Home / PDGF-AA / Recombinant Human PDGF-AA Protein, CF

Recombinant Human PDGF-AA Protein, CF

Catalog #: 221-AA
57 Citations 5 Reviews Datasheet
GMP Version Available: 221-GMP
GMP
Catalog # Availability Size / Price Qty
221-AA-010
221-AA-050
221-AA-025
221-AA-100
221-AA-01M
Graph showing bioactivity of PDGF-AA ability to induce NR6R-3T3 mouse fibroblast cell proliferation
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Product Details
Citations (57)
FAQs
Supplemental Products
Reviews (5)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human PDGF-AA Protein, CF Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109:749. The ED50 for this effect is 50-200 ng/mL in a fluorometric assay using the redox sensitive dye, Resazurin (Catalog # AR002).
Source
E. coli-derived human PDGF-AA protein
Ser87-Thr211, with and without an N-terminal Met
Accession #
P04085
N-terminal Sequence
Analysis
Ser87 and Met
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
14 kDa (monomer)

Product Datasheets

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221-AA

Product Datasheet

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

221-AA

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute at 100 μg/mL in sterile 4 mM HCl.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Graph showing bioactivity of PDGF-AA ability to induce NR6R-3T3 mouse fibroblast cell proliferation View Larger

Recombinant Human PDGF-AA 221-AA stimulates cell proliferation in the NR6R‑3T3 mouse fibroblast cell line in a dose-dependent manner. The ED50 for this effect is 50-200 ng/mL.

Cell Culture Staining of oligodendrocytes with anti-Oligodendrocyte Marker O4 in red and counterstained with DAPI in blue View Larger

D3 mouse embryonic stem cells were expanded in KO-ES Media supplemented with Bovine Fibronectin Protein (1030-FN) to support cell attachment and spreading, the ITS and N-2 Plus Media Supplements (AR013 and AR003), and a panel of growth factors for effective oligodendrocyte differentiation, including Recombinant Human FGF-basic, Recombinant Human EGF (236-EG), and Recombinant Human PDGF-AA (Catalog # 221-AA). Oligodendrocytes were detected using a Mouse Anti-Human/Mouse/Rat/Chicken Oligodendrocyte Marker O4 Monoclonal Antibody (MAB1326). The cells were stained with the NorthernLights™-557 Affinity-purified Goat Anti-Mouse IgM Secondary Antibody (NL019; red). The nuclei were counterstained with DAPI (5748; blue).

Background: PDGF-AA

Platelet-derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. It was found to be secreted from the alpha -granules of platelets activated during the coagulation of blood to form serum. Subsequent studies have demonstrated that PDGF is not one molecule but three, each a dimeric combination of two distinct but structurally related peptide chains designated A and B. The dimeric isoforms PDGF-AA, AB and BB are differentially expressed in various cell types and their effects are mediated through two distinct receptors, termed alpha and beta. Differences exist in isoform binding to each receptor. In general, PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. In addition to its activity as a mitogen, PDGF is chemotactic for fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. Other reported activities for PDGF include stimulation of granule release by neutrophils and monocytes, facilitation of steroid synthesis by Leydig cells, stimulation of neutrophil phagocytosis, inhibition of natural killer (NK) cell activity, stimulation of collagen synthesis, modulation of thrombospondin expression and secretion, stimulation of collagenase activity and secretion, induction of contraction of rat aorta strips in vitro, and transient induction of T cell IL-2 secretion accompanied by a down-regulation of IL-4 and IFN-gamma production, temporary effects that may allow clonal expansion of antigen-activated B and T helper lymphocytes prior to differentiation. PDGF also appears to be ubiquitous in neurons throughout the CNS, where it is suggested to play an important role in neuron survival and regeneration, and in mediation of glial cell proliferation and differentiation.

Long Name
Platelet-derived Growth Factor AA
Entrez Gene IDs
5154 (Human); 25266 (Rat)
Alternate Names
PDGF1; PDGF-A; PDGFAA; PDGF-AA

Citations for Recombinant Human PDGF-AA Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

57 Citations: Showing 1 - 10
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  1. Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor
    Authors: Guo, T;Pei, F;Zhang, M;Yamada, T;Feng, J;Jing, J;Ho, TV;Chai, Y;
    Cell stem cell
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs
    Authors: Krug, B;Hu, B;Chen, H;Ptack, A;Chen, X;Gretarsson, KH;Deshmukh, S;Kabir, N;Andrade, AF;Jabbour, E;Harutyunyan, AS;Lee, JJY;Hulswit, M;Faury, D;Russo, C;Xu, X;Johnston, MJ;Baguette, A;Dahl, NA;Weil, AG;Ellezam, B;Dali, R;Blanchette, M;Wilson, K;Garcia, BA;Soni, RK;Gallo, M;Taylor, MD;Kleinman, CL;Majewski, J;Jabado, N;Lu, C;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells
    Authors: Jovanovic, VM;Weber, C;Slamecka, J;Ryu, S;Chu, PH;Sen, C;Inman, J;De Sousa, JF;Barnaeva, E;Hirst, M;Galbraith, D;Ormanoglu, P;Jethmalani, Y;Mercado, JC;Michael, S;Ward, ME;Simeonov, A;Voss, TC;Tristan, CA;Singeç, I;
    Stem cell reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Pervasive environmental chemicals impair oligodendrocyte development
    Authors: EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar
    bioRxiv : the preprint server for biology, 2023-02-12;0(0):.
    Species: Human, Mouse
    Sample Types: Organoid, Whole Cells
    Applications: Bioassay
  5. Activating transcription factor-2 supports the antioxidant capacity and ability of human mesenchymal stem cells to prevent asthmatic airway inflammation
    Authors: H Ju, H Yun, Y Kim, YJ Nam, S Lee, J Lee, SM Jeong, J Heo, H Kwon, YS Cho, G Jeong, CM Ryu, DM Shin
    Experimental & Molecular Medicine, 2023-02-10;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome
    Authors: NB Campbell, Y Patel, TL Moore, M Medalla, E Zeldich
    International Journal of Molecular Sciences, 2023-02-09;24(4):.
    Species: Human
    Sample Types: Spheroid
    Applications: Bioassay
  7. Analysis of the chemotactic factors for tumor-infiltrating fibrocytes and their prognostic significances in lung cancer
    Authors: M Tobiume, A Mitsuhashi, A Saijo, H Ogino, T Afroj, H Ogawa, H Goto, S Sato, A Abe, K Haji, R Ozaki, H Takizawa, Y Nishioka
    Oncology Letters, 2022-09-30;24(5):417.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
    Authors: Y Tang, DJ Kwiatkowsk, EP Henske
    Nature Communications, 2022-08-26;13(1):5018.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay
    Authors: S Martin, KC Allan, O Pinkard, T Sweet, PJ Tesar, J Coller
    Nature Communications, 2022-08-25;13(1):5003.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. SM22alpha-lineage niche cells regulate intramembranous bone regeneration via PDGFRbeta-triggered hydrogen sulfide production
    Authors: X Zhou, J Liu, Y Zheng, Z Zhang, Y Wu, W Yang, J Liu, Y Huang, Y Yi, Z Zhao, H Xiao, X Mo, J Wang
    Cell Reports, 2022-05-03;39(5):110750.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. PDGFR-beta signaling mediates HMGB1 release in mechanically stressed vascular smooth muscle cells
    Authors: JO Kim, SE Baek, EY Jeon, JM Choi, EJ Jang, CD Kim
    PLoS ONE, 2022-03-16;17(3):e0265191.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  12. PDGFR&alpha: Expression and Function during Mitral Valve Morphogenesis
    Authors: K Moore, D Fulmer, L Guo, N Koren, J Glover, R Moore, C Gensemer, T Beck, J Morningsta, R Stairley, RA Norris
    Journal of cardiovascular development and disease, 2021-03-13;8(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells
    Authors: X Chamling, A Kallman, W Fang, CA Berlinicke, JL Mertz, P Devkota, IEM Pantoja, MD Smith, Z Ji, C Chang, A Kaushik, L Chen, KA Whartenby, PA Calabresi, HQ Mao, H Ji, TH Wang, DJ Zack
    Nature Communications, 2021-01-28;12(1):652.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response
    Authors: C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen, G Sun, J Wang, V Arumugaswa, Y Shi
    Cell Stem Cell, 2021-01-04;28(2):331-342.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Pluripotent epigenetic regulator OBP-801 maintains filtering blebs in glaucoma filtration surgery model
    Authors: Y Yamamoto, A Mukai, T Ikushima, Y Urata, S Kinoshita, J Hamuro, M Ueno, C Sotozono
    Scientific Reports, 2020-12-01;10(1):20936.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  16. PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney disease
    Authors: K Song, Y Qing, Q Guo, EK Peden, C Chen, WE Mitch, L Truong, J Cheng
    JCI Insight, 2020-11-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
    Authors: KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar
    Cell Stem Cell, 2020-10-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Establishment of a simple one-step method for oligodendrocyte progenitor cell preparation from rodent brains
    Authors: A Yoshida, K Takashima, T Shimonaga, M Kadokura, S Nagase, S Koda
    J. Neurosci. Methods, 2020-05-30;0(0):108798.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1-NRF2 pathway
    Authors: J Lim, J Heo, H Ju, JW Shin, Y Kim, S Lee, HY Yu, CM Ryu, H Yun, S Song, KS Hong, HM Chung, HR Kim, JS Roe, K Choi, IG Kim, EM Jeong, DM Shin
    Sci Adv, 2020-04-15;6(16):eaba1334.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Novel roles of PRK1 and PRK2 in cilia and cancer biology
    Authors: H Patel, J Li, A Herrero, J Kroboth, A Byron, AV Kriegsheim, V Brunton, N Carragher, T Hurd, M Frame
    Sci Rep, 2020-03-03;10(1):3902.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors
    Authors: M Matjusaiti, LJ Wagstaff, A Martella, B Baranowski, C Blin, S Gogolok, A Williams, SM Pollard
    Stem Cell Reports, 2019-11-07;13(6):1053-1067.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  22. The effects of Centella asiatica (L.) Urban on neural differentiation of human mesenchymal stem cells in vitro
    Authors: N Omar, Y Lokanathan, ZR Mohd Razi, R Bt Haji Id
    BMC Complement Altern Med, 2019-07-08;19(1):167.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  23. Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling
    Authors: Z Liu, M Osipovitch, A Benraiss, NPT Huynh, R Foti, J Bates, D Chandler-M, RL Findling, PJ Tesar, M Nedergaard, MS Windrem, SA Goldman
    Cell Rep, 2019-06-25;27(13):3832-3843.e6.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  24. Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair
    Authors: T Colunga, M Hayworth, S Kre beta, DM Reynolds, L Chen, KL Nazor, J Baur, AM Singh, JF Loring, M Metzger, S Dalton
    Cell Rep, 2019-03-05;26(10):2566-2579.e10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Selective estrogen receptor modulators enhance CNS remyelination independent of estrogen receptors
    Authors: KA Rankin, F Mei, K Kim, YA Shen, SR Mayoral, C Desponts, DS Lorrain, AJ Green, SE Baranzini, JR Chan, R Bove
    J. Neurosci., 2019-01-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures
    Authors: RM Marton, Y Miura, SA Sloan, Q Li, O Revah, RJ Levy, JR Huguenard, SP Pa?ca
    Nat. Neurosci., 2019-01-28;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation
    Authors: M Osipovitch, A Asenjo Mar, JN Mariani, A Cornwell, S Dhaliwal, L Zou, D Chandler-M, S Wang, X Li, SJ Benraiss, R Agate, A Lampp, A Benraiss, MS Windrem, SA Goldman
    Cell Stem Cell, 2018-12-13;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. STAT3 exacerbates survival of cancer stem-like tumorspheres in EGFR-positive colorectal cancers: RNAseq analysis and therapeutic screening
    Authors: CC Cheng, PN Liao, AS Ho, KH Lim, J Chang, YW Su, CG Chen, YW Chiang, BL Yang, HC Lin, YC Chang, CC Chang, YF Chang
    J. Biomed. Sci., 2018-08-02;25(1):60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy
    Authors: P Piñol-Jura, X Suárez-Cal, E Fernández-, E Gallardo, N de la Oliv, A Martínez-M, P Gómez-Gálv, LM Escudero, M Pérez-Peir, L Wollin, N de Luna, X Navarro, I Illa, J Díaz-Maner
    Cell Death Dis, 2018-07-10;9(7):776.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Teriflunomide promotes oligodendroglial differentiation and myelination
    Authors: P Göttle, A Manousi, D Kremer, L Reiche, HP Hartung, P Küry
    J Neuroinflammation, 2018-03-13;15(1):76.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics
    Authors: SB Mamer, S Chen, JC Weddell, A Palasz, A Wittenkell, M Kumar, PI Imoukhuede
    Sci Rep, 2017-11-27;7(1):16439.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance
  32. Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
    Authors: A Campbell, JM Hogestyn, CJ Folts, B Lopez, C Pröschel, D Mock, M Mayer-Prös
    Sci Rep, 2017-06-21;7(1):3978.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells
    Authors: R Santos, KC Vadodaria, BN Jaeger, A Mei, S Lefcochilo, APD Mendes, G Erikson, M Shokhirev, L Randolph-M, C Fredlender, S Dave, R Oefner, C Fitzpatric, M Pena, JJ Barron, M Ku, AM Denli, BE Kerman, P Charnay, JR Kelsoe, MC Marchetto, FH Gage
    Stem Cell Reports, 2017-06-06;8(6):1757-1769.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-? as a key for entry
    Authors: Y Wu, A Prager, S Boos, M Resch, I Brizic, M Mach, S Wildner, L Scrivano, B Adler
    PLoS Pathog., 2017-04-12;13(4):e1006281.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes
    Authors: ZS Nevin, DC Factor, RT Karl, P Douvaras, J Laukka, MS Windrem, SA Goldman, V Fossati, GM Hobson, PJ Tesar
    Am. J. Hum. Genet., 2017-03-30;100(4):617-634.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3
    Authors: H He, AE Kuriyan, CW Su, M Mahabole, Y Zhang, YT Zhu, HW Flynn, JM Parel, SC Tseng
    Sci Rep, 2017-03-02;7(0):43736.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Store-operated calcium entry is essential for glial calcium signalling in CNS white matter
    Authors: M Papanikola, A Lewis, AM Butt
    Brain Struct Funct, 2017-02-28;0(0):.
    Species: Mouse
    Sample Types: Optic Nerve Explant
    Applications: Bioassay
  38. Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells
    Authors: T Yamashita, Y Miyamoto, Y Bando, T Ono, S Kobayashi, A Doi, T Araki, Y Kato, T Shirakawa, Y Suzuki, J Yamauchi, S Yoshida, N Sato
    PLoS ONE, 2017-02-13;12(2):e0171947.
    Species: Primate
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Retinal Proteoglycans Act as Cellular Receptors for Basement Membrane Assembly to Control Astrocyte Migration and Angiogenesis
    Cell Rep, 2016-11-08;17(7):1832-1844.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Neuroprotective effects of oligodendrocyte progenitor cell transplantation in premature rat brain following hypoxic-ischemic injury.
    Authors: Chen, Long-Xia, Ma, Si-Min, Zhang, Peng, Fan, Zi-Chuan, Xiong, Man, Cheng, Guo-Qian, Yang, Yi, Qiu, Zi-Long, Zhou, Wen-Hao, Li, Jin
    PLoS ONE, 2015-03-19;10(3):e0115997.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Oligodendroglial maturation is dependent on intracellular protein shuttling.
    Authors: Gottle P, Sabo J, Heinen A, Venables G, Torres K, Tzekova N, Parras C, Kremer D, Hartung H, Cate H, Kury P
    J Neurosci, 2015-01-21;35(3):906-19.
    Species: Human, Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis.
    Authors: Hayes B, Riehle K, Shimizu-Albergine M, Bauer R, Hudkins K, Johansson F, Yeh M, Mahoney W, Yeung R, Campbell J
    PLoS ONE, 2014-03-25;9(3):e92925.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Biologic effects of platelet-derived growth factor receptor alpha blockade in uterine cancer.
    Authors: Roh J, Huang J, Hu W, Yang X, Jennings N, Sehgal V, Sohn B, Han H, Lee S, Thanapprapasr D, Bottsford-Miller J, Zand B, Dalton H, Previs R, Davis A, Matsuo K, Lee J, Ram P, Coleman R, Sood A
    Clin Cancer Res, 2014-03-14;20(10):2740-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst.
    Authors: Artus J, Panthier JJ, Hadjantonakis AK
    Development, 2010-09-08;137(20):3361-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity.
    Authors: Jones JL, Anderson JM, Phuah CL, Fox EJ, Selmaj K, Margolin D, Lake SL, Palmer J, Thompson SJ, Wilkins A, Webber DJ, Compston DA, Coles AJ
    Brain, 2010-07-21;133(0):2232-47.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells.
    Authors: Ball SG, Bayley C, Shuttleworth CA, Kielty CM
    Biochem. J., 2010-03-15;427(1):29-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Efficient Serum-Free Derivation of Oligodendrocyte Precursors from Neural Stem Cell-Enriched Cultures.
    Authors: Rao RC, Boyd J, Padmanabhan R, Chenoweth JG, McKay RD
    Stem Cells, 2009-01-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection.
    Authors: Soroceanu L, Akhavan A, Cobbs CS
    Nature, 2008-08-13;455(7211):391-5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression.
    Authors: Wagsater D, Zhu C, Bjorck HM, Eriksson P
    Atherosclerosis, 2008-05-22;202(2):415-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Development and validation of sandwich ELISA microarrays with minimal assay interference.
    Authors: Gonzalez RM, Seurynck-Servoss SL, Crowley SA
    J. Proteome Res., 2008-04-19;7(6):2406-14.
    Applications: ELISA (Standard)
  51. Musashi1 RNA-binding protein regulates oligodendrocyte lineage cell differentiation and survival.
    Authors: Dobson NR, Zhou YX, Flint NC, Armstrong RC
    Glia, 2008-02-01;56(3):318-30.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  52. PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines.
    Authors: Li R, Maminishkis A, Wang FE, Miller SS
    Invest. Ophthalmol. Vis. Sci., 2007-12-01;48(12):5722-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
    Authors: Ball SG, Shuttleworth CA, Kielty CM
    J. Cell Biol., 2007-04-30;177(3):489-500.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling.
    Authors: Jackson EL, Garcia-Verdugo JM, Gil-Perotin S, Roy M, Quinones-Hinojosa A, VandenBerg S, Alvarez-Buylla A
    Neuron, 2006-07-20;51(2):187-99.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  55. Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
    Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
    J. Cell. Physiol., 2005-04-01;203(1):35-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads.
    Authors: Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI
    Am. J. Respir. Cell Mol. Biol., 2004-01-12;30(6):816-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein.
    Authors: Mogi K, Goto M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi R
    Int. J. Dev. Biol., 2003-02-01;47(1):15-29.
    Species: Xenopus
    Sample Types: In Vivo
    Applications: In Vivo

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Reviews for Recombinant Human PDGF-AA Protein, CF

Average Rating: 4.4 (Based on 5 Reviews)

5 Star
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4 Star
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3 Star
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Recombinant Human PDGF-AA Protein, CF
By Abhijit Nirwane on 06/10/2021
Application: In vitro bioactivity in cell culture
Recombinant Human PDGF-AA Protein, CF
By Anonymous on 01/09/2020
Application: Stem/Immune cell maintenance or differentiation
Reason for Rating: PDGF-AA Protein was used to differentiate human iPS cells into oligodendrocytes precursors. Performed reliably and consistently
Stem/Immune cell maintenance or differentiation Recombinant Human PDGF-AA Protein, CF 221-AA
Recombinant Human PDGF-AA Protein, CF
By Anonymous on 07/19/2018
Application: Stem/Immune cell maintenance or differentiation
Stem/Immune cell maintenance or differentiation Recombinant Human PDGF-AA Protein, CF 221-AA
Recombinant Human PDGF-AA Protein, CF
By Punitha Senthil on 07/07/2018
Application: Stem/Immune cell maintenance or differentiation
Stem/Immune cell maintenance or differentiation Recombinant Human PDGF-AA Protein, CF 221-AA
Recombinant Human PDGF-AA Protein, CF
By Anonymous on 02/07/2018
Application: SDS-PAGE Control
SDS-PAGE Control Recombinant Human PDGF-AA Protein, CF 221-AA