Recombinant Mouse CCL1/TCA-3 Protein Summary
Product Specifications
Lys24-Cys92
Analysis
Product Datasheets
845-TC (with carrier)
845-TC/CF (carrier free)
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
845-TC
| Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. |
| Reconstitution | Reconstitute at 25 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
845-TC/CF
| Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Background: CCL1/I-309/TCA-3
Mouse TCA-3 is a member of the CC beta family of chemokines. The human chemokine I-309, which shares approximately 42% amino acid (aa) sequence identity, has been assumed to be the homologue of mouse TCA-3. Mouse TCA-3 and human I-309 also share significant sequence homology in the 5' flanking region of their genes and each contain an extra pair of cysteine residues not found in most other chemokines.
TCA-3 cDNA encodes a 92 aa residue precursor protein with a predicted 23 aa signal peptide that is cleaved to produce a 69 aa mature protein. The sequence of TCA-3 contains one potential N-linked glycosylation site. Mouse TCA-3 is found on the distal portion of mouse chromosome 11 in a cluster with MIP-1 alpha, MIP-1 beta and JE. TCA-3 acts by binding to the seven transmembrane spanning G-protein-coupled receptor, CCR8. TCA-3 has been shown to chemoattract T-cells.
- Goya, I. et al. (1998) J. Immunol. 160:1975.
- Burd, P. et al. (1987) J. Immunol. 139:3126.
Citations for Recombinant Mouse CCL1/TCA-3 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 9
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Gut-derived memory ?? T17 cells exacerbate sepsis-induced acute lung injury in mice
Authors: Xie, B;Wang, M;Zhang, X;Zhang, Y;Qi, H;Liu, H;Wu, Y;Wen, X;Chen, X;Han, M;Xu, D;Sun, X;Zhang, X;Zhao, X;Shang, Y;Yuan, S;Zhang, J;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CC chemokine CCL1 receptor CCR8 mediates conversion of mesenchymal stem cells to embryoid bodies expressing FOXP3+CCR8+ regulatory T cells
Authors: NS Haque, A Tuteja, N Haque
PLoS ONE, 2019-07-17;14(7):e0218944.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Sox2 Communicates With Tregs Through CCL1 To Promote The Stemness Property Of Breast Cancer Cells
Authors: Y Xu, X Dong, P Qi, Y Ye, W Shen, L Leng, L Wang, X Li, X Luo, Y Chen, P Sun, R Xiang, N Li
Stem Cells, 2017-12-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require ?4?1 Integrin To Migrate between the Peritoneum and Inflamed Skin
Authors: SA Geherin, D Gómez, RA Glabman, G Ruthel, A Hamann, GF Debes
J. Immunol, 2016-02-05;196(6):2514-25.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mast cell FcepsilonRI-induced early growth response 2 regulates CC chemokine ligand 1-dependent CD4+ T cell migration.
Authors: Wu Z, MacNeil A, Junkins R, Li B, Berman J, Lin T
J Immunol, 2013-03-27;190(9):4500-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.
Authors: Islam SA, Chang DS, Colvin RA
Nat. Immunol., 2011-01-09;12(2):167-77.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway.
Authors: Kearley J, Buckland KF, Mathie SA, Lloyd CM
Am. J. Respir. Crit. Care Med., 2009-01-29;179(9):772-81.
Applications: ELISA (Standard) -
CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling.
Authors: Kearley J, Robinson DS, Lloyd CM
J. Allergy Clin. Immunol., 2008-07-30;122(3):617-24.e6.
Applications: ELISA (Standard) -
Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1.
Authors: Najarro P, Lee HJ, Fox J, Pease J, Smith GL
J. Gen. Virol., 2003-12-01;84(0):3325-36.
Species: Virus
Sample Types: Whole Cells
Applications: Bioassay
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Average Rating: 4.5 (Based on 2 Reviews)
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Reason for Rating: SEC elution consistent with expected MW, material appears to be good quality
