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Recombinant Mouse IL-10 Protein

Catalog #: 417-ML
73 Citations 3 Reviews Datasheet

Carrier Free

Catalog # Availability Size / Price Qty
417-ML-005/CF
417-ML-025/CF
417-ML-100/CF
417-ML-250/CF

With Carrier

Catalog # Availability Size / Price Qty
417-ML-005
417-ML-025
417-ML-100
417-ML-250
Recombinant Mouse IL-10 Protein Bioactivity
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Product Details
Citations (73)
FAQs
Reviews (3)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse IL-10 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using MC/9‑2 mouse mast cells. Thompson-Snipes, L. et al. (1991) J. Exp. Med. 173:507. The ED50 for this effect is 0.1‑0.6 ng/mL.
Source
E. coli-derived mouse IL-10 protein
Ser19-Ser178
Accession #
NP_034678
N-terminal Sequence
Analysis
Ser19
Structure / Form
Noncovalently-linked homodimer
Predicted Molecular Mass
18 kDa
SDS-PAGE
17 kDa, reducing conditions

Product Datasheets

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417-ML (with carrier)

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417-ML/CF (carrier free)

Product Datasheet

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

417-ML

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

417-ML/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Mouse IL-10 Protein Bioactivity View Larger

Recombinant Mouse IL-10 (Catalog # 417-ML) stimulates cell proliferation of the MC/9‑2 mouse mast cell line. The ED50 for this effect is 0.1-0.6 ng/mL.

SDS-PAGE Recombinant Mouse IL-10 Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Mouse IL-10 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 17 kDa.

Background: IL-10

Interleukin 10, also known as cytokine synthesis inhibitory factor (CSIF), is the charter member of the IL-10 family of alpha -helical cytokines that also includes IL‑19, IL‑20, IL-22, and IL-24 (1, 2). IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts (2-5). Mature mouse IL-10 shares 85% amino acid sequence identity with rat and 70%-77% with bovine, canine, equine, feline, human, ovine, and porcine IL-10. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells (6, 7). IL-10 is a 178 amino acid molecule that contains two intrachain disulfide bridges and is expressed as a 36 kDa noncovalently associated homodimer (8-10). The IL-10 dimer binds to two IL-10 R alpha /IL-10 R1 chains, resulting in recruitment of two IL-10 R beta /IL-10 R2 chains and activation of a signaling cascade involving JAK1, TYK2, and STAT3 (11). IL-10 R beta does not bind IL-10 by itself but is required for signal transduction (1). IL-10 R beta also associates with IL‑20 R alpha, IL-22 R alpha, or IL-28 R alpha to form the receptor complexes for IL-22, IL-26, IL-28, and IL‑29 (12-14). IL-10 is a critical molecule in the control of viral infections and allergic and autoimmune inflammation (15-17). It promotes phagocytic uptake and Th2 responses but suppresses antigen presentation and Th1 proinflammatory responses (2).

References
  1. Pestka, S. et al. (2004) Annu. Rev. Immunol. 22:929.
  2. O’Garra, A. and P. Vieira (2007) Nat. Rev. Immunol. 7:425.
  3. Mathurin, P. et al. (2002) Am. J. Physiol. Gastrointest. Liver Physiol. 282:G981.
  4. Grewe, M. et al. (1995) J. Invest. Dermatol. 104:3.
  5. Szony, B.J. et al. (1999) Mol. Hum. Reprod. 5:1059.
  6. Vieira, P. et al. (1991) Proc. Natl. Acad. Sci. 88:1172.
  7. Hsu, D.-H. et al. (1990) Science 250:830.
  8. Moore, K. et al. (1990) Science 248:1230.
  9. Windsor, W.T. et al. (1993) Biochemistry 32:8807.
  10. Syto, R. et al. (1998) Biochemistry 37:16943.
  11. Kotenko, S.V. et al. (1997) EMBO J. 16:5894.
  12. Kotenko, S.V. et al. (2000) J. Biol. Chem. 276:2725.
  13. Hor, S. et al. (2004) J. Biol. Chem. 279:33343.
  14. Sheppard, P. et al. (2003) Nat. Immunol. 4:63.
  15. Fitzgerald, D.C. et al. (2007) Nat. Immunol. 8:1372.
  16. Wu, K. et al. (2007) Cell. Mol. Immunol. 4:269.
  17. Blackburn, S.D. and E.J. Wherry (2007) Trends Microbiol. 15:143.
Long Name
Interleukin 10
Entrez Gene IDs
3586 (Human); 16153 (Mouse); 25325 (Rat); 397106 (Porcine); 403628 (Canine); 102133450 (Cynomolgus Monkey); 493683 (Feline); 100715618 (Guinea Pig); 2949786 (Viral)
Alternate Names
CSIF; CSIFMGC126450; Cytokine synthesis inhibitory factor; GVHDS; IL10; IL-10; IL10A; IL-10MGC126451; interleukin 10; interleukin-10; TGIF

Citations for Recombinant Mouse IL-10 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

73 Citations: Showing 1 - 10
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  1. Inhalable SPRAY nanoparticles by modular peptide assemblies reverse alveolar inflammation in lethal Gram-negative bacteria infection
    Authors: Chen, D;Zhou, Z;Kong, N;Xu, T;Liang, J;Xu, P;Yao, B;Zhang, Y;Sun, Y;Li, Y;Wu, B;Yang, X;Wang, H;
    Science advances
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Tregs delivered post-myocardial infarction adopt an injury-specific phenotype promoting cardiac repair via macrophages in mice
    Authors: Alshoubaki, YK;Nayer, B;Lu, YZ;Salimova, E;Lau, SN;Tan, JL;Amann-Zalcenstein, D;Hickey, PF;Del Monte-Nieto, G;Vasanthakumar, A;Martino, MM;
    Nature communications
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes
    Authors: Hou, Y;Wei, D;Zhang, Z;Lei, T;Li, S;Bao, J;Guo, H;Tan, L;Xie, X;Zhuang, Y;Lu, Z;Zhao, Y;
    Cell reports
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release
    Authors: Adrian, M;Weber, M;Tsai, MC;Glock, C;Kahn, OI;Phu, L;Cheung, TK;Meilandt, WJ;Rose, CM;Hoogenraad, CC;
    Nature communications
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles
    Authors: Santiago, JV;Natu, A;Ramelow, CC;Rayaprolu, S;Xiao, H;Kumar, V;Seyfried, NT;Rangaraju, S;
    bioRxiv : the preprint server for biology
    Species: Mouse
    Sample Types: Whole Cells
  6. CD169+ macrophage intrinsic IL-10 production regulates immune homeostasis during sepsis
    Authors: ST Yeung, LJ Ovando, AJ Russo, VA Rathinam, KM Khanna
    Cell Reports, 2023-03-02;42(3):112171.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  7. Detection of Radiolabeled Inflammatory Cell Macrophage Subpopulations in Chronic Respiratory Diseases: Results from Preliminary Analyses
    Authors: AP Shaik, AS Shaik, M Abudawood, A Al Faraj
    BioMed Research International, 2022-10-06;2022(0):9470845.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Interleukin 10 Attenuates Angiotensin II-Induced Aortic Remodelling by Inhibiting Oxidative Stress-Induced Activation of the Vascular p38 and NF-kappaB Pathways
    Authors: M Qiu, H Shu, L Li, Y Shen, Y Tian, Y Ji, W Sun, Y Lu, X Kong
    Oxidative Medicine and Cellular Longevity, 2022-04-26;2022(0):8244497.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  9. Survival of stem cells and progenitors in the intestine is regulated by LPA5-dependent signaling
    Authors: Z Liang, P He, Y Han, CC Yun
    Cellular and Molecular Gastroenterology and Hepatology, 2022-04-04;0(0):.
    Species: Mouse
    Sample Types: Organoid
    Applications: Tissue Culture
  10. CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T�cell survival
    Authors: N Yogev, T Bedke, Y Kobayashi, L Brockmann, D Lukas, T Regen, AL Croxford, A Nikolav, N Hövelmeyer, E von Stebut, M Prinz, C Ubeda, KJ Maloy, N Gagliani, RA Flavell, A Waisman, S Huber
    Cell Reports, 2022-03-29;38(13):110565.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Lactobacillus paracasei KW3110 Prevents Inflammatory-Stress-Induced Mitochondrial Dysfunction in Mouse Macrophages
    Authors: T Yamazaki, S Yamada, K Ohshio, M Sugamata, Y Morita
    International Journal of Molecular Sciences, 2022-01-27;23(3):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Differential Cytokine-Induced Responses of Polarized Microglia
    Authors: P Chauhan, WS Sheng, S Hu, S Prasad, JR Lokensgard
    Brain sciences, 2021-11-10;11(11):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. The effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons
    Authors: Y Shi, S Li, H Zhang, J Zhu, T Che, B Yan, J Li, C Liu
    Journal of Neuroinflammation, 2021-11-08;18(1):261.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal &gamma&delta T�cells
    Authors: L Dupraz, A Magniez, N Rolhion, ML Richard, G Da Costa, S Touch, C Mayeur, J Planchais, A Agus, C Danne, C Michaudel, M Spatz, F Trottein, P Langella, H Sokol, ML Michel
    Cell Reports, 2021-07-06;36(1):109332.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages
    Authors: JK Dowling, R Afzal, LJ Gearing, MP Cervantes-, S Annett, GM Davis, C De Santi, N Assmann, K Dettmer, DJ Gough, GR Bantug, FI Hamid, FK Nally, CP Duffy, AL Gorman, AM Liddicoat, EC Lavelle, C Hess, PJ Oefner, DK Finlay, GP Davey, T Robson, AM Curtis, PJ Hertzog, BRG Williams, CE McCoy
    Nature Communications, 2021-03-05;12(1):1460.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Luteolin Regulates the Differentiation of Regulatory T Cells and Activates IL-10-Dependent Macrophage Polarization against Acute Lung Injury
    Authors: K Xie, YS Chai, SH Lin, F Xu, CJ Wang
    Journal of Immunology Research, 2021-01-18;2021(0):8883962.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Gut-licensed IFN&gamma+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
    Authors: LM Sanmarco, MA Wheeler, C Gutiérrez-, CM Polonio, M Linnerbaue, FA Pinho-Ribe, Z Li, F Giovannoni, KV Batterman, G Scalisi, SEJ Zandee, ES Heck, M Alsuwailm, DL Rosene, B Becher, IM Chiu, A Prat, FJ Quintana
    Nature, 2021-01-06;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Harnessing hyaluronic acid-based nanoparticles for combination therapy: A novel approach for suppressing systemic inflammation and to promote antitumor macrophage polarization
    Authors: VK Rangasami, S Samanta, VS Parihar, K Asawa, K Zhu, OP Varghese, Y Teramura, B Nilsson, J Hilborn, RA Harris, OP Oommen
    Carbohydrate polymers, 2020-10-27;254(0):117291.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Lactic acid bacterium, Lactobacillus paracasei KW3110, suppresses inflammatory stress-induced caspase-1 activation by promoting interleukin-10 production in mouse and human immune cells
    Authors: T Yamazaki, K Ohshio, M Sugamata, Y Morita
    PLoS ONE, 2020-08-17;15(8):e0237754.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression
    Authors: JPM Luiz, JE Toller-Kaw, PR Viacava, DC Nascimento, PT Pereira, AL Saraiva, DS Prado, M LeBert, E Giurisato, C Tournier, TM Cunha, FQ Cunha, V Quesniaux, B Ryffel, JC Alves-Filh
    J. Leukoc. Biol., 2020-08-03;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Progranulin Improves Acute Lung Injury through Regulating the Differentiation of Regulatory T Cells and Interleukin-10 Immunomodulation to Promote Macrophage Polarization
    Authors: YQ Chen, CJ Wang, K Xie, M Lei, YS Chai, F Xu, SH Lin
    Mediators Inflamm., 2020-05-31;2020(0):9704327.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Stimulation
  22. Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice
    Authors: AS Nelson, M Maddaloni, JR Abbott, C Hoffman, A Akgul, C Ohland, RZ Gharaibeh, C Jobin, TM Brusko, DW Pascual
    Sci Rep, 2020-04-09;10(1):6156.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Standard
  23. Macrophages employ quorum licensing to regulate collective activation
    Authors: JJ Muldoon, Y Chuang, N Bagheri, JN Leonard
    Nat Commun, 2020-02-13;11(1):878.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Impact of aging on transition of acute kidney injury to chronic kidney disease
    Authors: MG Kim, J Yang, YS Ko, HY Lee, SW Oh, WY Cho, SK Jo
    Sci Rep, 2019-12-05;9(1):18445.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Lipocalin-2 (Lcn-2) Attenuates Polymicrobial Sepsis with LPS Preconditioning (LPS Tolerance) in FcGRIIb Deficient Lupus Mice
    Authors: T Ondee, J Gillen, P Visitchana, P Somparn, J Issara-Amp, C Dang Phi, W Chancharoe, D Gurusamy, A Nita-Lazar, A Leelahavan
    Cells, 2019-09-11;8(9):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Lysophosphatidic acid up-regulates IL-10 production to inhibit TNF-α synthesis in M?s stimulated with LPS
    Authors: A Ciesielska, A Hromada-Ju, E Ziemli?ska, K Kwiatkowsk
    J. Leukoc. Biol., 2019-07-23;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages
    Authors: I Hayek, F Fischer, J Schulze-Lu, K Dettmer, K Sobotta, V Schatz, L Kohl, K Boden, R Lang, PJ Oefner, S Wirtz, J Jantsch, A Lührmann
    Cell Rep, 2019-03-26;26(13):3502-3510.e6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1
    Authors: K Paduch, A Debus, B Rai, U Schleicher, C Bogdan
    J. Immunol., 2019-01-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice.
    Authors: Maria J Forteza, Konstantinos A Polyzos, Roland Baumgartn, Bianca E Suur, Marion Mussbache, Daniel K Johansson, Andreas Hermansso, Göran K Hansson, Daniel F J Ketelhuth
    Frontiers in Immunology, 2018-05-07;0(0):1664-3224.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Differential Phagocytic Properties of CD45lowMicroglia and CD45highBrain Mononuclear Phagocytes-Activation and Age-Related Effects
    Authors: S Rangaraju, SA Raza, NX Li, R Betarbet, EB Dammer, D Duong, JJ Lah, NT Seyfried, AI Levey
    Front Immunol, 2018-03-02;9(0):405.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Murine ?-Herpesvirus 68 Induces Severe Lung Inflammation in IL-27-Deficient Mice with Liver Dysfunction Preventable by Oral Neomycin
    Authors: K Kanai, AM Park, A Watanabe, T Arikawa, T Yasui, H Yoshida, I Tsunoda, O Yoshie
    J. Immunol., 2018-03-02;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  32. A Novel Role for C5a in B-1 Cell Homeostasis
    Authors: K Bröker, J Figge, AF Magnusen, RA Manz, J Köhl, CM Karsten
    Front Immunol, 2018-02-19;9(0):258.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Reprograming Immunity to Food Allergens
    Authors: AL St John, GWX Ang, APS Rathore, SN Abraham
    J. Allergy Clin. Immunol., 2018-02-05;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  34. Interleukin 4 receptor-targeted pro-apoptotic peptide blocks tumor growth and metastasis by enhancing anti-tumor immunity
    Authors: SMP Vadevoo, JE Kim, GR Gunassekar, HK Jung, L Chi, DE Kim, SH Lee, SH Im, B Lee
    Mol. Cancer Ther., 2017-09-06;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency
    Authors: YY Sin, PR Price, LL Ballantyne, CD Funk
    Sci Rep, 2017-05-31;7(1):2585.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. IL-10 down-regulates the expression of survival associated gene hspX of Mycobacterium tuberculosis in murine macrophage
    Authors: B Jee, P Sharma, K Katoch, B Joshi, SK Awasthi
    Braz J Infect Dis, 2017-04-20;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Alternative activation-skewed microglia/macrophages promote hematoma resolution in experimental intracerebral hemorrhage
    Authors: CF Chang, J Wan, Q Li, SC Renfroe, NM Heller, J Wang
    Neurobiol. Dis., 2017-03-30;103(0):54-69.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  38. PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy
    Authors: S Gao, C Li, Y Zhu, Y Wang, A Sui, Y Zhong, B Xie, X Shen
    Sci Rep, 2017-02-17;7(0):42846.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Young microglia restore amyloid plaque clearance of aged microglia
    Authors: Anna Daria
    EMBO J, 2016-12-21;0(0):.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: Bioassay
  40. Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3(+)CD49b(-)Foxp3(-) regulatory T�cells
    Authors: W Dawicki, C Li, J Town, X Zhang, JR Gordon
    J. Allergy Clin. Immunol., 2016-10-26;139(5):1608-1620.e3.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA (Standard)
  41. Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta.
    Authors: Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J
    Immunol Cell Biol, 2016-05-10;94(8):747-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages.
    Authors: Zhu Y, Brown J, Sag D, Zhang L, Suttles J
    J Immunol, 2014-12-15;194(2):584-94.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
    Authors: Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y
    Cancer Res, 2014-12-09;75(2):306-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. GM-CSF treated F4/80+ BMCs improve murine hind limb ischemia similar to M-CSF differentiated macrophages.
    Authors: Kuwahara G, Nishinakamura H, Kojima D, Tashiro T, Kodama S
    PLoS ONE, 2014-09-09;9(9):e106987.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  45. TLR9 ligands induce S100A8 in macrophages via a STAT3-dependent pathway which requires IL-10 and PGE2.
    Authors: Hsu, Kenneth, Chung, Yuen Min, Endoh, Yasumi, Geczy, Carolyn
    PLoS ONE, 2014-08-06;9(8):e103629.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. TGF-beta signaling initiated in dendritic cells instructs suppressive effects on Th17 differentiation at the site of neuroinflammation.
    Authors: Speck S, Lim J, Shelake S, Matka M, Stoddard J, Farr A, Kuchroo V, Laouar Y
    PLoS ONE, 2014-07-29;9(7):e102390.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA (Standard)
  47. Wound administration of M2-polarized macrophages does not improve murine cutaneous healing responses.
    Authors: Jetten, Nadine, Roumans, Nadia, Gijbels, Marion J, Romano, Andrea, Post, Mark J, de Winther, Menno P, van der Hulst, Rene R W, Xanthoulea, Sofia
    PLoS ONE, 2014-07-28;9(7):e102994.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. beta-Arrestin 2 negatively regulates Toll-like receptor 4 (TLR4)-triggered inflammatory signaling via targeting p38 MAPK and interleukin 10.
    Authors: Li H, Hu D, Fan H, Zhang Y, LeSage G, Caudle Y, Stuart C, Liu Z, Yin D
    J Biol Chem, 2014-07-10;289(33):23075-85.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  49. miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORgammat and STAT3.
    Authors: Zhu E, Wang X, Zheng B, Wang Q, Hao J, Chen S, Zhao Q, Zhao L, Wu Z, Yin Z
    J Immunol, 2014-05-19;192(12):5599-609.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.
    Authors: Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C
    J Immunol, 2014-03-21;192(8):3569-81.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ELISA (Standard)
  51. IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation.
    Authors: Veremeyko, Tatyana, Siddiqui, Shafiudd, Sotnikov, Ilya, Yung, Amanda, Ponomarev, Eugene D
    PLoS ONE, 2013-12-16;8(12):e81774.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Thioredoxin-interacting protein gene expression via MondoA is rapidly and transiently suppressed during inflammatory responses.
    Authors: Kanari Y, Sato Y, Aoyama S, Muta T
    PLoS ONE, 2013-03-08;8(3):e59026.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. WNT5A Signaling Contributes to Abeta-Induced Neuroinflammation and Neurotoxicity.
    Authors: Li B, Zhong L, Yang X, Andersson T, Huang M, Tang SJ
    PLoS ONE, 2011-08-17;6(8):e22920.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
    J. Virol., 2010-09-29;84(24):12703-12.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  56. Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection.
    Authors: Findlay EG, Greig R, Stumhofer JS
    J. Immunol., 2010-07-14;185(4):2482-92.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  57. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.
    Authors: Ilarregui JM, Croci DO, Bianco GA, Toscano MA, Salatino M, Vermeulen ME, Geffner JR, Rabinovich GA
    Nat. Immunol., 2009-08-09;10(9):981-91.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Role of interleukin 10 in murine postoperative ileus.
    Authors: Stoffels B, Schmidt J, Nakao A, Nazir A, Chanthaphavong RS, Bauer AJ
    Gut, 2009-05-01;58(5):648-60.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  59. The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies.
    Authors: Tewari N, Kalkunte S, Murray DW, Sharma S
    J. Biol. Chem., 2009-03-30;284(22):15224-32.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  60. ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T
    Microbes Infect., 2009-03-13;11(4):524-30.
    Applications: ELISA (Standard)
  61. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T
    Immunology, 2008-04-03;125(2):272-9.
    Applications: ELISA (Standard)
  62. Adverse functions of IL-17A in experimental sepsis.
    Authors: Flierl MA, Rittirsch D, Gao H, Hoesel LM, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ferrara JL, Ward PA
    FASEB J., 2008-02-25;22(7):2198-205.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Dendritic cells loaded with apoptotic antibody-coated tumor cells provide protective immunity against B-cell lymphoma in vivo.
    Authors: Franki SN, Steward KK, Betting DJ, Kafi K, Yamada RE, Timmerman JM
    Blood, 2007-11-09;111(3):1504-11.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  64. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells.
    Authors: Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA
    J. Immunol., 2007-02-15;178(4):2018-27.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors.
    Authors: Hajjar AM, Harvey MD, Shaffer SA, Goodlett DR, Sjostedt A, Edebro H, Forsman M, Bystrom M, Pelletier M, Wilson CB, Miller SI, Skerrett SJ, Ernst RK
    Infect. Immun., 2006-09-18;74(12):6730-8.
    Applications: ELISA (Standard)
  66. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.
    Authors: Osuchowski MF, Welch K, Siddiqui J, Remick DG
    J. Immunol., 2006-08-01;177(3):1967-74.
    Applications: ELISA (Standard)
  67. In vivo IL-10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF-beta in the lung.
    Authors: Nakagome K, Dohi M, Okunishi K, Tanaka R, Miyazaki J, Yamamoto K
    Thorax, 2006-06-29;61(10):886-94.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile.
    Authors: Wen H, Hogaboam CM, Gauldie J, Kunkel SL
    Am. J. Pathol., 2006-06-01;168(6):1940-50.
    Applications: ELISA (Standard)
  69. Sequential ELISA to profile multiple cytokines from small volumes.
    Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
    J. Immunol. Methods, 2005-07-01;302(1):172-81.
    Applications: ELISA (Standard)
  70. Selective macrophage suppression during sepsis.
    Authors: Ellaban E, Bolgos G, Remick D
    Cell. Immunol., 2005-02-26;231(1):103-11.
    Applications: ELISA (Standard)
  71. IL-22 increases the innate immunity of tissues.
    Authors: Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R
    Immunity, 2004-08-01;21(2):241-54.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  72. IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis.
    Authors: Sharif MN, Tassiulas I, Hu Y, Mecklenbrauker I, Tarakhovsky A, Ivashkiv LB
    J. Immunol., 2004-05-15;172(10):6476-81.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.
    Authors: Chen, WanJun, Jin, Wenwen, Hardegen, Neil, Lei, Ke-Jian, Li, Li, Marinos, Nancy, McGrady, George, Wahl, Sharon M
    J Exp Med, 2003-12-15;198(12):1875-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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