Recombinant Mouse IL-4 Protein Summary
Product Specifications
His23-Ser140, with an N-terminal Met
Analysis
Product Datasheets
404-ML (with carrier)
404-ML/CF (carrier free)
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
404-ML
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. |
Reconstitution | Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
404-ML/CF
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution | Reconstitute at 100 μg/mL in sterile PBS. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Scientific Data
Recombinant Mouse IL-4 (Catalog # 404-ML) has a molecular weight (MW) of 13.2 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.
Recombinant Mouse IL-4 (Catalog # 404-ML) stimulates cell proliferation of the HT‑2 mouse T cell line. The ED50 for this effect is 0.3-1.5 ng/mL.
1 μg/lane of Recombinant Mouse IL-4 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 12 kDa.
Background: IL-4
Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a monomeric, approximately 13 kDa-18 kDa Th2 cytokine that shows pleiotropic effects during immune responses (1-4). It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four alpha -helix structure (5). Mouse IL-4 is synthesized with a 24 aa signal sequence. Mature mouse IL-4 shares 39%, 39%, and 59% aa sequence identity with bovine, human, and rat IL-4, respectively. Human, mouse, and rat IL-4 are species-specific in their activities (6-8). IL-4 exerts its effects through two receptor complexes (9, 10). The type I receptor, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R alpha and the common gamma chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and
-21). The type II receptor on nonhematopoietic cells consists of IL‑4 R alpha and IL‑13 R alpha 1. The type II receptor also transduces IL‑13 mediated signals. IL-4 is primarily expressed by Th2‑biased CD4+ T cells, mast cells, basophils, and eosinophils (1, 2). It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells (11 ‑ 14). IL-4 plays a dominant role in the development of allergic inflammation and asthma (13, 15).
- Benczik, M. and S.L. Gaffen (2004) Immunol. Invest. 33:109.
- Chomarat, P. and J. Banchereau (1998) Int. Rev. Immunol. 17:1.
- Lee, F. et al. (1986) Proc. Natl. Acad. Sci. 83:2061.
- Noma, Y. et al. (1986) Nature 319:640.
- Redfield, C. et al. (1991) Biochemistry 30:11029.
- Ramirez, F. et al. (1988) J. Immunol. Meth. 221:141.
- Leitenberg, D. and T.L. Feldbush (1988) Cell. Immunol. 111:451.
- Mosman, T.R. et al. (1987) J. Immunol. 138:1813.
- Mueller, T.D. et al. (2002) Biochim. Biophys. Acta 1592:237.
- Nelms, K. et al. (1999) Annu. Rev. Immunol. 17:701.
- Paludan, S.R. (1998) Scand. J. Immunol. 48:459.
- Corthay, A. (2006) Scand. J. Immunol. 64:93.
- Ryan, J.J. et al. (2007) Crit. Rev. Immunol. 27:15.
- Grone, A. (2002) Vet. Immunol. Immunopathol. 88:1.
- Rosenberg, H.F. et al. (2007) J. Allergy Clin. Immunol. 119:1303.
Citations for Recombinant Mouse IL-4 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Fatty acid derivatization and cyclization of the immunomodulatory peptide RP-182 targeting CD206high macrophages improves anti-tumor activity
Authors: Singh, SS;Calvo, R;Kumari, A;Sable, RV;Fang, Y;Tao, D;Hu, X;Castle, SG;Nahar, S;Li, D;Major, E;Sanchez, TW;Kato, R;Xu, X;Zhou, J;Liu, L;LeClair, CA;Simeonov, A;Baljinnyam, B;Henderson, MJ;Marugan, J;Rudloff, U;
Molecular cancer therapeutics
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CD11c+ dendritic cells PlexinD1 deficiency exacerbates airway hyperresponsiveness, IgE and mucus production in a mouse model of allergic asthma
Authors: Shan, L;Matloubi, M;Okwor, I;Kung, S;Almiski, MS;Basu, S;Halayko, A;Koussih, L;Gounni, AS;
PloS one
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Exercise-stimulated Resolvin Biosynthesis in Adipose Tissue is Abrogated by High Fat Diet-induced Adrenergic Deficiency
Authors: Pena Calderin, EH;Zheng, JJ;Boyd, NL;Lynch, W;Sansbury, BE;Spite, M;Hill, BG;Hellmann, J;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells
Authors: Lim, YJ;Park, SA;Wang, D;Jin, W;Ku, WL;Zhang, D;Xu, J;Patiño, LC;Liu, N;Chen, W;Kazmi, R;Zhao, K;Zhang, YE;Sun, L;Chen, W;
Cell reports
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MerTK Induces Dysfunctional Dendritic Cells by Metabolic Reprogramming
Authors: Zewdie, EY;Edwards, GM;Hunter, DM;Earp, HS;Holtzhausen, A;
Cancer immunology research
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Monitoring macrophage polarization with gene expression reporters and bioluminescence phasor analysis
Authors: Tedeschi, G;Navarro, MX;Scipioni, L;Sondhi, TK;Prescher, JA;Digman, MA;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BRWD1 establishes epigenetic states for germinal center initiation, maintenance, and function
Authors: Wright, NE;Kennedy, DE;Ai, J;Veselits, ML;Attaway, M;Yoon, YM;Durkee, MS;Veselits, J;Maienschein-Cline, M;Mandal, M;Clark, MR;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice
Authors: Durand, A;Bonilla, N;Level, T;Ginestet, Z;Lombès, A;Guichard, V;Germain, M;Jacques, S;Letourneur, F;Do Cruzeiro, M;Marchiol, C;Renault, G;Le Gall, M;Charvet, C;Le Bon, A;Martin, B;Auffray, C;Lucas, B;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Upregulation of IL4-induced gene 1 enzyme by B2 cells during melanoma progression impairs their antitumor properties
Authors: Bekkat, F;Seradj, M;Lengagne, R;Fiore, F;Kato, M;Lucas, B;Castellano, F;Molinier-Frenkel, V;Richard, Y;Prévost-Blondel, A;
European journal of immunology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment
Authors: Hardaker, EL;Sanseviero, E;Karmokar, A;Taylor, D;Milo, M;Michaloglou, C;Hughes, A;Mai, M;King, M;Solanki, A;Magiera, L;Miragaia, R;Kar, G;Standifer, N;Surace, M;Gill, S;Peter, A;Talbot, S;Tohumeken, S;Fryer, H;Mostafa, A;Mulgrew, K;Lam, C;Hoffmann, S;Sutton, D;Carnevalli, L;Calero-Nieto, FJ;Jones, GN;Pierce, AJ;Wilson, Z;Campbell, D;Nyoni, L;Martins, CP;Baker, T;Serrano de Almeida, G;Ramlaoui, Z;Bidar, A;Phillips, B;Boland, J;Iyer, S;Barrett, JC;Loembé, AB;Fuchs, SY;Duvvuri, U;Lou, PJ;Nance, MA;Gomez Roca, CA;Cadogan, E;Critichlow, SE;Fawell, S;Cobbold, M;Dean, E;Valge-Archer, V;Lau, A;Gabrilovich, DI;Barry, ST;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pirfenidone alleviates chronic pancreatitis via suppressing the activation of pancreatic stellate cells and the M1 polarization of macrophages
Authors: Guo, HL;Liang, XS;Zeng, XP;Liu, Y;Li, ZS;Wang, LJ;Hu, LH;
International immunopharmacology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Trappc1 intrinsically prevents ferroptosis of naive T cells to avoid spontaneous autoinflammatory disease in mice
Authors: Zhang, Z;Zhao, C;Sun, L;Cheng, C;Tian, Q;Wu, C;Xu, Y;Dong, X;Zhang, B;Zhang, L;Zhao, Y;
European journal of immunology
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity
Authors: Zhang, H;Xue, K;Li, W;Yang, X;Gou, Y;Su, X;Qian, F;Sun, L;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes
Authors: Hou, Y;Wei, D;Zhang, Z;Lei, T;Li, S;Bao, J;Guo, H;Tan, L;Xie, X;Zhuang, Y;Lu, Z;Zhao, Y;
Cell reports
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice
Authors: King, A;Reichl, P;Metson, JS;Parker, R;Munro, D;Oliveira, C;Becker, JR;Biggs, D;Preece, C;Davies, B;Chapman, JR;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge
Authors: Lin, YL;Cheng, PY;Chin, CL;Chuang, KT;Lin, JY;Chang, N;Pan, CK;Lin, CS;Pan, SC;Chiang, BL;
Journal of biomedical science
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mutual modulation of gut microbiota and the immune system in type 1 diabetes models
Authors: Rosell-Mases, E;Santiago, A;Corral-Pujol, M;Yáñez, F;Varela, E;Egia-Mendikute, L;Arpa, B;Cosovanu, C;Panosa, A;Serrano-Gómez, G;Mora, C;Verdaguer, J;Manichanh, C;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Osteoprotective effect by interleukin-4 (IL-4) on lipoprotein-induced periodontitis
Authors: Lima Teixeira, JF;Henning, P;Cintra Magalhães, FA;Coletto-Nunes, G;Floriano-Marcelino, T;Westerlund, A;Movérare-Skrtic, S;Oliveira, GJPL;Lerner, UH;Souza, PPC;
Cytokine
Species: Mouse
Sample Types: In Vivo
Applications: In vivo assay -
The mechanism underlying the inverse proportion between serum IgE concentration and Stat3 transcriptional activity depends on Stat3 mutation type
Authors: Wang, Y;Chen, X;Zhou, L;Chinn, E;Yue, J;
International immunopharmacology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release
Authors: Adrian, M;Weber, M;Tsai, MC;Glock, C;Kahn, OI;Phu, L;Cheung, TK;Meilandt, WJ;Rose, CM;Hoogenraad, CC;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice
Authors: Alexander, ET;Fahey, E;Phanstiel, O;Gilmour, SK;
Biomedicines
Species: Transgenic Mouse, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
O-alg-THAM/gel hydrogels functionalized with engineered microspheres based on mesenchymal stem cell secretion recruit endogenous stem cells for cartilage repair
Authors: Li, Y;Li, L;Wang, M;Yang, B;Huang, B;Bai, S;Zhang, X;Hou, N;Wang, H;Yang, Z;Tang, C;Li, Y;Yuk-Wai Lee, W;Feng, L;Tortorella, MD;Li, G;
Bioactive materials
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation
Authors: Chen, S;Wang, J;Zhang, K;Ma, B;Li, X;Wei, R;Nian, H;
Cell death & disease
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations
Authors: Zhang, J;Koolmeister, C;Han, J;Filograna, R;Hanke, L;Àdori, M;Sheward, DJ;Teifel, S;Gopalakrishna, S;Shao, Q;Liu, Y;Zhu, K;Harris, RA;McInerney, G;Murrell, B;Aoun, M;Bäckdahl, L;Holmdahl, R;Pekalski, M;Wedell, A;Engvall, M;Wredenberg, A;Karlsson Hedestam, GB;Castro Dopico, X;Rorbach, J;
JCI insight
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CD40L modulates CD4+ T cell activation through receptor for activated C kinase 1
Authors: van Os, BW;Vos, WG;Bosmans, LA;van Tiel, CM;Toom, MD;Beckers, L;Admiraal, M;Hoeksema, MA;de Winther, MP;Lutgens, E;
European journal of immunology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Lysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation
Authors: Wu, J;Hu, Y;Song, J;Xu, J;Zhang, Q;Chai, Y;Wang, X;Wang, B;Zhao, Y;Cao, X;Xu, X;
Cell death & disease
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ZEB1 promotes non-homologous end joining double-strand break repair
Authors: Genetta, TL;Hurwitz, JC;Clark, EA;Herold, BT;Khalil, S;Abbas, T;Larner, JM;
Nucleic acids research
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
(-)-Guaiol inhibit epithelial-mesenchymal transition in lung cancer via suppressing M2 macrophages mediated STAT3 signaling pathway
Authors: Cao, Y;Wu, Y;Tu, H;Gu, Z;Yu, F;Huang, W;Shen, L;Wang, L;Li, Y;
Heliyon
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Microglia Negatively Regulate the Proliferation and Neuronal Differentiation of Neural Stem/Progenitor Cells Isolated from Poststroke Mouse Brains
Authors: Hirano, Y;Nakagomi, T;Nakano-Doi, A;Kubo, S;Minato, Y;Sawano, T;Sakagami, M;Tsuzuki, K;
Cells
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
PHRF1 promotes the class switch recombination of IgA in CH12F3-2A cells
Authors: Lee, JY;Chou, NL;Yu, YR;Shih, HA;Lin, HW;Lee, CK;Chang, MS;
PloS one
Species: Mouse
Sample Types: Whole Cells, Transfected Whole Cells
Applications: Bioassay -
iAstrocytes do not restrain T cell proliferation in vitro
Authors: Colombo, E;De Angelis, A;Bassani, C;Ruffini, F;Ottoboni, L;Garzetti, L;Finardi, A;Martino, G;Furlan, R;Farina, C;
BMC neuroscience
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages
Authors: Lu, Y;Zhang, H;Pan, H;Zhang, Z;Zeng, H;Xie, H;Yin, J;Tang, W;Lin, R;Zeng, C;Cai, D;
Journal of translational medicine
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MTHFD2 reprograms macrophage polarization by inhibiting PTEN
Authors: Shang, M;Ni, L;Shan, X;Cui, Y;Hu, P;Ji, Z;Shen, L;Zhang, Y;Zhou, J;Bing Chen, ;Wang, T;Yu, Q;
Cell reports
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development
Authors: Cheu, JW;Chiu, DK;Kwan, KK;Yang, C;Yuen, VW;Goh, CC;Chui, NN;Shen, W;Law, CT;Li, Q;Zhang, MS;Bao, MH;Wong, BP;Chan, CY;Liu, CX;Sit, GF;Ooi, ZY;Deng, H;Tse, AP;Ng, IO;Wong, CC;
Science advances
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-4 Signaling Promotes Myoblast Differentiation and Fusion by Enhancing the Expression of MyoD, Myogenin, and Myomerger
Authors: Kurosaka, M;Hung, YL;Machida, S;Kohda, K;
Cells
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells
Authors: CE Rivera, Y Zhou, DP Chupp, H Yan, AD Fisher, R Simon, H Zan, Z Xu, P Casali
Science Advances, 2023-04-28;9(17):eade8928.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Distinct Responses to IL4 in Macrophages Mediated by JNK
Authors: Arpa, L;Batlle, C;Jiang, P;Caelles, C;Lloberas, J;Celada, A;
Cells
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The RNA-binding protein hnRNP F is required for the germinal center B cell response
Authors: H Huang, Y Li, G Zhang, GX Ruan, Z Zhu, W Chen, J Zou, R Zhang, J Wang, Y Ouyang, S Xu, X Ou
Nature Communications, 2023-03-30;14(1):1731.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity
Authors: KA Read, DM Jones, S Pokhrel, EDS Hales, A Varkey, JA Tuazon, CD Eisele, O Abdouni, A Saadey, MR Leonard, RT Warren, MD Powell, JM Boss, EA Hemann, JS Yount, G Xin, HE Ghoneim, CJ Lio, AG Freud, PL Collins, KJ Oestreich
Nature Communications, 2023-03-24;14(1):1652.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Nsun2 coupling with RoRgammat shapes the fate of Th17 cells and promotes colitis
Authors: WL Yang, W Qiu, T Zhang, K Xu, ZJ Gu, Y Zhou, HJ Xu, ZZ Yang, B Shen, YL Zhao, Q Zhou, Y Yang, W Li, PY Yang, YG Yang
Nature Communications, 2023-02-16;14(1):863.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model
Authors: N Beckmann, A Neuhaus, S Zurbruegg, P Volkmer, C Patino, S Joller, D Feuerbach, A Doelemeyer, T Schweizer, S Rudin, U Neumann, R Berth, W Frieauff, F Gasparini, DR Shimshek
Journal of Neuroinflammation, 2023-02-08;20(1):29.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Crosstalk between ILC2s and Th2 cells varies among mouse models
Authors: RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu
Cell Reports, 2023-02-02;42(2):112073.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CCR7 Mediates Dendritic-Cell-Derived Exosome Migration and Improves Cardiac Function after Myocardial Infarction
Authors: Y Zhang, W Gao, J Yuan, X Zhong, K Yao, R Luo, H Liu
Pharmaceutics, 2023-01-30;15(2):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress
Authors: Z Li, K Chen, Q Shao, H Lu, X Zhang, Y Pu, X Sun, H He, L Cao
Journal of Neuroinflammation, 2023-01-30;20(1):16.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway
Authors: WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee
International Journal of Molecular Sciences, 2023-01-29;24(3):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Toll-like receptor 2 mediates Acanthamoeba-induced allergic airway inflammatory response in mice
Authors: MK Park, HK Park, HS Yu
PloS Neglected Tropical Diseases, 2023-01-27;17(1):e0011085.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Rac1 controls cell turnover and reversibility of the involution process in postpartum mammary glands
Authors: A Mironov, M Fisher, P Narayanan, R Elsayed, M Karabuluto, N Akhtar
PloS Biology, 2023-01-19;21(1):e3001583.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity
Authors: J Liu, Y Cheng, X Zhang, Y Chen, H Zhu, K Chen, S Liu, Z Li, X Cao
Cell Reports, 2023-01-18;42(1):111991.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A Novel Engineered AAV-based Neoantigen Vaccine in Combination with Radiotherapy Eradicates Tumors
Authors: KC Huang, CY Lai, WZ Hong, HY Chang, PC Lin, SF Chiang, TW Ke, JA Liang, AC Shiau, PC Yang, WT Chen, KSC Chao
Cancer Immunology Research, 2023-01-03;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway
Authors: WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee
International Journal of Molecular Sciences, 2023;24(3):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Role of Adenylyl Cyclase Type 7 in Functions of BV-2 Microglia
Authors: Y Hu, RA Hill, M Yoshimura
International Journal of Molecular Sciences, 2022-12-25;24(1):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Guidelines for mouse and human DC functional assays
Authors: BE Clausen, L Amon, RA Backer, L Berod, T Bopp, A Brand, S Burgdorf, L Chen, M Da, U Distler, RJ Dress, D Dudziak, CA Dutertre, C Eich, A Gabele, M Geiger, F Ginhoux, L Giusiano, GJ Godoy, AEI Hamouda, L Hatscher, L Heger, GF Heidkamp, LC Hernandez, L Jacobi, T Kaszubowsk, WT Kong, CHK Lehmann, T López-Lópe, K Mahnke, D Nitsche, J Renkawitz, RA Reza, PJ Sáez, L Schlautman, MT Schmitt, A Seichter, M Sielaff, T Sparwasser, P Stoitzner, G Tchitashvi, S Tenzer, NR Tochoedo, D Vurnek, F Zink, T Hieronymus
European Journal of Immunology, 2022-12-23;0(0):.
Species: Mouse
Sample Types:
-
Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer
Authors: CY Chang, R You, D Armstrong, A Bandi, YT Cheng, PM Burkhardt, L Becerra-Do, MC Madison, HY Tung, Z Zeng, Y Wu, L Song, PE Phillips, P Porter, JM Knight, N Putluri, X Yuan, DC Marcano, EA McHugh, JM Tour, A Catic, L Maneix, BM Burt, HS Lee, DB Corry, F Kheradmand
Science Advances, 2022-11-16;8(46):eabq0615.
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism
Authors: Y Hou, D Wei, Z Zhang, H Guo, S Li, J Zhang, P Zhang, L Zhang, Y Zhao
Cell Reports, 2022-11-15;41(7):111668.
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation
Authors: SA Park, YJ Lim, WL Ku, D Zhang, K Cui, LY Tang, C Chia, P Zanvit, Z Chen, W Jin, D Wang, J Xu, O Liu, F Wang, A Cain, N Guo, H Nakatsukas, C Wu, YE Zhang, K Zhao, W Chen
Nature Communications, 2022-10-14;13(1):6069.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target
Authors: H Cho, HY Kwon, A Sharma, SH Lee, X Liu, N Miyamoto, JJ Kim, SH Im, NY Kang, YT Chang
Nature Communications, 2022-10-10;13(1):5974.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Detection of Radiolabeled Inflammatory Cell Macrophage Subpopulations in Chronic Respiratory Diseases: Results from Preliminary Analyses
Authors: AP Shaik, AS Shaik, M Abudawood, A Al Faraj
BioMed Research International, 2022-10-06;2022(0):9470845.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes
Authors: KC Fernandez, L Feeney, RM Smolkin, WF Yen, AJ Matthews, W Alread, JHJ Petrini, J Chaudhuri
Elife, 2022-10-03;11(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Homoharringtonine Attenuates Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-kappaB Signaling
Authors: J Liu, L Shi, W Huang, Z Zheng, X Huang, Y Su
Mediators of Inflammation, 2022-09-29;2022(0):3441357.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination
Authors: SI Tsukumo, PG Subramani, N Seija, M Tabata, Y Maekawa, Y Mori, C Ishifune, Y Itoh, M Ota, K Fujio, JM Di Noia, K Yasutomo
Science Advances, 2022-08-24;8(34):eabq0008.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Macrophage-Specific, Mafb-Deficient Mice Showed Delayed Skin Wound Healing
Authors: Y Inoue, CW Liao, Y Tsunakawa, IL Tsai, S Takahashi, M Hamada
International Journal of Molecular Sciences, 2022-08-19;23(16):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Monocyte pro-inflammatory phenotypic control by Ephrin type-A receptor 4 mediates neural tissue damage
Authors: EA Kowalski, E Soliman, C Kelly, EK Gudenschwa, J Leonard, KJ Pridham, J Ju, AM Cash, A Hazy, C de Jager, AM Kaloss, H Ding, RD Hernandez, GM Coleman, X Wang, ML Olsen, AM Pickrell, MH Theus
JCI Insight, 2022-08-08;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain
Authors: C Vasavda, R Xu, J Liew, R Kothari, RS Dhindsa, ER Semenza, BD Paul, DP Green, MF Sabbagh, JY Shin, W Yang, AM Snowman, LK Albacarys, A Moghekar, CA Pardo-Vill, M Luciano, J Huang, C Bettegowda, SG Kwatra, X Dong, M Lim, SH Snyder
Science Advances, 2022-08-03;8(31):eabo5633.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Intratracheal administration of mesenchymal stem cells modulates lung macrophage polarization and exerts anti-asthmatic effects
Authors: Y Mo, H Kang, JY Bang, JW Shin, HY Kim, SH Cho, HR Kang
Scientific Reports, 2022-07-11;12(1):11728.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation
Authors: R Guo, X Jia, Z Ding, G Wang, M Jiang, B Li, S Chen, B Xia, Q Zhang, J Liu, R Zheng, Z Gao, X Xie
Theranostics, 2022-07-04;12(11):5220-5236.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload
Authors: MK Ameka, WN Beavers, CM Shaver, LB Ware, VE Kerchberge, KQ Schoenfelt, L Sun, T Koyama, EP Skaar, L Becker, AH Hasty
International Journal of Molecular Sciences, 2022-07-03;23(13):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects
Authors: R Mary, F Chalmin, T Accogli, M Bruchard, C Hibos, J Melin, C Truntzer, E Limagne, V Derangère, M Thibaudin, E Humblin, R Boidot, S Chevrier, L Arnould, C Richard, Q Klopfenste, A Bernard, Y Urade, JA Harker, L Apetoh, F Ghiringhel, F Végran
Cancer Immunology Research, 2022-07-01;0(0):OF1-OF17.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32
Authors: J Yin, H Zeng, K Fan, H Xie, Y Shao, Y Lu, J Zhu, Z Yao, L Liu, H Zhang, B Luo, X Wang, C Zeng, X Bai, H Zhang, D Cai
Cell Death & Disease, 2022-06-24;13(6):567.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization
Authors: JH Lee, SH Lee, EH Lee, JY Cho, DK Song, YJ Lee, TK Kwon, BC Oh, KW Cho, TF Osborne, TI Jeon, SS Im
Journal of advanced research, 2022-05-31;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis
Authors: Y Jin, Y Liu, L Xu, J Xu, Y Xiong, Y Peng, K Ding, S Zheng, N Yang, Z Zhang, L Li, L Tan, H Song, J Fu
Cell Death & Disease, 2022-05-31;13(5):512.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations
Authors: AP Leinroth, AJ Mirando, D Rouse, Y Kobayahsi, PR Tata, HE Rueckert, Y Liao, JT Long, JV Chakkalaka, MJ Hilton
Cell Reports, 2022-05-10;39(6):110785.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization
Authors: K Ming-Chin, AA Achuthan, DP De Souza, TJ Lupancu, KJ Binger, MKS Lee, Y Xu, MJ McConville, NA de Weerd, D Dragoljevi, PJ Hertzog, AJ Murphy, JA Hamilton, AJ Fleetwood
Cell Reports, 2022-04-19;39(3):110719.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Metabolic reprogramming of tumor-associated macrophages by collagen turnover promotes fibrosis in pancreatic cancer
Authors: MM LaRue, S Parker, J Puccini, M Cammer, AC Kimmelman, D Bar-Sagi
Proceedings of the National Academy of Sciences of the United States of America, 2022-04-11;119(16):e2119168119.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Self-assembled BPIV3 nanoparticles can induce comprehensive immune responses and protection against BPIV3 challenge by inducing dendritic cell maturation in mice
Authors: Z Qu, M Li, R An, H Dai, Y Yu, C Li, C Cao, Y Meng, J Wang, M Gao
Veterinary Microbiology, 2022-03-31;268(0):109415.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity
Authors: CJ Ortiz-Boni, TP Uccello, SA Gerber, EM Lord, EM Messing, YF Lee
International Journal of Molecular Sciences, 2022-03-08;23(6):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice
Authors: JD Hathaway-S, JD Aartun, NA Poulides, MB Kuhn, BE McCormick, ME Chew, E Huang, RP Darveau, C Westwater, CM Novince
JCI Insight, 2022-02-22;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
53BP1-shieldin-dependent DSB processing in BRCA1-deficient cells requires CST-Polalpha-primase fill-in synthesis
Authors: Z Mirman, NK Sasi, A King, JR Chapman, T de Lange
Nature Cell Biology, 2022-01-13;24(1):51-61.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis
Authors: D Zhao, C Wang, X Liu, N Liu, S Zhuang, Q Zhang, X Bao, S Xu, X Zhou, Q Meng, S Li, L Tang
Mediators of Inflammation, 2021-12-30;2021(0):7858746.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dihydroartemisinin inhibits Lewis Lung carcinoma progression by inducing macrophages M1 polarization via AKT/mTOR pathway
Authors: X Xiao, Y Li, Y Wang, Y Zhang, J Chen, W Liu, J Tang, F Yue, J Yang
International immunopharmacology, 2021-12-15;103(0):108427.
Species: Mouse
Sample Types: Whole Cells
Applications: Polarization -
Immunosuppressive effect of Columbianadin on maturation, migration, allogenic T cell stimulation and phagocytosis capacity of TNF-alpha induced dendritic cells
Authors: S Chen, Y Bai, Y Wang, C Liang, K Du, S Wang, J Li, YX Chang
Journal of ethnopharmacology, 2021-12-14;285(0):114918.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection
Authors: A Di Pietro, J Polmear, L Cooper, T Damelang, T Hussain, L Hailes, K O'Donnell, V Udupa, T Mi, S Preston, A Shtewe, U Hershberg, SJ Turner, NL La Gruta, AW Chung, DM Tarlinton, CD Scharer, KL Good-Jacob
Nature Immunology, 2021-11-29;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation
Authors: Y Feng, C Li, JA Stewart, P Barbulescu, NS Desivo, A Álvarez-Qu, RC Pezo, MLW Perera, K Chan, AHY Tong, R Mohamad-Ra, M Berru, D Nakib, G Li, GA Kardar, JR Carlyle, J Moffat, D Durocher, JM Di Noia, AS Bhagwat, A Martin
Nature, 2021-11-24;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Loop extrusion promotes an alternate pathway for isotype switching
Authors: HM Shen, R Wuerffel, JF Cantillo, S Priyadarsh, X Lei, J Liang, YL Wu, AL Kenter
Cell Reports, 2021-11-23;37(8):110059.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity
Authors: L Long, J Wei, SA Lim, JL Raynor, H Shi, JP Connelly, H Wang, C Guy, B Xie, NM Chapman, G Fu, Y Wang, H Huang, W Su, J Saravia, I Risch, YD Wang, Y Li, M Niu, Y Dhungana, A Kc, P Zhou, P Vogel, J Yu, SM Pruett-Mil, J Peng, H Chi
Nature, 2021-11-18;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Deleterious Role of Th9 Cells in Pulmonary Fibrosis
Authors: KM Deng, XS Yang, Q Luo, YX She, QY Yu, XX Tang
Cells, 2021-11-17;10(11):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons
Authors: Y Shi, S Li, H Zhang, J Zhu, T Che, B Yan, J Li, C Liu
Journal of Neuroinflammation, 2021-11-08;18(1):261.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tumor-Released Products Promote Bone Marrow-Derived Macrophage Survival and Proliferation
Authors: JM Motta, VM Rumjanek, A Mantovani, M Locati
Biomedicines, 2021-10-04;9(10):.
Species: Mouse
Sample Types: Whole Cells
Applications: Differentiation, Differentiation -
Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling
Authors: J Hu, C Wang, X Huang, S Yi, S Pan, Y Zhang, G Yuan, Q Cao, X Ye, H Li
Cell Reports, 2021-09-21;36(12):109726.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis
Authors: H Muto, T Ito, T Tanaka, S Yokoyama, K Yamamoto, N Imai, Y Ishizu, K Maeda, T Honda, T Ishikawa, A Kato, T Ohshiro, F Kano, A Yamamoto, K Sakai, H Hibi, M Ishigami, M Fujishiro
Scientific Reports, 2021-09-21;11(1):18778.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration
Authors: M Qadri, GD Jay, LX Zhang, TA Schmidt, J Totonchy, KA Elsaid
Arthritis Research & Therapy, 2021-09-14;23(1):241.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Elevated beta-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer's disease
Authors: L Dai, Q Wang, X Lv, F Gao, Z Chen, Y Shen
Brain, Behavior, and Immunity, 2021-09-06;98(0):337-348.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection
Authors: F Zhao, W Kim, H Gao, C Liu, Y Zhang, Y Chen, M Deng, Q Zhou, J Huang, Q Hu, SH Chen, S Nowsheen, JA Kloeber, B Qin, P Yin, X Tu, G Guo, S Qin, C Zhang, M Gao, K Luo, Y Liu, Z Lou, J Yuan
Nature Cell Biology, 2021-08-05;23(8):894-904.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells
Authors: NR Nabar, CN Heijjer, CS Shi, IY Hwang, S Ganesan, MCI Karlsson, JH Kehrl
Autophagy, 2021-07-27;0(0):19-Jan.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hemin-primed dendritic cells suppress allergic airway inflammation through releasing extracellular vesicles
Authors: Y Wu, Q Yu, M Zhang, Y Zhou, X Su, M Wu, J Lv, Z Xia
Journal of leukocyte biology, 2021-07-23;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs
Authors: A Ortega-Mol, C Lebrero-Fe, A Sanz, N Deleyto-Se, AB Plata-Góme, C Menéndez, O Graña-Cast, E Caleiras, A Efeyan
Cell Reports, 2021-07-13;36(2):109372.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pneumococcal Extracellular Vesicles Modulate Host Immunity
Authors: SS Yerneni, S Werner, JH Azambuja, N Ludwig, R Eutsey, SD Aggarwal, PC Lucas, N Bailey, TL Whiteside, PG Campbell, NL Hiller
MBio, 2021-07-13;0(0):e0165721.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication
Authors: D Wang, J Ma, MV Botuyan, G Cui, Y Yan, D Ding, Y Zhou, EW Krueger, J Pei, X Wu, L Wang, H Pei, MA McNiven, D Ye, G Mer, H Huang
Science Advances, 2021-06-18;7(25):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity
Authors: J Zhou, X Zhang, J Hu, R Qu, Z Yu, H Xu, H Chen, L Yan, C Ding, Q Zou, Y Ye, Z Wang, RA Flavell, HB Li
Science Advances, 2021-06-16;7(25):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis
Authors: M Kurosaka, Y Ogura, S Sato, K Kohda, T Funabashi
Skeletal Muscle, 2021-05-29;11(1):14.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-&kappaB pathway
Authors: Y Lu, L Liu, J Pan, B Luo, H Zeng, Y Shao, H Zhang, H Guan, D Guo, C Zeng, R Zhang, X Bai, H Zhang, D Cai
Cell Death & Disease, 2021-05-25;12(6):533.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Docosahexaenoic acid ameliorates autoimmune inflammation by activating GPR120 signaling pathway in dendritic cells
Authors: C Feng, L Li, Q Li, K Switzer, M Liu, S Han, B Zheng
International immunopharmacology, 2021-04-28;97(0):107698.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Light-induced dynamic RGD pattern for sequential modulation of macrophage phenotypes
Authors: Y Luo, X Zheng, P Yuan, X Ye, L Ma
Bioactive materials, 2021-04-21;6(11):4065-4072.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice
Authors: D Wan, S Ai, H Ouyang, L Cheng
Experimental & Molecular Medicine, 2021-04-15;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Immune modulation mediated by extracellular vesicles of intestinal organoids is disrupted by opioids
Authors: Y Zhang, Y Yan, J Meng, M Girotra, S Ramakrishn, S Roy
Mucosal Immunology, 2021-04-14;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity
Authors: Y Wang, M Song, M Liu, G Zhang, X Zhang, MO Li, X Ma, JJ Zhang, XY Huang
Cell Reports, 2021-04-06;35(1):108948.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation
Authors: TJ Kopper, B Zhang, WM Bailey, KE Bethel, JC Gensel
Scientific Reports, 2021-03-18;11(1):6341.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases
Authors: A Sripada, K Sirohi, L Michalec, L Guo, JT McKay, S Yadav, M Verma, J Good, D Rollins, MM Gorska, R Alam
PloS Biology, 2021-03-08;19(3):e3001063.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Airway-Associated Macrophages in Homeostasis and Repair
Authors: AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock
Cell Reports, 2020-12-29;33(13):108553.
Species: Transgenic Mouse
Sample Types: Spheroid
Applications: Bioassay -
The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses
Authors: L Kealy, A Di Pietro, L Hailes, S Scheer, L Dalit, JR Groom, C Zaph, KL Good-Jacob
Cell Reports, 2020-12-15;33(11):108504.
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation
Authors: RK Arya, R Goswami, SO Rahaman
The Journal of Biological Chemistry, 2020-12-04;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
The frequency of follicular T helper cells differs in acute and chronic neuroinflammation
Authors: A Baniahmad, K Birkner, J Görg, J Loos, F Zipp, B Wasser, S Bittner
Sci Rep, 2020-11-24;10(1):20485.
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway
Authors: R Yang, G Wang, L Li, H He, M Zheng, L Lu, S Wu
J Transl Med, 2020-11-23;18(1):444.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Na�ve CD4 T Lymphocytes
Authors: SH Shin, HY Kim, HS Yoon, WJ Park, DR Adams, NJ Pyne, S Pyne, JW Park
Int J Mol Sci, 2020-11-08;21(21):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease
Authors: DM de Graaf, RJA Maas, SP Smeekens, E Eisenmesse, JS Redzic, MM Helsen, NE Powers, S Li, V Kalabokis, MS Gresnigt, LAB Joosten, CA Dinarello, FL van de Vee
Cytokine, 2020-10-28;137(0):155334.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Harnessing hyaluronic acid-based nanoparticles for combination therapy: A novel approach for suppressing systemic inflammation and to promote antitumor macrophage polarization
Authors: VK Rangasami, S Samanta, VS Parihar, K Asawa, K Zhu, OP Varghese, Y Teramura, B Nilsson, J Hilborn, RA Harris, OP Oommen
Carbohydrate polymers, 2020-10-27;254(0):117291.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its anti-inflammatory properties
Authors: CY Han, I Kang, M Omer, S Wang, T Wietecha, TN Wight, A Chait
JCI Insight, 2020-09-24;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining
Authors: P Francica, M Mutlu, VA Blomen, C Oliveira, Z Nowicka, A Trenner, NM Gerhards, P Bouwman, E Stickel, ML Hekkelman, L Lingg, I Klebic, M van de Ven, R de Korte-G, D Howald, J Jonkers, AA Sartori, W Fendler, JR Chapman, T Brummelkam, S Rottenberg
Cell Rep, 2020-08-25;32(8):108068.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity
Authors: J Tur, S Pereira-Lo, T Vico, EA Marín, JP Muñoz, M Hernández-, PJ Cardona, A Zorzano, J Lloberas, A Celada
Cell Rep, 2020-08-25;32(8):108079.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lipid mediators and biomarkers associated with type 1 diabetes development
Authors: AJ Nelson, DJ Stephenson, RN Bone, CL Cardona, MA Park, YG Tusing, X Lei, G Kokotos, CL Graves, CE Mathews, J Kramer, MJ Hessner, CE Chalfant, S Ramanadham
JCI Insight, 2020-08-20;5(16):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation
Authors: MA Maqbool, L Pioger, AZ El Aabidin, N Karasu, AM Molitor, LTM Dao, G Charbonnie, F van Laethe, R Fenouil, F Koch, G Lacaud, I Gut, M Gut, S Amigorena, O Joffre, T Sexton, S Spicuglia, JC Andrau
Cell Rep, 2020-08-18;32(7):108048.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay, Cell Culture -
Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition
Authors: JM Inclan-Ric, JJ Ponessa, N Valero-Pac, CM Hernandez, CB Sy, AD Lemenze, AM Beaulieu, MC Siracusa
Nat. Immunol., 2020-08-17;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sclerostin expression in trabecular bone is downregulated by osteoclasts
Authors: M Koide, T Yamashita, K Murakami, S Uehara, K Nakamura, M Nakamura, M Matsushita, T Ara, H Yasuda, JM Penninger, N Takahashi, N Udagawa, Y Kobayashi
Sci Rep, 2020-08-13;10(1):13751.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay, Cell Culture -
TGF-beta2 interfering oligonucleotides used as adjuvants for microbial vaccines
Authors: L Tu, X Sun, L Yang, T Zhang, X Zhang, X Li, B Dong, Y Liu, M Yang, L Wang, Y Yu
J. Leukoc. Biol., 2020-08-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression
Authors: JPM Luiz, JE Toller-Kaw, PR Viacava, DC Nascimento, PT Pereira, AL Saraiva, DS Prado, M LeBert, E Giurisato, C Tournier, TM Cunha, FQ Cunha, V Quesniaux, B Ryffel, JC Alves-Filh
J. Leukoc. Biol., 2020-08-03;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Immunoglobulin Class Switch Recombination is initiated by rare cytosine deamination events at switch regions
Authors: A Kim, L Han, K Yu
Mol. Cell. Biol., 2020-07-29;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial &gamma&delta T cell compartments
Authors: A Jandke, D Melandri, L Monin, DS Ushakov, AG Laing, P Vantourout, P East, T Nitta, T Narita, H Takayanagi, R Feederle, A Hayday
Nat Commun, 2020-07-28;11(1):3769.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Classically activated mouse macrophages produce methylglyoxal that induces a TLR4- and RAGE-independent proinflammatory response
Authors: D Prantner, S Nallar, K Richard, D Spiegel, KD Collins, SN Vogel
J. Leukoc. Biol., 2020-07-17;0(0):.
Species: Mouse
Sample Types: Primary Cells
Applications: Cell Culture -
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Authors: B Mahata, J Pramanik, L van der We, K Polanski, G Kar, A Riedel, X Chen, NA Fonseca, K Kundu, LS Campos, E Ryder, G Duddy, I Walczak, K Okkenhaug, DJ Adams, JD Shields, SA Teichmann
Nat Commun, 2020-07-17;11(1):3588.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Isoliquiritigenin ameliorates caerulein-induced chronic pancreatitis by inhibiting the activation of PSCs and pancreatic infiltration of macrophages
Authors: LJ Wang, L He, L Hao, HL Guo, XP Zeng, YW Bi, GT Lu, ZS Li, LH Hu
J. Cell. Mol. Med., 2020-07-17;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity
Authors: CY Han, I Kang, IA Harten, JA Gebe, CK Chan, M Omer, KM Alonge, LJ den Hartig, D Gomes Kjer, L Goodspeed, S Subramania, S Wang, F Kim, DE Birk, TN Wight, A Chait
Cell Rep, 2020-06-30;31(13):107818.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
Authors: J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham
Cell Rep, 2020-06-30;31(13):107820.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
An Erg-driven transcriptional program controls B cell lymphopoiesis
Authors: AP Ng, HD Coughlan, S Hediyeh-Za, K Behrens, TM Johanson, MSY Low, CC Bell, O Gilan, YC Chan, AJ Kueh, T Boudier, R Feltham, A Gabrielyan, L DiRago, CD Hyland, H Ierino, S Mifsud, E Viney, T Willson, MA Dawson, RS Allan, MJ Herold, K Rogers, DM Tarlinton, GK Smyth, MJ Davis, SL Nutt, WS Alexander
Nat Commun, 2020-06-15;11(1):3013.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Adjuvant activity of Mycobacteria-derived mycolic acids
Authors: M Kubota, E Iizasa, Y Chuuma, H Kiyohara, H Hara, H Yoshida
Heliyon, 2020-05-27;6(5):e04064.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation
Authors: IS Kang, JS Jang, C Kim
Sci Rep, 2020-04-27;10(1):7024.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice
Authors: W Lei, R Duan, J Li, X Liu, A Huston, BF Boyce, Z Yao
Sci Rep, 2020-04-24;10(1):7004.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Macrophage M2 polarization induced by exosomes from adipose-derived stem cells contributes to the exosomal proangiogenic effect on mouse ischemic hindlimb
Authors: D Zhu, TK Johnson, Y Wang, M Thomas, K Huynh, Q Yang, VC Bond, YE Chen, D Liu
Stem Cell Res Ther, 2020-04-22;11(1):162.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response
Authors: H Gan, T Shen, DP Chupp, JR Taylor, HN Sanchez, X Li, Z Xu, H Zan, P Casali
Sci Adv, 2020-04-01;6(14):eaay2793.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
CXCL14 Overexpression Attenuates Sepsis-Associated Acute Kidney Injury by Inhibiting Proinflammatory Cytokine Production
Authors: J Lv, ZL Wu, Z Gan, P Gui, SL Yao
Mediators Inflamm., 2020-03-31;2020(0):2431705.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Radiation-induced small extracellular vesicles as "carriages" promote tumor antigen release and trigger antitumor immunity
Authors: W Lin, Y Xu, X Chen, J Liu, Y Weng, Q Zhuang, F Lin, Z Huang, S Wu, J Ding, L Chen, X Qiu, L Zhang, J Wu, D Lin, S Qiu
Theranostics, 2020-03-26;10(11):4871-4884.
Species: Mouse
Sample Types: bone marrow cells
Applications: Cell Culture -
Effects of senataxin and RNA exosome on B-cell chromosomal integrity
Authors: D Kazadi, J Lim, G Rothschild, V Grinstein, B Laffleur, O Becherel, MJ Lavin, U Basu
Heliyon, 2020-03-12;6(3):e03442.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Serine/threonine phosphatase PP2A is essential for optimal B cell function
Authors: E Meidan, H Li, W Pan, M Kono, S Yu, VC Kyttaris, C Ioannidis, N Rodriguez, JC Crispin, SA Apostolidi, P Lee, J Manis, A Sharabi, MG Tsokos, GC Tsokos
JCI Insight, 2020-03-12;5(5):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis
Authors: Y Zhao, J Wang, Z Min, L Peng, S Qi, W Lin
Mediators Inflamm., 2020-03-10;2020(0):6947482.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
mRNA Vaccines Encoding the HA Protein of Influenza A H1N1 Virus Delivered by Cationic Lipid Nanoparticles Induce Protective Immune Responses in Mice
Authors: X Zhuang, Y Qi, M Wang, N Yu, F Nan, H Zhang, M Tian, C Li, H Lu, N Jin
Vaccines (Basel), 2020-03-10;8(1):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Myo1e modulates the recruitment of activated B cells to inguinal lymph nodes
Authors: DA Girón-Pére, E Vadillo, M Schnoor, L Santos-Arg
J. Cell. Sci., 2020-03-02;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
HDAC8 inhibitor attenuates airway responses to antigen stimulus through synchronously suppressing galectin-3 expression and reducing macrophage-2 polarization
Authors: ML Li, XM Su, Y Ren, X Zhao, LF Kong, J Kang
Respir. Res., 2020-02-28;21(1):62.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Anticancer Activity of Liquid Treated with Microwave Plasma-Generated Gas through Macrophage Activation
Authors: CB Lee, IH Seo, MW Chae, JW Park, EH Choi, HS Uhm, KY Baik
Oxid Med Cell Longev, 2020-01-31;2020(0):2946820.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
High activation of STAT5A drives peripheral T-cell lymphoma and leukemia
Authors: B Maurer, H Nivarthi, B Wingelhofe, HTT Pham, M Schlederer, T Suske, R Grausenbur, AI Schiefer, M Prchal-Mur, D Chen, S Winkler, O Merkel, C Kornauth, M Hofbauer, B Hochgatter, G Hoermann, A Hoelbl-Kov, J Prochazkov, C Lobello, AA Cumaraswam, J Latzka, M Kitzwögere, A Chott, A Janikova, Š Pospíšilov, JI Loizou, S Kubicek, P Valent, T Kolbe, F Grebien, L Kenner, PT Gunning, R Kralovics, M Herling, M Müller, T Rülicke, V Sexl, R Moriggl
Haematologica, 2020-01-31;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
Authors: FC Simões, TJ Cahill, A Kenyon, D Gavriouchk, JM Vieira, X Sun, D Pezzolla, C Ravaud, E Masmanian, M Weinberger, S Mayes, ME Lemieux, DN Barnette, M Gunadasa-R, RM Williams, DR Greaves, LA Trinh, SE Fraser, SL Dallas, RP Choudhury, T Sauka-Spen, PR Riley
Nat Commun, 2020-01-30;11(1):600.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Environmental arginine controls multinuclear giant cell metabolism and formation
Authors: JS Brunner, L Vulliard, M Hofmann, M Kieler, A Lercher, A Vogel, M Russier, JB Brüggenthi, M Kerndl, V Saferding, B Niederreit, A Junza, A Frauenstei, C Scholtysek, Y Mikami, K Klavins, G Krönke, A Bergthaler, JJ O'Shea, T Weichhart, F Meissner, JS Smolen, P Cheng, O Yanes, J Menche, PJ Murray, O Sharif, S Blüml, G Schabbauer
Nat Commun, 2020-01-22;11(1):431.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-kappaB Activation for Antibody Class-Switching
Authors: H Yan, M Fernandez, J Wang, S Wu, R Wang, Z Lou, JB Moroney, CE Rivera, JR Taylor, H Gan, H Zan, D Kolvaskyy, D Liu, P Casali, Z Xu
J. Immunol., 2020-01-13;204(5):1146-1157.
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation
Authors: RK Arya, R Goswami, SO Rahaman
The Journal of Biological Chemistry, 2020-01-01;296(0):100129.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Modulation of the humoral immune response by constitutively active STAT6 expression in murine B cells
Authors: P Haase, L Mokada-Gop, D Radtke, D Voehringer
Eur. J. Immunol., 2019-12-15;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Stimulation -
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
Authors: E Khattar, KZY Maung, CL Chew, A Ghosh, MMH Mok, P Lee, J Zhang, WHJ Chor, G Cildir, CQ Wang, NK Mohd-Ismai, DWL Chin, SC Lee, H Yang, YJ Shin, DH Nam, L Chen, AP Kumar, LW Deng, M Ikawa, J Gunaratne, M Osato, V Tergaonkar
Nat Commun, 2019-12-13;10(1):5349.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
LncRNA PTPRE-AS1 modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE
Authors: X Han, S Huang, P Xue, J Fu, L Liu, C Zhang, L Yang, L Xia, L Sun, SK Huang, Y Zhou
Sci Adv, 2019-12-11;5(12):eaax9230.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Impact of aging on transition of acute kidney injury to chronic kidney disease
Authors: MG Kim, J Yang, YS Ko, HY Lee, SW Oh, WY Cho, SK Jo
Sci Rep, 2019-12-05;9(1):18445.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CD226 deficiency on regulatory T cells aggravates renal fibrosis via up-regulation of Th2 cytokines through miR-340
Authors: Y Mu, J Zhang, Y Liu, J Ma, D Jiang, X Zhang, X Yi, K Cheng, S Shen, Y Yang, R Zhuang, Y Zhang
J. Leukoc. Biol., 2019-12-04;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction
Authors: S McLaughlin, B McNeill, J Podrebarac, K Hosoyama, V Sedlakova, G Cron, D Smyth, R Seymour, K Goel, W Liang, KJ Rayner, M Ruel, EJ Suuronen, EI Alarcon
Nat Commun, 2019-10-25;10(1):4866.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing
Authors: S Mahmoudi, E Mancini, L Xu, A Moore, F Jahanbani, K Hebestreit, R Srinivasan, X Li, K Devarajan, L Prélot, CE Ang, Y Shibuya, BA Benayoun, ALS Chang, M Wernig, J Wysocka, MT Longaker, MP Snyder, A Brunet
Nature, 2019-10-23;574(7779):553-558.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice
Authors: GR Martin, CM Blomquist, KL Henare, FR Jirik
Sci Rep, 2019-10-03;9(1):14281.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity
Authors: LP Garo, AK Ajay, M Fujiwara, V Beynon, C Kuhn, G Gabriely, S Sadhukan, R Raheja, S Rubino, HL Weiner, G Murugaiyan
Cell Rep, 2019-09-24;28(13):3353-3366.e5.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Cathepsin L secretion by host and neoplastic cells potentiates invasion
Authors: SS Dykes, HO Fasanya, DW Siemann
Oncotarget, 2019-09-17;10(53):5560-5568.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer
Authors: A El-Kenawi, C Gatenbee, M Robertson-, R Bravo, J Dhillon, Y Balaguruna, A Berglund, N Visvakarma, A Ibrahim-Ha, J Choi, K Luddy, R Gatenby, S Pilon-Thom, A Anderson, B Ruffell, R Gillies
Br. J. Cancer, 2019-08-16;121(7):556-566.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cells and M2 macrophage play an important role in suppression of Th2-mediated inflammation by adipose stem cells-derived extracellular vesicles
Authors: KS Cho, SA Kang, SD Kim, SJ Mun, HS Yu, HJ Roh
Stem Cell Res, 2019-07-12;39(0):101500.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein
Authors: PAM Cavalcante, N Alenina, A Budu, LC Freitas-Li, T Alves-Silv, JSH Agudelo, F Qadri, NOS Camara, M Bader, RC Araújo
Mediators Inflamm., 2019-07-10;2019(0):9086758.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Anti-cervical carcinoma effect of Portulaca oleracea L. polysaccharides by oral administration on intestinal dendritic cells
Authors: R Zhao, X Shao, G Jia, Y Huang, Z Liu, B Song, J Hou
BMC Complement Altern Med, 2019-07-05;19(1):161.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation
Authors: JQ Yang, KW Kalim, Y Li, Y Zheng, F Guo
J. Leukoc. Biol., 2019-07-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism
Authors: J Liu, L Zhu, J Wang, L Qiu, Y Chen, RE Davis, G Cheng
PLoS Pathog., 2019-06-04;15(6):e1007817.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Ampk regulates IgD expression but not energy stress with B cell activation
Authors: LR Waters, FM Ahsan, J Ten Hoeve, JS Hong, DNH Kim, A Minasyan, D Braas, TG Graeber, TA Zangle, MA Teitell
Sci Rep, 2019-06-03;9(1):8176.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation
Authors: M Bolger-Mun, K Choi, JM Scurll, L Abraham, RS Chappell, D Sheen, M Dang-Lawso, X Wu, JJ Priatel, D Coombs, JA Hammer, MR Gold
Elife, 2019-06-03;8(0):.
Species: Complex Species Category
Sample Types: Whole Cells
Applications: Bioassay -
Transcriptomics Analysis Reveals New Insights into the Roles of Notch1 Signaling on Macrophage Polarization
Authors: CP Hans, N Sharma, S Sen, S Zeng, R Dev, Y Jiang, A Mahajan, T Joshi
Sci Rep, 2019-05-29;9(1):7999.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CD45Rb-low effector T cells require IL-4 to induce IL-10 in FoxP3 Tregs and to protect mice from inflammation
Authors: MB Jones, CA Alvarez, JL Johnson, JY Zhou, N Morris, BA Cobb
PLoS ONE, 2019-05-23;14(5):e0216893.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Notch ligand DNER regulates macrophage IFN? release in chronic obstructive pulmonary disease
Authors: C Ballester-, TM Conlon, Z Ertüz, FR Greiffo, M Irmler, SE Verleden, J Beckers, IE Fernandez, O Eickelberg, AÖ Yildirim
EBioMedicine, 2019-05-04;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Distinct Requirements of CHD4 during B Cell Development and Antibody Response
Authors: WF Yen, R Sharma, M Cols, CM Lau, A Chaudhry, P Chowdhury, WT Yewdell, B Vaidyanath, A Sun, M Coffre, JN Pucella, CC Chen, M Jasin, JC Sun, AY Rudensky, SB Koralov, J Chaudhuri
Cell Rep, 2019-04-30;27(5):1472-1486.e5.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cutting Edge: ATM Influences Germinal Center Integrity
Authors: L Nicolas, M Cols, R Smolkin, KC Fernandez, WT Yewdell, WF Yen, S Zha, BQ Vuong, J Chaudhuri
J. Immunol., 2019-04-26;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Effects of Immunosuppressive Factors on Primary Dendritic Cells from C57BL/6 and CBA Mice
Authors: VV Kurilin, JN Khantakova, VP Tereschenk, JA Lopatnikov, IA Obleukhova, SV Sennikov
J Immunol Res, 2019-04-18;2019(0):7029726.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis
Authors: YB Kim, YH Ahn, JH Jung, YJ Lee, JH Lee, JL Kang
Cell. Mol. Immunol., 2019-03-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis
Authors: P Handa, S Thomas, V Morgan-Ste, BD Maliken, E Gochanour, S Boukhar, MM Yeh, KV Kowdley
J. Leukoc. Biol., 2019-03-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe
Authors: PM Ryan, EH Stolte, LEE London, JM Wells, SL Long, SA Joyce, CGM Gahan, GF Fitzgerald, RP Ross, NM Caplice, C Stanton
BMC Microbiol., 2019-02-08;19(1):33.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
Authors: K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota
Nat Commun, 2019-02-01;10(1):549.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses
Authors: JN Pucella, M Cols, WF Yen, S Xu, J Chaudhuri
J. Immunol., 2019-01-25;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Vitamin D improves sunburns by increasing autophagy in M2 macrophages
Authors: LM Das, AM Binko, ZP Traylor, H Peng, KQ Lu
Autophagy, 2019-01-24;0(0):1-14.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1
Authors: K Paduch, A Debus, B Rai, U Schleicher, C Bogdan
J. Immunol., 2019-01-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
-
Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1
Authors: AJ Freemerman, L Zhao, AK Pingili, B Teng, AJ Cozzo, AM Fuller, AR Johnson, JJ Milner, MF Lim, JA Galanko, MA Beck, JE Bear, JD Rotty, L Bezavada, HS Smallwood, MA Puchowicz, J Liu, JW Locasale, DP Lee, BJ Bennett, ED Abel, JC Rathmell, L Makowski
J. Immunol., 2019-01-18;0(0):.
Species: Mouse
Sample Types: Whole Cells
-
Group 2 innate lymphoid cells (ILC2) are regulated by stem cell factor during chronic asthmatic disease
Authors: W Fonseca, AJ Rasky, C Ptaschinsk, SH Morris, SKK Best, M Phillips, CA Malinczak, NW Lukacs
Mucosal Immunol, 2019-01-07;12(2):445-456.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Trabectedin Reduces Skeletal Prostate Cancer Tumor Size in Association with Effects on M2 Macrophages and Efferocytosis
Authors: JD Jones, BP Sinder, D Paige, FN Soki, AJ Koh, S Thiele, Y Shiozawa, LC Hofbauer, S Daignault, H Roca, LK McCauley
Neoplasia, 2018-12-31;21(2):172-184.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
REV-ERB? Regulates TH17 Cell Development and Autoimmunity
Authors: M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt
Cell Rep, 2018-12-26;25(13):3733-3749.e8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
Authors: D Menolfi, W Jiang, BJ Lee, T Moiseeva, Z Shao, V Estes, MG Frattini, CJ Bakkenist, S Zha
Nat Commun, 2018-12-17;9(1):5351.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide
Authors: R Sugamata, A Donko, Y Murakami, HE Boudreau, CF Qi, J Kwon, TL Leto
J. Immunol., 2018-12-17;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming
Authors: L Simula, I Pacella, A Colamatteo, C Procaccini, V Cancila, M Bordi, C Tregnago, M Corrado, M Pigazzi, V Barnaba, C Tripodo, G Matarese, S Piconese, S Campello
Cell Rep, 2018-12-11;25(11):3059-3073.e10.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes
Authors: H Chiu, LV Jackson, KI Oh, A Mai, ZA Ronai, D Ruggero, DA Fruman
J. Immunol., 2018-12-10;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling
Authors: X Liu, P Zhang, Y Zhang, Z Wang, S Xu, Y Li, W Huai, Q Zhou, X Chen, X Chen, N Li, P Wang, Y Li, X Cao
Cell Res., 2018-12-04;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation
Authors: W Sun, N Meednu, A Rosenberg, J Rangel-Mor, V Wang, J Glanzman, T Owen, X Zhou, H Zhang, BF Boyce, JH Anolik, L Xing
Nat Commun, 2018-12-03;9(1):5127.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation
Authors: C Skon-Hegg, J Zhang, X Wu, M Sagolla, N Ota, A Wuster, J Tom, E Doran, N Ramamoorth, P Caplazi, J Monroe, WP Lee, TW Behrens
J. Immunol., 2018-12-03;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity
Authors: MT Rached, SJ Millership, SMA Pedroni, AI Choudhury, ASH Costa, DG Hardy, JA Glegola, EE Irvine, C Selman, MC Woodberry, VK Yadav, S Khadayate, A Vidal-Puig, S Virtue, C Frezza, DJ Withers
Mol Metab, 2018-11-28;20(0):38-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
AMPK Activation Regulates LTBP4-Dependent TGF-?1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy
Authors: G Juban, M Saclier, H Yacoub-You, A Kernou, L Arnold, C Boisson, S Ben Larbi, M Magnan, S Cuvellier, M Théret, BJ Petrof, I Desguerre, J Gondin, R Mounier, B Chazaud
Cell Rep, 2018-11-20;25(8):2163-2176.e6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Authors: AN Billin, SE Honeycutt, AV McDougal, JP Kerr, Z Chen, JM Freudenber, DK Rajpal, G Luo, HF Kramer, RS Geske, F Fang, B Yao, RV Clark, J Lepore, A Cobitz, R Miller, K Nosaka, AC Hinken, AJ Russell
Skelet Muscle, 2018-11-13;8(1):35.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Androgen and Androgen Receptor as Enhancers of M2 Macrophage Polarization in Allergic Lung Inflammation
Authors: M Becerra-Dí, AB Strickland, A Keselman, NM Heller
J. Immunol., 2018-10-10;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mechanisms underlying immune tolerance caused by recombinant Echinococcus granulosus antigens Eg mMDH and Eg10 in dendritic cells
Authors: Y Wang, S Lv, Q Wang, C Wang, M Zhu, Z Ma, W Zhao
PLoS ONE, 2018-09-27;13(9):e0204868.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Astaxanthin exerts anti-inflammatory and antioxidant effects in macrophages in NRF2-dependent and independent manners
Authors: C Farruggia, MB Kim, M Bae, Y Lee, TX Pham, Y Yang, MJ Han, YK Park, JY Lee
J. Nutr. Biochem., 2018-09-19;62(0):202-209.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins
Authors: S Trezise, A Karnowski, PL Fedele, S Mithraprab, Y Liao, K D'Costa, AJ Kueh, MP Hardy, CM Owczarek, MJ Herold, A Spencer, W Shi, SN Willis, SL Nutt, LM Corcoran
Int J Mol Sci, 2018-07-24;19(8):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection
Authors: HA Ting, D de Almeida, AJ Rasky, CA Malinczak, IP Maillard, MA Schaller, NW Lukacs
Mucosal Immunol, 2018-07-23;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The shieldin complex mediates 53BP1-dependent DNA repair
Authors: SM Noordermee, S Adam, D Setiaputra, M Barazas, SJ Pettitt, AK Ling, M Olivieri, A Álvarez-Qu, N Moatti, M Zimmermann, S Annunziato, DB Krastev, F Song, I Brandsma, J Frankum, R Brough, A Sherker, S Landry, RK Szilard, MM Munro, A McEwan, T Goullet de, ZY Lin, T Hart, J Moffat, AC Gingras, A Martin, H van Attiku, J Jonkers, CJ Lord, S Rottenberg, D Durocher
Nature, 2018-07-18;560(7716):117-121.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage
Authors: S Nowsheen, K Aziz, K Luo, M Deng, B Qin, J Yuan, KB Jeganathan, J Yu, H Zhang, W Ding, JM van Deurse, Z Lou
Nat Commun, 2018-07-16;9(1):2736.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Myeloid p38? signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis
Authors: C Youssif, M Cubillos-R, M Comalada, E Llonch, C Perna, N Djouder, AR Nebreda
EMBO Mol Med, 2018-07-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Endogenous protection from ischemic brain injury by preconditioned monocytes
Authors: L Garcia-Bon, D Brea, C Benakis, D Lane, M Murphy, J Moore, G Racchumi, X Jiang, C Iadecola, J Anrather
J. Neurosci., 2018-06-26;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
Authors: BG Barwick, CD Scharer, RJ Martinez, MJ Price, AN Wein, RR Haines, APR Bally, JE Kohlmeier, JM Boss
Nat Commun, 2018-05-15;9(1):1900.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Chronic Alterations in Systemic Immune Function After Traumatic Brain Injury
Authors: R Ritzel, S Doran, J Barrett, R Henry, E Ma, A Faden, DJ Loane
J. Neurotrauma, 2018-05-03;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs
Authors: CD Scharer, BG Barwick, M Guo, APR Bally, JM Boss
Nat Commun, 2018-04-27;9(1):1698.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A new RelB-dependent CD117+CD172a+murine dendritic cell subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo
Authors: N Andreas, M Riemann, CN Castro, M Groth, I Koliesnik, C Engelmann, T Sparwasser, T Kamradt, R Haenold, F Weih
Eur. J. Immunol., 2018-04-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Enhanced Pro-Inflammatory Response of Macrophages to Interleukin-33 in an Allergic Environment
Authors: N Chia, RK Kumar, PS Foster, C Herbert
Int. Arch. Allergy Immunol., 2018-04-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression
Authors: Y Han, Q Liu, J Hou, Y Gu, Y Zhang, Z Chen, J Fan, W Zhou, S Qiu, Y Zhang, T Dong, N Li, Z Jiang, H Zhu, Q Zhang, Y Ma, L Zhang, Q Wang, Y Yu, N Li, X Cao
Cell, 2018-03-29;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage
Authors: S Nowsheen, K Aziz, A Aziz, M Deng, B Qin, K Luo, KB Jeganathan, H Zhang, T Liu, J Yu, Y Deng, J Yuan, W Ding, JM van Deurse, Z Lou
Nat. Cell Biol., 2018-03-26;20(4):455-464.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
Authors: G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo
Immunity, 2018-03-20;48(3):556-569.e7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
Authors: C Li, T Irrazabal, CC So, M Berru, L Du, E Lam, AK Ling, JL Gommerman, Q Pan-Hammar, A Martin
Nat Commun, 2018-03-08;9(1):1006.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Characterization and allergic role of IL-33-induced neutrophil polarization
Authors: B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao
Cell. Mol. Immunol., 2018-03-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Differential Phagocytic Properties of CD45lowMicroglia and CD45highBrain Mononuclear Phagocytes-Activation and Age-Related Effects
Authors: S Rangaraju, SA Raza, NX Li, R Betarbet, EB Dammer, D Duong, JJ Lah, NT Seyfried, AI Levey
Front Immunol, 2018-03-02;9(0):405.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist
Authors: K Lee, N Park, H Jung, YA Rim, Y Nam, J Lee, SH Park, JH Ju
PLoS ONE, 2018-02-26;13(2):e0193086.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Utilization of host polyamines in alternatively activated macrophages promotes chronic infection by Brucella abortus
Authors: T Kerrinnes, MG Winter, BM Young, VE Diaz-Ochoa, SE Winter, RM Tsolis
Infect. Immun., 2018-02-20;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Activated leukocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy
Authors: YS Kim, MN Kim, KE Lee, JY Hong, MS Oh, SY Kim, KW Kim, MH Sohn
Clin. Exp. Immunol., 2018-02-20;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
?M?2Is Antiatherogenic in Female but Not Male Mice
Authors: D Szpak, L Izem, D Verbovetsk, DA Soloviev, VP Yakubenko, E Pluskota
J. Immunol., 2018-02-19;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution
Authors: MJ Tol, MJC van der Li, TL Gabriel, JJ Hagen, S Scheij, T Veenendaal, J Klumperman, WE Donker-Koo, AJ Verhoeven, H Overkleeft, JM Aerts, CA Argmann, M van Eijk
Autophagy, 2018-02-17;0(0):1-13.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84
Authors: L Gagnon, M Leduc, JF Thibodeau, MZ Zhang, B Grouix, F Sarra-Bour, W Gagnon, K Hince, M Tremblay, L Geerts, CRJ Kennedy, RL Hébert, A Gutsol, CE Holterman, E Kamto, L Gervais, J Ouboudinar, J Richard, A Felton, A Laverdure, JC Simard, S Létourneau, MP Cloutier, FA Leblond, SD Abbott, C Penney, JS Duceppe, B Zacharie, J Dupuis, A Calderone, QT Nguyen, RC Harris, P Laurin
Am. J. Pathol., 2018-02-16;0(0):.
Species: Mouse
Sample Types: Whole Cells
-
Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis
Authors: C Rossi, M Cusimano, M Zambito, A Finardi, A Capotondo, JM Garcia-Man, G Comi, R Furlan, G Martino, L Muzio
Cell Death Dis, 2018-02-14;9(2):250.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
SOCS3 deficiency in myeloid cells promotes retinal degeneration and angiogenesis through arginase-1 up-regulation in experimental autoimmune uveoretinitis
Authors: M Chen, J Zhao, IH Ali, S Marry, J Augustine, M Bhuckory, A Lynch, A Kissenpfen, H Xu
Am. J. Pathol., 2018-02-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Collagen-derived peptides modulate CD4T-cell differentiation and suppress allergic responses in mice
Authors: A Nishikimi, YI Koyama, S Ishihara, S Kobayashi, C Tometsuka, M Kusubata, K Kuwaba, O Hayashida, S Hattori, K Katagiri
Immun Inflamm Dis, 2018-02-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
High-Resolution Mapping and Dynamics of the Transcriptome, Transcription Factors, and Transcription Co-Factor Networks in Classically and Alternatively Activated Macrophages
Authors: A Das, CS Yang, S Arifuzzama, S Kim, SY Kim, KH Jung, YS Lee, YG Chai
Front Immunol, 2018-01-18;9(0):22.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Crucial role of OX40/OX40L signaling in a murine model of asthma
Authors: W Lei, D Zeng, G Liu, Y Zhu, J Wang, H Wu, J Jiang, J Huang
Mol Med Rep, 2018-01-18;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation
Authors: X Xiao, Y Fan, J Li, X Zhang, X Lou, Y Dou, X Shi, P Lan, Y Xiao, L Minze, XC Li
J. Exp. Med., 2018-01-16;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial�Changes
Authors: Y Kasagi, PM Chandramou, KA Whelan, K Tanaka, V Giroux, M Sharma, J Wang, AJ Benitez, M DeMarshall, JW Tobias, KE Hamilton, GW Falk, JM Spergel, AJ Klein-Szan, AK Rustgi, AB Muir, H Nakagawa
Cell Mol Gastroenterol Hepatol, 2018-01-03;5(3):333-352.
Species: Mouse
Sample Types: Organoids
Applications: Bioassay -
Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
Authors: SN Willis, J Tellier, Y Liao, S Trezise, A Light, K O'Donnell, LA Garrett-Si, W Shi, DM Tarlinton, SL Nutt
Nat Commun, 2017-11-10;8(1):1426.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis
Authors: R Bruen, S Curley, S Kajani, D Crean, ME O'Reilly, MB Lucitt, CG Godson, FC McGillicud, O Belton
Cardiovasc Diabetol, 2017-11-06;16(1):143.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection
Authors: RM Valanparam, M Tam, PP Gros, JP Auger, M Segura, P Gros, A Jardim, TG Geary, K Ozato, MM Stevenson
PLoS Pathog., 2017-10-02;13(10):e1006647.
Species: Mouse
Sample Types: Recombinant Protein
Applications: ELISA (Standard) -
The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
Authors: S Mroczek, J Chlebowska, TM Kuli?ski, O Gewartowsk, J Gruchota, D Cysewski, V Liudkovska, E Borsuk, D Nowis, A Dziembowsk
Nat Commun, 2017-09-20;8(1):619.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
Authors: T Rivera Var, Z Cai, Y Shen, M Dosset, I Benoit-Liz, T Martin, A Roussey, RA Flavell, F Ghiringhel, L Apetoh
Nat Commun, 2017-09-15;8(1):559.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
Authors: DK Chiu, AP Tse, IM Xu, J Di Cui, RK Lai, LL Li, HY Koh, FH Tsang, LL Wei, CM Wong, IO Ng, CC Wong
Nat Commun, 2017-09-11;8(1):517.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction
Authors: N Akbar, JE Digby, TJ Cahill, AN Tavare, AL Corbin, S Saluja, S Dawkins, L Edgar, N Rawlings, K Ziberna, E McNeill, E Johnson, AA Aljabali, RA Dragovic, M Rohling, TG Belgard, IA Udalova, DR Greaves, KM Channon, PR Riley, DC Anthony, RP Choudhury
JCI Insight, 2017-09-07;2(17):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin 4 receptor-targeted pro-apoptotic peptide blocks tumor growth and metastasis by enhancing anti-tumor immunity
Authors: SMP Vadevoo, JE Kim, GR Gunassekar, HK Jung, L Chi, DE Kim, SH Lee, SH Im, B Lee
Mol. Cancer Ther., 2017-09-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Detection of immune responses after immunotherapy in glioblastoma using PET and MRI
Authors: JP Antonios, H Soto, RG Everson, DL Moughon, AC Wang, J Orpilla, C Radu, BM Ellingson, JT Lee, T Cloughesy, ME Phelps, J Czernin, LM Liau, RM Prins
Proc. Natl. Acad. Sci. U.S.A., 2017-09-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bone-induced expression of integrin ?3 enables targeted nanotherapy of breast cancer metastases
Authors: MH Ross, AK Esser, GC Fox, AH Schmieder, X Yang, G Hu, D Pan, X Su, Y Xu, DV Novack, T Walsh, GA Colditz, GH Lukaszewic, E Cordell, JS Novack, JAJ Fitzpatric, DL Waning, KS Mohammad, TA Guise, GM Lanza, KN Weilbaeche
Cancer Res., 2017-08-30;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4(+) Th Cells
Authors: KA Read, MD Powell, CE Baker, BK Sreekumar, VM Ringel-Sca, H Bachus, RE Martin, ID Cooley, IC Allen, A Ballestero, KJ Oestreich
J. Immunol., 2017-08-28;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function
Authors: T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh
J. Immunol., 2017-08-02;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-4-secreting eosinophils promote endometrial stromal cell proliferation and prevent Chlamydia-induced upper genital tract damage
Authors: RD Vicetti Mi, NE Quispe Cal, D Dixon, RA Foster, A Gambotto, SD Pavelko, L Hall-Stood, TL Cherpes
Proc. Natl. Acad. Sci. U.S.A., 2017-08-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Small Rho GTPase TC10 Modulates B Cell Immune Responses
Authors: M Burbage, SJ Keppler, B Montaner, PK Mattila, FD Batista
J. Immunol., 2017-07-26;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent colitis
Authors: X Pei, D Zheng, S She, J Ma, C Guo, X Mo, Y Zhang, Q Song, Y Zhang, D Ma, Y Wang
Sci Rep, 2017-07-11;7(1):5107.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-4 upregulates cyclooxygenase-1 expression in macrophages
Authors: AE Shay, BT Diwakar, BJ Guan, V Narayan, JF Urban, KS Prabhu
J. Biol. Chem., 2017-07-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells
Authors: IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman
Eur. J. Immunol., 2017-06-29;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
Authors: J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng
J. Immunol., 2017-06-26;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Preferred M2 Polarization by ASC-Based Hydrogel Accelerated Angiogenesis and Myogenesis in Volumetric Muscle Loss Rats
Authors: H Huang, J Liu, H Hao, D Chen, L Zhizhong, M Li, H Song, R Xiang, C Jiang, X Fu, W Han
Stem Cells Int, 2017-06-14;2017(0):2896874.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
miR-181a and miR-150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1-STAT1/c-Fos pathway
Authors: J Zhu, K Yao, J Guo, H Shi, L Ma, Q Wang, H Liu, W Gao, A Sun, Y Zou, J Ge
J. Cell. Mol. Med., 2017-06-09;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency
Authors: YY Sin, PR Price, LL Ballantyne, CD Funk
Sci Rep, 2017-05-31;7(1):2585.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
Authors: J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen
Nat. Immunol., 2017-05-15;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity
Authors: A Rialdi, J Hultquist, D Jimenez-Mo, Z Peralta, L Campisi, R Fenouil, N Moshkina, ZZ Wang, B Laffleur, RM Kaake, MJ McGregor, K Haas, E Pefanis, RA Albrecht, L Pache, S Chanda, J Jen, J Ochando, M Byun, U Basu, A García-Sas, N Krogan, H van Bakel, I Marazzi
Cell, 2017-05-04;169(4):679-692.e14.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry
Authors: J Lim, PK Giri, D Kazadi, B Laffleur, W Zhang, V Grinstein, E Pefanis, LM Brown, E Ladewig, O Martin, Y Chen, R Rabadan, F Boyer, G Rothschild, M Cogné, E Pinaud, H Deng, U Basu
Cell, 2017-04-20;169(3):523-537.e15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1
Authors: G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu
J. Exp. Med., 2017-04-11;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CD11b regulates antibody class switching via induction of AID
Authors: S Park, H Sim, HI Kim, D Jeong, G Wu, SY Cho, YS Lee, HJ Kwon, K Lee
Mol. Immunol., 2017-04-11;87(0):47-59.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population
Authors: DC Nascimento, PH Melo, AR Piñeros, RG Ferreira, DF Colón, PB Donate, FV Castanheir, A Gozzi, PG Czaikoski, W Niedbala, MC Borges, DS Zamboni, FY Liew, FQ Cunha, JC Alves-Filh
Nat Commun, 2017-04-04;8(0):14919.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
VISTA deficiency accelerates the development of fatal murine lupus nephritis
Authors: Sabrina Ceeraz
Arthritis & rheumatology (Hoboken, N.J.), 2017-04-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
mTORC2 controls Th9 polarization and allergic airway inflammation
Authors: H Chen, L Zhang, P Wang, H Su, W Wang, Z Chu, L Zhang, X Zhang, Y Zhao
Allergy, 2017-03-29;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mouse model of Epstein-Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative disease
Authors: T Minamitani, Y Ma, H Zhou, H Kida, CY Tsai, M Obana, D Okuzaki, Y Fujio, A Kumanogoh, B Zhao, H Kikutani, E Kieff, BE Gewurz, T Yasui
Proc. Natl. Acad. Sci. U.S.A, 2017-03-28;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Enhancement of antitumor immunity by combination of anti-CTLA-4 antibody and radioimmunotherapy through the suppression of Tregs
Authors: CH Son, J Bae, HR Lee, K Yang, YS Park
Oncol Lett, 2017-03-28;13(5):3781-3786.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Identification of Novel STAT6-Regulated Proteins in Mouse B Cells by Comparative Transcriptome and Proteome Analysis
Authors: L Mokada-Gop, A Boeser, CH Lehmann, F Drepper, D Dudziak, B Warscheid, D Voehringer
J. Immunol, 2017-03-27;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs
Authors: J Wang, H Ye, D Zhang, K Cheng, Y Hu, X Yu, L Lu, J Hu, C Zuo, B Qian, Y Yu, S Liu, G Liu, C Mao, S Liu
Theranostics, 2017-03-24;7(6):1407-1421.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pro-inflammatory M1 macrophages promote osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway
Authors: LY Lu, F Loi, K Nathan, TH Lin, J Pajarinen, E Gibon, A Nabeshima, L Cordova, E Jämsen, Z Yao, SB Goodman
J. Orthop. Res, 2017-03-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk
Authors: V Piccolo, A Curina, M Genua, S Ghisletti, M Simonatto, A Sabò, B Amati, R Ostuni, G Natoli
Nat. Immunol, 2017-03-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Robust growth of avirulent phase II Coxiella burnetii in bone marrow-derived murine macrophages
Authors: DC Cockrell, CM Long, SJ Robertson, JG Shannon, HE Miller, L Myers, CL Larson, T Starr, PA Beare, RA Heinzen
PLoS ONE, 2017-03-09;12(3):e0173528.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function
Authors: P Drané, ME Brault, G Cui, K Meghani, S Chaubey, A Detappe, N Parnandi, Y He, XF Zheng, MV Botuyan, A Kalousi, WT Yewdell, C Münch, JW Harper, J Chaudhuri, E Soutoglou, G Mer, D Chowdhury
Nature, 2017-02-27;543(7644):211-216.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy
Authors: S Gao, C Li, Y Zhu, Y Wang, A Sui, Y Zhong, B Xie, X Shen
Sci Rep, 2017-02-17;7(0):42846.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Crosstalk between glucocorticoids and IL-4 modulates Ym1 expression in alternatively activated myeloid cells
Authors: N Ng Kuet Le, F Brombacher, AH Dalpke, M Weitnauer
Immunobiology, 2017-02-09;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
Authors: H Zan, C Tat, Z Qiu, JR Taylor, JA Guerrero, T Shen, P Casali
Nat Commun, 2017-02-08;8(0):14244.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Crebbp Acetyltransferase is a Haploinsufficient Tumor Suppressor in B Cell Lymphoma
Authors: J Zhang, S Vlasevska, VA Wells, S Nataraj, AB Holmes, R Duval, SN Meyer, T Mo, K Basso, PK Brindle, S Hussein, R Dalla-Fave, L Pasqualucc
Cancer Discov, 2017-01-09;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The aryl hydrocarbon receptor controls cell-fate decisions in B cells
Authors: Bharat Vaidyanath
J. Exp. Med, 2016-12-23;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE
Authors: Yee Ling Wu
J. Exp. Med, 2016-12-19;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
Sci Rep, 2016-12-01;6(0):37977.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-?3 production
Proc. Natl. Acad. Sci. U.S.A., 2016-11-30;113(50):E8131-E8140.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching
Sci Rep, 2016-11-17;6(0):37215.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Soluble TNF Regulates TACE via AP-2? Transcription Factor in Mouse Dendritic Cells
Authors: L Ge, NL Vujanovic
J. Immunol., 2016-11-16;198(1):417-427.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections
Sci Rep, 2016-11-15;6(0):37211.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy
J. Immunol., 2016-11-09;197(12):4750-4761.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3(+)CD49b(-)Foxp3(-) regulatory T�cells
Authors: W Dawicki, C Li, J Town, X Zhang, JR Gordon
J. Allergy Clin. Immunol., 2016-10-26;139(5):1608-1620.e3.
Species: Mouse
Sample Types: Serum
Applications: ELISA (Standard) -
M1/M2-macrophage phenotypes regulate renal calcium oxalate crystal development.
Authors: Kazumi Taguchi, Atsushi Okada, Shuzo Hamamoto, Rei Unno, Yoshinobu Moritoki, Ryosuke Ando, Kentaro Mizuno, Keiichi Tozawa, Kenjiro Kohri, Takahiro Yasui
Scientific Reports, 2016-10-12;0(0):2045-2322.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Polarization of macrophages towards M2 phenotype is favored by reduction in iPLA2?
J Biol Chem, 2016-09-20;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interferon regulatory factor 4 (IRF4) controls myeloid-derived suppressor cell (MDSC) differentiation and function
J Leukoc Biol, 2016-09-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21
J Immunol, 2016-08-15;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Role of interleukin-4, the chemokine CCL3 and its receptor CCR5 in neuropathic pain
Mol Immunol, 2016-08-11;77(0):184-192.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
Circ Res, 2016-07-14;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
M2-polarized macrophages contribute to neovasculogenesis, leading to relapse of oral cancer following radiation
Authors: Makiko Okubo
Sci Rep, 2016-06-08;6(0):27548.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A Lipid Based Antigen Delivery System Efficiently Facilitates MHC Class-I Antigen Presentation in Dendritic Cells to Stimulate CD8(+) T Cells
Authors: Mithun Maji
Sci Rep, 2016-06-02;6(0):27206.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus
Authors: Ahmed S Elshikha
PLoS ONE, 2016-05-27;11(5):e0156583.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
Nat Commun, 2016-05-23;7(0):11624.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU)
PLoS ONE, 2016-05-19;11(5):e0155953.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta.
Authors: Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J
Immunol Cell Biol, 2016-05-10;94(8):747-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Elastin-Derived Peptides Promote Abdominal Aortic Aneurysm Formation by Modulating M1/M2 Macrophage Polarization
J Immunol, 2016-05-04;196(11):4536-43.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-12p40/IL-10 Producing preCD8?/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection
Authors: D Torres, A Köhler, S Delbauve, I Caminschi, MH Lahoud, K Shortman, V Flamand
PLoS Pathog, 2016-04-13;12(4):e1005561.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis
Authors: C Shimojima, H Takeuchi, S Jin, B Parajuli, H Hattori, A Suzumura, H Hibi, M Ueda, A Yamamoto
J Immunol, 2016-04-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response
Authors: Shweta Pasi
J Biol Chem, 2016-03-28;291(23):12358-69.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKC? Kinase Activity
Authors: E Naik, VM Dixit
J Immunol, 2016-03-02;196(8):3438-51.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining.
Authors: Lu G, Duan J, Shu S, Wang X, Gao L, Guo J, Zhang Y
Proc Natl Acad Sci U S A, 2016-01-19;113(5):1256-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination.
Authors: Masani S, Han L, Meek K, Yu K
Proc Natl Acad Sci U S A, 2016-01-19;113(5):1261-6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
p(70S6K1) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.
Authors: Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, Ghosh P
Eur J Immunol, 2015-11-19;46(1):212-22.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Protease activity of Per a 10 potentiates Th2 polarization by increasing IL-23 and OX40L.
Authors: Agrawal K, Kale S, Arora N
Eur J Immunol, 2015-10-16;45(12):3375-85.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells.
Authors: Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, Deng L, Zanvit P, Tu E, Jin W, Abbatiello B, Goldberg N, Chen Q, Sun L, Zhao K, Chen W
Nat Immunol, 2015-08-31;16(10):1077-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo.
Authors: DeMicco A, Naradikian M, Sindhava V, Yoon J, Gorospe M, Wertheim G, Cancro M, Bassing C
J Immunol, 2015-08-28;195(7):3449-62.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling.
Authors: Fleming B, Chandrasekaran P, Dillon L, Dalby E, Suresh R, Sarkar A, El-Sayed N, Mosser D
J Leukoc Biol, 2015-06-05;98(3):395-407.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer.
Authors: Gao F, Liu C, Guo J, Sun W, Xian L, Bai D, Liu H, Cheng Y, Li B, Cui J, Zhang C, Cai J
Sci Rep, 2015-04-29;5(0):9613.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease.
Authors: Olsan E, Matsushita T, Rezaei M, Weimbs T
J Biol Chem, 2015-04-28;290(25):15679-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
LKB1 inhibition of NF-kappaB in B cells prevents T follicular helper cell differentiation and germinal center formation.
Authors: Walsh N, Waters L, Fowler J, Lin M, Cunningham C, Brooks D, Rehg J, Morse H, Teitell M
EMBO Rep, 2015-04-26;16(6):753-68.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Immunosuppression in early postnatal days induces persistent and allergen-specific immune tolerance to asthma in adult mice.
Authors: Chen, Yan, Zhang, Jin, Lu, Yong, Wang, Libo
PLoS ONE, 2015-04-10;10(4):e0122990.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo.
Authors: Raich-Regue D, Rosborough B, Watson A, McGeachy M, Turnquist H, Thomson A
J Immunol, 2015-04-03;194(10):4767-76.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sca-1+Lin-CD117- mesenchymal stem/stromal cells induce the generation of novel IRF8-controlled regulatory dendritic cells through Notch-RBP-J signaling.
Authors: Liu X, Ren S, Ge C, Cheng K, Zenke M, Keating A, Zhao R
J Immunol, 2015-03-30;194(9):4298-308.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Glycogen Synthase Kinase-3beta (GSK-3beta) Inhibition Enhances Dendritic Cell-based Cancer Vaccine Potency via Suppression of Interferon-gamma-induced Indoleamine 2,3-Dioxygenase Expression.
Authors: Noh K, Son K, Jung I, Kang T, Choi C, Park Y
J Biol Chem, 2015-03-26;290(19):12394-402.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Concentrated protein body product derived from rice endosperm as an oral tolerogen for allergen-specific immunotherapy--a new mucosal vaccine formulation against Japanese cedar pollen allergy.
Authors: Wakasa Y, Takagi H, Watanabe N, Kitamura N, Fujiwara Y, Ogo Y, Hayashi S, Yang L, Ohta M, Thet Tin W, Sekikawa K, Takano M, Ozawa K, Hiroi T, Takaiwa F
PLoS ONE, 2015-03-16;10(3):e0120209.
Species: Mouse
Sample Types: In Vivo
-
Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-beta using BV2 microglial cells and APP/PS1 transgenic mice.
Authors: Latta C, Sudduth T, Weekman E, Brothers H, Abner E, Popa G, Mendenhall M, Gonzalez-Oregon F, Braun K, Wilcock D
J Neuroinflammation, 2015-03-04;12(0):41.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.
Authors: Sag D, Cekic C, Wu R, Linden J, Hedrick C
Nat Commun, 2015-02-27;6(0):6354.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.
Authors: Khairnar V, Duhan V, Maney S, Honke N, Shaabani N, Pandyra A, Seifert M, Pozdeev V, Xu H, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf A, Haussinger D, Lang F, Dittmer U, Kuppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Gothert J, Singer B, Lang P, Lang K
Nat Commun, 2015-02-18;6(0):6217.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cytokine-induced killer cells co-cultured with dendritic cells loaded with the protein lysate produced by radiofrequency ablation induce a specific antitumor response.
Authors: Shan, Chan-Cha, Shi, Liang-Ro, Ding, Mei-Qian, Zhu, Yi-Bei, Li, Xiao-Don, Xu, Bin, Jiang, Jing-Tin, Wu, Chang-Pi
Oncol Lett, 2015-02-17;9(4):1549-1556.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor.
Authors: Freeman S, Jaumouille V, Choi K, Hsu B, Wong H, Abraham L, Graves M, Coombs D, Roskelley C, Das R, Grinstein S, Gold M
Nat Commun, 2015-02-03;6(0):6168.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Essential engagement of Toll-like receptor 2 in initiation of early protective Th1 response against rough variants of Mycobacterium abscessus.
Authors: Kim J, Kang M, Kim W, Han S, Kim H, Kim H, Kwon K, Kim S, Cha S, Eum S, Koh W, Cho S, Park J, Shin S
Infect Immun, 2015-02-02;83(4):1556-67.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lymphocytes from chronically stressed mice confer antidepressant-like effects to naive mice.
Authors: Brachman R, Lehmann M, Maric D, Herkenham M
J Neurosci, 2015-01-28;35(4):1530-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Constraints contributed by chromatin looping limit recombination targeting during Ig class switch recombination.
Authors: Feldman S, Achour I, Wuerffel R, Kumar S, Gerasimova T, Sen R, Kenter A
J Immunol, 2015-01-26;194(5):2380-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
An essential role for RGS protein/Galphai2 interactions in B lymphocyte-directed cell migration and trafficking.
Authors: Hwang I, Park C, Harrison K, Boularan C, Gales C, Kehrl J
J Immunol, 2015-01-23;194(5):2128-39.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury.
Authors: Ballinger M, Newstead M, Zeng X, Bhan U, Mo X, Kunkel S, Moore B, Flavell R, Christman J, Standiford T
J Immunol, 2015-01-16;194(4):1894-904.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization.
Authors: Liu K, Zhao E, Ilyas G, Lalazar G, Lin Y, Haseeb M, Tanaka K, Czaja M
Autophagy, 2015-01-01;11(2):271-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
Authors: Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y
Cancer Res, 2014-12-09;75(2):306-15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Authors: Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang O, Cochran A, Vasser M, Fauber B, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick D, Lill J, Ouyang W, Dixit V
Nature, 2014-12-03;518(7539):417-21.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Conditional IL-4/IL-13-deficient mice reveal a critical role of innate immune cells for protective immunity against gastrointestinal helminths.
Authors: Oeser K, Schwartz C, Voehringer D
Mucosal Immunol, 2014-10-22;8(3):672-82.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency.
Authors: Ghonim M, Pyakurel K, Ju J, Rodriguez P, Lammi M, Davis C, Abughazleh M, Mansy M, Naura A, Boulares A
J Allergy Clin Immunol, 2014-10-19;135(2):425-40.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of Ca2+-independent phospholipase A2beta (iPLA2beta) ameliorates islet infiltration and incidence of diabetes in NOD mice.
Authors: Bone R, Gai Y, Magrioti V, Kokotou M, Ali T, Lei X, Tse H, Kokotos G, Ramanadham S
Diabetes, 2014-09-11;64(2):541-54.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Germinal center B cell maintenance and differentiation are controlled by distinct NF-kappaB transcription factor subunits.
Authors: Heise N, De Silva N, Silva K, Carette A, Simonetti G, Pasparakis M, Klein U
J Exp Med, 2014-09-01;211(10):2103-18.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A potential protein adjuvant derived from Mycobacterium tuberculosis Rv0652 enhances dendritic cells-based tumor immunotherapy.
Authors: Lee S, Shin S, Lee M, Lee M, Kang T, Park W, Soh B, Park J, Shin Y, Kim H, Yun C, Jung I, Park Y
PLoS ONE, 2014-08-07;9(8):e104351.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Noncoding RNA transcription targets AID to divergently transcribed loci in B cells.
Authors: Pefanis, Evangelo, Wang, Jiguang, Rothschild, Gerson, Lim, Junghyun, Chao, Jaime, Rabadan, Raul, Economides, Aris N, Basu, Uttiya
Nature, 2014-08-06;514(7522):389-93.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Role of Blimp-1 in programing Th effector cells into IL-10 producers.
Authors: Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A
J Exp Med, 2014-07-29;211(9):1807-19.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
Authors: Colegio O, Chu N, Szabo A, Chu T, Rhebergen A, Jairam V, Cyrus N, Brokowski C, Eisenbarth S, Phillips G, Cline G, Phillips A, Medzhitov R
Nature, 2014-07-13;513(7519):559-63.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses.
Authors: Sahin E, Haubenwallner S, Kuttke M, Kollmann I, Halfmann A, Dohnal A, Chen L, Cheng P, Hoesel B, Einwallner E, Brunner J, Kral J, Schrottmaier W, Thell K, Saferding V, Bluml S, Schabbauer G
J Immunol, 2014-07-11;193(4):1717-27.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Enhancement of tumor-specific T cell-mediated immunity in dendritic cell-based vaccines by Mycobacterium tuberculosis heat shock protein X.
Authors: Jung I, Shin S, Lee M, Kang T, Han H, Lee S, Kim W, Kim H, Park W, Kim H, Yun C, Lee E, Wu T, Park Y
J Immunol, 2014-07-02;193(3):1233-45.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IkappaB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm.
Authors: Stouch A, Zaynagetdinov R, Barham W, Stinnett A, Slaughter J, Yull F, Hoffman H, Blackwell T, Prince L
J Immunol, 2014-06-30;193(3):1184-93.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes.
Authors: Hu, Jiazhi, Tepsuporn, Suprawee, Meyers, Robin M, Gostissa, Monica, Alt, Frederic
Proc Natl Acad Sci U S A, 2014-06-30;111(28):10269-74.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization.
Authors: Downey C, Aghaei M, Schwendener R, Jirik F
PLoS ONE, 2014-06-18;9(6):e99988.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Binding of AID to DNA does not correlate with mutator activity.
Authors: Matthews A, Husain S, Chaudhuri J
J Immunol, 2014-05-30;193(1):252-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.
Authors: Dingler F, Kemmerich K, Neuberger M, Rada C
Eur J Immunol, 2014-05-27;44(7):1925-35.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
Authors: Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R
BMC Biol, 2014-05-09;12(0):32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lysosomal stress in obese adipose tissue macrophages contributes to MITF-dependent Gpnmb induction.
Authors: Gabriel T, Tol M, Ottenhof R, van Roomen C, Aten J, Claessen N, Hooibrink B, de Weijer B, Serlie M, Argmann C, van Elsenburg L, Aerts J, van Eijk M
Diabetes, 2014-05-01;63(10):3310-23.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia.
Authors: Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, Greil R, Geisberger R
Eur J Immunol, 2014-04-15;44(7):2175-87.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.
Authors: Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C
J Immunol, 2014-03-21;192(8):3569-81.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: ELISA (Standard) -
Acanthamoeba protease activity promotes allergic airway inflammation via protease-activated receptor 2.
Authors: Park, Mi Kyung, Cho, Min Kyou, Kang, Shin Ae, Park, Hye-Kyun, Kim, Dong-Hee, Yu, Hak Sun
PLoS ONE, 2014-03-21;9(3):e92726.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Improved repair of dermal wounds in mice lacking microRNA-155.
Authors: van Solingen C, Araldi E, Chamorro-Jorganes A, Fernandez-Hernando C, Suarez Y
J Cell Mol Med, 2014-03-17;18(6):1104-12.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A role for the ITAM signaling module in specifying cytokine-receptor functions.
Authors: Bezbradica J, Rosenstein R, DeMarco R, Brodsky I, Medzhitov R
Nat Immunol, 2014-03-09;15(4):333-42.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Preferential macrophage recruitment and polarization in LPS-induced animal model for COPD: noninvasive tracking using MRI.
Authors: Al Faraj, Achraf, Sultana Shaik, Asma, Pureza, Mary Ang, Alnafea, Mohammad, Halwani, Rabih
PLoS ONE, 2014-03-05;9(3):e90829.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
Authors: Ramkhelawon B, Hennessy E, Menager M, Ray T, Sheedy F, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner K, Moore K
Nat Med, 2014-03-02;20(4):377-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models.
Authors: Nakajima S, Kitoh A, Egawa G, Natsuaki Y, Nakamizo S, Moniaga C, Otsuka A, Honda T, Hanakawa S, Amano W, Iwakura Y, Nakae S, Kubo M, Miyachi Y, Kabashima K
J Invest Dermatol, 2014-03-02;134(8):2122-30.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Colony-stimulating factor-1 signaling suppresses renal crystal formation.
Authors: Taguchi K, Okada A, Kitamura H, Yasui T, Naiki T, Hamamoto S, Ando R, Mizuno K, Kawai N, Tozawa K, Asano K, Tanaka M, Miyoshi I, Kohri K
J Am Soc Nephrol, 2014-02-27;25(8):1680-97.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Aging is associated with increased regulatory T-cell function.
Authors: Garg S, Delaney C, Toubai T, Ghosh A, Reddy P, Banerjee R, Yung R
Aging Cell, 2014-02-25;13(3):441-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Immunomodulatory glycan lacto-N-fucopentaose III requires clathrin-mediated endocytosis to induce alternative activation of antigen-presenting cells.
Authors: Srivastava, Leena, Tundup, Smanla, Choi, Beak-San, Norberg, Thomas, Harn, Donald
Infect Immun, 2014-02-24;82(5):1891-903.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization.
Authors: Tatano Y, Shimizu T, Tomioka H
Sci Rep, 2014-02-20;4(0):4146.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
S100A8 induces IL-10 and protects against acute lung injury.
Authors: Hiroshima Y, Hsu K, Tedla N, Chung Y, Chow S, Herbert C, Geczy C
J Immunol, 2014-02-14;192(6):2800-11.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity.
Authors: Benasciutti E, Mariani E, Oliva L, Scolari M, Perilli E, Barras E, Milan E, Orfanelli U, Fazzalari N, Campana L, Capobianco A, Otten L, Particelli F, Acha-Orbea H, Baruffaldi F, Faccio R, Sitia R, Reith W, Cenci S
J Bone Miner Res, 2014-02-01;29(2):290-303.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation.
Authors: Dufort, Fay J, Gumina, Maria R, Ta, Nathan L, Tao, Yongzhen, Heyse, Shannon, Scott, David A, Richardson, Adam D, Seyfried, Thomas N, Chiles, Thomas C
J Biol Chem, 2014-01-27;289(10):7011-24.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of the structure and immunostimulatory activity of a vaccine adjuvant, de-O-acylated lipooligosaccharide.
Authors: Han, Ji Eun, Wui, Seo Ri, Kim, Kwang Su, Cho, Yang Je, Cho, Wan Je, Lee, Na Gyong
PLoS ONE, 2014-01-22;9(1):e85838.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.
Authors: Asai H, Ikezu S, Woodbury M, Yonemoto G, Cui L, Ikezu T
Am J Pathol, 2014-01-10;184(3):808-18.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization.
Authors: Date D, Das R, Narla G, Simon D, Jain M, Mahabeleshwar G
J Biol Chem, 2014-01-02;289(15):10318-29.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses.
Authors: Terra R, Wang X, Hu Y, Charpentier T, Lamarre A, Zhong M, Sun H, Mao J, Qi S, Luo H, Wu J
PLoS ONE, 2013-12-31;8(12):e82808.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Activated macrophages release microvesicles containing polarized M1 or M2 mRNAs.
Authors: Garzetti, Livia, Menon, Ramesh, Finardi, Annamari, Bergami, Alessand, Sica, Antonio, Martino, Gianvito, Comi, Giancarl, Verderio, Claudia, Farina, Cinthia, Furlan, Roberto
J Leukoc Biol, 2013-12-30;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation.
Authors: Veremeyko, Tatyana, Siddiqui, Shafiudd, Sotnikov, Ilya, Yung, Amanda, Ponomarev, Eugene D
PLoS ONE, 2013-12-16;8(12):e81774.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.
Authors: Lam T, Thomas L, White C, Li G, Pone E, Xu Z, Casali P
PLoS ONE, 2013-11-25;8(11):e80414.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TRAF5 negatively regulates TLR signaling in B lymphocytes.
Authors: Buchta C, Bishop G
J Immunol, 2013-11-20;192(1):145-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism.
Authors: Chattopadhyay, Gouri, Shevach, Ethan M
J Immunol, 2013-11-11;191(12):5875-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The exonuclease Trex1 restrains macrophage proinflammatory activation.
Authors: Pereira-Lopes S, Celhar T, Sans-Fons G, Serra M, Fairhurst A, Lloberas J, Celada A
J Immunol, 2013-11-11;191(12):6128-35.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis.
Authors: Dowdle J, Mehta M, Kass E, Vuong B, Inagaki A, Egli D, Jasin M, Keeney S
PLoS Genet, 2013-11-07;9(11):e1003945.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) and nuclear factor-kappaB (NF-kappaB): a feed-forward loop for systemic and vascular inflammation.
Authors: Leslie K, Song G, Barrick S, Wehbi V, Vilardaga J, Bauer P, Bisello A
J Biol Chem, 2013-11-06;288(51):36426-36.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity.
Authors: Palm N, Rosenstein R, Yu S, Schenten D, Florsheim E, Medzhitov R
Immunity, 2013-10-24;39(5):976-85.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses.
Authors: Wang X, Hu Y, Charpentier T, Lamarre A, Qi S, Wu J, Luo H
J Immunol, 2013-10-18;191(11):5420-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
Authors: Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R
Immunity, 2013-09-26;39(4):722-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Failed renoprotection by alternatively activated bone marrow macrophages is due to a proliferation-dependent phenotype switch in vivo.
Authors: Cao Q, Wang Y, Zheng D, Sun Y, Wang C, Wang X, Lee V, Wang Y, Zheng G, Tan T, Wang Y, Alexander S, Harris D
Kidney Int, 2013-09-18;85(4):794-806.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mycobacterium tuberculosis RpfB drives Th1-type T cell immunity via a TLR4-dependent activation of dendritic cells.
Authors: Kim J, Kim W, Choi H, Jang B, Lee K, Park J, Kim H, Cho S, Shin S
J Leukoc Biol, 2013-07-03;94(4):733-49.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells.
Authors: Nundel K, Busto P, Debatis M, Marshak-Rothstein A
J Leukoc Biol, 2013-06-26;94(5):865-75.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism.
Authors: Zhao Y, Zhao H, Sun Y, Hao J, Qi X, Zhou X, Wu Z, Wang P, Kaech S, Weaver C, Flavell R, Zhao L, Yao Z, Yin Z
J Leukoc Biol, 2013-06-14;94(6):1103-12.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery.
Authors: Jacome-Galarza C, Lee S, Lorenzo J, Aguila H
J Bone Miner Res, 2013-05-01;28(5):1203-13.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice.
Authors: Chen M, Hombrebueno J, Luo C, Penalva R, Zhao J, Colhoun L, Pandi S, Forrester J, Xu H
PLoS ONE, 2013-04-18;8(4):e61381.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Prostate cancer stem cells are targets of both innate and adaptive immunity and elicit tumor-specific immune responses.
Authors: Jachetti, Elena, Mazzoleni, Stefania, Grioni, Matteo, Ricupito, Alessia, Brambillasca, Chiara, Generoso, Luca, Calcinotto, Arianna, Freschi, Massimo, Mondino, Anna, Galli, Rossella, Bellone, Matteo
Oncoimmunology, 2013-04-16;2(5):e24520.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice.
Authors: Park J, Lim M, Cho M, Ryu J, Moon Y, Jhun J, Byun J, Kim E, Hwang S, Ju J, Kwok S, Kim H
Arthritis Rheum, 2013-04-01;65(4):949-59.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Differential requirements of CD4(+) T-cell signals for effector cytotoxic T-lymphocyte (CTL) priming and functional memory CTL development at higher CD8(+) T-cell precursor frequency.
Authors: Umeshappa C, Nanjundappa R, Xie Y, Freywald A, Xu Q, Xiang J
Immunology, 2013-04-01;138(4):298-306.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dissociation of endotoxin tolerance and differentiation of alternatively activated macrophages.
Authors: Rajaiah R, Perkins D, Polumuri S, Zhao A, Keegan A, Vogel S
J Immunol, 2013-03-29;190(9):4763-72.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration.
Authors: Gartlan K, Wee J, Demaria M, Nastovska R, Chang T, Jones E, Apostolopoulos V, Pietersz G, Hickey M, van Spriel A, Wright M
Eur J Immunol, 2013-03-25;43(5):1208-19.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Rgs13 constrains early B cell responses and limits germinal center sizes.
Authors: Hwang I, Hwang K, Park C, Harrison K, Kehrl J
PLoS ONE, 2013-03-22;8(3):e60139.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.
Authors: Knosp C, Schiering C, Spence S, Carroll H, Nel H, Osbourn M, Jackson R, Lyubomska O, Malissen B, Ingram R, Fitzgerald D, Powrie F, Fallon P, Johnston J, Kissenpfennig A
J Immunol, 2013-03-01;190(7):3235-45.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Functional education of invariant NKT cells by dendritic cell tuning of SHP-1.
Authors: Napolitano, Anna, Pittoni, Paola, Beaudoin, Lucie, Lehuen, Agnes, Voehringer, David, MacDonald, H Robson, Dellabona, Paolo, Casorati, Giulia
J Immunol, 2013-02-20;190(7):3299-308.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination.
Authors: Masani, Shahnaz, Han, Li, Yu, Kefei
Mol Cell Biol, 2013-02-04;33(7):1468-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis.
Authors: Kumar M, Roe K, Orillo B, Muruve D, Nerurkar V, Gale M, Verma S
J Virol, 2013-01-09;87(7):3655-67.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.
Authors: Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem G, Singh S, Dinda A, Biswal S, Agrawal A, Ghosh B
Sci Rep, 2013-01-01;3(0):1540.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Breast regression protein-39 (BRP-39) promotes dendritic cell maturation in vitro and enhances Th2 inflammation in murine model of asthma.
Authors: Xu Q, Chai S, Qian Y, Zhang M, Wang K
Acta Pharmacol Sin, 2012-11-26;33(12):1525-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
The MSHA Strain of Pseudomonas Aeruginosa Activated TLR Pathway and Enhanced HIV-1 DNA Vaccine Immunoreactivity.
Authors: Hou J, Liu Y, Liu Y, Shao Y
PLoS ONE, 2012-10-15;7(10):e47724.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands.
Authors: Munich S, Sobo-Vujanovic A, Buchser W, Beer-Stolz D, Vujanovic N
Oncoimmunology, 2012-10-01;1(7):1074-1083.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
An epigenetic silencing pathway controlling T helper 2 cell lineage commitment.
Authors: Allan RS, Zueva E, Cammas F, Schreiber HA, Masson V, Belz GT, Roche D, Maison C, Quivy JP, Almouzni G, Amigorena S
Nature, 2012-07-12;487(7406):249-53.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
Nat. Med., 2012-07-08;1248(0):18.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TNFR-Associated Factor 2 Deficiency in B Lymphocytes Predisposes to Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in Mice.
Authors: Perez-Chacon G, Llobet D, Pardo C, Pindado J, Choi Y, Reed JC, Zapata JM
J. Immunol., 2012-06-18;189(2):1053-61.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CCL25 induces alpha 4 beta 7 integrin-dependent migration of IL-17+ gamma/delta T lymphocytes during an allergic reaction.
Authors: Costa MF, Bornstein VU, Candea AL, Henriques-Pons A, Henriques MG, Penido C
Eur. J. Immunol., 2012-05-01;42(5):1250-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia.
Authors: Noh KT, Son KH, Jung ID, Kang HK, Hwang SA, Lee WS, You JC, Park YM
J. Biol. Chem., 2012-03-05;287(17):14226-33.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function.
Authors: Jin W, Qi S, Luo H
BMC Immunol., 2011-12-19;12(0):68.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
J. Virol., 2010-09-29;84(24):12703-12.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages.
Authors: Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA
J. Immunol., 2010-07-21;185(4):2044-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
Authors: Yoshizaki A, Yanaba K, Iwata Y
J. Immunol., 2010-07-12;185(4):2502-15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
PEGylation of interleukin-10 for the mitigation of enhanced pain states.
Authors: Soderquist RG, Milligan ED, Harrison JA, Chavez RA, Johnson KW, Watkins LR, Mahoney MJ
J Biomed Mater Res A, 2010-06-01;93(3):1169-79.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.
Authors: Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, Jabeen R, McKinley C, Ahyi AN, Han L, Nguyen ET, Robertson MJ, Perumal NB, Tepper RS, Nutt SL, Kaplan MH
Nat. Immunol., 2010-05-02;11(6):527-34.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node.
Authors: Perona-Wright G, Mohrs K, Mohrs M
Nat. Immunol., 2010-04-25;11(6):520-6.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Oncostatin M induces dendritic cell maturation and Th1 polarization.
Authors: Jung ID, Noh KT, Lee CM, Chun SH, Jeong SK, Park JW, Park WS, Kim HW, Yun CH, Shin YK, Park YM
Biochem. Biophys. Res. Commun., 2010-03-04;394(2):272-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
Authors: Kotarsky K, Sitnik KM, Stenstad H, Kotarsky H, Schmidtchen A, Koslowski M, Wehkamp J, Agace WW
Mucosal Immunol, 2009-10-07;3(1):40-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis.
Authors: Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T
Microbes Infect., 2009-03-13;11(4):524-30.
Applications: ELISA (Standard) -
The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.
Authors: Claudio E, Sonder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U
J. Immunol., 2009-02-01;182(3):1617-30.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming.
Authors: Richez C, Yasuda K, Watkins AA
J. Immunol., 2009-01-15;182(2):820-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
Authors: Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M
J. Exp. Med., 2009-01-12;206(1):69-78.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.
Authors: McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK
J. Immunol., 2008-09-15;181(6):4089-97.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Adenosine receptors in regulation of dendritic cell differentiation and function.
Authors: Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM
Blood, 2008-06-17;112(5):1822-31.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Direct B cell stimulation by dendritic cells in a mouse model of lupus.
Authors: Wan S, Zhou Z, Duan B, Morel L
Arthritis Rheum., 2008-06-01;8(0):1741-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium: a nitric oxide regulatory feedback mechanism.
Authors: Norman MU, Zbytnuik L, Kubes P
Eur. J. Immunol., 2008-05-01;38(5):1368-80.
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
Authors: Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T
Immunology, 2008-04-03;125(2):272-9.
Applications: ELISA (Standard) -
A mechanism for the initiation of allergen-induced T helper type 2 responses.
Authors: Sokol CL, Barton GM, Farr AG, Medzhitov R
Nat. Immunol., 2008-03-01;9(3):310-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Controlled delivery of T-box21 small interfering RNA ameliorates autoimmune alopecia (Alopecia Areata) in a C3H/HeJ mouse model.
Authors: Nakamura M, Jo J, Tabata Y, Ishikawa O
Am. J. Pathol., 2008-02-02;172(3):650-8.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia.
Authors: Kudlacz E, Conklyn M, Andresen C, Whitney-Pickett C, Changelian P
Eur. J. Pharmacol., 2007-12-28;582(1):154-61.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Liposomal retinoic acids modulate asthma manifestations in mice.
Authors: Maret M, Ruffie C, Periquet B, Campo AM, Menevret M, Phelep A, Dziewiszek K, Druilhe A, Pretolani M
J. Nutr., 2007-12-01;137(12):2730-6.
Applications: ELISA (Standard) -
In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.
Authors: Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F
J. Clin. Invest., 2007-12-01;117(12):3868-3878.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice.
Authors: King VL, Cassis LA, Daugherty A
Am. J. Pathol., 2007-11-30;171(6):2040-7.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Dendritic cells loaded with apoptotic antibody-coated tumor cells provide protective immunity against B-cell lymphoma in vivo.
Authors: Franki SN, Steward KK, Betting DJ, Kafi K, Yamada RE, Timmerman JM
Blood, 2007-11-09;111(3):1504-11.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.
Authors: Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L
Eur. J. Immunol., 2007-10-01;37(10):2695-706.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The endothelial cell-produced antiangiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation.
Authors: Tian F, Grimaldo S, Fujita M, Fugita M, Cutts J, Vujanovic NL, Li LY
J. Immunol., 2007-09-15;179(6):3742-51.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development.
Authors: Khaled WT, Read EK, Nicholson SE, Baxter FO, Brennan AJ, Came PJ, Sprigg N, McKenzie AN, Watson CJ
Development, 2007-07-04;134(15):2739-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.
Authors: Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ
Immunity, 2007-04-12;26(4):445-59.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo.
Authors: Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW
J. Invest. Dermatol., 2007-03-29;127(8):1964-72.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines.
Authors: Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R
Mol. Ther., 2007-03-20;15(5):971-80.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
J. Allergy Clin. Immunol., 2007-03-01;119(3):662-70.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells.
Authors: Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA
J. Immunol., 2007-02-15;178(4):2018-27.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation.
Authors: Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW
J. Immunol., 2007-01-01;178(1):480-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages.
Authors: Ogawa K, Funaba M, Chen Y, Tsujimoto M
J. Immunol., 2006-11-15;177(10):6787-94.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator.
Authors: Chiang YM, Chang CL, Chang SL, Yang WC, Shyur LF
J Ethnopharmacol, 2006-10-19;110(3):532-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation.
Authors: de la Fuente MA, Kumar L, Lu B, Geha RS
Mol. Cell. Biol., 2006-07-01;26(14):5214-25.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile.
Authors: Wen H, Hogaboam CM, Gauldie J, Kunkel SL
Am. J. Pathol., 2006-06-01;168(6):1940-50.
Applications: ELISA (Standard) -
Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation.
Authors: Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X
Biochem. Biophys. Res. Commun., 2006-05-12;345(3):1122-30.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis.
Authors: Butovsky O, Landa G, Kunis G, Ziv Y, Avidan H, Greenberg N, Schwartz A, Smirnov I, Pollack A, Jung S, Schwartz M
J. Clin. Invest., 2006-03-23;116(4):905-15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus.
Authors: Howell MD, Gallo RL, Boguniewicz M, Jones JF, Wong C, Streib JE, Leung DY
Immunity, 2006-03-01;24(3):341-8.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells.
Authors: Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M
Mol. Cell. Neurosci., 2005-11-16;31(1):149-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.
Authors: Harrington, Laurie E, Hatton, Robin D, Mangan, Paul R, Turner, Henriett, Murphy, Theresa, Murphy, Kenneth, Weaver, Casey T
Nat Immunol, 2005-10-02;6(11):1123-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-1 mediates TNF-induced osteoclastogenesis.
Authors: Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL
J. Clin. Invest., 2005-02-01;115(2):282-90.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation.
Authors: Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP
J. Immunol., 2005-01-01;174(1):215-22.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Vaccination of apoptotic Fas ligand-expressing tumors decreased antitumor responses by enhanced production of immunosuppressive cytokines.
Authors: Wada A, Tada Y, Shimozato O, Takiguchi Y, Tatsumi K, Kuriyama T, Tagawa M
Anticancer Res., 2005-01-01;25(1):299-303.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.
Authors: Borg C, Jalil A, Laderach D, Maruyama K, Wakasugi H, Charrier S, Ryffel B, Cambi A, Figdor C, Vainchenker W, Galy A, Caignard A, Zitvogel L
Blood, 2004-07-08;104(10):3267-75.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow.
Authors: Bleier JI, Pillarisetty VG, Shah AB, DeMatteo RP
J. Immunol., 2004-06-15;172(12):7408-16.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Control of Leishmania major in the absence of Tyk2 kinase.
Authors: Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, Muller M, Werner-Felmayer G, Bogdan C
Eur. J. Immunol., 2004-02-01;34(2):519-29.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Intracellular thiols contribute to Th2 function via a positive role in IL-4 production.
Authors: Monick MM, Samavati L, Butler NS, Mohning M, Powers LS, Yarovinsky T, Spitz DR, Hunninghake GW
J. Immunol., 2003-11-15;171(10):5107-15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dual roles of IL-4 in lung injury and fibrosis.
Authors: Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH
Proteins containing BRCA1 C-terminal (BRCT) domains play crucial roles in response to and repair of DNA damage. Epithelial cell transforming factor ECT2 is a member of the BRCT protein family, but it, 2003-02-15;170(4):2083-92.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses.
Authors: Larbi KY, Dangerfield JP, Culley FJ, Marshall D, Haskard DO, Jose PJ, Williams TJ, Nourshargh S
J. Leukoc. Biol., 2003-01-01;73(1):65-73.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity.
Authors: Lukacs NW, Berlin A, Schols D, Skerlj RT, Bridger GJ
Am. J. Pathol., 2002-04-01;160(4):1353-60.
Applications: ELISA (Standard) -
The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice.
Authors: Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M
Arch. Dermatol. Res., 2001-11-01;293(10):508-14.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation.
Authors: Morelli AE, Zahorchak AF, Larregina AT
Blood, 2001-09-01;98(5):1512-23.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function.
Authors: Gabrilovich DI, 2018, Ishida T, Nadaf S, Ohm JE, Carbone DP
1537, 1999-10-01;5(10):2963-70.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
FAQs
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Has recombinant mouse IL-4, Catalog # 404-ML, been tested for activity on human cells?
We have not evaluated the bioactivity of Recombinant Mouse IL-4 Protein (Catalog # 404-ML) with human cells. However, we recommend reviewing our list of publications under the Citations tab on the product web page to find reported use of this product with human cells. We do offer a Recombinant Human IL-4 Protein (Catalog # 204-IL), which is suitable for use with human cells.
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What concentration of recombinant mouse IL-4, Catalog # 404-ML, should I use for my cell culture experiment?
We evaluate the bioactivity of Recombinant Mouse IL-4 Protein (Catalog # 404-ML) in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is 0.5-1.5 ng/mL. This ED50 range can provide a starting point for your experiment, but we would recommend end-users perform a dose-response to determine the best concentration for their assay system. We also recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.
Reviews for Recombinant Mouse IL-4 Protein
Average Rating: 4.9 (Based on 18 Reviews)
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Reason for Rating: Recombinant IL-4 protein works well
Reason for Rating: IL-4 was used to differentiate THP-1 into M2 phenotype macrophages. We used immunofluorescence staining to show that after treatment the cells are CD206 positive, which means the treatment is successful in the phenotype change of THP-1 into M2 macrophage.
Reason for Rating: MAB404 binds rhuIL-13Ra2