Vitro
Authors: J Zhu, Y Ma, J Wang, Y Wang, W Ali, H Zou, H Zhao, X Tong, R Song, Z Liu
International Journal of Molecular Sciences, 2023-01-12;24(2):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Isopsoralen suppresses receptor activator of nuclear factor kappa-beta ligand-induced osteoclastogenesis by inhibiting the NF-kappaB signaling
Authors: W Zhan, B Ruan, H Dong, C Wang, S Wu, H Yu, X Xu, H Sun, J Cai
PeerJ, 2023-01-10;11(0):e14560.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Phosphatidyl Inositol 3-Kinase (PI3K)-Inhibitor CDZ173 protects against LPS-induced osteolysis
Authors: Z Wu, X Li, X Chen, X He, Y Chen, L Zhang, Z Li, M Yang, G Yuan, B Shi, N Chen, N Li, H Feng, M Zhou, G Rui, F Xu, R Xu
Frontiers in Pharmacology, 2023-01-06;13(0):1021714.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
The role played by ailanthone in inhibiting bone metastasis of breast cancer by regulating tumor-bone microenvironment through the RANKL-dependent pathway
Authors: Y Wang, Z Zhong, M Ma, Y Zhao, C Zhang, Z Qian, B Wang
Frontiers in Pharmacology, 2023-01-05;13(0):1081978.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
IL-1 Generated by Oral Squamous Cell Carcinoma Stimulates Tumor-Induced and RANKL-Induced Osteoclastogenesis: A Possible Mechanism of Bone Resorption Induced by the Infiltration of Oral Squamous Cell Carcinoma
Authors: Y Fukawa, K Kayamori, M Tsuchiya, T Ikeda
International Journal of Molecular Sciences, 2022-12-30;24(1):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Nanoparticle delivery of CD40 siRNA suppresses alloimmune responses by inhibiting activation and differentiation of DCs and macrophages
Authors: J Wang, K Mao, X Cong, H Tan, C Wu, Z Hu, YG Yang, T Sun
Science Advances, 2022-12-21;8(51):eabq3699.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Mechanistic target of rapamycin complex 1 orchestrates the interplay between hepatocytes and Kupffer cells to determine the outcome of immune-mediated hepatitis
Authors: X Sun, Y Ni, Q Lu, Y Liang, M Gu, X Xue, C Dai
Cell Death & Disease, 2022-12-09;13(12):1031.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Polysaccharides from Annona�muricata leaves protect against cisplatin?induced cytotoxicity in macrophages by alleviating mitochondrial dysfunction
Authors: JM Han, HY Song, KI Kim, WY Park, SH Park, EB Byun, EH Byun
Molecular Medicine Reports, 2022-12-01;27(1):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Double knockin mice show NF-kappaB trajectories in immune signaling and aging
Authors: SMT Rahman, M Aqdas, EW Martin, F Tomassoni, P Songkiatis, KS Oh, S Uderhardt, S Yun, QC Claybourne, RA McDevitt, V Greco, RN Germain, L Tessarollo, MH Sung
Cell Reports, 2022-11-22;41(8):111682.
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Evaluation of culture conditions for osteoclastogenesis in RAW264.7 cells
Authors: Y Cheng, H Liu, J Li, Y Ma, C Song, Y Wang, P Li, Y Chen, Z Zhang
PLoS ONE, 2022-11-17;17(11):e0277871.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer
Authors: CY Chang, R You, D Armstrong, A Bandi, YT Cheng, PM Burkhardt, L Becerra-Do, MC Madison, HY Tung, Z Zeng, Y Wu, L Song, PE Phillips, P Porter, JM Knight, N Putluri, X Yuan, DC Marcano, EA McHugh, JM Tour, A Catic, L Maneix, BM Burt, HS Lee, DB Corry, F Kheradmand
Science Advances, 2022-11-16;8(46):eabq0615.
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Microglial WNT5A supports dendritic spines maturation and neuronal firing
Authors: H Yeh, M Woodbury, K Ingraham-D, T Ikezu, S Ikezu
Brain, Behavior, and Immunity, 2022-11-15;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration
Authors: C Lin, Q Yang, D Guo, J Xie, YS Yang, S Chaugule, N DeSouza, WT Oh, R Li, Z Chen, AA John, Q Qiu, LJ Zhu, MB Greenblatt, S Ghosh, S Li, G Gao, C Haynes, CP Emerson, JH Shim
Nature Communications, 2022-11-11;13(1):6869.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis
Authors: HK Kwon, KE Yu, SV Cahill, KD Alder, CM Dussik, SH Kim, L Sharma, J Back, I Oh, FY Lee
Embo Molecular Medicine, 2022-11-10;0(0):e15284.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
von Willebrand factor links primary hemostasis to innate immunity
Authors: C Drakeford, S Aguila, F Roche, K Hokamp, J Fazavana, MP Cervantes, AM Curtis, HC Hawerkamp, SPS Dhami, H Charles-Me, EE Hackett, A Chion, S Ward, A Ahmad, I Schoen, E Breen, J Keane, R Murphy, RJS Preston, JM O'Sullivan, FJ Sheedy, P Fallon, JS O'Donnell
Nature Communications, 2022-11-03;13(1):6320.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton
Authors: K Nagano, K Yamana, H Saito, R Kiviranta, AC Pedroni, D Raval, C Niehrs, F Gori, R Baron
Elife, 2022-11-02;11(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Berbamine inhibits RANKL- and M-CSF-mediated osteoclastogenesis and alleviates ovariectomy-induced bone loss
Authors: G Qi, Z Jiang, W Lu, D Li, W Chen, X Yang, L Ding, H Yuan
Frontiers in Pharmacology, 2022-11-02;13(0):1032866.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Divergent regulation of basement membrane trafficking by human macrophages and cancer cells
Authors: JC Bahr, XY Li, TY Feinberg, L Jiang, SJ Weiss
Nature Communications, 2022-10-27;13(1):6409.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
High Cholesterol-Induced Bone Loss Is Attenuated by Arctiin via an Action in Osteoclasts
Authors: G Li, JN Park, HJ Park, JH Suh, HS Choi
Nutrients, 2022-10-25;14(21):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Brain milieu induces early microglial maturation through the BAX-Notch axis
Authors: F Zhao, J He, J Tang, N Cui, Y Shi, Z Li, S Liu, Y Wang, M Ma, C Zhao, L Luo, L Li
Nature Communications, 2022-10-17;13(1):6117.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function
Authors: JX Sun, KY Zhu, YM Wang, DJ Wang, MZ Zhang, H Sarlus, I Benito-Cue, XQ Zhao, ZF Zou, QY Zhong, Y Feng, S Wu, YQ Wang, RA Harris, J Wang
Acta pharmacologica Sinica, 2022-10-13;0(0):.
Species: Mouse
Sample Types: Whole Cell
-
Detection of Radiolabeled Inflammatory Cell Macrophage Subpopulations in Chronic Respiratory Diseases: Results from Preliminary Analyses
Authors: AP Shaik, AS Shaik, M Abudawood, A Al Faraj
BioMed Research International, 2022-10-06;2022(0):9470845.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling
Authors: M Tomimatsu, K Matsumoto, M Ashizuka, S Kumagai, S Tanaka, T Nakae, K Yokota, S Kominami, R Kajiura, D Okuzaki, D Motooka, A Shiraishi, T Abe, H Matsuda, Y Okada, M Maeda, S Seno, M Obana, Y Fujio
Scientific Reports, 2022-10-05;12(1):16656.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction
Authors: Q Li, T Yue, X Du, Z Tang, J Cui, W Wang, W Xia, B Ren, S Kan, C Li, C Wu, X Niu, B Li, K Lin, J Luo, G Chen, Z Wang
Cell Death and Differentiation, 2022-10-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of Neddylation Suppresses Osteoclast Differentiation and Function In Vitro and Alleviates Osteoporosis In Vivo
Authors: MH Wu, WB Hsu, MH Chen, CS Shi
Biomedicines, 2022-09-21;10(10):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis
Authors: W Zhu, W Liang, H Lu, L Chang, J Zhang, YE Chen, Y Guo
Cells, 2022-09-15;11(18):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
LysM-positive neurons drive Tuberous Sclerosis Complex (TSC)-associated brain lesions
Authors: J Zhang, S Xu, K Liang, X Cao, Z Ye, W Huang, X Bai, Y Zhang
Cellular Signalling, 2022-09-15;0(0):110468.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments
Authors: Z Hu, Y Li, W Yuan, L Jin, WK Leung, C Zhang, Y Yang
International journal of biological sciences, 2022-09-11;18(15):5753-5769.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dietary 7-ketocholesterol exacerbates myocardial ischemia-reperfusion injury in mice through monocyte/macrophage-mediated inflammation
Authors: T Uchikawa, T Matoba, T Kawahara, I Baba, S Katsuki, JI Koga, Y Hashimoto, R Yamasaki, I Ichi, H Akita, H Tsutsui
Scientific Reports, 2022-09-01;12(1):14902.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer
Authors: YF Wang, L Yu, ZL Hu, YF Fang, YY Shen, MF Song, Y Chen
Cell Death & Disease, 2022-08-29;13(8):748.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Succinate and inosine coordinate innate immune response to bacterial infection
Authors: M Jiang, ZG Chen, H Li, TT Zhang, MJ Yang, XX Peng, B Peng
PloS Pathogens, 2022-08-26;18(8):e1010796.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Peimine suppresses collagen-induced arthritis, activated fibroblast-like synoviocytes and TNFalpha-induced MAPK pathways
Authors: J Zhou, Y Mao, X Shi, Y Zhang, X Yu, X Liu, L Diao, X Yang, C Liu, D Liu, X Tan, M Liu
International immunopharmacology, 2022-08-24;111(0):109181.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Macrophage-Specific, Mafb-Deficient Mice Showed Delayed Skin Wound Healing
Authors: Y Inoue, CW Liao, Y Tsunakawa, IL Tsai, S Takahashi, M Hamada
International Journal of Molecular Sciences, 2022-08-19;23(16):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Graphene oxide/gallium nanoderivative as a multifunctional modulator of osteoblastogenesis and osteoclastogenesis for the synergistic therapy of implant-related bone infection
Authors: Y Yang, M Li, B Zhou, X Jiang, D Zhang, H Luo
Bioactive materials, 2022-07-21;25(0):594-614.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Multiepitope supramolecular peptide nanofibers eliciting coordinated humoral and cellular antitumor immune responses
Authors: Y Wu, H Wen, ZJ Bernstein, KM Hainline, TS Blakney, KL Congdon, DJ Snyder, JH Sampson, L Sanchez-Pe, JH Collier
Science Advances, 2022-07-20;8(29):eabm7833.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Periosteal stem cells control growth plate stem cells during postnatal skeletal growth
Authors: M Tsukasaki, N Komatsu, T Negishi-Ko, NC Huynh, R Muro, Y Ando, Y Seki, A Terashima, W Pluemsakun, T Nitta, T Nakamura, T Nakashima, S Ohba, H Akiyama, K Okamoto, R Baron, H Takayanagi
Oncogene, 2022-07-18;13(1):4166.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mechanical force regulates root resorption in rats through RANKL and OPG
Authors: J Zhou, L Guo, Y Yang, Y Liu, C Zhang
BMC Oral Health, 2022-07-16;22(1):290.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A Novel Inhibitor INF 39 Promotes Osteogenesis via Blocking the NLRP3/IL-1beta Axis
Authors: W Chen, P Tang, S Fan, X Jiang
BioMed Research International, 2022-07-13;2022(0):7250578.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants
Authors: T Hoyler, B Bannert, C André, D Beck, T Boulay, D Buffet, N Caesar, T Calzascia, J Dawson, D Kyburz, R Hennze, C Huppertz, A Littlewood, P Loetscher, KD Mertz, S Niwa, G Robert, JS Rush, G Ruzzante, S Sarret, T Stein, I Touil, G Wieczorek, G Zipfel, S Hawtin, T Junt
JCI Insight, 2022-07-08;7(13):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-19 Promotes Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy
Authors: J Zou, W Tan, B Li, Z Wang, Y Li, J Zeng, B Jiang, S Yoshida, Y Zhou
Investigative Ophthalmology & Visual Science, 2022-07-08;63(8):9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation
Authors: R Guo, X Jia, Z Ding, G Wang, M Jiang, B Li, S Chen, B Xia, Q Zhang, J Liu, R Zheng, Z Gao, X Xie
Theranostics, 2022-07-04;12(11):5220-5236.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Suppression of osteoclast multinucleation via a posttranscriptional regulation-based spatiotemporally selective delivery system
Authors: Q Wang, H Wang, H Yan, H Tian, Y Wang, W Yu, Z Dai, P Chen, Z Liu, R Tang, C Jiang, S Fan, X Liu, X Lin
Oncogene, 2022-06-29;8(26):eabn3333.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cbp1, a fungal virulence factor under positive selection, forms an effector complex that drives macrophage lysis
Authors: D Azimova, N Herrera, L Duvenage, M Voorhies, RA Rodriguez, BC English, JC Hoving, O Rosenberg, A Sil
Oncogene, 2022-06-22;18(6):e1010417.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Melatonin inhibits osteoclastogenesis via RANKL/OPG suppression mediated by Rev-Erbalpha in osteoblasts
Authors: Y Tian, J Ming
Oncogene, 2022-06-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pexmetinib suppresses osteoclast formation and breast cancer induced osteolysis via P38/STAT3 signal pathway
Authors: Z Jie, S Wang, Q Ma, Y Shen, X Zhao, H Yu, Z Xie, C Jiang
Journal of Bone Oncology, 2022-06-11;35(0):100439.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Trichinella spiralis cystatin alleviates polymicrobial sepsis through activating regulatory macrophages
Authors: H Li, D Qiu, Y Yuan, X Wang, F Wu, H Yang, S Wang, M Ma, Y Qian, B Zhan, X Yang
Oncogene, 2022-06-09;109(0):108907.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Long noncoding RNA Gm31629 promotes bone regeneration by maintaining bone marrow mesenchymal stem cells activity
Authors: G Cai, Y Xiao, M Yang, Q Guo, T Su, Y Liu, T Jiang, C Li
PeerJ, 2022-06-09;10(0):e13475.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Targeting parvalbumin promotes M2 macrophage polarization and energy expenditure in mice
Authors: S Lin, A Zhang, L Yuan, Y Wang, C Zhang, J Jiang, H Xu, H Yuan, H Yao, Q Zhang, Y Zhang, M Lou, P Wang, ZN Zhang, B Luan
Nature Communications, 2022-06-08;13(1):3301.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1
Authors: H Qu, R Heinbäck, H Salo, E Ewing, A Espinosa, C Aulin, H Erlandsson
Biomolecules, 2022-06-02;12(6):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
NLRP3 Inflammasome Negatively Regulates RANKL-Induced Osteoclastogenesis of Mouse Bone Marrow Macrophages but Positively Regulates It in the Presence of Lipopolysaccharides
Authors: MI Alam, M Mae, F Farhana, M Oohira, Y Yamashita, Y Ozaki, E Sakai, A Yoshimura
Oncogene, 2022-05-29;23(11):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1
Authors: Y Zhang, M Yang, S Zhang, Z Yang, Y Zhu, Y Wang, Z Chen, X Lv, Z Huang, Y Xie, L Cai
Cell & bioscience, 2022-05-26;12(1):70.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Anoctamin 1 controls bone resorption by coupling Cl- channel activation with RANKL-RANK signaling transduction
Authors: W Sun, S Guo, Y Li, J Li, C Liu, Y Chen, X Wang, Y Tan, H Tian, C Wang, R Du, G Zhong, S Shi, B Ma, C Qu, J Fu, X Jin, D Zhao, Y Zhan, S Ling, H An, Y Li
Nature Communications, 2022-05-24;13(1):2899.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Carnosol inhibits osteoclastogenesis in�vivo and in�vitro by blocking the RANKL?induced NF?kappaB signaling pathway
Authors: P Cai, S Yan, Y Lu, X Zhou, X Wang, M Wang, Z Yin
Molecular Medicine Reports, 2022-05-20;26(1):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts
Authors: N Matsumoto, M Sekiya, GH Sun-Wada, Y Wada, M Nakanishi-
Scientific Reports, 2022-05-19;12(1):8455.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Locally Secreted Semaphorin 4D Is Engaged in Both Pathogenic Bone Resorption and Retarded Bone Regeneration in a Ligature-Induced Mouse Model of Periodontitis
Authors: T Ishii, M Ruiz-Torru, K Yamamoto, T Yamaguchi, A Heidari, R Pierrelus, E Leon, S Shindo, M Rawas-Qala, MR Pastore, A Ikeda, S Nakamura, H Mawardi, U Kandalam, P Hardigan, L Witek, PG Coelho, T Kawai
International Journal of Molecular Sciences, 2022-05-18;23(10):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages
Authors: H Tao, Y Tao, C Yang, W Li, W Zhang, X Li, Y Gu, Y Hong, H Yang, Y Liu, X Yang, D Geng
Frontiers in Pharmacology, 2022-05-12;13(0):875611.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Epac1 activation by cAMP regulates cellular SUMOylation and promotes the formation of biomolecular condensates
Authors: W Yang, WG Robichaux, FC Mei, W Lin, L Li, S Pan, MA White, Y Chen, X Cheng
Science Advances, 2022-04-20;8(16):eabm2960.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Network Pharmacology Deciphers the Action of Bioactive Polypeptide in Attenuating Inflammatory Osteolysis via the Suppression of Oxidative Stress and Restoration of Bone Remodeling Balance
Authors: Z Cui, C Feng, J Chen, Y Wang, Q Meng, S Zhao, Y Zhang, D Feng, Z Li, S Sun
Oxidative Medicine and Cellular Longevity, 2022-04-14;2022(0):4913534.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Erythrocyte-derived extracellular vesicles aggravate inflammation by promoting the proinflammatory macrophage phenotype through TLR4-MyD88-NF-kappaB-MAPK pathway
Authors: Y Gao, H Jin, H Tan, X Cai, Y Sun
Journal of leukocyte biology, 2022-04-12;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Osteoclast formation from mouse bone marrow cells on micro/nano-scale patterned surfaces
Authors: T Akasaka, H Hayashi, M Tamai, Y Yoshimura, YI Tagawa, H Miyaji, K Nakanishi, Y Yoshida
Journal of oral biosciences, 2022-04-07;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Chemical Modulation of SQSTM1/p62-mediated Xenophagy that Targets a Broad Range of Pathogenic Bacteria
Authors: YJ Lee, JK Kim, CH Jung, YJ Kim, EJ Jung, SH Lee, HR Choi, YS Son, SM Shim, SM Jeon, JH Choe, SH Lee, J Whang, KC Sohn, GM Hur, HT Kim, J Yeom, EK Jo, YT Kwon
Autophagy, 2022-04-05;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35/NFkappaB p65 pathway
Authors: T Shi, Y Shi, H Gao, Y Ma, Q Wang, S Shen, X Shao, W Gong, X Chen, J Qin, J Wu, Q Jiang, B Xue
Journal of Orthopaedic Translation, 2022-04-04;35(0):1-12.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mitochondria-targeted supramolecular coordination container encapsulated with exogenous itaconate for synergistic therapy of joint inflammation
Authors: X Chen, C Li, X Cao, X Jia, X Chen, Z Wang, W Xu, F Dai, S Zhang
Theranostics, 2022-04-04;12(7):3251-3272.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
7-Ketocholesterol-Induced Micro-RNA-107-5p Increases Number and Activity of Osteoclasts by Targeting MKP1
Authors: G Li, OJ Sul, R Yu, HS Choi
International Journal of Molecular Sciences, 2022-03-28;23(7):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss
Authors: C Yang, H Tao, H Zhang, Y Xia, J Bai, G Ge, W Li, W Zhang, L Xiao, Y Xu, Z Wang, Y Gu, H Yang, Y Liu, D Geng
Autophagy, 2022-03-24;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
P2X7 receptor knockdown suppresses osteoclast differentiation by inhibiting autophagy and Ca2+/calcineurin signaling
Authors: Y Ma, R Di, H Zhao, R Song, H Zou, Z Liu
Molecular Medicine Reports, 2022-03-10;25(5):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Inhibition of myeloid PD-L1 suppresses osteoclastogenesis and cancer bone metastasis
Authors: H Zuo, Y Wan
Cancer Gene Therapy, 2022-03-07;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Piperlongumine Inhibits Titanium Particles-Induced Osteolysis, Osteoclast Formation, and RANKL-Induced Signaling Pathways
Authors: X Liu, L Diao, Y Zhang, X Yang, J Zhou, Y Mao, X Shi, F Zhao, M Liu
International Journal of Molecular Sciences, 2022-03-05;23(5):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mitochondrial pyruvate carrier blockade results in decreased osteoclastogenesis and bone resorption via regulating mitochondrial energy production
Authors: Q Guo, H Zhao, H Cheng, H Kang, Y Dong, R Peng, M Zhu, Z Fang, F Li
The Journal of Biological Chemistry, 2022-03-04;0(0):101775.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Plumbagin is a NF-kappaB-Inducing Kinase Inhibitor with Dual Anabolic and Anti-Resorptive Effects that Prevents Menopausal-Related Osteoporosis in Mice
Authors: G Shen, X Liu, W Lei, R Duan, Z Yao
The Journal of Biological Chemistry, 2022-02-27;0(0):101767.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Amino acids suppress macropinocytosis and promote release of CSF1 receptor in macrophages
Authors: ZI Mendel, MB Reynolds, BH Abuaita, MX O'Riordan, JA Swanson
Journal of Cell Science, 2022-02-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
The Modulatory Effects of DMF on Microglia in Aged Mice Are Sex-Specific
Authors: V Mela, A Sayd Gaban, E O'Neill, S Bechet, A Walsh, MA Lynch
Cells, 2022-02-18;11(4):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes
Authors: JM Kim, YS Yang, J Xie, O Lee, J Kim, J Hong, B Boldyreff, O Filhol, H Chun, MB Greenblatt, G Gao, JH Shim
Cell Death and Differentiation, 2022-02-15;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dual-sgRNA CRISPR/Cas9 knockout of PD-L1 in human U87 glioblastoma tumor cells inhibits proliferation, invasion, and tumor-associated macrophage polarization
Authors: J Fierro, J DiPasquale, J Perez, B Chin, Y Chokpapone, AM Tran, A Holden, C Factoriza, N Sivagnanak, R Aguilar, S Mazal, M Lopez, H Dou
Scientific Reports, 2022-02-14;12(1):2417.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Divalent metal cations stimulate skeleton interoception for new bone formation in mouse injury models
Authors: W Qiao, D Pan, Y Zheng, S Wu, X Liu, Z Chen, M Wan, S Feng, KMC Cheung, KWK Yeung, X Cao
Nature Communications, 2022-01-27;13(1):535.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
Authors: KK Richardson, W Ling, K Krager, Q Fu, SD Byrum, R Pathak, N Aykin-Burn, HN Kim
International Journal of Molecular Sciences, 2022-01-08;23(2):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1
Authors: SJ Hwang, BJ Ahn, MW Shin, YS Song, Y Choi, GT Oh, KW Kim, HJ Lee
Cell Death and Differentiation, 2022-01-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bortezomib Rescues Ovariectomy-Induced Bone Loss via SMURF-Mediated Ubiquitination Pathway
Authors: Y Fang, Y Liu, Z Zhao, Y Lu, X Shen, T Zhu, M Hou, F He, H Yang, Y Zhang, Q Shi, X Zhu
Oxidative Medicine and Cellular Longevity, 2021-12-31;2021(0):9661200.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Anti-Periodontitis Effect of Ethanol Extracts of Alpinia Katsumadai Seeds
Authors: SW Shin, YS Hwang
Nutrients, 2021-12-28;14(1):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages
Authors: Y Zou, J Zhang, J Xu, L Fu, Y Xu, X Wang, Z Li, L Zhu, H Sun, H Zheng, J Guo
Cell & bioscience, 2021-12-14;11(1):210.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Galectin-3 Contributes to the Inhibitory Effect of lalpha,25-(OH)2D3 on Osteoclastogenesis
Authors: J Gu, X Zhang, C Zhang, Y Li, J Bian, X Liu, Y Yuan, H Zou, X Tong, Z Liu
International Journal of Molecular Sciences, 2021-12-11;22(24):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Role of Cytokines Produced via the NLRP3 Inflammasome in Mouse Macrophages Stimulated with Dental Calculus in Osteoclastogenesis
Authors: M Mae, MI Alam, Y Yamashita, Y Ozaki, K Higuchi, SM Ziauddin, JL Montenegro, E Sakai, T Tsukuba, A Yoshimura
International Journal of Molecular Sciences, 2021-11-18;22(22):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment
Authors: E Kim, H Um, J Park, JW Jung, JE Kim, H Lee, EA Shin, Y Pinanga, H Lee, SH Nam, JW Lee
Cell Reports, 2021-11-16;37(7):110018.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ULK1 Suppresses Osteoclast Differentiation and Bone Resorption via Inhibiting Syk-JNK through DOK3
Authors: Y Zhang, S Zhang, Y Wang, Z Yang, Z Chen, N Wen, M Yang, Z Huang, Y Xie, L Cai
Oxidative Medicine and Cellular Longevity, 2021-11-15;2021(0):2896674.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation
Authors: C Zhuang, Z Wang, W Chen, H Wang, B Tian, H Lin
Frontiers in Pharmacology, 2021-11-11;12(0):762543.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response
Authors: AE Hinman, C Jani, SC Pringle, WR Zhang, N Jain, AJ Martinot, AK Barczak
Elife, 2021-11-10;10(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CNC-bZIP protein NFE2L1 regulates osteoclast differentiation in antioxidant-dependent and independent manners
Authors: Z Liu, H Wang, Y Hou, Y Yang, J Jia, J Wu, Z Zuo, T Gao, S Ren, Y Bian, S Liu, J Fu, Y Sun, J Li, M Yamamoto, Q Zhang, Y Xu, J Pi
Redox Biology, 2021-11-06;48(0):102180.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity
Authors: RD Hu, W Zhang, L Li, ZQ Zuo, M Ma, JF Ma, TT Yin, CY Gao, SH Yang, ZB Zhao, ZJ Li, GB Qiao, ZX Lian, K Qu
Cell Death & Disease, 2021-10-29;12(11):1023.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tumor-Released Products Promote Bone Marrow-Derived Macrophage Survival and Proliferation
Authors: JM Motta, VM Rumjanek, A Mantovani, M Locati
Biomedicines, 2021-10-04;9(10):.
Species: Mouse
Sample Types: Whole Cells
Applications: Differentiation, Differentiation -
Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury
Authors: J Amo-Aparic, J Garcia-Gar, I Francos-Qu, A Urpi, A Esteve-Cod, M Gut, A Quintana, R Lopez-Vale
Theranostics, 2021-10-03;11(20):9805-9820.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis
Authors: H Muto, T Ito, T Tanaka, S Yokoyama, K Yamamoto, N Imai, Y Ishizu, K Maeda, T Honda, T Ishikawa, A Kato, T Ohshiro, F Kano, A Yamamoto, K Sakai, H Hibi, M Ishigami, M Fujishiro
Scientific Reports, 2021-09-21;11(1):18778.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Proteopathic tau primes and activates interleukin-1beta via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway
Authors: S Jiang, NM Maphis, J Binder, D Chisholm, L Weston, W Duran, C Peterson, A Zimmerman, MA Mandell, SD Jett, E Bigio, C Geula, N Mellios, JP Weick, GA Rosenberg, E Latz, MT Heneka, K Bhaskar
Cell Reports, 2021-09-21;36(12):109720.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Ang II-Induced Hypertension Exacerbates the Pathogenesis of Tuberculosis
Authors: SN Cho, JA Choi, J Lee, SH Son, SA Lee, TD Nguyen, SY Choi, CH Song
Cells, 2021-09-19;10(9):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Myeloid Lineage Ablation of Phlpp1 Regulates M-CSF Signaling and Tempers Bone Resorption in Female Mice
Authors: IY Karkache, JR Damodaran, DHH Molstad, KC Mansky, EW Bradley
International Journal of Molecular Sciences, 2021-09-08;22(18):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Danlou Tablets Inhibit Atherosclerosis in Apolipoprotein E-Deficient Mice by Inducing Macrophage Autophagy: The Role of the PI3K-Akt-mTOR Pathway
Authors: C Liu, G Chen, Y Chen, Y Dang, G Nie, D Wu, J Li, Z Chen, H Yang, D He, X Li, J Sun, J Lu, L Wang
Frontiers in Pharmacology, 2021-09-08;12(0):724670.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Innate immune responses after stimulation with Toll-like receptor agonists in ex vivo microglial cultures and an in vivo model using mice with reduced microglia
Authors: JA Carroll, B Race, K Williams, JF Striebel, B Chesebro
Journal of Neuroinflammation, 2021-09-06;18(1):194.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The MEMIC is an ex vivo system to model the complexity of the tumor microenvironment
Authors: L Janská, L Anandi, NC Kirchberge, ZS Marinkovic, LT Schachtner, G Guzelsoy, C Carmona-Fo
Disease Models & Mechanisms, 2021-08-18;14(8):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
RSPO3 is important for trabecular bone and fracture risk in mice and humans
Authors: KH Nilsson, P Henning, ME Shahawy, M Nethander, TL Andersen, C Ejersted, J Wu, KL Gustafsson, A Koskela, J Tuukkanen, PPC Souza, J Tuckermann, M Lorentzon, LE Ruud, T Lehtimäki, JH Tobias, S Zhou, UH Lerner, JB Richards, S Movérare-S, C Ohlsson
Nature Communications, 2021-08-13;12(1):4923.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion
Authors: C Fang, JW Guo, YJ Wang, XQ Li, H Zhang, J Cui, Y Hu, YY Jing, X Chen, JC Su
Acta pharmacologica Sinica, 2021-08-11;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Rufomycin Exhibits Dual Effects Against Mycobacterium abscessus Infection by Inducing Host Defense and Antimicrobial Activities
Authors: CR Park, S Paik, YJ Kim, JK Kim, SM Jeon, SH Lee, J Whang, J Cheng, JW Suh, J Cao, G Shetye, SN Chen, J McAlpine, GF Pauli, S Franzblau, S Cho, EK Jo
Frontiers in Microbiology, 2021-08-10;12(0):695024.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Disrupted macrophage metabolic reprogramming in aged soleus muscle during early recovery following disuse atrophy
Authors: DK Fix, HA Ekiz, JJ Petrocelli, AM Mckenzie, ZS Mahmassani, RM O'Connell, MJ Drummond
Aging Cell, 2021-08-08;0(0):e13448.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Correction: Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol
Authors: MG Dorrington, CJ Bradfield, JB Lack, B Lin, SP John, JJ Liang, T Starr, O Ernst, JL Gross, J Sun, AH Miller, O Steele-Mor, IDC Fraser
PloS Pathogens, 2021-08-04;17(8):e1009821.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
STING suppresses bone cancer pain via immune and neuronal modulation
Authors: K Wang, CR Donnelly, C Jiang, Y Liao, X Luo, X Tao, S Bang, A McGinnis, M Lee, MJ Hilton, RR Ji
Nature Communications, 2021-07-27;12(1):4558.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bioinspired peptide adhesion on Ti implants alleviates wear particle-induced inflammation and improves interfacial osteogenesis
Authors: X Guo, J Bai, G Ge, Z Wang, Q Wang, K Zheng, H Tao, L Zhang, H Zhang, D Wang, X Zhang, H Li, G Pan, D Geng
Journal of colloid and interface science, 2021-07-24;605(0):410-424.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C
Authors: TT Chu, X Tu, K Yang, J Wu, JJ Repa, N Yan
Nature, 2021-07-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
N-3-Hydroxy Dodecanoyl-DL-homoserine Lactone (OH-dDHL) Triggers Apoptosis of Bone Marrow-Derived Macrophages through the ER- and Mitochondria-Mediated Pathways
Authors: K Woo, DH Kim, MH Oh, HS Park, CH Choi
International Journal of Molecular Sciences, 2021-07-15;22(14):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Protective Effect of Polysaccharides Extracted from Cudrania tricuspidata Fruit against Cisplatin-Induced Cytotoxicity in Macrophages and a Mouse Model
Authors: EB Byun, HY Song, WS Kim, JM Han, HS Seo, SH Park, K Kim, EH Byun
International Journal of Molecular Sciences, 2021-07-13;22(14):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt
Authors: AS Tooley, D Kazyken, C Bodur, IE Gonzalez, DC Fingar
The Journal of Biological Chemistry, 2021-07-08;0(0):100942.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Development of a Macrophage-Based ADCC Assay
Authors: MB Uccellini, S Aslam, STH Liu, F Alam, A García-Sas
Vaccines, 2021-06-17;9(6):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Patchouli Alcohol Modulates the Pregnancy X Receptor/Toll-like Receptor 4/Nuclear Factor Kappa B Axis to Suppress Osteoclastogenesis
Authors: Q Lu, C Jiang, J Hou, H Qian, F Chu, W Zhang, M Ye, Z Chen, J Liu, H Yao, J Zhang, J Xu, T Wang, S Fan, Q Wang
Frontiers in Pharmacology, 2021-06-08;12(0):684976.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Astragalus polysaccharide attenuates LPS-related inflammatory osteolysis by suppressing osteoclastogenesis by reducing the MAPK signalling pathway
Authors: J Yang, L Qin, J Huang, Y Li, S Xu, H Wang, S Zhu, J Wang, B Zhu, F Li, W Huang, X Gong, N Hu
Journal of Cellular and Molecular Medicine, 2021-06-02;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Disulfide and Fully Reduced HMGB1 Induce Different Macrophage Polarization and Migration Patterns
Authors: H Salo, H Qu, D Mitsiou, H Aucott, J Han, XM Zhang, C Aulin, H Erlandsson
Biomolecules, 2021-05-28;11(6):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
7-ketocholesterol enhances autophagy via the ROS-TFEB signaling pathway in osteoclasts: 7-KC in osteoclasts
Authors: OJ Sul, G Li, JE Kim, ES Kim, HS Choi
The Journal of nutritional biochemistry, 2021-05-21;0(0):108783.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BMI1 regulates multiple myeloma-associated macrophage's pro-myeloma functions
Authors: D Zhang, J Huang, F Wang, H Ding, Y Cui, Y Yang, J Xu, H Luo, Y Gao, L Pan, Y Wu, Y Gong, L Xie, Z Liu, Y Qu, L Zhang, W Liu, W Zhang, S Zhao, Q Yi, T Niu, Y Zheng
Cell Death & Disease, 2021-05-15;12(5):495.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Multi-Functional MPT Protein as a Therapeutic Agent against Mycobacterium tuberculosis
Authors: JS Kim, E Cho, SJ Mun, S Kim, SY Kim, DG Kim, W Son, HI Jeon, HK Kim, YJ Jeong, S Jang, HS Kim, CS Yang
Biomedicines, 2021-05-13;9(5):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Plastrum testudinis extract suppresses osteoclast differentiation via the NF-&kappaB signaling pathway and ameliorates senile osteoporosis
Authors: H Chen, G Shen, Q Shang, P Zhang, D Yu, X Yu, Z Zhang, W Zhao, Z Wu, F Tang, Liang, X Jiang, H Ren
Journal of ethnopharmacology, 2021-05-08;276(0):114195.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BCG Cell Wall Skeleton As a Vaccine Adjuvant Protects Both Infant and Old-Aged Mice from Influenza Virus Infection
Authors: KH Kim, YT Lee, Y Park, EJ Ko, YJ Jung, YJ Kim, EK Jo, SM Kang
Biomedicines, 2021-05-05;9(5):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
PP2Ac&alpha promotes macrophage accumulation and activation to exacerbate tubular cell death and kidney fibrosis through activating Rap1 and TNF&alpha production
Authors: Y Liang, X Sun, M Wang, Q Lu, M Gu, L Zhou, Q Hou, M Tan, S Wang, X Xue, C Dai
Cell Death and Differentiation, 2021-05-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response
Authors: P Xue, X Hu, E Chang, L Wang, M Chen, TH Wu, DJ Lee, BL Foster, HC Tseng, CC Ko
Experimental & Molecular Medicine, 2021-04-16;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling
Authors: N Li, X Li, K Zheng, J Bai, W Zhang, H Sun, G Ge, W Wang, Z Wang, Y Gu, Y Xue, Y Xu, D Geng, J Zhou
International journal of biological sciences, 2021-04-03;17(5):1382-1394.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
Authors: MJ Strowitzki, G Kimmer, JS Wehrmann, AS Ritter, P Radhakrish, VM Opitz, C Tuffs, M Biller, J Kugler, U Keppler, JM Harnoss, J Klose, T Schmidt, A Blanco, CT Taylor, M Schneider
JCI Insight, 2021-03-30;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis
Authors: X Liu, Y Chai, G Liu, W Su, Q Guo, X Lv, P Gao, B Yu, G Ferbeyre, X Cao, M Wan
Nature Communications, 2021-03-23;12(1):1832.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol
Authors: MG Dorrington, CJ Bradfield, JB Lack, B Lin, JJ Liang, T Starr, O Ernst, JL Gross, J Sun, AH Miller, O Steele-Mor, IDC Fraser
PloS Pathogens, 2021-03-08;17(3):e1009395.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
p300/CBP inhibitor A-485 inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss
Authors: S Huo, X Liu, S Zhang, Z Lyu, J Zhang, Y Wang, B Nie, B Yue
International immunopharmacology, 2021-02-21;94(0):107458.
Species: Mouse, Rat
Sample Types: Whole Cells
Applications: Bioassay -
Schistosoma�japonicum cystatin suppresses osteoclastogenesis via manipulating the NF?&kappaB signaling pathway
Authors: Y Chen, B Wei, P Xu, H Tang, L Yang, Y Wang, Y Fu, X Yang, Y Mao
Molecular Medicine Reports, 2021-02-12;23(4):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Development of a method for the identification of receptor activator of nuclear factor-&kappaB+ populations in vivo
Authors: M Kawakami, H Yasuda, D Nishida, A Katakura, T Mizoguchi
Journal of oral biosciences, 2021-01-28;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Airway-Associated Macrophages in Homeostasis and Repair
Authors: AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock
Cell Reports, 2020-12-29;33(13):108553.
Species: Transgenic Mouse
Sample Types: Spheroid
Applications: Bioassay -
CCR3 deficiency is associated with increased osteoclast activity and reduced cortical bone volume in adult male mice
Authors: S Rosendahl, R Sulniute, M Eklund, C Koskinen H, MJO Johansson, E Kindstedt, S Lindquist, P Lundberg
The Journal of Biological Chemistry, 2020-12-17;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Oleate-induced aggregation of LC3 at the trans-Golgi network is linked to a protein trafficking blockade
Authors: G Cerrato, M Leduc, K Müller, P Liu, L Zhao, J Humeau, W Xie, S Zhang, O Kepp, A Sauvat, G Kroemer
Cell Death and Differentiation, 2020-12-17;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response
Authors: G Gupta, Z Mou, P Jia, R Sharma, R Zayats, SM Viana, L Shan, A Barral, VS Boaventura, TT Murooka, A Soussi-Gou, CI de Oliveir, JE Uzonna
Cell Reports, 2020-12-15;33(11):108513.
-
Myeloid-derived suppressor cells therapy enhance immunoregulatory properties in acute graft versus host disease with combination of regulatory T cells
Authors: MJ Park, JA Baek, SY Kim, KA Jung, JW Choi, SH Park, SK Kwok, ML Cho
Journal of Translational Medicine, 2020-12-14;18(1):483.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Overexpression of c-Fos reverses osteoprotegerin-mediated suppression of osteoclastogenesis by increasing the Beclin1-induced autophagy
Authors: X Tong, M Chen, R Song, H Zhao, J Bian, J Gu, Z Liu
Journal of Cellular and Molecular Medicine, 2020-12-04;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Mycobacterium tuberculosis Rv2626c-derived peptide as a therapeutic agent for sepsis
Authors: SY Kim, D Kim, S Kim, D Lee, SJ Mun, E Cho, W Son, K Jang, CS Yang
Embo Molecular Medicine, 2020-12-01;12(12):e12497.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Tetrandrine Inhibits Titanium Particle-Induced Inflammatory Osteolysis through the Nuclear Factor-&kappaB Pathway
Authors: Z Liu, Y Li, F Guo, C Zhang, G Song, J Yang, D Chen
Mediators of Inflammation, 2020-11-27;2020(0):1926947.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis
Authors: M Timmen, H Hidding, M Götte, TE Khassawna, D Kronenberg, R Stange
Sci Rep, 2020-11-25;10(1):20510.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1&beta production
Authors: G Yang, W Song, J Xu, JL Postoak, F Cheng, J Martinez, J Zhang, L Wu, L Van Kaer
Cell Mol Immunol, 2020-11-24;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Dopamine suppresses osteoclast differentiation via cAMP/PKA/CREB pathway
Authors: L Wang, L Han, P Xue, X Hu, SW Wong, M Deng, HC Tseng, BW Huang, CC Ko
Cell Signal, 2020-11-24;78(0):109847.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
M2 macrophage-derived exosomes promote angiogenesis and growth of pancreatic ductal adenocarcinoma by targeting E2F2
Authors: Y Yang, Z Guo, W Chen, X Wang, M Cao, X Han, K Zhang, B Teng, J Cao, W Wu, P Cao, C Huang, Z Qiu
Mol Ther, 2020-11-20;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
NLRP3 Inflammasome Activation Is Involved in LPA1-Mediated Brain Injury after Transient Focal Cerebral Ischemia
Authors: CH Lee, A Sapkota, BP Gaire, JW Choi
Int J Mol Sci, 2020-11-14;21(22):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Toxoplasma gondii GRA9 Regulates the Activation of NLRP3 Inflammasome to Exert Anti-Septic Effects in Mice
Authors: JS Kim, SJ Mun, E Cho, D Kim, W Son, HI Jeon, HK Kim, K Jang, CS Yang
Int J Mol Sci, 2020-11-10;21(22):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase
Authors: AT Holdbrooks, KE Ankenbauer, J Hwang, SL Bellis
PLoS ONE, 2020-11-09;15(11):e0241850.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-&kappaB signaling pathways
Authors: L Xiao, M Zhong, Y Huang, J Zhu, W Tang, D Li, J Shi, A Lu, H Yang, D Geng, H Li, Z Wang
Aging (Albany NY), 2020-11-07;12(21):21706-21729.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Transcriptomic profiling of feline teeth highlights the role of matrix metalloproteinase 9 (MMP9) in tooth resorption
Authors: S Lee, SJ Bush, S Thorne, N Mawson, C Farquharso, GT Bergkvist
Sci Rep, 2020-11-03;10(1):18958.
Species: Feline
Sample Types: Whole Cells
Applications: Cell Culture -
MAIR-II deficiency ameliorates cardiac remodelling post-myocardial infarction by suppressing TLR9-mediated macrophage activation
Authors: S Yonebayash, K Tajiri, N Murakoshi, D Xu, S Li, D Feng, Y Okabe, Z Yuan, Z Song, K Aonuma, A Shibuya, K Aonuma, M Ieda
J Cell Mol Med, 2020-11-02;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Nepetin inhibits osteoclastogenesis by inhibiting RANKL-induced activation of NF-&kappaB and MAPK signalling pathway, and autophagy
Authors: B Chu, S Chen, X Zheng, J Ye, X Cheng, L Zhang, D Guo, P Wang, D Hong, Z Hong
J Cell Mol Med, 2020-11-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
The HMGB1/RAGE axis induces bone pain associated with colonization of 4T1 mouse breast cancer in bone
Authors: T Okui, M Hiasa, S Ryumon, K Ono, Y Kunisada, S Ibaragi, A Sasaki, GD Roodman, FA White, T Yoneda
Journal of Bone Oncology, 2020-10-28;26(0):100330.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
CSF1R signaling is a regulator of pathogenesis in progressive MS
Authors: N Hagan, JL Kane, D Grover, L Woodworth, C Madore, J Saleh, J Sancho, J Liu, Y Li, J Proto, M Zelic, A Mahan, M Kothe, AA Scholte, M Fitzgerald, B Gisevius, A Haghikia, O Butovsky, D Ofengeim
Cell Death Dis, 2020-10-23;11(10):904.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Maackiain dampens osteoclastogenesis via attenuating RANKL-stimulated NF-&kappaB signalling pathway and NFATc1 activity
Authors: Y Liu, W Zeng, C Ma, Z Wang, C Wang, S Li, W He, Q Zhang, J Xu, C Zhou
J. Cell. Mol. Med., 2020-09-16;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk
Authors: Z Najafova, P Liu, F Wegwitz, M Ahmad, L Tamon, RL Kosinsky, W Xie, SA Johnsen, J Tuckermann
Cell Death Differ., 2020-09-08;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo
Authors: J Peng, K Zhao, J Zhu, Y Wang, P Sun, Q Yang, T Zhang, W Han, W Hu, W Yang, J Ruan, Y Qian
Drug Des Devel Ther, 2020-08-24;14(0):3435-3447.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
C9orf72 in myeloid cells suppresses STING-induced inflammation
Authors: ME McCauley, JG O'Rourke, A Yáñez, JL Markman, R Ho, X Wang, S Chen, D Lall, M Jin, AKMG Muhammad, S Bell, J Landeros, V Valencia, M Harms, M Arditi, C Jefferies, RH Baloh
Nature, 2020-08-19;585(7823):96-101.
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cytisine attenuates bone loss of ovariectomy mouse by preventing RANKL-induced osteoclastogenesis
Authors: Z Qian, Z Zhong, S Ni, D Li, F Zhang, Y Zhou, Z Kang, J Qian, B Yu
J. Cell. Mol. Med., 2020-08-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Collagen VIalpha2 chain deficiency causes trabecular bone loss by potentially promoting osteoclast differentiation through enhanced TNFalpha signaling
Authors: HT Pham, V Kram, QA Dar, T Komori, Y Ji, P Mohassel, J Rooney, L Li, TM Kilts, C Bonnemann, S Lamande, MF Young
Sci Rep, 2020-08-13;10(1):13749.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tectoridin inhibits osteoclastogenesis and bone loss in a murine model of ovariectomy-induced osteoporosis
Authors: J Wang, Y Tang, X Lv, J Zhang, B Ma, X Wen, Y Bao, G Wang
Exp. Gerontol., 2020-08-13;140(0):111057.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Knockdown of Tcirg1 inhibits large-osteoclast generation by down-regulating NFATc1 and IP3R2 expression
Authors: D Zhang, L Lin, B Yang, Z Meng, B Zhang
PLoS ONE, 2020-08-13;15(8):e0237354.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay, Cell Culture -
Extracellular vesicle-encapsulated IL-10 as novel nanotherapeutics against ischemic AKI
Authors: TT Tang, B Wang, M Wu, ZL Li, Y Feng, JY Cao, D Yin, H Liu, RN Tang, SD Crowley, LL Lv, BC Liu
Sci Adv, 2020-08-12;6(33):eaaz0748.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Oridonin ameliorates inflammation-induced bone loss in mice via suppressing DC-STAMP expression
Authors: BH Zou, YH Tan, WD Deng, JH Zheng, Q Yang, MH Ke, ZB Ding, XJ Li
Acta Pharmacol. Sin., 2020-08-04;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin
Authors: T Velletri, Y Huang, Y Wang, Q Li, M Hu, N Xie, Q Yang, X Chen, Q Chen, P Shou, Y Gan, E Candi, AP Margherita, M Agostini, H Yang, G Melino, Y Shi, Y Wang
Cell Death Differ., 2020-07-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages
Authors: K Maruyama, H Kidoya, N Takemura, E Sugisawa, O Takeuchi, T Kondo, MMA Eid, H Tanaka, MM Martino, N Takakura, Y Takayama, S Akira, A Vandenbon, Y Kumagai
Cell Rep, 2020-07-14;32(2):107906.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The key royal jelly component 10-hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-&kappaB signaling downstream of FFAR4
Authors: Y Tsuchiya, M Hayashi, K Nagamatsu, T Ono, M Kamakura, T Iwata, T Nakashima
J. Biol. Chem., 2020-07-09;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Role of microglia in the dissemination of Zika virus from mother to fetal brain
Authors: P Xu, C Shan, TJ Dunn, X Xie, H Xia, J Gao, J Allende La, J Zou, PP Villarreal, CR Schlagal, Y Yu, G Vargas, SL Rossi, N Vasilakis, PY Shi, SC Weaver, P Wu
PLoS Negl Trop Dis, 2020-07-06;14(7):e0008413.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
PD-1 blockade inhibits osteoclast formation and murine bone cancer pain
Authors: K Wang, Y Gu, Y Liao, S Bang, CR Donnelly, O Chen, X Tao, AJ Mirando, MJ Hilton, RR Ji
J. Clin. Invest., 2020-07-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dual role of phosphatidylserine and its receptors in osteoclastogenesis
Authors: JH Kang, HM Ko, GD Han, SY Lee, JS Moon, MS Kim, JT Koh, SH Kim
Cell Death Dis, 2020-07-01;11(7):497.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-&kappaB signaling pathway
Authors: M Chen, Y Zhang, P Zhou, X Liu, H Zhao, X Zhou, Q Gu, B Li, X Zhu, Q Shi
Bioact Mater, 2020-06-30;5(4):880-890.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Neobavaisoflavone inhibits osteoclastogenesis through blocking RANKL signalling-mediated TRAF6 and c-Src recruitment and NF-&kappaB, MAPK and Akt pathways
Authors: H Chen, C Fang, X Zhi, S Song, Y Gu, X Chen, J Cui, Y Hu, W Weng, Q Zhou, Y Wang, Y Wang, H Jiang, X Li, L Cao, X Chen, J Su
J. Cell. Mol. Med., 2020-06-30;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice
Authors: KS Shim, YH Hwang, SA Jang, T Kim, H Ha
Nutrients, 2020-06-29;12(7):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Ablation of Gadd45beta ameliorates the inflammation and renal fibrosis caused by unilateral ureteral obstruction
Authors: SJ Moon, JH Kim, YK Choi, CH Lee, JH Hwang
J. Cell. Mol. Med., 2020-06-22;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Recombinant Protein EphB4-Fc Changes the Ti Particle-Mediated Imbalance of OPG/RANKL via EphrinB2/EphB4 Signaling Pathway and Inhibits the Release of Proinflammatory Factors In Vivo
Authors: YW Ge, K Feng, XL Liu, HF Chen, ZY Sun, CF Wang, ZQ Liu, HW Wang, JW Zhang, DG Yu, YQ Mao
Oxid Med Cell Longev, 2020-06-05;2020(0):1404915.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Progranulin inhibits LPS-induced macrophage M1 polarization via NF-?B and MAPK pathways
Authors: L Liu, H Guo, A Song, J Huang, Y Zhang, S Jin, S Li, L Zhang, C Yang, P Yang
BMC Immunol., 2020-06-05;21(1):32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cells-derived interferon-lambda1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis
Authors: Y Chen, Y Wang, R Tang, J Yang, C Dou, Y Dong, D Sun, C Zhang, L Zhang, Y Tang, Q Dai, F Luo, J Xu, S Dong
Cell Death Dis, 2020-06-02;11(6):414.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across Schwann Cell-Neuron-Microglia
Authors: Z Hu, N Deng, K Liu, N Zhou, Y Sun, W Zeng
Cell Rep, 2020-05-19;31(7):107657.
Species: Mouse
Sample Types:
Applications: In Vivo -
Genetic and pharmacological activation of Hedgehog signaling inhibits osteoclastogenesis and attenuates titanium particle-induced osteolysis partly through suppressing the JNK/c-Fos-NFATc1 cascade
Authors: L Zhang, Y Yang, Z Liao, Q Liu, X Lei, M Li, Saijilafu, Z Zhang, D Hong, M Zhu, B Li, H Yang, J Chen
Theranostics, 2020-05-17;10(15):6638-6660.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
Authors: JM Kim, YS Yang, KH Park, X Ge, R Xu, N Li, M Song, H Chun, S Bok, JF Charles, O Filhol-Coc, B Boldyreff, T Dinter, PB Yu, N Kon, W Gu, T Takarada, MB Greenblatt, JH Shim
Nat Commun, 2020-05-08;11(1):2289.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity
Authors: Y Huang, H Wang, Y Hao, H Lin, M Dong, J Ye, L Song, Y Wang, Q Li, B Shan, Y Jiang, H Li, Z Shao, G Kroemer, H Zhang, L Bai, T Jin, C Wang, Y Ma, Y Cai, C Ding, S Liu, Y Pan, W Jiang, R Zhou
Nat. Cell Biol., 2020-05-04;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Distinct iron homeostasis in C57BL/6 and Balb/c mouse strains
Authors: P Saha, X Xiao, Y Li, RM Golonka, AA Abokor, BS Yeoh, M Vijay-Kuma
Physiol Rep, 2020-05-01;8(9):e14441.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxis
Authors: E van den Bo, B Ambrosy, M Horsthemke, S Walbaum, AC Bachg, N Wettschure, G Innamorati, TM Wilkie, PJ Hanley
J. Biol. Chem., 2020-04-24;0(0):.
Species: Mouse
Sample Types: Whole Cell
Applications: Bioassay -
Prion protein N1 cleavage peptides stimulate microglial interaction with surrounding cells
Authors: JA Carroll, BR Groveman, K Williams, R Moore, B Race, CL Haigh
Sci Rep, 2020-04-20;10(1):6654.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of Smo in Macrophage/Osteoclast Lineage Prevents Age-Related Bone Loss
Authors: Y Kohara, R Haraguchi, R Kitazawa, Y Imai, S Kitazawa
Int J Mol Sci, 2020-04-15;21(8):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Rosuvastatin Prevents the Exacerbation of Atherosclerosis in Ligature-Induced Periodontal Disease Mouse Model
Authors: JS Suh, SH Lee, Z Fouladian, JY Lee, T Kim, MK Kang, AJ Lusis, KI Boström, RH Kim, NH Park
Sci Rep, 2020-04-14;10(1):6383.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Perturbed mitochondrial dynamics is a novel feature of colitis that can be targeted to lessen disease
Authors: NL Mancini, L Goudie, W Xu, R Sabouny, S Rajeev, A Wang, N Esquerre, A Al Rajabi, TS Jayme, E van Tilbur, Y Nasser, JGP Ferraz, T Shutt, J Shearer, DM McKay
Cell Mol Gastroenterol Hepatol, 2020-04-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
CD39 Produced from Human GMSCs Regulates the Balance of Osteoclasts and Osteoblasts through the Wnt/&beta-Catenin Pathway in Osteoporosis
Authors: W Wu, Z Xiao, Y Chen, Y Deng, D Zeng, Y Liu, F Huang, J Wang, Y Liu, JA Bellanti, L Rong, SG Zheng
Mol. Ther., 2020-04-11;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mycobacterium avium subsp. paratuberculosis MAP1889c Protein Induces Maturation of Dendritic Cells and Drives Th2-biased Immune Responses
Authors: HS Park, YW Back, YJ Son, HJ Kim
Cells, 2020-04-11;9(4):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway
Authors: C Goda, D Balli, M Black, D Milewski, T Le, V Ustiyan, X Ren, VV Kalinichen, TV Kalin
PLoS Genet., 2020-04-09;16(4):e1008692.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Passenger Mutations Confound Phenotypes of SARM1-Deficient Mice
Authors: MB Uccellini, SV Bardina, MT Sánchez-Ap, KM White, YJ Hou, JK Lim, A García-Sas
Cell Rep, 2020-04-07;31(1):107498.
Species: Mouse
Sample Types: N/A, Whole Cells
Applications: Bioassay -
MsrA Suppresses Inflammatory Activation of Microglia and Oxidative Stress to Prevent Demyelination via Inhibition of the NOX2-MAPKs/NF-&kappaB Signaling Pathway
Authors: H Fan, D Li, X Guan, Y Yang, J Yan, J Shi, R Ma, Q Shu
Drug Des Devel Ther, 2020-04-05;14(0):1377-1389.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Tussilagone Inhibits Osteoclastogenesis and Periprosthetic Osteolysis by Suppressing the NF-&kappaB and P38 MAPK Signaling Pathways
Authors: X Hu, Z Yin, X Chen, G Jiang, D Yang, Z Cao, S Li, Z Liu, D Peng, P Dou
Front Pharmacol, 2020-04-03;11(0):385.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Magnoflorine Suppresses MAPK and NF-&kappaB Signaling to Prevent Inflammatory Osteolysis Induced by Titanium Particles In Vivo and Osteoclastogenesis via RANKL In Vitro
Authors: Z Sun, J Zeng, W Wang, X Jia, Q Wu, D Yu, Y Mao
Front Pharmacol, 2020-04-02;11(0):389.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Differential regulation of breast cancer bone metastasis by PARP1 and PARP2
Authors: H Zuo, D Yang, Q Yang, H Tang, YX Fu, Y Wan
Nat Commun, 2020-03-27;11(1):1578.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss
Authors: X Sun, C Zhang, H Guo, J Chen, Y Tao, F Wang, X Lin, Q Liu, L Su, A Qin
Front Pharmacol, 2020-03-27;11(0):360.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo
Authors: K Miyagawa, Y Ohata, J Delgado-Ca, J Teramachi, H Zhou, DW Dempster, MA Subler, JJ Windle, J Chirgwin, GD Roodman, N Kurihara
JCI Insight, 2020-03-26;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Guaiacol suppresses osteoclastogenesis by blocking interactions of RANK with TRAF6 and C-Src and inhibiting NF-&kappaB, MAPK and AKT pathways
Authors: X Zhi, C Fang, Y Gu, H Chen, X Chen, J Cui, Y Hu, W Weng, Q Zhou, Y Wang, Y Wang, H Jiang, X Li, L Cao, X Chen, J Su
J. Cell. Mol. Med., 2020-03-17;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
F2r negatively regulates osteoclastogenesis through inhibiting the Akt and NF&kappaB signaling pathways
Authors: Y Zhang, H Wang, G Zhu, A Qian, W Chen
Int. J. Biol. Sci., 2020-03-12;16(9):1629-1639.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis
Authors: YR Kim, JS Kim, SJ Gu, S Jo, S Kim, S Young Kim, D Lee, K Jang, H Choo, TH Kim, JU Jung, SJ Min, CS Yang
Sci Rep, 2020-03-12;10(1):4570.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
The Peroxisome Proliferator-Activated Receptor &alpha- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections
Authors: YS Kim, JK Kim, BTB Hanh, SY Kim, HJ Kim, YJ Kim, SM Jeon, CR Park, GT Oh, JW Park, JM Kim, J Jang, EK Jo
Cells, 2020-03-06;9(3):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Osthole-loaded N-octyl-O-sulfonyl chitosan micelles (NSC-OST) inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in rats
Authors: L Wang, S Zheng, G Huang, J Sun, Y Pan, Y Si, P Tu, G Xu, Y Ma, Y Guo
J. Cell. Mol. Med., 2020-03-03;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Transient Inhibition of PI3K&delta Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus
Authors: MS Ferguson, LS Chard Dunm, R Gangeswara, G Marelli, JR Tysome, E Burns, MA Whitehead, E Aksoy, G Alusi, C Hiley, J Ahmed, B Vanhaesebr, NR Lemoine, Y Wang
Mol. Ther., 2020-02-28;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis
Authors: H Liu, Y Zhu, Y Gao, D Qi, L Zhao, L Zhao, C Liu, T Tao, C Zhou, X Sun, F Guo, J Xiao
Cell Death Dis, 2020-02-18;11(2):129.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities
Authors: S Ikezu, H Yeh, JC Delpech, ME Woodbury, AA Van Enoo, Z Ruan, S Sivakumara, Y You, C Holland, T Guillamon-, A Yoshii-Kit, MB Botros, C Madore, PH Chao, A Desani, S Manimaran, SV Kalavai, WE Johnson, O Butovsky, M Medalla, JI Luebke, T Ikezu
Mol. Psychiatry, 2020-02-18;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury
Authors: FQ Kong, SJ Zhao, P Sun, H Liu, J Jie, T Xu, AD Xu, YQ Yang, Y Zhu, J Chen, Z Zhou, DF Qian, CJ Gu, Q Chen, GY Yin, HW Zhang, J Fan
J Neuroinflammation, 2020-02-17;17(1):62.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Regulation of bone metabolism by megakaryocytes in a paracrine manner
Authors: YS Lee, MK Kwak, SA Moon, YJ Choi, JE Baek, SY Park, BJ Kim, SH Lee, JM Koh
Sci Rep, 2020-02-10;10(1):2277.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Environmental arginine controls multinuclear giant cell metabolism and formation
Authors: JS Brunner, L Vulliard, M Hofmann, M Kieler, A Lercher, A Vogel, M Russier, JB Brüggenthi, M Kerndl, V Saferding, B Niederreit, A Junza, A Frauenstei, C Scholtysek, Y Mikami, K Klavins, G Krönke, A Bergthaler, JJ O'Shea, T Weichhart, F Meissner, JS Smolen, P Cheng, O Yanes, J Menche, PJ Murray, O Sharif, S Blüml, G Schabbauer
Nat Commun, 2020-01-22;11(1):431.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion
Authors: JR Plemel, JA Stratton, NJ Michaels, KS Rawji, E Zhang, S Sinha, CS Baaklini, Y Dong, M Ho, K Thorburn, TN Friedman, S Jawad, C Silva, AV Caprariell, V Hoghooghi, J Yue, A Jaffer, K Lee, BJ Kerr, R Midha, PK Stys, J Biernaskie, VW Yong
Sci Adv, 2020-01-15;6(3):eaay6324.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Cell Culture -
Pharmacological Properties of JTE-952, an Orally Available and Selective Colony Stimulating Factor 1 Receptor Kinase Inhibitor
Authors: N Uesato, N Miyagawa, K Inagaki, R Kakefuda, Y Kitagawa, Y Matsuo, T Yamaguchi, T Hata, K Ikegashira, M Matsushita
Biol. Pharm. Bull., 2020-01-01;43(2):325-333.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation
Authors: RK Arya, R Goswami, SO Rahaman
The Journal of Biological Chemistry, 2020-01-01;296(0):100129.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hdac3 regulates bone modeling by suppressing osteoclast responsiveness to RANKL
Authors: DHH Molstad, AM Mattson, DL Begun, JJ Westendorf, EW Bradley
J Biol Chem, 2020-01-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibitory effects of dabigatran etexilate, a direct thrombin inhibitor, on osteoclasts and osteoblasts
Authors: AL Rocha, RL Bighetti-T, LF Duffles, JAA de Arruda, TM Taira, BRD Assis, S Macari, IMA Diniz, MM Beloti, AL Rosa, SY Fukada, GAC Goulart, DD Ribeiro, LG Abreu, TA Silva
Thromb. Res., 2019-12-23;186(0):45-53.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Gas6/MerTK signaling is negatively regulated by NF-&kappaB and supports lung carcinogenesis
Authors: SV Novitskiy, R Zaynagetdi, G Vasiukov, S Gutor, W Han, A Serezani, A Matafonov, LA Gleaves, TP Sherrill, VV Polosukhin, TS Blackwell
Oncotarget, 2019-12-17;10(66):7031-7042.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The protective effect of WKYMVm peptide on inflammatory osteolysis through regulating NF-kappaB and CD9/gp130/STAT3 signalling pathway
Authors: J Hu, X Li, Y Chen, X Han, L Li, Z Yang, L Duan, H Lu, Q He
J. Cell. Mol. Med., 2019-12-14;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-27 Is Essential for Type 1 Diabetes Development and Sj�gren Syndrome-like Inflammation
Authors: AE Ciecko, B Foda, JY Barr, S Ramanathan, MA Atkinson, DV Serreze, AM Geurts, SM Lieberman, YG Chen
Cell Rep, 2019-12-03;29(10):3073-3086.e5.
Species: Mouse
Sample Types: Whole Tissue
Applications: Tissue Culture -
P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation
Authors: J Nagai, B Balestrier, LB Fanning, T Kyin, H Cirka, J Lin, M Idzko, A Zech, EY Kim, PJ Brennan, JA Boyce
J. Clin. Invest., 2019-12-02;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A Novel Sulforaphane-Regulated Gene Network in Suppression of Breast Cancer-Induced Osteolytic Bone Resorption
Authors: SK Pore, ER Hahm, SH Kim, KB Singh, L Nyiranshut, JD Latoche, CJ Anderson, J Adamik, DL Galson, KR Weiss, RJ Watters, B Lee, PN Kumta, SV Singh
Mol. Cancer Ther., 2019-11-29;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Diterpenoids from the aerial parts of Flueggea acicularis and their activity against RANKL-induced osteoclastogenesis
Authors: D Huang, X Luo, Z Yin, J Xu, Q Gu
Bioorg. Chem., 2019-11-23;0(0):103453.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mitofusin 2-Deficiency Suppresses Mycobacterium tuberculosis Survival in Macrophages
Authors: J Lee, JA Choi, SN Cho, SH Son, CH Song
Cells, 2019-10-30;8(11):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
MicroRNA-29a Counteracts Glucocorticoid Induction of Bone Loss through Repressing TNFSF13b Modulation of Osteoclastogenesis
Authors: RW Wu, WS Lian, YS Chen, CW Kuo, HC Ke, CK Hsieh, SY Wang, JY Ko, FS Wang
Int J Mol Sci, 2019-10-17;20(20):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Cell Culture -
Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice
Authors: J Wang, G Chen, Q Zhang, F Zhao, X Yu, X Ma, M Liu
Front Pharmacol, 2019-10-17;10(0):1188.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
PRMT6 promotes lung tumor progression via the alternate activation of tumor-associated macrophages
Authors: S Avasarala, PY Wu, SQ Khan, S Yanlin, M Van Scoyk, J Bao, A Di Lorenzo, O David, MT Bedford, V Gupta, RA Winn, RK Bikkavilli
Mol. Cancer Res., 2019-10-16;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation
Authors: N Wu, XN Nguyen, L Wang, R Appourchau, C Zhang, B Panthu, H Gruffat, C Journo, S Alais, J Qin, N Zhang, K Tartour, F Catez, R Mahieux, T Ohlmann, M Liu, B Du, A Cimarelli
PLoS Pathog., 2019-10-10;15(10):e1008093.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROS/TRPML1/TFEB to Reduce LPS-Induced Bone Loss
Authors: HJ Park, M Gholam-Zad, JH Suh, HS Choi
Oxid Med Cell Longev, 2019-10-08;2019(0):8982147.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Nobiletin-loaded micelles reduce ovariectomy-induced bone loss by suppressing osteoclastogenesis
Authors: Y Wang, J Xie, Z Ai, J Su
Int J Nanomedicine, 2019-09-26;14(0):7839-7849.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12
Authors: WS Lian, JY Ko, YS Chen, HJ Ke, CK Hsieh, CW Kuo, SY Wang, BW Huang, JG Tseng, FS Wang
Cell Death Dis, 2019-09-23;10(10):705.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cathepsin L secretion by host and neoplastic cells potentiates invasion
Authors: SS Dykes, HO Fasanya, DW Siemann
Oncotarget, 2019-09-17;10(53):5560-5568.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cleavage of RIPK1 by caspase-8�is crucial for limiting apoptosis and necroptosis
Authors: K Newton, KE Wickliffe, DL Dugger, A Maltzman, M Roose-Girm, M Dohse, L K?m?ves, JD Webster, VM Dixit
Nature, 2019-09-11;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Development of bone seeker-functionalised microspheres as a targeted local antibiotic delivery system for bone infections
Authors: SG Rotman, K Thompson, DW Grijpma, RG Richards, TF Moriarty, D Eglin, O Guillaume
J Orthop Translat, 2019-08-30;21(0):136-145.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-?b signaling
Authors: X Sun, Z Xie, B Hu, B Zhang, Y Ma, X Pan, H Huang, J Wang, X Zhao, Z Jie, P Shi, Z Chen
Redox Biol, 2019-08-27;28(0):101309.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer
Authors: A El-Kenawi, C Gatenbee, M Robertson-, R Bravo, J Dhillon, Y Balaguruna, A Berglund, N Visvakarma, A Ibrahim-Ha, J Choi, K Luddy, R Gatenby, S Pilon-Thom, A Anderson, B Ruffell, R Gillies
Br. J. Cancer, 2019-08-16;121(7):556-566.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Stachydrine prevents LPS-induced bone loss by inhibiting osteoclastogenesis via NF-κB and Akt signalling
Authors: J Meng, C Zhou, W Zhang, W Wang, B He, B Hu, G Jiang, Y Wang, J Hong, S Li, J He, S Yan, W Yan
J. Cell. Mol. Med., 2019-07-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome
Authors: L Sun, W Ma, W Gao, Y Xing, L Chen, Z Xia, Z Zhang, Z Dai
Cell Death Dis, 2019-07-17;10(8):542.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Salmonella Coiled-Coil- and TIR-Containing TcpS Evades the Innate Immune System and Subdues Inflammation
Authors: D Xiong, L Song, S Geng, Y Jiao, X Zhou, H Song, X Kang, Y Zhou, X Xu, J Sun, Z Pan, X Jiao
Cell Rep, 2019-07-16;28(3):804-818.e7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis
Authors: YS Yang, J Xie, D Wang, JM Kim, PWL Tai, E Gravallese, G Gao, JH Shim
Nat Commun, 2019-07-04;10(1):2958.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Adult stem cell deficits drive Slc29a3 disorders in mice
Authors: S Nair, AM Strohecker, AK Persaud, B Bissa, S Muruganand, C McElroy, R Pathak, M Williams, R Raj, A Kaddoumi, A Sparreboom, AM Beedle, R Govindaraj
Nat Commun, 2019-07-03;10(1):2943.
Species: Mouse
Sample Types: Whole Cells
Applications: Differentiation, Differentiation -
Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy
Authors: SS Welc, I Flores, M Wehling-He, J Ramos, Y Wang, C Bertoni, JG Tidball
Nat Commun, 2019-06-26;10(1):2788.
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sfrp4 repression of the Ror2/Jnk cascade in osteoclasts protects cortical bone from excessive endosteal resorption
Authors: K Chen, PY Ng, R Chen, D Hu, S Berry, R Baron, F Gori
Proc. Natl. Acad. Sci. U.S.A., 2019-06-25;0(0):.
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dehydrocostus lactone attenuates osteoclastogenesis and osteoclast-induced bone loss by modulating NF-?B signalling pathway
Authors: B Hu, F Wu, Z Shi, B He, X Zhao, H Wu, S Yan
J. Cell. Mol. Med., 2019-06-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Rab32 GTPase, as a direct target of miR-30b/c, controls the intracellular survival of Burkholderia pseudomallei by regulating phagosome maturation
Authors: ZQ Hu, CL Rao, ML Tang, Y Zhang, XX Lu, JG Chen, C Mao, L Deng, Q Li, XH Mao
PLoS Pathog., 2019-06-14;15(6):e1007879.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice
Authors: AM Mattson, DL Begun, DHH Molstad, MA Meyer, MJ Oursler, JJ Westendorf, EW Bradley
J. Biol. Chem., 2019-06-12;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors
Authors: J Gilmour, L O'Connor, CP Middleton, P Keane, N Gillemans, JB Cazier, S Philipsen, C Bonifer
Epigenetics Chromatin, 2019-06-04;12(1):33.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Nerve modulation therapy in gouty arthritis: targeting increased sFRP2 expression in dorsal root ganglion regulates macrophage polarization and alleviates endothelial damage
Authors: J Mei, F Zhou, H Qiao, H Li, T Tang
Theranostics, 2019-05-31;9(13):3707-3722.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Transcriptomics Analysis Reveals New Insights into the Roles of Notch1 Signaling on Macrophage Polarization
Authors: CP Hans, N Sharma, S Sen, S Zeng, R Dev, Y Jiang, A Mahajan, T Joshi
Sci Rep, 2019-05-29;9(1):7999.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice
Authors: S Marino, D de Ridder, RT Bishop, N Renema, M Ponzetti, A Sophocleou, M Capulli, A Aljeffery, G Carrasco, MD Gens, A Khogeer, SH Ralston, J Gertsch, F Lamoureux, D Heymann, N Rucci, AI Idris
EBioMedicine, 2019-05-29;44(0):452-466.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression
Authors: S Lotinun, Y Ishihara, K Nagano, R Kiviranta, V Carpentier, L Neff, V Parkman, N Ide, D Hu, P Dann, D Brooks, ML Bouxsein, J Wysolmersk, F Gori, R Baron
J. Clin. Invest., 2019-05-21;130(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury
Authors: LL Lv, Y Feng, M Wu, B Wang, ZL Li, X Zhong, WJ Wu, J Chen, HF Ni, TT Tang, RN Tang, HY Lan, BC Liu
Cell Death Differ., 2019-05-16;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease
Authors: SW Wong, BW Huang, X Hu, E Ho Kim, JP Kolb, RJ Padilla, P Xue, L Wang, TH Oguin, PA Miguez, HC Tseng, CC Ko, J Martinez
Cell Death Differ., 2019-05-10;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Caspase-1 initiates apoptosis in the absence of gasdermin D
Authors: K Tsuchiya, S Nakajima, S Hosojima, D Thi Nguyen, T Hattori, T Manh Le, O Hori, MR Mahib, Y Yamaguchi, M Miura, T Kinoshita, H Kushiyama, M Sakurai, T Shiroishi, T Suda
Nat Commun, 2019-05-07;10(1):2091.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Tumor derived EDIL3 modulates the expansion and osteoclastogenesis of myeloid derived suppressor cells in murine breast cancer model
Authors: Z Kun, G Xin, W Tao, Z Chenglong, W Dongsheng, T Liang, L Tielong, X Jianru
J Bone Oncol, 2019-04-29;16(0):100238.
Species: Mouse
Sample Types: Tumor Cells
Applications: Bioassay -
A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice
Authors: HK Kwon, MC Patra, HJ Shin, X Gui, A Achek, S Panneersel, DJ Kim, SJ Song, R Hong, KS Kim, YG Kim, FY Lee, DH Hahm, SH Lee, S Choi
Exp. Mol. Med., 2019-04-26;51(4):50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis
Authors: NE Putnam, LE Fulbright, JM Curry, CA Ford, JR Petronglo, AS Hendrix, JE Cassat
PLoS Pathog., 2019-04-12;15(4):e1007744.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Discovery of new inhibitors against both NF-?B and osteoclastogenesis from in-house library with ?, ?-unsaturated-enone fragment
Authors: C Zhao, D Huang, R Li, J Xu, Q Gu, J Xu
Bioorg. Chem., 2019-03-28;87(0):638-646.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
PI3K activation increases SDF-1 production and number of osteoclast precursors, and enhances SDF-1-mediated osteoclast precursor migration
Authors: NS Adapala, S Root, J Lorenzo, H Aguila, A Sanjay
Bone Rep, 2019-03-22;10(0):100203.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4
Authors: N Funk, M Munz, T Ott, K Brockmann, A Wenninger-, R Kühn, D Vogt-Weise, F Giesert, W Wurst, T Gasser, S Biskup
Sci Rep, 2019-03-14;9(1):4515.
Species: Mouse, Rat
Sample Types: Whole Cells
Applications: Bioassay -
Rg6, a rare ginsenoside, inhibits systemic inflammation through the induction of interleukin-10 and microRNA-146a
Authors: S Paik, JH Choe, GE Choi, JE Kim, JM Kim, GY Song, EK Jo
Sci Rep, 2019-03-13;9(1):4342.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mycobacterium tuberculosis Rv3463 induces mycobactericidal activity in macrophages by enhancing phagolysosomal fusion and exhibits therapeutic potential
Authors: HS Park, YW Back, KW Shin, HS Bae, KI Lee, HG Choi, S Choi, HH Lee, CH Choi, JK Park, HJ Kim
Sci Rep, 2019-03-12;9(1):4246.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Characterisation of genes differentially expressed in macrophages by virulent and attenuated Mycobacterium tuberculosis through RNA-Seq analysis
Authors: J Lee, SG Lee, KK Kim, YJ Lim, JA Choi, SN Cho, C Park, CH Song
Sci Rep, 2019-03-11;9(1):4027.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis
Authors: P Handa, S Thomas, V Morgan-Ste, BD Maliken, E Gochanour, S Boukhar, MM Yeh, KV Kowdley
J. Leukoc. Biol., 2019-03-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions
Authors: TS Kim, YB Jin, YS Kim, S Kim, JK Kim, HM Lee, HW Suh, JH Choe, YJ Kim, BS Koo, HN Kim, M Jung, SH Lee, DK Kim, C Chung, JW Son, JJ Min, JM Kim, CX Deng, HS Kim, SR Lee, EK Jo
Autophagy, 2019-03-04;0(0):20-Jan.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy
Authors: J Wang, J Sun, LN Liu, DB Flies, X Nie, M Toki, J Zhang, C Song, M Zarr, X Zhou, X Han, KA Archer, T O'Neill, RS Herbst, AN Boto, MF Sanmamed, S Langermann, DL Rimm, L Chen
Nat. Med., 2019-03-04;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host
Authors: M Ahn, DE Anderson, Q Zhang, CW Tan, BL Lim, K Luko, M Wen, WN Chia, S Mani, LC Wang, JHJ Ng, RM Sobota, CA Dutertre, F Ginhoux, ZL Shi, AT Irving, LF Wang
Nat Microbiol, 2019-02-25;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Long noncoding RNA Malat1 regulates differential activation of macrophage and response to lung injury
Authors: H Cui, S Banerjee, S Guo, N Xie, J Ge, D Jiang, M Zörnig, VJ Thannickal, G Liu
JCI Insight, 2019-02-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Fasciola hepatica GST downregulates NF-?B pathway effectors and inflammatory cytokines while promoting survival in a mouse septic shock model
Authors: V Aguayo, BN Valdés Fer, M Rodríguez-, C Ruiz-Jimén, MJ Ramos-Bení, LB Méndez, AM Espino
Sci Rep, 2019-02-19;9(1):2275.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways
Authors: X Rao, S Zhao, Z Braunstein, H Mao, M Razavi, L Duan, Y Wei, AC Toomey, S Rajagopala, J Zhong
EBioMedicine, 2019-02-07;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CD200 Modulates S. aureus-Induced Innate Immune Responses Through Suppressing p38 Signaling
Authors: B Zhu, Y Yu, X Liu, Q Han, Y Kang, L Shi
Int J Mol Sci, 2019-02-03;20(3):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A potential therapeutic target for regulating osteoporosis via suppression of osteoclast differentiation
Authors: Q Sun, B Zhang, W Zhu, W Wei, J Ma, FR Tay
J Dent, 2019-02-01;0(0):.
Species: Mouse
Sample Types:
Applications: Bioassay -
Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82
Authors: A Bergsma, SS Ganguly, ME Wiegand, D Dick, BO Williams, CK Miranti
Bone Rep, 2019-01-30;10(0):100196.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
L-caldesmon alters cell spreading and adhesion force in RANKL-induced osteoclasts
Authors: CL Chan, JY Chen, MC Shih, CA Wang, YM Liou
J. Biomed. Sci., 2019-01-24;26(1):12.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The neurosteroid, pregnenolone promotes degradation of key proteins in the innate immune signalling to suppress inflammation
Authors: S Murugan, P Jakka, S Namani, V Mujumdar, G Radhakrish
J. Biol. Chem., 2019-01-15;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
Authors: R Singh, S Chandrashe, SR Bodduluri, BV Baby, B Hegde, NG Kotla, AA Hiwale, T Saiyed, P Patel, M Vijay-Kuma, MGI Langille, GM Douglas, X Cheng, EC Rouchka, SJ Waigel, GW Dryden, H Alatassi, HG Zhang, B Haribabu, PK Vemula, VR Jala
Nat Commun, 2019-01-09;10(1):89.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ISRE-Reporter Mouse Reveals High Basal and Induced Type I IFN Responses in Inflammatory Monocytes
Authors: MB Uccellini, A García-Sas
Cell Rep, 2018-12-04;25(10):2784-2796.e3.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Induction of Kr�ppel-like factor 2 reduces K/BxN serum-induced arthritis
Authors: M Das, D Laha, S Kanji, M Joseph, R Aggarwal, OH Iwenofu, VJ Pompili, MK Jain, H Das
J. Cell. Mol. Med., 2018-12-03;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Skeletal phenotype of the neuropeptide Y knockout mouse
Authors: NKY Wee, BP Sinder, S Novak, X Wang, C Stoddard, BG Matthews, I Kalajzic
Neuropeptides, 2018-11-30;73(0):78-88.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Protective effects of a traditional herbal extract from Stellaria dichotoma var. lanceolata against Mycobacterium abscessus infections
Authors: SJ Bae, JW Choi, BJ Park, J Lee, EK Jo, YH Lee, SB Kim, JM Yuk
PLoS ONE, 2018-11-19;13(11):e0207696.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Evodiamine inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in mice
Authors: H Jin, L Yao, K Chen, Y Liu, Q Wang, Z Wang, Q Liu, Z Cao, J Kenny, J Tickner, X Wang, J Xu
J. Cell. Mol. Med., 2018-11-19;23(1):522-534.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of STAT5A promotes osteogenesis by DLX5 regulation
Authors: KM Lee, KH Park, JS Hwang, M Lee, DS Yoon, HA Ryu, HS Jung, KW Park, J Kim, SW Park, SH Kim, YM Chun, WJ Choi, JW Lee
Cell Death Dis, 2018-11-14;9(11):1136.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Authors: AN Billin, SE Honeycutt, AV McDougal, JP Kerr, Z Chen, JM Freudenber, DK Rajpal, G Luo, HF Kramer, RS Geske, F Fang, B Yao, RV Clark, J Lepore, A Cobitz, R Miller, K Nosaka, AC Hinken, AJ Russell
Skelet Muscle, 2018-11-13;8(1):35.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival
Authors: K Subramania, DR Neill, HA Malak, L Spelmink, S Khandaker, G Dalla Libe, E Dearing, A Kirby, M Yang, A Achour, J Nilvebrant, PÅ Nygren, L Plant, A Kadioglu, B Henriques-
Nat Microbiol, 2018-11-12;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Exosomes released from tumor-associated macrophages transfer miRNAs that induce a Treg/Th17 cell imbalance in epithelial ovarian cancer
Authors: J Zhou, X Li, X Wu, T Zhang, Q Zhu, X Wang, H Wang, K Wang, Y Lin, X Wang
Cancer Immunol Res, 2018-11-05;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression
Authors: MN Lee, HS Hwang, SH Oh, A Roshanzade, JW Kim, JH Song, ES Kim, JT Koh
Exp. Mol. Med., 2018-11-05;50(11):142.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages
Authors: V Beneke, F Küster, AL Neehus, C Hesse, E Lopez-Rodr, K Haake, A Rafiei Has, JW Schott, D Walter, A Braun, WF Wolkers, M Ackermann, N Lachmann
Sci Rep, 2018-11-02;8(1):16281.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice
Authors: T Hara, PT Phuong, D Fukuda, K Yamaguchi, C Murata, S Nishimoto, S Yagi, K Kusunose, H Yamada, T Soeki, T Wakatsuki, I Imoto, M Shimabukur, M Sata
Circulation, 2018-10-16;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections
Authors: JK Kim, YS Kim, HM Lee, HS Jin, C Neupane, S Kim, SH Lee, JJ Min, M Sasai, JH Jeong, SK Choe, JM Kim, M Yamamoto, HE Choy, JB Park, EK Jo
Nat Commun, 2018-10-10;9(1):4184.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bone marrow mesenchymal stem cells tune the differentiation of myeloid-derived suppressor cells in bleomycin-induced lung injury
Authors: X Su, L Yang, Y Yin, J Huang, F Qiao, Y Fang, L Yu, Y Wang, K Zhou, J Wang
Stem Cell Res Ther, 2018-09-26;9(1):253.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Stevioside Prevents Wear Particle-Induced Osteolysis by Inhibiting Osteoclastogenesis and Inflammatory Response via the Suppression of TAK1 Activation
Authors: J Meng, C Zhou, B Hu, M Luo, Y Yang, Y Wang, W Wang, G Jiang, J Hong, S Li, H Wu, S Yan, W Yan
Front Pharmacol, 2018-09-26;9(0):1053.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in silico
Authors: E Mobarak, L Håversen, M Manna, M Rutberg, M Levin, R Perkins, T Rog, I Vattulaine, J Borén
Sci Rep, 2018-09-11;8(1):13600.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Artemisinin-Daumone Hybrid Inhibits Cancer Cell-Mediated Osteolysis by Targeting Cancer Cells and Osteoclasts
Authors: GT Ma, SK Lee, KK Park, J Park, SH Son, M Jung, WY Chung
Cell. Physiol. Biochem., 2018-09-11;49(4):1460-1475.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans
Authors: X Xiang, TM Piers, B Wefers, K Zhu, A Mallach, B Brunner, G Kleinberge, W Song, M Colonna, J Herms, W Wurst, JM Pocock, C Haass
Mol Neurodegener, 2018-09-06;13(1):49.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Coupling of bone resorption and formation by RANKL reverse signalling
Authors: Y Ikebuchi, S Aoki, M Honma, M Hayashi, Y Sugamori, M Khan, Y Kariya, G Kato, Y Tabata, JM Penninger, N Udagawa, K Aoki, H Suzuki
Nature, 2018-09-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of ?-amyloid
Authors: A Rubio-Arai, OM Finucane, S Keogh, MA Lynch
J Neuroinflammation, 2018-08-31;15(1):247.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Silencing LAIR-1 in human THP-1 macrophage increases foam cell formation by modulating PPAR? and M2 polarization
Authors: X Yi, J Zhang, R Zhuang, S Wang, S Cheng, D Zhang, J Xie, W Hu, X Liu, Y Zhang, Y Ding, Y Zhang
Cytokine, 2018-08-31;111(0):194-205.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and ?v?3 integrin for osteoporosis therapy
Authors: Y Zur, L Rosenfeld, CA Keshelman, N Dalal, G Guterman-R, A Orenbuch, Y Einav, N Levaot, N Papo
PLoS Biol., 2018-08-24;16(8):e2002979.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Effects of metal ions on caspase-1 activation and interleukin-1? release in murine bone marrow-derived macrophages
Authors: MA Ferko, I Catelas
PLoS ONE, 2018-08-23;13(8):e0199936.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model
Authors: G Locatelli, D Theodorou, A Kendirli, MJC Jordão, O Staszewski, K Phulphagar, L Cantuti-Ca, A Dagkalis, A Bessis, M Simons, F Meissner, M Prinz, M Kerschenst
Nat. Neurosci., 2018-08-20;21(9):1196-1208.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis
Authors: C McCarthy, E Lee, JP Bridges, A Sallese, T Suzuki, JC Woods, BJ Bartholmai, T Wang, C Chalk, BC Carey, P Arumugam, K Shima, EJ Tarling, BC Trapnell
Nat Commun, 2018-08-07;9(1):3127.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Modulating bone marrow hematopoietic lineage potential to prevent bone metastasis in breast cancer
Authors: JM Ubellacker, N Baryawno, N Severe, MJ DeCristo, J Sceneay, JN Hutchinson, MT Haider, CS Rhee, Y Qin, WM Gregory, AC Garrido-Ca, I Holen, JE Brown, RE Coleman, DT Scadden, SS McAllister
Cancer Res., 2018-07-31;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inflammatory response of microglia to prions is controlled by sialylation of PrPSc
Authors: S Srivastava, E Katorcha, N Makarava, JP Barrett, DJ Loane, IV Baskakov
Sci Rep, 2018-07-27;8(1):11326.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
In Silico Discovery of Plant-Origin Natural Product Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-?B Ligand (RANKL)
Authors: G Melagraki, E Ntougkos, D Papadopoul, V Rinotas, G Leonis, E Douni, A Afantitis, G Kollias
Front Pharmacol, 2018-07-25;9(0):800.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Human umbilical cord-derived mesenchymal stem cells direct macrophage polarization to alleviate pancreatic islets dysfunction in type 2 diabetic mice
Authors: Y Yin, H Hao, Y Cheng, L Zang, J Liu, J Gao, J Xue, Z Xie, Q Zhang, W Han, Y Mu
Cell Death Dis, 2018-07-09;9(7):760.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation
Authors: MGA Broeren, I Di Ceglie, MB Bennink, PLEM van Lent, WB van den Be, MI Koenders, EN Blaney Dav, PM van der Kr, FAJ van de Loo
PeerJ, 2018-05-30;6(0):e4771.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
SLC15A2 and SLC15A4 Mediate the Transport of Bacterially Derived Di/Tripeptides To Enhance the Nucleotide-Binding Oligomerization Domain-Dependent Immune Response in Mouse Bone Marrow-Derived Macrophages
Authors: Y Hu, F Song, H Jiang, G Nuñez, DE Smith
J. Immunol., 2018-05-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CD82 hypomethylation is essential for tuberculosis pathogenesis via regulation of RUNX1-Rab5/22
Authors: HJ Koh, YR Kim, JS Kim, JS Yun, S Kim, SY Kim, K Jang, CS Yang
Exp. Mol. Med., 2018-05-14;50(5):62.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Fc? receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis
Authors: I Di Ceglie, G Ascone, NAJ Cremers, AW Sloetjes, B Walgreen, T Vogl, J Roth, JS Verbeek, FAJ van de Loo, MI Koenders, PM van der Kr, AB Blom, MHJ van den Bo, PLEM van Lent
Arthritis Res. Ther., 2018-05-02;20(1):80.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation
Authors: S Kinsella, M Fichtner, O Watters, HG König, JHM Prehn
J Neuroinflammation, 2018-05-02;15(1):130.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Allogeneic transplantation of programmable cells of monocytic origin (PCMO) improves angiogenesis and tissue recovery in critical limb ischemia (CLI): a translational approach
Authors: R Berndt, L Hummitzsch, K He beta, M Albrecht, K Zitta, R Rusch, B Sarras, A Bayer, J Cremer, F Faendrich, J Gro beta
Stem Cell Res Ther, 2018-04-27;9(1):117.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Neogambogic Acid Suppresses Receptor Activator of Nuclear Factor ?B Ligand (RANKL)-Induced Osteoclastogenesis by Inhibiting the JNK and NF-?B Pathways in Mouse Bone Marrow-Derived Monocyte/Macrophages
Authors: G Jin, FF Wang, T Li, DD Jia, Y Shen, HC Xu
Med. Sci. Monit., 2018-04-26;24(0):2569-2577.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Reduced oxidative capacity in macrophages results in systemic insulin resistance
Authors: SB Jung, MJ Choi, D Ryu, HS Yi, SE Lee, JY Chang, HK Chung, YK Kim, SG Kang, JH Lee, KS Kim, HJ Kim, CS Kim, CH Lee, RW Williams, H Kim, HK Lee, J Auwerx, M Shong
Nat Commun, 2018-04-19;9(1):1551.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Poria cocos polysaccharide attenuates RANKL-induced osteoclastogenesis by suppressing NFATc1 activity and phosphorylation of ERK and STAT3
Authors: D Song, Z Cao, J Tickner, H Qiu, C Wang, K Chen, Z Wang, C Guo, S Dong, J Xu
Arch. Biochem. Biophys., 2018-04-17;647(0):76-83.
Species: Mouse
Sample Types: Whole Tissue
Applications: Cell Culture -
Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models
Authors: CEJ Waterborg, S Beermann, MGA Broeren, MB Bennink, MI Koenders, PLEM van Lent, WB van den Be, PM van der Kr, FAJ van de Loo
Front Immunol, 2018-04-13;9(0):742.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
LncRNA-AK131850 Sponges MiR-93-5p in Newborn and Mature Osteoclasts to Enhance the Secretion of Vascular Endothelial Growth Factor a Promoting Vasculogenesis of Endothelial Progenitor Cells
Authors: H Quan, M Liang, N Li, C Dou, C Liu, Y Bai, W Luo, J Li, F Kang, Z Cao, X Yang, H Jiang, S Dong
Cell. Physiol. Biochem., 2018-03-23;46(1):401-417.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages
Authors: H Cui, S Banerjee, S Guo, N Xie, G Liu
J. Immunol., 2018-03-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MTOR Suppresses Environmental Particle-Induced Inflammatory Response in Macrophages
Authors: Z Li, Y Wu, H Chen, C Zhu, L Dong, Y Wang, H Liu, X Xu, J Zhou, Y Wu, W Li, S Ying, H Shen, Z Chen
J. Immunol., 2018-03-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo
Authors: E Yoshida, T Suzuki, M Morita, K Taguchi, K Tsuchida, H Motohashi, M Doita, M Yamamoto
Genes Cells, 2018-03-15;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Fraxinellone Attenuates Rheumatoid Inflammation in Mice
Authors: SM Jung, J Lee, SY Baek, J Lee, SG Jang, SM Hong, JS Park, ML Cho, SH Park, SK Kwok
Int J Mol Sci, 2018-03-13;19(3):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9
Authors: T Ishii, M Ruiz-Torru, A Ikeda, S Shindo, A Movila, H Mawardi, A Albassam, RA Kayal, AA Al-Dharrab, K Egashira, W Wisitrasam, K Yamamoto, AI Mira, K Sueishi, X Han, MA Taubman, T Miyamoto, T Kawai
FASEB J., 2018-03-13;0(0):fj201701424R.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner
Authors: M Datta, O Staszewski, E Raschi, M Frosch, N Hagemeyer, TL Tay, T Blank, M Kreutzfeld, D Merkler, S Ziegler-Wa, P Matthias, M Meyer-Lueh, M Prinz
Immunity, 2018-03-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
PGC1? Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation
Authors: Y Zhang, N Rohatgi, DJ Veis, J Schilling, SL Teitelbaum, W Zou
J. Bone Miner. Res., 2018-03-11;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
RGC32 Promotes Bleomycin-Induced Systemic Sclerosis in a Murine Disease Model by Modulating Classically Activated Macrophage Function
Authors: C Sun, SY Chen
J. Immunol., 2018-03-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair
Authors: D Gr?evi?, M Sironi, S Valentino, L Deban, H Cvija, A Inforzato, N Kova?i?, V Katavi?, T Kelava, I Kalajzi?, A Mantovani, B Bottazzi
Front Immunol, 2018-03-05;9(0):417.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TNF-?-mediated ER stress causes elimination of Mycobacterium fortuitum reservoirs by macrophage apoptosis
Authors: SM Oh, YJ Lim, JA Choi, J Lee, SN Cho, D Go, SH Kim, CH Song
FASEB J., 2018-02-26;0(0):fj201701407R.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Neither Lys- and DAP-type peptidoglycans stimulate mouse or human innate immune cells via Toll-like receptor 2
Authors: M Langer, AW Girton, NI Popescu, T Burgett, JP Metcalf, KM Coggeshall
PLoS ONE, 2018-02-23;13(2):e0193207.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia
Authors: SA O'Sullivan, C O'Sullivan, LM Healy, KK Dev, GK Sheridan
J. Neurochem., 2018-02-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-?B Ligand-Induced Osteoclast Differentiation
Authors: ZK Jia, HY Li, YL Liang, LA Potempa, SR Ji, Y Wu
Front Immunol, 2018-02-19;9(0):234.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Adenosine Areceptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis
Authors: A Mediero, T Wilder, L Shah, BN Cronstein
FASEB J., 2018-02-02;0(0):fj201700217R.
Species: Mouse
Sample Types: Whole Cells
Applications: Differentiation, Differentiation -
Toll-Interacting Protein, Tollip, Inhibits IL-13-Mediated Pulmonary Eosinophilic Inflammation in Mice
Authors: Y Ito, N Schaefer, A Sanchez, D Francisco, R Alam, RJ Martin, JG Ledford, C Stevenson, D Jiang, L Li, M Kraft, HW Chu
J Innate Immun, 2018-01-27;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
High-Resolution Mapping and Dynamics of the Transcriptome, Transcription Factors, and Transcription Co-Factor Networks in Classically and Alternatively Activated Macrophages
Authors: A Das, CS Yang, S Arifuzzama, S Kim, SY Kim, KH Jung, YS Lee, YG Chai
Front Immunol, 2018-01-18;9(0):22.
Species: Mouse
Sample Types: Whole Cells
Applications: Differentiation, Differentiation -
Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice
Authors: Q Ye, G Li, S Liu, Y Guan, Y Li, J Li, H Jia, X Li, Q Li, R Huang, H Wang, Y Zhang
Int. J. Mol. Med., 2018-01-17;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss
Authors: S Lucas, Y Omata, J Hofmann, M Böttcher, A Iljazovic, K Sarter, O Albrecht, O Schulz, B Krishnacou, G Krönke, M Herrmann, D Mougiakako, T Strowig, G Schett, MM Zaiss
Nat Commun, 2018-01-04;9(1):55.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects
Authors: JE Draper, P Sroczynska, MZH Fadlullah, R Patel, G Newton, W Breitwiese, V Kouskoff, G Lacaud
PLoS Genet., 2018-01-04;14(1):e1007127.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice
Authors: D Quach, F Collins, N Parameswar, L McCabe, RA Britton
mSphere, 2018-01-03;3(1):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis
Authors: J Ahn, S Son, SC Oliveira, GN Barber
Cell Rep, 2017-12-26;21(13):3873-3884.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The HIV co-receptor CCR5 regulates osteoclast function
Authors: JW Lee, A Hoshino, K Inoue, T Saitou, S Uehara, Y Kobayashi, S Ueha, K Matsushima, A Yamaguchi, Y Imai, T Iimura
Nat Commun, 2017-12-20;8(1):2226.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Metformin Mediates Protection against Legionella Pneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species
Authors: C Kajiwara, Y Kusaka, S Kimura, T Yamaguchi, Y Nanjo, Y Ishii, H Udono, TJ Standiford, K Tateda
J. Immunol., 2017-12-15;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MiR-30a attenuates osteoclastogenesis via targeting DC-STAMP-c-Fos-NFATc1 signaling
Authors: Y Yin, L Tang, J Chen, X Lu
Am J Transl Res, 2017-12-15;9(12):5743-5753.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis
Authors: EM Grössinger, M Kang, L Bouchareyc, R Sarin, DR Haudenschi, LN Borodinsky, IE Adamopoulo
J. Immunol., 2017-12-15;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Systemic administration of ?-glucan of 200�kDa modulates melanoma microenvironment and suppresses metastatic cancer
Authors: M Zhang, L Chun, V Sandoval, H Graor, J Myers, J Nthale, P Rauhe, Z Senders, K Choong, AY Huang, J Kim
Oncoimmunology, 2017-10-30;7(2):e1387347.
Species: Mouse
Sample Types: Whole Cell
Applications: Cell Culture -
Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neurons
Authors: L Parviainen, S Dihanich, GW Anderson, AM Wong, HR Brooks, R Abeti, P Rezaie, G Lalli, S Pope, SJ Heales, HM Mitchison, BP Williams, JD Cooper
Acta Neuropathol Commun, 2017-10-17;5(1):74.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pharmacological HIF-inhibition attenuates postoperative adhesion formation
Authors: MJ Strowitzki, AS Ritter, P Radhakrish, JM Harnoss, VM Opitz, M Biller, J Wehrmann, U Keppler, J Scheer, M Wallwiener, T Schmidt, A Ulrich, M Schneider
Sci Rep, 2017-10-13;7(1):13151.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Small leucine rich proteoglycans, a novel link to osteoclastogenesis
Authors: V Kram, TM Kilts, N Bhattachar, L Li, MF Young
Sci Rep, 2017-10-03;7(1):12627.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response
Authors: BF Westendorp, NVJA Büller, ON Karpus, WA van Dop, J Koster, R Versteeg, PJ Koelink, CY Snel, S Meisner, JJTH Roelofs, A Uhmann, E Ver Loren, J Heijmans, H Hahn, V Muncan, ME Wildenberg, GR van den Br
Cell Mol Gastroenterol Hepatol, 2017-09-05;5(1):67-82.e1.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ESRRA (estrogen related receptor, alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense
Authors: SY Kim, CS Yang, HM Lee, JK Kim, YS Kim, YR Kim, JS Kim, TS Kim, JM Yuk, CR Dufour, SH Lee, JM Kim, HS Choi, V Giguère, EK Jo
Autophagy, 2017-09-01;0(0):0.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CLEC5A is a critical receptor in innate immunity against Listeria infection
Authors: ST Chen, FJ Li, TY Hsu, SM Liang, YC Yeh, WY Liao, TY Chou, NJ Chen, M Hsiao, WB Yang, SL Hsieh
Nat Commun, 2017-08-21;8(1):299.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation
Authors: SB Mkaddem, A Murua, H Flament, D Titeca-Bea, C Bounaix, L Danelli, P Launay, M Benhamou, U Blank, E Daugas, N Charles, RC Monteiro
Nat Commun, 2017-08-15;8(1):246.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Specific calpain inhibition protects kidney against inflammaging
Authors: G Hanouna, L Mesnard, S Vandermeer, J Perez, S Placier, JP Haymann, F Campagne, J Moroch, A Bataille, L Baud, E Letavernie
Sci Rep, 2017-08-14;7(1):8016.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-13 reduces cardiac injury and prevents heart dysfunction in viral myocarditis via enhanced M2 macrophage polarization
Authors: H Yang, Y Chen, C Gao
Oncotarget, 2017-08-10;8(59):99495-99503.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The influence of macrophage growth factors on Theiler's Murine Encephalomyelitis Virus (TMEV) infection and activation of macrophages
Authors: KM Schneider, NB Watson, SB Minchenber, PT Massa
Cytokine, 2017-08-09;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Extracellular MicroRNAs Induce Potent Innate Immune Responses via TLR7/MyD88-Dependent Mechanisms
Authors: Y Feng, L Zou, D Yan, H Chen, G Xu, W Jian, P Cui, W Chao
J. Immunol., 2017-08-02;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health
Authors: CM Novince, CR Whittow, JD Aartun, JD Hathaway, N Poulides, MB Chavez, HM Steinkamp, KA Kirkwood, E Huang, C Westwater, KL Kirkwood
Sci Rep, 2017-07-18;7(1):5747.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CCL11, a novel mediator of inflammatory bone resorption
Authors: E Kindstedt, CK Holm, R Sulniute, I Martinez-C, R Lundmark, P Lundberg
Sci Rep, 2017-07-13;7(1):5334.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent colitis
Authors: X Pei, D Zheng, S She, J Ma, C Guo, X Mo, Y Zhang, Q Song, Y Zhang, D Ma, Y Wang
Sci Rep, 2017-07-11;7(1):5107.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hypomorphic A20 expression confers susceptibility to psoriasis
Authors: A Aki, M Nagasaki, BA Malynn, A Ma, T Kagari
PLoS ONE, 2017-06-28;12(6):e0180481.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Preferred M2 Polarization by ASC-Based Hydrogel Accelerated Angiogenesis and Myogenesis in Volumetric Muscle Loss Rats
Authors: H Huang, J Liu, H Hao, D Chen, L Zhizhong, M Li, H Song, R Xiang, C Jiang, X Fu, W Han
Stem Cells Int, 2017-06-14;2017(0):2896874.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Activity-independent targeting of mTOR to lysosomes in primary osteoclasts
Authors: A Wang, LR Carraro-La, C Owen, B Gao, PN Corey, P Tyrrell, JH Brumell, I Voronov
Sci Rep, 2017-06-07;7(1):3005.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
Authors: G Colaianni, T Mongelli, C Cuscito, P Pignataro, L Lippo, G Spiro, A Notarnicol, I Severi, G Passeri, G Mori, G Brunetti, B Moretti, U Tarantino, SC Colucci, JE Reseland, R Vettor, S Cinti, M Grano
Sci Rep, 2017-06-06;7(1):2811.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Colony-stimulating factor 1 receptor blockade inhibits tumor growth by altering the polarization of tumor-associated macrophages in hepatocellular carcinoma
Authors: JY Ao, XD Zhu, ZT Chai, H Cai, YY Zhang, KZ Zhang, LQ Kong, N Zhang, BG Ye, DN Ma, HC Sun
Mol. Cancer Ther., 2017-06-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Up-Regulation of RANK Expression via ERK1/2 by Insulin Contributes to the Enhancement of Osteoclast Differentiation
Authors: JH Oh, NK Lee
Mol. Cells, 2017-05-22;40(5):371-377.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Barley Seedling Extracts Inhibit RANKL-Induced Differentiation, Fusion, and Maturation of Osteoclasts in the Early-to-Late Stages of Osteoclastogenesis
Authors: SW Choi, SH Kim, KS Lee, HJ Kang, MJ Lee, KI Park, JH Lee, KD Park, WD Seo
Evid Based Complement Alternat Med, 2017-05-08;2017(0):6072573.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Muramyl Dipeptide, a Shared Structural Motif of Peptidoglycans, Is a Novel Inducer of Bone Formation through Induction of Runx2
Authors: OJ Park, J Kim, J Yang, CH Yun, SH Han
J. Bone Miner. Res, 2017-04-27;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6
Authors: E Kim, J Beon, S Lee, SJ Park, H Ahn, MG Kim, JE Park, W Kim, JM Yuk, SJ Kang, SH Lee, EK Jo, RH Seong, S Kim
Sci Adv, 2017-04-21;3(4):e1602296.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population
Authors: DC Nascimento, PH Melo, AR Piñeros, RG Ferreira, DF Colón, PB Donate, FV Castanheir, A Gozzi, PG Czaikoski, W Niedbala, MC Borges, DS Zamboni, FY Liew, FQ Cunha, JC Alves-Filh
Nat Commun, 2017-04-04;8(0):14919.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents
Authors: OC Olson, H Kim, DF Quail, EA Foley, JA Joyce
Cell Rep, 2017-04-04;19(1):101-113.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
VISTA deficiency accelerates the development of fatal murine lupus nephritis
Authors: Sabrina Ceeraz
Arthritis & rheumatology (Hoboken, N.J.), 2017-04-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
PPAR-? Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism
Authors: YS Kim, HM Lee, JK Kim, CS Yang, TS Kim, M Jung, HS Jin, S Kim, J Jang, GT Oh, JM Kim, EK Jo
J. Immunol, 2017-03-08;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Cytokine Response to Lipopolysaccharide Does Not Predict the Host Response to Infection
Authors: BA Fensterhei, Y Guo, ER Sherwood, JK Bohannon
J. Immunol, 2017-03-08;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors
Authors: A Itoh-Nakad, M Matsumoto, H Kato, J Sasaki, Y Uehara, Y Sato, R Ebina-Shib, M Morooka, R Funayama, K Nakayama, K Ochiai, A Muto, K Igarashi
Cell Rep, 2017-03-07;18(10):2401-2414.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice
Authors: Erivan S Ramos-Juni
J. Bone Miner. Res, 2017-03-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Metabolic origins of spatial organization in the tumor microenvironment
Authors: C Carmona-Fo, M Deforet, L Akkari, CB Thompson, JA Joyce, JB Xavier
Proc. Natl. Acad. Sci. U.S.A, 2017-02-28;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
25-hydroxycholesterol promotes RANKL-induced osteoclastogenesis through coordinating NFATc1 and Sp1 complex in the transcription of miR-139-5p
Authors: L Zhang, Y Lv, G Xian, Y Lin
Biochem. Biophys. Res. Commun, 2017-02-28;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TRPV1 deletion impaired fracture healing and inhibited osteoclast and osteoblast differentiation
Authors: LH He, M Liu, Y He, E Xiao, L Zhao, T Zhang, HQ Yang, Y Zhang
Sci Rep, 2017-02-22;7(0):42385.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy
Authors: S Gao, C Li, Y Zhu, Y Wang, A Sui, Y Zhong, B Xie, X Shen
Sci Rep, 2017-02-17;7(0):42846.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors
Authors: F Strålberg, A Kassem, F Kasprzykow, M Abrahamson, A Grubb, C Lindholm, UH Lerner
J. Leukoc. Biol, 2017-02-14;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dynamics of the sealing zone in cultured osteoclasts
Authors: Sarit Batsir
Cytoskeleton (Hoboken), 2017-02-08;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury
Authors: HH Chen, H Yuan, H Cho, Y Feng, S Ngoy, AT Kumar, R Liao, W Chao, L Josephson, DE Sosnovik
Theranostics, 2017-02-08;7(4):814-825.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Gastrodin inhibits osteoclastogenesis via down-regulating the NFATc1 signaling pathway and stimulates osseointegration in vitro
Authors: F Zhou, Y Shen, B Liu, X Chen, L Wan, D Peng
Biochem. Biophys. Res. Commun, 2017-02-02;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKC�
Authors: HJ Koh, YR Kim, JS Kim, JS Yun, K Jang, CS Yang
PLoS Pathog, 2017-01-26;13(1):e1006126.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
OCLI-023, a Novel Pyrimidine Compound, Suppresses Osteoclastogenesis In Vitro and Alveolar Bone Resorption In Vivo
Authors: HJ Ihn, T Lee, JA Kim, D Lee, ND Kim, HI Shin, YC Bae, EK Park
PLoS ONE, 2017-01-13;12(1):e0170159.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
NF-?B activation is critical for bacterial lipoprotein tolerance-enhanced bactericidal activity in macrophages during microbial infection
Authors: J Liu, J Xiang, X Li, S Blankson, S Zhao, J Cai, Y Jiang, HP Redmond, JH Wang
Sci Rep, 2017-01-12;7(0):40418.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Scaling of titanium implants entrains inflammation-induced osteolysis
Authors: M Eger, N Sterer, T Liron, D Kohavi, Y Gabet
Sci Rep, 2017-01-06;7(0):39612.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mycobacterium avium MAV2054 protein induces macrophage apoptosis by targeting mitochondria and reduces intracellular bacterial growth
Sci Rep, 2016-11-30;6(0):37804.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation
Authors: Janko Kos
Neuropharmacology, 2016-11-23;114(0):88-100.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Treatment with cestode parasite antigens recruits CCR2+ myeloid cells, the adoptive transfer of which ameliorates colitis
Infect Immun, 2016-11-18;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections
Sci Rep, 2016-11-15;6(0):37211.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Docosahexaenoic acid signaling attenuates the proliferation and differentiation of bone marrow-derived osteoclast precursors and promotes apoptosis in mature osteoclasts
Authors: Young-Ran Yoon
Cell. Signal., 2016-11-09;29(0):226-232.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Theaflavin-3,3'-digallate represses osteoclastogenesis and prevents wear debris-induced osteolysis via suppression of ERK pathway
Authors: Dechun Geng
Acta Biomater, 2016-11-09;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart
Eur J Immunol, 2016-10-25;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages
Oncotarget, 2016-10-11;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mycobacterium abscessus ESX-3 plays an important role in host inflammatory and pathological responses during infection
Microbes Infect, 2016-09-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Spatiotemporal expression of endogenous TLR4 ligands leads to inflammation and bone erosion in mouse collagen-induced arthritis
Eur J Immunol, 2016-09-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Defect density in multiwalled carbon nanotubes influences ovalbumin adsorption and promotes macrophage activation and CD4(+) T-cell proliferation
Int J Nanomedicine, 2016-09-02;11(0):4357-71.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
EMBO Mol Med, 2016-09-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Role of Prostate Apoptosis Response-4 (Par-4) in Mycobacterium tuberculosis Infected Macrophages
Sci Rep, 2016-08-24;6(0):32079.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Negative regulation of NF-?B p65 activity by serine 536 phosphorylation.
Authors: Jean-Philippe Pradère, Céline Hernandez, Christiane Koppe, Richard A Friedman, Tom Luedde, Robert F Schwabe
Science Signaling, 2016-08-23;0(0):1937-9145.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNAs: Potential Biomarkers and Therapeutic Targets for Alveolar Bone Loss in Periodontal Disease
Int J Mol Sci, 2016-08-11;17(8):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
Cell, 2016-08-11;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
Circ Res, 2016-07-14;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus
Authors: L Bossaller, A Christ, K Pelka, K Nündel, PI Chiang, C Pang, N Mishra, P Busto, RG Bonegio, RE Schmidt, E Latz, A Marshak-Ro
J. Immunol., 2016-06-27;197(4):1044-53.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The role of MyD88- and TRIF-dependent signaling in monophosphoryl lipid A-induced expansion and recruitment of innate immunocytes.
Authors: Hernandez A, Bohannon J, Luan L, Fensterheim B, Guo Y, Patil N, McAdams C, Wang J, Sherwood E
J Leukoc Biol, 2016-06-27;100(6):1311-1322.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Negative regulation of bacterial killing and inflammation by two novel CD16 ligands
Eur J Immunol, 2016-06-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease
Authors: J Fu, S Li, R Feng, H Ma, F Sabeh, GD Roodman, J Wang, S Robinson, XE Guo, T Lund, D Normolle, MY Mapara, SJ Weiss, S Lentzsch
J Clin Invest, 2016-04-04;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome.
Authors: Khor E, Fanshawe B, Qi Y, Zolotukhin S, Kulkarni R, Enriquez R, Purtell L, Lee N, Wee N, Croucher P, Campbell L, Herzog H, Baldock P
PLoS ONE, 2016-01-29;11(1):e0148155.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta.
Authors: McCarthy R, Lu D, Alkhateeb A, Gardeck A, Lee C, Wessling-Resnick M
J Neuroinflammation, 2016-01-27;13(1):21.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
Authors: Wertz I, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, Popovych N, Helgason E, Schoeffler A, Jeet S, Ramamoorthi N, Kategaya L, Newman R, Horikawa K, Dugger D, Sandoval W, Mukund S, Zindal A, Martin F, Quan C, Tom J, Fairbrother W, Townsend M, Warming S, DeVoss J, Liu J, Dueber E, Caplazi P, Lee W, Goodnow C, Balazs M, Yu K, Kolumam G, Dixit V
Nature, 2015-12-09;528(7582):370-5.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Analysis of the Effects of the Bruton's tyrosine kinase (Btk) Inhibitor Ibrutinib on Monocyte Fc? Receptor (Fc?R) Function
Authors: L Ren, A Campbell, H Fang, S Gautam, S Elavazhaga, K Fatehchand, P Mehta, A Stiff, BF Reader, X Mo, JC Byrd, WE Carson, JP Butchar, S Tridandapa
J. Biol. Chem, 2015-12-01;291(6):3043-52.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Iron Chelation Inhibits Osteoclastic Differentiation In Vitro and in Tg2576 Mouse Model of Alzheimer's Disease.
Authors: Guo J, Pan J, Xiong L, Xia W, Cui S, Xiong W
PLoS ONE, 2015-11-17;10(11):e0139395.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mouse Resistin (mRetn): cloning, expression and purification in Escherichia coli and the potential regulative effects on murine bone marrow hematopoiesis.
Authors: Wang F, Gao J, Malisani A, Xi X, Han W, Wan X
BMC Biotechnol, 2015-11-16;15(0):105.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibitory Effects of KP-A159, a Thiazolopyridine Derivative, on Osteoclast Differentiation, Function, and Inflammatory Bone Loss via Suppression of RANKL-Induced MAP Kinase Signaling Pathway.
Authors: Ihn H, Lee D, Lee T, Kim S, Shin H, Bae Y, Hong J, Park E
PLoS ONE, 2015-11-04;10(11):e0142201.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Brucella abortus Invasion of Osteocytes Modulates Connexin 43 and Integrin Expression and Induces Osteoclastogenesis via Receptor Activator of NF-kappaB Ligand and Tumor Necrosis Factor Alpha Secretion.
Authors: Pesce Viglietti A, Arriola Benitez P, Gentilini M, Velasquez L, Fossati C, Giambartolomei G, Delpino M
Infect Immun, 2015-10-12;84(1):11-20.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lipocalin (LCN) 2 Mediates Pro-Atherosclerotic Processes and Is Elevated in Patients with Coronary Artery Disease.
Authors: Oberoi R, Bogalle E, Matthes L, Schuett H, Koch A, Grote K, Schieffer B, Schuett J, Luchtefeld M
PLoS ONE, 2015-09-14;10(9):e0137924.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bone Cell-autonomous Contribution of Type 2 Cannabinoid Receptor to Breast Cancer-induced Osteolysis.
Authors: Sophocleous A, Marino S, Logan J, Mollat P, Ralston S, Idris A
J Biol Chem, 2015-07-20;290(36):22049-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CHMP5 controls bone turnover rates by dampening NF-kappaB activity in osteoclasts.
Authors: Greenblatt M, Park K, Oh H, Kim J, Shin D, Lee J, Lee J, Singh A, Lee K, Hu D, Xiao C, Charles J, Penninger J, Lotinun S, Baron R, Ghosh S, Shim J
J Exp Med, 2015-07-20;212(8):1283-301.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans.
Authors: Yu H, Herbert B, Valerio M, Yarborough L, Hsu L, Argraves K
Lipids Health Dis, 2015-07-04;14(0):66.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERalpha Signaling in Osteoblasts and Osteoclasts.
Authors: Ucer S, Iyer S, Bartell S, Martin-Millan M, Han L, Kim H, Weinstein R, Jilka R, O'Brien C, Almeida M, Manolagas S
J Bone Miner Res, 2015-07-01;30(7):1138-49.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-kappaB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts.
Authors: Kassem A, Henning P, Lundberg P, Souza P, Lindholm C, Lerner U
J Biol Chem, 2015-06-17;290(33):20147-58.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism.
Authors: Tan Z, Xie N, Cui H, Moellering D, Abraham E, Thannickal V, Liu G
J Immunol, 2015-05-11;194(12):6082-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sexual Dimorphism in MAPK-Activated Protein Kinase-2 (MK2) Regulation of RANKL-Induced Osteoclastogenesis in Osteoclast Progenitor Subpopulations.
Authors: Herbert B, Valerio M, Gaestel M, Kirkwood K
PLoS ONE, 2015-05-06;10(5):e0125387.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation.
Authors: Mediero A, Ramkhelawon B, Perez-Aso M, Moore K, Cronstein B
J Bone Miner Res, 2015-05-01;30(5):837-54.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection.
Authors: Kim J, Yuk J, Kim S, Kim T, Jin H, Yang C, Jo E
J Immunol, 2015-04-27;194(11):5355-65.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of L-type Voltage Gated Calcium Channel CACNA1S in Macrophages upon Mycobacterium tuberculosis Infection.
Authors: Antony C, Mehto S, Tiwari B, Singh Y, Natarajan K
PLoS ONE, 2015-04-27;10(4):e0124263.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ERK5 Activation Is Essential for Osteoclast Differentiation.
Authors: Amano, Shigeru, Chang, Yu-Tzu, Fukui, Yasuhisa
PLoS ONE, 2015-04-17;10(4):e0125054.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling.
Authors: Maeda A, Ono M, Holmbeck K, Li L, Kilts T, Kram V, Noonan M, Yoshioka Y, McNerny E, Tantillo M, Kohn D, Lyons K, Robey P, Young M
J Biol Chem, 2015-04-11;290(22):14004-18.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
15-deoxy-delta12,14-prostaglandin j2 inhibits osteolytic breast cancer bone metastasis and estrogen deficiency-induced bone loss.
Authors: Kim K, Kim H, Lee S, Ma G, Park K, Chung W
PLoS ONE, 2015-04-10;10(4):e0122764.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Immune complexes regulate bone metabolism through FcRgamma signalling.
Authors: Negishi-Koga T, Gober H, Sumiya E, Komatsu N, Okamoto K, Sawa S, Suematsu A, Suda T, Sato K, Takai T, Takayanagi H
Nat Commun, 2015-03-31;6(0):6637.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
Authors: Jha A, Huang S, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart K, Ashall J, Everts B, Pearce E, Driggers E, Artyomov M
Immunity, 2015-03-17;42(3):419-30.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Fasciola hepatica fatty acid binding protein inhibits TLR4 activation and suppresses the inflammatory cytokines induced by lipopolysaccharide in vitro and in vivo.
Authors: Martin I, Caban-Hernandez K, Figueroa-Santiago O, Espino A
J Immunol, 2015-03-16;194(8):3924-36.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation.
Authors: Li, Chang-Ju, Cheng, Peng, Liang, Meng-Ke, Chen, Yu-Si, Lu, Qiong, Wang, Jin-Yu, Xia, Zhu-Ying, Zhou, Hou-De, Cao, Xu, Xie, Hui, Liao, Er-Yuan, Luo, Xiang-Ha
J Clin Invest, 2015-03-09;125(4):1509-22.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.
Authors: Shimizu K, Nakajima A, Sudo K, Liu Y, Mizoroki A, Ikarashi T, Horai R, Kakuta S, Watanabe T, Iwakura Y
J Immunol, 2015-02-27;194(7):3156-68.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
Authors: Youm Y, Nguyen K, Grant R, Goldberg E, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti T, Kang S, Horvath T, Fahmy T, Crawford P, Biragyn A, Alnemri E, Dixit V
Nat Med, 2015-02-16;21(3):263-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome.
Authors: Yang C, Kim J, Kim T, Lee P, Kim S, Lee H, Shin D, Nguyen L, Lee M, Jin H, Kim K, Lee C, Kim M, Park S, Kim J, Choi H, Jo E
Nat Commun, 2015-02-06;6(0):6115.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Anabolic bone formation via a site-specific bone-targeting delivery system by interfering with semaphorin 4D expression.
Authors: Zhang Y, Wei L, Miron R, Shi B, Bian Z
J Bone Miner Res, 2015-02-01;30(2):286-96.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A novel phthalimide derivative, TC11, has preclinical effects on high-risk myeloma cells and osteoclasts.
Authors: Matsushita M, Ozaki Y, Hasegawa Y, Terada F, Tabata N, Shiheido H, Yanagawa H, Oikawa T, Matsuo K, Du W, Yamada T, Hozumi M, Ichikawa D, Hattori Y
PLoS ONE, 2015-01-24;10(1):e0116135.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sim1 inhibits bone formation by enhancing the sympathetic tone in male mice.
Authors: Wang X, Wei W, Zinn A, Wan Y
Endocrinology, 2015-01-21;156(4):1408-15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures.
Authors: Fowler T, Kamalakar A, Akel N, Kurten R, Suva L, Gaddy D
J Cell Sci, 2015-01-20;128(4):683-94.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases.
Authors: Ozanne J, Prescott A, Clark K
Biochem J, 2015-01-15;465(2):271-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
GPCR-mediated PLCbetagamma/PKCbeta/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis.
Authors: Xu X, Gera N, Li H, Yun M, Zhang L, Wang Y, Wang Q, Jin T
Mol Biol Cell, 2015-01-07;26(5):874-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization.
Authors: Liu K, Zhao E, Ilyas G, Lalazar G, Lin Y, Haseeb M, Tanaka K, Czaja M
Autophagy, 2015-01-01;11(2):271-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate.
Authors: Purdue, P Edward, Crotti, Tania N, Shen, Zhenxin, Swantek, Jennifer, Li, Jun, Hill, Jonathan, Hanidu, Adedayo, Dimock, Janice, Nabozny, Gerald, Goldring, Steven R, McHugh, Kevin P
Sci Rep, 2014-12-23;4(0):7595.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Differential expression of claudin family members during osteoblast and osteoclast differentiation: Cldn-1 is a novel positive regulator of osteoblastogenesis.
Authors: Alshbool F, Mohan S
PLoS ONE, 2014-12-05;9(12):e114357.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Macrophage-inducible C-type lectin Mincle-expressing dendritic cells contribute to control of splenic Mycobacterium bovis BCG infection in mice.
Authors: Behler F, Maus R, Bohling J, Knippenberg S, Kirchhof G, Nagata M, Jonigk D, Izykowski N, Magel L, Welte T, Yamasaki S, Maus U
Infect Immun, 2014-10-20;83(1):184-96.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Targeted 25-hydroxyvitamin D3 1alpha-hydroxylase adoptive gene therapy ameliorates dss-induced colitis without causing hypercalcemia in mice.
Authors: Li B, Baylink D, Walter M, Lau K, Meng X, Wang J, Cherkas A, Tang X, Qin X
Mol Ther, 2014-10-20;23(2):339-51.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
GM-CSF treated F4/80+ BMCs improve murine hind limb ischemia similar to M-CSF differentiated macrophages.
Authors: Kuwahara G, Nishinakamura H, Kojima D, Tashiro T, Kodama S
PLoS ONE, 2014-09-09;9(9):e106987.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Toll-like receptor 9 mediated responses in cardiac fibroblasts.
Authors: Ohm I, Alfsnes K, Belland Olsen M, Ranheim T, Sandanger O, Dahl T, Aukrust P, Finsen A, Yndestad A, Vinge L
PLoS ONE, 2014-08-15;9(8):e104398.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lipocalin 2 is a regulator of macrophage polarization and NF-kappaB/STAT3 pathway activation.
Authors: Guo H, Jin D, Chen X
Mol Endocrinol, 2014-08-15;28(10):1616-28.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase.
Authors: Tang, Songqing, Chen, Taoyong, Yu, Zhou, Zhu, Xuhui, Yang, Mingjin, Xie, Bin, Li, Nan, Cao, Xuetao, Wang, Jianli
Nat Commun, 2014-08-14;5(0):4657.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Modulation of osteoclastogenesis with macrophage M1- and M2-inducing stimuli.
Authors: Jeganathan S, Fiorino C, Naik U, Sun H, Harrison R
PLoS ONE, 2014-08-07;9(8):e104498.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IFN-gamma primes macrophage activation by increasing phosphatase and tensin homolog via downregulation of miR-3473b.
Authors: Wu C, Xue Y, Wang P, Lin L, Liu Q, Li N, Xu J, Cao X
J Immunol, 2014-08-04;193(6):3036-44.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
An unexpected twist to the activation of IKKbeta: TAK1 primes IKKbeta for activation by autophosphorylation.
Authors: Zhang J, Clark K, Lawrence T, Peggie M, Cohen P
Biochem J, 2014-08-01;461(3):531-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Identification of novel transcription factors in osteoclast differentiation using genome-wide analysis of open chromatin determined by DNase-seq.
Authors: Inoue K, Imai Y
J Bone Miner Res, 2014-08-01;29(8):1823-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Myeloid-derived suppressor cells are involved in lysosomal acid lipase deficiency-induced endothelial cell dysfunctions.
Authors: Zhao T, Ding X, Du H, Yan C
J Immunol, 2014-07-07;193(4):1942-53.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.
Authors: Krzeszinski J, Wei W, Huynh H, Jin Z, Wang X, Chang T, Xie X, He L, Mangala L, Lopez-Berestein G, Sood A, Mendell J, Wan Y
Nature, 2014-06-25;512(7515):431-5.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8.
Authors: Abe T, Shin J, Hosur K, Udey M, Chavakis T, Hajishengallis G
J Immunol, 2014-06-23;193(3):1383-91.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
DLX3 regulates bone mass by targeting genes supporting osteoblast differentiation and mineral homeostasis in vivo.
Authors: Isaac, J, Erthal, J, Gordon, J, Duverger, O, Sun, H-W, Lichtler, A C, Stein, G S, Lian, J B, Morasso, M I
Cell Death Differ, 2014-06-20;21(9):1365-76.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy.
Authors: Wu L, Ong S, Talor M, Barin J, Baldeviano G, Kass D, Bedja D, Zhang H, Sheikh A, Margolick J, Iwakura Y, Rose N, Cihakova D
J Exp Med, 2014-06-16;211(7):1449-64.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Authors: Mercken E, Mitchell S, Martin-Montalvo A, Minor R, Almeida M, Gomes A, Scheibye-Knudsen M, Palacios H, Licata J, Zhang Y, Becker K, Khraiwesh H, Gonzalez-Reyes J, Villalba J, Baur J, Elliott P, Westphal C, Vlasuk G, Ellis J, Sinclair D, Bernier M, de Cabo R
Aging Cell, 2014-06-16;13(5):787-96.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1.
Authors: Zhao C, Pavicic P, Datta S, Sun D, Novotny M, Hamilton T
J Immunol, 2014-06-11;193(2):879-88.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-kappaB.
Authors: Zhang H, Hilton M, Anolik J, Welle S, Zhao C, Yao Z, Li X, Wang Z, Boyce B, Xing L
J Clin Invest, 2014-06-02;124(7):3200-14.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A nonapoptotic role for CASP2/caspase 2: modulation of autophagy.
Authors: Tiwari, Meenaksh, Sharma, Lokendra, Vanegas, Difernan, Callaway, Danielle, Bai, Yidong, Lechleiter, James D, Herman, Brian
Autophagy, 2014-06-01;10(6):1054-70.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone.
Authors: Teramachi J, Zhou H, Subler M, Kitagawa Y, Galson D, Dempster D, Windle J, Kurihara N, Roodman G
J Bone Miner Res, 2014-06-01;29(6):1456-65.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL.
Authors: Ohba T, Cole H, Cates J, Slosky D, Haro H, Ando T, Schwartz H, Schoenecker J
J Bone Miner Res, 2014-06-01;29(6):1431-45.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.
Authors: Gilmour J, Assi S, Jaegle U, Kulu D, van de Werken H, Clarke D, Westhead D, Philipsen S, Bonifer C
Development, 2014-05-21;141(12):2391-401.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
miR-27a regulates inflammatory response of macrophages by targeting IL-10.
Authors: Xie N, Cui H, Banerjee S, Tan Z, Salomao R, Fu M, Abraham E, Thannickal V, Liu G
J Immunol, 2014-05-16;193(1):327-34.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Reactive oxygen species induce the association of SHP-1 with c-Src and the oxidation of both to enhance osteoclast survival.
Authors: Ke K, Sul O, Choi E, Safdar A, Kim E, Choi H
Am J Physiol Endocrinol Metab, 2014-05-13;307(1):E61-70.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment.
Authors: Chaturvedi, Pallavi, Gilkes, Daniele, Takano, Naoharu, Semenza, Gregg L
Proc Natl Acad Sci U S A, 2014-05-05;111(20):E2120-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation.
Authors: Bartell, Shoshana, Kim, Ha-Neui, Ambrogini, Elena, Han, Li, Iyer, Srividhy, Serra Ucer, S, Rabinovitch, Peter, Jilka, Robert L, Weinstein, Robert S, Zhao, Haibo, O'Brien, Charles, Manolagas, Stavros, Almeida, Maria
Nat Commun, 2014-04-30;5(0):3773.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction.
Authors: Chang Y, Chen T, Wu Y, Chen G, Weng T, Tseng P, Hsieh S, Fu S, Lin C, Chen C, Chu C, Chio I, Mak T, Chen N
J Cell Mol Med, 2014-04-24;18(7):1344-57.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The pro-inflammatory cytokine, interleukin-6, enhances the polarization of alternatively activated macrophages.
Authors: Fernando M, Reyes J, Iannuzzi J, Leung G, McKay D
PLoS ONE, 2014-04-15;9(4):e94188.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
NRROS negatively regulates reactive oxygen species during host defence and autoimmunity.
Authors: Noubade, Rajkumar, Wong, Kit, Ota, Naruhisa, Rutz, Sascha, Eidenschenk, Celine, Valdez, Patricia, Ding, Jiabing, Peng, Ivan, Sebrell, Andrew, Caplazi, Patrick, DeVoss, Jason, Soriano, Robert H, Sai, Tao, Lu, Rongze, Modrusan, Zora, Hackney, Jason, Ouyang, Wenjun
Nature, 2014-04-13;509(7499):235-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Kruppel like factor 4 promoter undergoes active demethylation during monocyte/macrophage differentiation.
Authors: Karpurapu M, Ranjan R, Deng J, Chung S, Lee Y, Xiao L, Nirujogi T, Jacobson J, Park G, Christman J
PLoS ONE, 2014-04-02;9(4):e93362.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts.
Authors: Sharma, Ramaswam, Callaway, Danielle, Vanegas, Difernan, Bendele, Michelle, Lopez-Cruzan, Marisa, Horn, Diane, Guda, Teja, Fajardo, Roberto, Abboud-Werner, Sherry, Herman, Brian
PLoS ONE, 2014-04-01;9(4):e93696.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Distinct actions of akt1 on skeletal architecture and function.
Authors: Mukherjee, Aditi, Larson, Emily A, Klein, Robert F, Rotwein, Peter
PLoS ONE, 2014-03-24;9(3):e93040.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
C5L2 is required for C5a-triggered receptor internalization and ERK signaling.
Authors: Hsu W, Yang F, Lin C, Hsieh S, Chen N
Cell Signal, 2014-03-12;26(7):1409-19.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Osteocytes produce interferon-beta as a negative regulator of osteoclastogenesis.
Authors: Hayashida C, Ito J, Nakayachi M, Okayasu M, Ohyama Y, Hakeda Y, Sato T
J Biol Chem, 2014-03-07;289(16):11545-55.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Preferential macrophage recruitment and polarization in LPS-induced animal model for COPD: noninvasive tracking using MRI.
Authors: Al Faraj, Achraf, Sultana Shaik, Asma, Pureza, Mary Ang, Alnafea, Mohammad, Halwani, Rabih
PLoS ONE, 2014-03-05;9(3):e90829.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Changes of microRNA profile and microRNA-mRNA regulatory network in bones of ovariectomized mice.
Authors: An J, Ohn J, Song J, Yang J, Park H, Choi H, Kim S, Kim S, Park W, Shin C
J Bone Miner Res, 2014-03-01;29(3):644-56.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCgamma-independent Ca2+ oscillation.
Authors: Yeon J, Kim K, Choi S, Moon S, Park Y, Ryu B, Oh J, Kim M, Erkhembaatar M, Son Y, Kim S
PLoS ONE, 2014-02-21;9(2):e88974.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization.
Authors: Tatano Y, Shimizu T, Tomioka H
Sci Rep, 2014-02-20;4(0):4146.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1alpha with Th17/Treg control.
Authors: Yang E, Lee J, Lee S, Kim E, Moon Y, Jung Y, Park S, Cho M
PLoS ONE, 2014-02-18;9(2):e86062.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes.
Authors: Jego G, Lanneau D, de Thonel A, Berthenet K, Hazoume A, Droin N, Hamman A, Girodon F, Bellaye P, Wettstein G, Jacquel A, Duplomb L, Le Mouel A, Papanayotou C, Christians E, Bonniaud P, Lallemand-Mezger V, Solary E, Garrido C
Leukemia, 2014-02-07;28(8):1676-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A macrophage-specific synthetic promoter for therapeutic application of adiponectin.
Authors: Kang, W S, Kwon, J S, Kim, H B, Jeong, H-Y, Kang, H J, Jeong, M H, Cho, J G, Park, J C, Kim, Y S, Ahn, Y
Gene Ther, 2014-02-06;21(4):353-62.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.
Authors: Gwyer Findlay, Emily, Danks, Lynett, Madden, Jodie, Cavanagh, Mary M, McNamee, Kay, McCann, Fiona, Snelgrove, Robert J, Shaw, Stevan, Feldmann, Marc, Taylor, Peter Ch, Horwood, Nicole J, Hussell, Tracy
Proc Natl Acad Sci U S A, 2014-01-27;111(6):2289-94.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The RhoGAP activity of myosin IXB is critical for osteoclast podosome patterning, motility, and resorptive capacity.
Authors: McMichael B, Scherer K, Franklin N, Lee B
PLoS ONE, 2014-01-23;9(1):e87402.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.
Authors: David M, Machuca-Gayet I, Kikuta J, Ottewell P, Mima F, LeBlanc R, Bonnelye E, Ribeiro J, Holen I, Lopez Vales R, Jurdic P, Chun J, Clezardin P, Ishii M, Peyruchaud O
J Biol Chem, 2014-01-15;289(10):6551-64.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis.
Authors: Yao C, Yao G, Sun B, Zhang C, Tommasini S, Insogna K
J Biol Chem, 2014-01-06;289(10):6775-90.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization.
Authors: Date D, Das R, Narla G, Simon D, Jain M, Mahabeleshwar G
J Biol Chem, 2014-01-02;289(15):10318-29.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MafB promotes atherosclerosis by inhibiting foam-cell apoptosis.
Authors: Hamada, Michito, Nakamura, Megumi, Tran, Mai Thi, Moriguchi, Takashi, Hong, Cynthia, Ohsumi, Takayuki, Dinh, Tra Thi, Kusakabe, Manabu, Hattori, Motochik, Katsumata, Tokio, Arai, Satoko, Nakashima, Katsuhik, Kudo, Takashi, Kuroda, Etsushi, Wu, Chien-Hu, Kao, Pei-Han, Sakai, Masaharu, Shimano, Hitoshi, Miyazaki, Toru, Tontonoz, Peter, Takahashi, Satoru
Nat Commun, 2014-01-01;5(0):3147.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation.
Authors: Sun Q, Sammut B, Wang F, Kurihara N, Windle J, Roodman G, Galson D
J Bone Miner Res, 2014-01-01;29(1):90-102.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5-Dusp axis in the osteoclast.
Authors: Hirose J, Masuda H, Tokuyama N, Omata Y, Matsumoto T, Yasui T, Kadono Y, Hennighausen L, Tanaka S
J Exp Med, 2013-12-23;211(1):153-63.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.
Authors: Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone J, Takayanagi H
Nat Med, 2013-12-22;20(1):62-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Aged mice are unable to mount an effective myeloid response to sepsis.
Authors: Nacionales D, Gentile L, Vanzant E, Lopez M, Cuenca A, Cuenca A, Ungaro R, Li Y, Baslanti T, Bihorac A, Moore F, Baker H, Leeuwenburgh C, Moldawer L, Efron P
J Immunol, 2013-12-13;192(2):612-22.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The newly discovered cytokine IL-34 is expressed in gingival fibroblasts, shows enhanced expression by pro-inflammatory cytokines, and stimulates osteoclast differentiation.
Authors: Bostrom E, Lundberg P
PLoS ONE, 2013-12-10;8(12):e81665.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation.
Authors: Xiu Y, Xu H, Zhao C, Li J, Morita Y, Yao Z, Xing L, Boyce B
J Clin Invest, 2013-12-09;124(1):297-310.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-kappaB pathway and attenuating ROS production.
Authors: Lee S, Lee K, Yi S, Kook S, Lee J
PLoS ONE, 2013-12-04;8(12):e80873.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Identification of transcription factors for lineage-specific ESC differentiation.
Authors: Yamamizu K, Piao Y, Sharov A, Zsiros V, Yu H, Nakazawa K, Schlessinger D, Ko M
Stem Cell Reports, 2013-11-27;1(6):545-59.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease.
Authors: Stalvey M, Clines K, Havasi V, McKibbin C, Dunn L, Chung W, Clines G
PLoS ONE, 2013-11-13;8(11):e80098.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
T-cell costimulation protects obesity-induced adipose inflammation and insulin resistance.
Authors: Zhong, Jixin, Rao, Xiaoquan, Braunstein, Zachary, Taylor, Anne, Narula, Vimal, Hazey, Jeffrey, Mikami, Dean, Needleman, Bradley, Rutsky, Jessica, Sun, Qinghua, Deiuliis, Jeffrey, Satoskar, Abhay R, Rajagopalan, Sanjay
Diabetes, 2013-11-12;63(4):1289-302.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphoma.
Authors: Song K, Herzog B, Sheng M, Fu J, McDaniel J, Chen H, Ruan J, Xia L
Cancer Res, 2013-10-24;73(24):7254-64.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src.
Authors: Biosse Duplan, Martin, Zalli, Detina, Stephens, Sebastie, Zenger, Serhan, Neff, Lynn, Oelkers, J Margit, Lai, Frank P, Horne, William, Rottner, Klemens, Baron, Roland
Mol Cell Biol, 2013-10-21;34(1):16-29.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine.
Authors: Xia W, Jung J, Shun C, Xiong S, Xiong L, Shi X, Mei L, Xiong W
J Bone Miner Res, 2013-10-01;28(10):2122-35.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis.
Authors: Muruganandan S, Dranse H, Rourke J, McMullen N, Sinal C
Stem Cells, 2013-10-01;31(10):2172-82.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Liver X receptor activation inhibits osteoclastogenesis by suppressing NF-kappaB activity and c-Fos induction and prevents inflammatory bone loss in mice.
Authors: Kim H, Yoon K, Yoon H, Hong J, Lee M, Lee I, Kim S
J Leukoc Biol, 2013-05-08;94(1):99-107.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors.
Authors: Hunter, K E, Palermo, C, Kester, J C, Simpson, K, Li, J-P, Tang, L H, Klimstra, D S, Vlodavsky, I, Joyce, J A
Oncogene, 2013-05-06;33(14):1799-808.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery.
Authors: Jacome-Galarza C, Lee S, Lorenzo J, Aguila H
J Bone Miner Res, 2013-05-01;28(5):1203-13.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover.
Authors: Braun T, Lepper J, Ruiz Heiland G, Hofstetter W, Siegrist M, Lezuo P, Gaestel M, Rumpler M, Thaler R, Klaushofer K, Distler J, Schett G, Zwerina J
J Bone Miner Res, 2013-04-01;28(4):936-47.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
RNA interference-mediated silencing of Atp6i prevents both periapical bone erosion and inflammation in the mouse model of endodontic disease.
Authors: Ma, Junqing, Chen, Wei, Zhang, Lijie, Tucker, Byron, Zhu, Guochun, Sasaki, Hajime, Hao, Liang, Wang, Lin, Ci, Honglian, Jiang, Hongbing, Stashenko, Philip, Li, Yi-Ping
Infect Immun, 2013-04-01;81(4):1021-30.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Differential immune responses to Segniliparus rotundus and Segniliparus rugosus infection and analysis of their comparative virulence profiles.
Authors: Kim J, Kim W, Lee K, Won C, Kim J, Eum S, Koh W, Shin S
PLoS ONE, 2013-03-29;8(3):e59646.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity.
Authors: Yang Z, Grinchuk V, Urban J, Bohl J, Sun R, Notari L, Yan S, Ramalingam T, Keegan A, Wynn T, Shea-Donohue T, Zhao A
2013-03-25;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers.
Authors: Elcombe S, Naqvi S, van den Bosch M, Mackenzie K, Cianfanelli F, Brown G, Arthur J
PLoS ONE, 2013-03-22;8(3):e60086.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling.
Authors: Xia W, Tang F, Xiong L, Xiong S, Jung J, Lee D, Li X, Feng X, Mei L, Xiong W
J Cell Biol, 2013-03-18;200(6):821-37.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Toll-like receptor 2 ligands regulate monocyte Fcgamma receptor expression and function.
Authors: Shah P, Fatehchand K, Patel H, Fang H, Justiniano S, Mo X, Jarjoura D, Tridandapani S, Butchar J
J Biol Chem, 2013-03-15;288(17):12345-52.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Fas-mediated inflammatory response in Listeria monocytogenes infection.
Authors: Uchiyama R, Yonehara S, Tsutsui H
J Immunol, 2013-03-15;190(8):4245-54.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation.
Authors: Sandig H, Jobbings C, Roldan N, Whittingham-Dowd J, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S
Eur J Immunol, 2013-03-06;43(4):979-88.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Caffeine enhances osteoclast differentiation and maturation through p38 MAP kinase/Mitf and DC-STAMP/CtsK and TRAP pathway.
Authors: Choi J, Choi S, Lee S, Lee J, Kim H, Lee S, Lee N
Cell Signal, 2013-02-19;25(5):1222-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Overexpression of developmentally regulated GTP-binding protein-2 increases bone loss.
Authors: Ke K, Sul O, Kim W, Lee M, Ko M, Suh J, Kim H, Kim S, Park J, Choi H
Am J Physiol Endocrinol Metab, 2013-01-29;304(7):E703-10.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Identification of a lupus-susceptibility locus leading to impaired clearance of apoptotic debris on New Zealand Black chromosome 13.
Authors: Pau E, Loh C, Minty G, Chang N, Wither J
Genes Immun, 2013-01-17;14(3):154-61.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34).
Cytokine, 2012-12-19;61(2):630-8.
Species: Feline
Sample Types: Whole Cells
Applications: Bioassay -
Talin1 and Rap1 are critical for osteoclast function.
Authors: Zou W, Izawa T, Zhu T, Chappel J, Otero K, Monkley S, Critchley D, Petrich B, Morozov A, Ginsberg M, Teitelbaum S
Mol Cell Biol, 2012-12-10;33(4):830-44.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis.
Authors: Lamothe B, Lai Y, Xie M, Schneider M, Darnay B
Mol Cell Biol, 2012-11-19;33(3):582-95.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Role of c-Jun N-terminal protein kinase 1/2 (JNK1/2) in macrophage-mediated MMP-9 production in response to Moraxella catarrhalis lipooligosaccharide (LOS).
Authors: Hassan F, Ren D, Zhang W
PLoS ONE, 2012-05-24;7(5):e37912.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Osteoprotection by semaphorin 3A.
Authors: Hayashi M, Nakashima T, Taniguchi M, Kodama T, Kumanogoh A, Takayanagi H
Nature, 2012-05-03;485(7396):69-74.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer.
Authors: Zhao E, Wang L, Dai J, Kryczek I, Wei S, Vatan L, Altuwaijri S, Sparwasser T, Wang G, Keller E, Zou W
Oncoimmunology, 2012-03-01;1(2):152-161.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Macrophages participate in IL-17-mediated inflammation.
Authors: Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Quader F, Chen P, Zheng D, Caturegli P, Rose NR, Cihakova D
Eur. J. Immunol., 2012-01-23;42(3):726-36.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inactivation of glycogen synthase kinase-3beta is required for osteoclast differentiation.
Authors: Jang HD, Shin JH, Park DR, Hong JH, Yoon K, Ko R, Ko CY, Kim HS, Jeong D, Kim N, Lee SY
J. Biol. Chem., 2011-09-23;286(45):39043-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Macrophage infiltration predicts a poor prognosis for human ewing sarcoma.
Authors: Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y
Am. J. Pathol., 2011-07-21;179(3):1157-70.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment.
Authors: Cook BD, Liu S, Evans T
Blood, 2011-04-22;117(24):6489-97.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of osteoclastogenesis by mechanically loaded osteocytes: involvement of MEPE.
Authors: Kulkarni RN, Bakker AD, Everts V, Klein-Nulend J
Calcif. Tissue Int., 2010-08-20;87(5):461-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
B7-h3 augments the inflammatory response and is associated with human sepsis.
Authors: Zhang G, Wang J, Kelly J
J. Immunol., 2010-08-09;185(6):3677-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.
Authors: Scapini P, Hu Y, Chu CL
J. Exp. Med., 2010-07-12;207(8):1757-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Osteoclast inhibitory peptide-1 binding to the Fc gammaRIIB inhibits osteoclast differentiation.
Authors: Shanmugarajan S, Beeson CC, Reddy SV
Endocrinology, 2010-07-07;151(9):4389-99.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Transient overexpression of sonic hedgehog alters the architecture and mechanical properties of trabecular bone.
Authors: Kiuru M, Solomon J, Ghali B, van der Meulen M, Crystal RG, Hidaka C
J. Bone Miner. Res., 2009-09-01;24(9):1598-607.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro.
Authors: Wang L, Zhao R, Shi X, Wei T, Halloran BP, Clark DJ, Jacobs CR, Kingery WS
Bone, 2009-04-18;45(2):309-20.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis.
Authors: Binder NB, Niederreiter B, Hoffmann O, Stange R, Pap T, Stulnig TM, Mack M, Erben RG, Smolen JS, Redlich K
Nat. Med., 2009-03-29;15(4):417-24.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling.
Authors: Walker EC, McGregor NE, Poulton IJ, Pompolo S, Allan EH, Quinn JM, Gillespie MT, Martin TJ, Sims NA
J. Bone Miner. Res., 2008-12-01;23(12):2025-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment.
Authors: Jinushi M, Nakazaki Y, Carrasco DR, Draganov D, Souders N, Johnson M, Mihm MC, Dranoff G
Cancer Res., 2008-11-01;68(21):8889-98.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival.
Authors: Krum SA, Miranda-Carboni GA, Hauschka PV, Carroll JS, Lane TF, Freedman LP, Brown M
EMBO J., 2008-01-24;27(3):535-45.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Imatinib promotes osteoblast differentiation by inhibiting PDGFR signaling and inhibits osteoclastogenesis by both direct and stromal cell-dependent mechanisms.
Authors: O'Sullivan S, Naot D, Callon K, Porteous F, Horne A, Wattie D, Watson M, Cornish J, Browett P, Grey A
J. Bone Miner. Res., 2007-11-01;22(11):1679-89.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction.
Authors: Niki Y, Takaishi H, Takito J, Miyamoto T, Kosaki N, Matsumoto H, Toyama Y, Tada N
J. Immunol., 2007-07-01;179(1):639-46.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bacterial lipopolysaccharide induces osteoclast formation in RAW 264.7 macrophage cells.
Authors: Islam S, Hassan F, Tumurkhuu G, Dagvadorj J, Koide N, Naiki Y, Mori I, Yoshida T, Yokochi T
Biochem. Biophys. Res. Commun., 2007-06-12;360(2):346-51.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Fas/Fas ligand system inhibits differentiation of murine osteoblasts but has a limited role in osteoblast and osteoclast apoptosis.
Authors: Kovacic N, Lukic IK, Grcevic D, Katavic V, Croucher P, Marusic A
J. Immunol., 2007-03-15;178(6):3379-89.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hematopoietic stem cell-targeted neonatal gene therapy reverses lethally progressive osteopetrosis in oc/oc mice.
Authors: Johansson MK, de Vries TJ, Schoenmaker T, Ehinger M, Brun AC, Fasth A, Karlsson S, Everts V, Richter J
Blood, 2007-03-01;109(12):5178-85.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells.
Authors: Nakanishi M, Niidome T, Matsuda S, Akaike A, Kihara T, Sugimoto H
Eur. J. Neurosci., 2007-02-01;25(3):649-58.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of prostate tumor growth and bone remodeling by the vascular targeting agent VEGF121/rGel.
Authors: Mohamedali KA, Poblenz AT, Sikes CR, Navone NM, Thorpe PE, Darnay BG, Rosenblum MG
Cancer Res., 2006-11-15;66(22):10919-28.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density.
Authors: Jia D, O'Brien CA, Stewart SA, Manolagas SC, Weinstein RS
Endocrinology, 2006-08-24;147(12):5592-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions.
Authors: Kim SY, Nguyen AD, Gao JL, Murphy PM, Mansfield BC, Chou JY
J. Biol. Chem., 2006-08-04;281(39):28794-801.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts.
Authors: de Vries TJ, Schoenmaker T, Wattanaroonwong N, van den Hoonaard M, Nieuwenhuijse A, Beertsen W, Everts V
J. Cell. Biochem., 2006-05-15;98(2):370-82.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580.
Authors: Conway</LastName><ForeNam JG</Initia, Conway JG, McDonald B, Parham J, Keith B, Rusnak DW, Shaw E, Jansen M, Lin P, Payne A, Crosby RM, Johnson JH, Frick L, Lin MH, Depee S, Tadepalli S, Votta B, James I, Fuller K, Chambers TJ, Kull FC, Chamberlain SD, Hutchins JT
Proc. Natl. Acad. Sci. U.S.A., 2005-10-25;102(44):16078-83.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine).
Authors: Gevrey JC, Isaac BM, Cox D
J. Immunol., 2005-09-15;175(6):3737-45.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Development of a culture system that supports adult microglial cell proliferation and maintenance in the resting state.
Authors: Ponomarev ED, Novikova M, Maresz K, Shriver LP, Dittel BN
J. Immunol. Methods, 2005-04-26;300(1):32-46.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis.
Authors: Sharif MN, Tassiulas I, Hu Y, Mecklenbrauker I, Tarakhovsky A, Ivashkiv LB
J. Immunol., 2004-05-15;172(10):6476-81.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells.
Authors: Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL
J. Biol. Chem., 2002-11-06;278(3):1561-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
FAQs
-
How long will recombinant mouse M-CSF last in cell culture?
End-users will need to determine the appropriate concentration and timing when adding Recombinant Mouse M-CSF Proteins to cell culturing experiments. The addition of protein may be dependent on certain culture conditions, including the cell number, density, and media content. For techniques and methodologies, we recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.
Reviews for Recombinant Mouse M-CSF Protein
Average Rating: 4.7 (Based on 18 Reviews)
Have you used Recombinant Mouse M-CSF Protein?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Reason for Rating: It works good in a 10ng/ml concentration.
Reason for Rating: We used this to induce the bone derived macrophage in mice. It worked good even in a low concentration.
Reason for Rating: We used this in bone marrow macrophages to induce osteoblast. It works great cells can easily been seen under a scope. We later ran TRAP staining
Reason for Rating: The cells migrated well attracted by the M-CSF
Reason for Rating: We use this to induce the bone derived macrophage from mouse. It worked well in a relatively low concentration.
Reason for Rating: Due to the tight budget plan, we used the M-CFS as a relatively low concentration as 10ng/ml. But it works well.
Reason for Rating: Worked as expected